{"id":792336,"date":"2026-06-03T17:57:10","date_gmt":"2026-06-03T09:57:10","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=792336"},"modified":"2026-06-03T17:57:10","modified_gmt":"2026-06-03T09:57:10","slug":"13%e5%b9%b4%e6%96%b0%e8%8d%af%e7%a9%ba%e7%99%bd%e7%bb%88%e7%bb%93%ef%bc%8c%e7%97%9b%e9%a3%8e%e5%88%9b%e6%96%b0%e8%8d%af%e5%a4%a7%e5%8d%96%ef%bc%8c%e5%9b%bd%e4%ba%a7%e9%a6%96%e4%b8%aa%e5%88%9a%e8%8e%b7","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=792336","title":{"rendered":"13\u5e74\u65b0\u836f\u7a7a\u767d\u7ec8\u7ed3\uff0c\u75db\u98ce\u521b\u65b0\u836f\u5927\u5356\uff0c\u56fd\u4ea7\u9996\u4e2a\u521a\u83b7\u6279"},"content":{"rendered":"
\n

\u6587 | vb\u52a8\u8109\u7f51<\/p>\n<\/blockquote>\n

\u75db\u98ce\u521b\u65b0<\/a>\u836f\u5e02\u573a\u5f00\u59cb\u5546\u4e1a\u5316\u5151\u73b0\uff0c\u5e76\u4ea4\u51fa\u9996\u5f20\u5546\u4e1a\u5316\u6210\u7ee9\u5355\u3002<\/p>\n

\u4ece\u5e02\u573a\u53cd\u9988\u4e0a\u770b\uff0c\u4e24\u6b3e\u5df2\u83b7\u6279\u75db\u98ce\u521b\u65b0\u836f\u5f00\u59cb\u653e\u91cf\uff0c\u5206\u522b\u662f\u536b\u6750\u7684\u591a\u66ff\u8bfa\u96f7\uff08Dotinurad \u4f18\u4e50\u601d®\uff09\u548c\u91d1\u8d5b\u836f\u4e1a\u7684\u4f0f\u6b23\u5947\u62dc\u5355\u6297\uff08\u91d1\u84d3\u6b23\uff09\u3002<\/p>\n

\u591a\u66ff\u8bfa\u96f7\u662f\u9ad8\u9009\u62e9\u6027\u5c3f\u9178\u76d0\u8f6c\u8fd0\u86cