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\u9664\u57fa\u56e0\u6d4b\u5e8f\u5916\uff0c\u5b89\u5e8f\u6e90\u540c\u65f6\u5e03\u5c40\u975e\u6d4b\u5e8f\u7c7b\u5206\u5b50\u8bca\u65ad\u5e02\u573a\u3002\u8fd9\u4e00\u9886\u57df\u5168\u7403\u5e02\u573a\u9ad8\u5ea6\u5206\u6563\uff0c\u4f46\u5934\u90e8\u4f01\u4e1a\u4f18\u52bf\u540c\u6837\u660e\u663e\u30022024\u5e74\u4e2d\u56fd\u975e\u6d4b\u5e8f\u5206\u5b50\u68c0\u6d4b\u5e02\u573a\u524d\u4e94\u5927\u4f01\u4e1a\u5408\u8ba1\u5360\u636e\u8d85\u8fc750%\u7684\u4efd\u989d\uff0c\u5176\u4e2d\u6700\u5927\u4f01\u4e1a\u5e02\u573a\u4efd\u989d\u8fbe13.2%\u3002<\/p>\n

\u800c\u5728\u7535\u5316\u5b66\u591a\u91cdPCR\u5fae\u9635\u5217\u68c0\u6d4b\u8fd9\u4e00\u7ec6\u5206\u9886\u57df\uff0c\u622a\u81f32025\u5e7412\u670831\u65e5\uff0c\u56fd\u5185\u4ec5\u6709\u4e24\u6b3e\u4ea7\u54c1\u83b7\u6279\uff0c\u5b89\u5e8f\u6e90\u7684EL-100\u4fbf\u662f\u5176\u4e2d\u4e4b\u4e00\u3002\u8fd9\u6b3e\u4ea7\u54c1\u91cd\u91cf\u4ec56.15\u516c\u65a4\uff0c\u91c7\u7528\u5c0f\u578b\u4fbf\u643a\u8bbe\u8ba1\u3002<\/p>\n

\u62db\u80a1\u4e66\u6307\u51fa\uff0c\u5b83\u201c\u4e0d\u540c\u4e8e\u4e13\u4e3a\u96c6\u4e2d\u5f0f\u3001\u9ad8\u901a\u91cf\u73af\u5883\u8bbe\u8ba1\u7684\u5927\u578b\u4eea\u5668\u201d\uff0c\u7279\u522b\u9002\u7528\u4e8e\u7a7a\u95f4\u6709\u9650\u7684\u5206\u5e03\u5f0f\u68c0\u6d4b\u573a\u666f\uff0c\u4f8b\u5982\u5c0f\u578b\u533b\u9662\u6216\u533a\u57df\u8bca\u6240\uff0c\u6709\u6548\u8865\u5145\u4e86PCR\u4eea\u5668\u4e0e\u57fa\u56e0\u6d4b\u5e8f\u4eea\u4e4b\u95f4\u7684\u5e02\u573a\u7f3a\u53e3\u3002<\/p>\n

\u5b89\u5e8f\u6e90\u8bd5\u56fe\u4ece\u6210\u672c\u7aef\u89e3\u51b3\u57fa\u5c42\u68c0\u6d4b\u201c\u7528\u4e0d\u8d77\u201d\u9ad8\u7cbe\u5ea6\u5206\u5b50\u8bca\u65ad\u7684\u75db\u70b9\u3002\u6839\u636e\u707c\u8bc6\u54a8\u8be2\u5728\u62db\u80a1\u4e66\u4e2d\u7684\u6570\u636e\uff0c\u7535\u5316\u5b66\u5e73\u53f0\u7684\u4eea\u5668\u6210\u672c\u4ec5\u4e3a\u4f20\u7edf\u8367\u5149\u5b9a\u91cfPCR\u4eea\u76841\/3\u81f31\/2\uff0c\u8bd5\u5242\u6210\u672c\u4e5f\u4ec5\u4e3a\u8367\u5149\u68c0\u6d4b\u8bd5\u5242\u76841\/2\u3002<\/p>\n

\u76ee\u524d\u5b89\u5e8f\u6e90\u591a\u6b3e\u4ea7\u54c1\u7ba1\u7ebf\u7a33\u6b65\u63a8\u8fdb\u843d\u5730\uff1aEL-100\u5df2\u4e8e2026\u5e743\u6708\u5b8c\u6210\u7f8e\u56fd\u4e34\u5e8a\u524d\u578b\u68c0\uff0c\u8ba1\u5212\u540c\u5e74\u4e09\u5b63\u5ea6\u542f\u52a8\u7f8e\u56fd\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u6d4b\u5e8f\u6838\u5fc3\u4ea7\u54c1AXP-100\u5df2\u4e8e2025\u5e7412\u6708\u5b8c\u6210\u56fd\u5185\u578b\u68c0\uff0c\u5b9a\u4e8e2026\u5e74\u4e09\u5b63\u5ea6\u5f00\u542f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u6b64\u5916\uff0c\u5347\u7ea7\u6b3eEL-100\uff08\u62d3\u5c55\u6838\u9178\u3001\u86cb\u767d\u8d28\u5168\u54c1\u7c7b\u68c0\u6d4b\uff09\u3001\u901a\u91cf\u63d0\u5347\u5341\u500d\u7684AXP-1000\u6d4b\u5e8f\u4eea\uff0c\u4ee5\u53ca\u591a\u6b3e\u9057\u4f20\u75c5\u3001\u75c5\u539f\u4f53\u68c0\u6d4b\u8bd5\u5242\u76d2\u5747\u5728\u7814\u53d1\u63a8\u8fdb\u4e2d\uff0c\u9884\u8ba12027\u5e74\u8d77\u9646\u7eed\u83b7\u6279\u5546\u4e1a\u5316\u3002<\/p>\n

\"3\u5e74\u70e7\u63894.6\u4ebf\uff0c\u4e09\u95ef\u6e2f\u80a1\uff0c\u5b89\u5e8f\u6e90\u4e3a\u82af\u7247\u6d4b\u5e8f\u8d4c\u4e0a\u5168\u90e8\u8eab\u5bb6\"<\/p>\n

\u4e00\u4e2a\u7269\u7406\u535a\u58eb\u7684\u201c\u66ff\u4ee3\u201d\u8def\u5f84<\/strong><\/p>\n

\u5728\u521b\u7acb\u5b89\u5e8f\u6e90\u4e4b\u524d\uff0c\u7530\u6656\u662f\u66fe\u89c1\u8bc1\u8fc7\u201c\u534a\u5bfc\u4f53\u6539\u9020\u4e00\u4e2a\u884c\u4e1a\u201d\u7684\u3002<\/p>\n

2000\u5e74\uff0c\u7530\u6656\u4ece\u65af\u5766\u798f\u62ff\u5230\u5e94\u7528\u7269\u7406\u535a\u58eb\u5b66\u4f4d\uff0c\u8fdb\u5165\u534a\u5bfc\u4f53\u884c\u4e1a\uff0c\u4ece\u4e8bCMOS \u56fe\u50cf\u4f20\u611f\u5668\u82af\u7247\u7814\u53d1\u3002\u5f7c\u65f6\uff0cCCD\u662f\u56fe\u50cf\u4f20\u611f\u9886\u57df\u7684\u738b\u8005\uff0c\u753b\u8d28\u6700\u597d\uff0c\u4f46\u5de5\u827a\u590d\u6742\u3001\u529f\u8017\u9ad8\u3001\u65e0\u6cd5\u4e0e\u5468\u8fb9\u7535\u8def\u96c6\u6210\u3002CMOS\u5219\u76f8\u53cd\uff0c\u753b\u8d28\u8fdc\u4e0d\u5982CCD\uff0c\u4f46\u4fbf\u5b9c\u3001\u7701\u7535\u3001\u80fd\u7528\u6807\u51c6\u534a\u5bfc\u4f53\u751f\u4ea7\u7ebf\u5236\u9020\u3002<\/p>\n

\u63a5\u4e0b\u6765\u8fd1\u5341\u5e74\uff0c\u7530\u6656\u5728Pixim\u3001InVisage\u3001Aptina\u7b49\u516c\u53f8\u4eb2\u8eab\u53c2\u4e0e\u4e86\u4e00\u573a\u66ff\u4ee3\uff1aCMOS\u82af\u7247\u4e00\u5bf8\u4e00\u5bf8\u5730\u8695\u98dfCCD\u7684\u5e02\u573a\uff0c\u56e0\u4e3a\u5b83\u628a\u201c\u62cd\u7167\u201d\u4ece\u7cbe\u5bc6\u5149\u5b66\u95ee\u9898\u53d8\u6210\u4e86\u534a\u5bfc\u4f53\u96c6\u6210\u95ee\u9898\u3002\u4e8e\u662f\uff0c\u6210\u672c\u964d\u4e0b\u6765\u4e86\uff0c\u4f53\u79ef\u7f29\u5c0f\u4e86\uff0c\u62cd\u7167\u529f\u80fd\u5d4c\u5165\u4e86\u624b\u673a\u3002<\/p>\n

\u6700\u540e\u7684\u7ed3\u5c40\uff0c\u5927\u5bb6\u90fd\u77e5\u9053\u4e86\uff1a\u624b\u673a\u201c\u6740\u6b7b\u201d\u4e86\u6570\u7801\u76f8\u673a\u3002<\/p>\n

\"3\u5e74\u70e7\u63894.6\u4ebf\uff0c\u4e09\u95ef\u6e2f\u80a1\uff0c\u5b89\u5e8f\u6e90\u4e3a\u82af\u7247\u6d4b\u5e8f\u8d4c\u4e0a\u5168\u90e8\u8eab\u5bb6\"<\/p>\n

\u56fe\uff5c\u5b89\u5e8f\u6e90\u5b98\u7f51<\/p>\n

2013\u5e74\uff0c\u7530\u6656\u8f6c\u8eab\u52a0\u5165Genia\u516c\u53f8\uff0c\u8d1f\u8d23\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\u82af\u7247\u7684\u7814\u53d1\u548c\u91cf\u4ea7\u3002\u5f7c\u65f6\u7684Genia\u4fe1\u5949\u7684\u7406\u5ff5\u5f02\u5e38\u8d85\u524d\uff1a\u5c06\u534a\u5bfc\u4f53\u82af\u7247\u4e0e\u7eb3\u7c73\u5b54\u6280\u672f\u7ed3\u5408\u3002\u8fd9\u6b63\u662f\u534a\u5bfc\u4f53\u6d4b\u5e8f\u8def\u7ebf\u4eceIon Torrent\u53d1\u7aef\u4e4b\u540e\u7684\u4e0b\u4e00\u4ee3\u6f14\u5316\u65b9\u5411\u3002\u4e00\u5e74\u540e\uff0cGenia\u88ab\u7f57\u6c0f\u4ee53.5\u4ebf\u7f8e\u5143\u6536\u5165\u9ebe\u4e0b\uff0c\u7530\u6656\u6210\u4e3a\u7f57\u6c0f\u6d4b\u5e8f\u90e8\u95e8\u7684\u526f\u603b\u88c1\u3002<\/p>\n

\u8fd9\u6bb5\u7ecf\u5386\uff0c\u8ba9\u4ed6\u6070\u597d\u5b8c\u6210\u4e86\u4ece\u534a\u5bfc\u4f53\u5230\u751f\u7269\u6d4b\u5e8f\u7684\u6700\u5173\u952e\u8ba4\u77e5\u8fc1\u79fb\u3002<\/p>\n

2016\u5e74\uff0c\u5728\u7845\u8c37<\/a>\u7684\u4e00\u95f4\u529e\u516c\u5ba4\u91cc\uff0c\u7530\u6656\u4e0e\u4fc4\u7f57\u65af<\/a>\u88d4\u8fde\u7eed\u521b\u4e1a<\/a>\u5bb6Igor Ivanov\u6df1\u8c08\u957f\u8c08\u540e\u4e00\u62cd\u5373\u5408\uff0c\u5728\u7f8e\u56fd\u521b\u7acb\u4e86\u5b89\u5e8f\u6e90\u7684\u524d\u8eabACH\u3002Igor Ivanov\u662f\u7530\u6656\u5728InVisage\u671f\u95f4\u7684\u540c\u4e8b\uff0c\u5c65\u5386\u4e0a\u6a2a\u8de8\u534a\u5bfc\u4f53\u6750\u6599\u4e0e\u7eb3\u7c73\u5de5\u827a\u7b49\u591a\u4e2a\u6280\u672f\u9886\u57df\uff0c\u5148\u540e\u521b\u7acb\u5e76\u51fa\u552e\u8fc7\u6570\u5bb6\u79d1\u6280\u516c\u53f8\uff0c\u5728\u534a\u5bfc\u4f53\u53ca\u79d1\u6280\u884c\u4e1a<\/a>\u62e5\u6709\u903e30\u5e74\u7ecf\u9a8c\u3002<\/p>\n

2016\u5e74\uff0c\u5b89\u5e8f\u6e90\u6210\u7acb\u540e\uff0c\u5148\u662f\u5728\u6df1\u5733\u8bbe\u7acb\u603b\u90e8\uff0c\u4f46\u6b64\u540e\u5b83\u53c8\u5c06\u6838\u5fc3\u751f\u4ea7\u57fa\u5730\u843d\u5728\u4e86\u6c5f\u82cf\u65e0\u9521\u3002\u4ece2016\u20142022\u5e74\uff0c\u5b89\u5e8f\u6e90\u7ecf\u5386\u4e864\u8f6e\u878d\u8d44<\/a>\uff0c\u5171\u8ba1\u83b7\u5f97\u7ea61.16\u4ebf\u7f8e\u5143\u7684\u8d44\u91d1\u652f\u6301\uff0c2022\u5e745\u6708\u6700\u540e\u4e00\u8f6e\u878d\u8d44\u540e\uff0c\u5176\u4f30\u503c\u5df2\u8fbe\u52303.48\u4ebf\u7f8e\u5143\uff0c\u6295\u8d44<\/a>\u65b9\u5305\u62ec\u4e91\u950b\u57fa\u91d1\u3001\u4e94\u6e90\u8d44\u672c\u7b49\u77e5\u540d\u673a\u6784\u3002<\/p>\n<\/p>\n

\u4e0e\u65f6\u95f4\u8d5b\u8dd1<\/strong><\/p>\n

\u6280\u672f\u6545\u4e8b\u60f3\u8c61\u7a7a\u95f4\u5341\u8db3\uff0c\u4f46\u73b0\u5b9e\u7684\u9500\u552e\u6570\u636e\u5374\u6781\u5ea6\u9aa8\u611f\u3002<\/p>\n

\u62db\u80a1\u4e66\u6570\u636e\u52fe\u52d2\u51fa\u5b89\u5e8f\u6e90\u7684\u8d22\u52a1\u5904\u5883\uff1a2025\u5e74\u5b9e\u73b0\u8425\u6536121\u4e07\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f153%\uff0c\u4f46\u51c0\u4e8f\u635f\u9ad8\u8fbe2227\u4e07\u7f8e\u5143\uff0c\u7ecf\u8c03\u6574\u51c0\u4e8f\u635f1266\u4e07\u7f8e\u5143\u3002\u52a0\u4e0a2023\u5e74\u30012024\u5e74\u7684\u4e8f\u635f\uff0c\u4e09\u5e74\u7d2f\u4e8f\u7ea66859\u4e07\u7f8e\u5143\uff08\u7ea6\u5408\u4eba\u6c11\u5e01<\/a>4.6\u4ebf\uff09\u3002<\/p>\n

\u5355\u770b\u6536\u5165\u8868\uff0c\u5b83\u5f88\u96be\u652f\u6491\u4e00\u4e2a\u9ad8\u4f30\u503c\u6545\u4e8b\u3002\u5b83\u7684\u6536\u5165\u7ed3\u6784\u975e\u5e38\u5355\u4e00\u3002\u76ee\u524d\u5168\u90e8\u6536\u5165\u6765\u81ea\u7814\u7a76\u7528\u9014\u7684AxiLona AXP-100\u57fa\u56e0\u6d4b\u5e8f\u4eea\u7684\u9500\u552e\uff0c\u5916\u52a0\u4e00\u5c0f\u90e8\u5206\u5411\u7b2c\u4e09\u65b9\u5ba2\u6237\u63d0\u4f9b\u7684\u5206\u5b50\u8bca\u65ad\u89e3\u51b3\u65b9\u6848\uff0c\u8bd5\u5242\u9500\u552e\u6536\u5165\u4e3a\u96f6\u3002<\/p>\n

\u597d\u5728\u516c\u53f8\u7684\u6bdb\u5229\u7387\u5e76\u4e0d\u4f4e\uff0c2025\u5e74\u6574\u4f53\u6bdb\u5229\u7387\u4e3a69.1%\uff0c\u5176\u4e2d\u6838\u5fc3\u4eea\u5668\u4ea7\u54c1\u7684\u6bdb\u5229\u7387\u66f4\u662f\u8fbe\u523082.9%\u3002\u5bf9\u4e8e\u5c1a\u672a\u76c8\u5229\u768418A \u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5e02\u573a\u672c\u5c31\u4e0d\u4ee5\u5f53\u671f\u76c8\u4e8f\u5b9a\u4ef7\uff0c\u6838\u5fc3\u770b\u6280\u672f\u58c1\u5792\u3001\u7ba1\u7ebf\u8fdb\u5ea6\u3001\u4e34\u5e8a\u843d\u5730\u7a7a\u95f4\u3002<\/p>\n

\u5b89\u5e8f\u6e90\u7684\u4f30\u503c\u903b\u8f91\uff0c\u4e5f\u662f\u62bc\u6ce8\u5728 EL-NGS \u7535\u5316\u5b66\u6d4b\u5e8f\u80fd\u5426\u8dd1\u901a\u8def\u5f84\u3002\u4f46\u4ece\u6837\u673a\u5230\u4e34\u5e8a\u3001\u4ece\u79d1\u7814\u5ba2\u6237\u5230\u89c4\u6a21\u5316\u5546\u4e1a\u91c7\u8d2d\uff0c\u518d\u5230\u642d\u5efa\u8bd5\u5242\u751f\u6001\u4e0e\u6e20\u9053\u4f53\u7cfb\uff0c\u5b89\u5e8f\u6e90\u4f3c\u4e4e\u8fd8\u8981\u8de8\u8d8a\u591a\u91cd\u4ea7\u4e1a\u5316\u9e3f\u6c9f\u3002<\/p>\n

\u8fd8\u6709\u5206\u6790\u6307\u51fa\uff0cIllumina\u3001Oxford Nanopore\u3001PacBio\u7b49\u56fd\u9645\u5de8\u5934\u5747\u5728\u957f\u8bfb\u957f\u6d4b\u5e8f\u9886\u57df\u6301\u7eed\u6295\u5165\uff0c\u82e5\u5176\u6210\u672c\u3001\u51c6\u786e\u7387\u6216\u751f\u6001\u65b9\u9762\u91cd\u65b0\u62c9\u5f00\u5dee\u8ddd\uff0c\u516c\u53f8\u7684\u6280\u672f\u6ea2\u4ef7\u5c06\u88ab\u538b\u7f29\u3002<\/p>\n

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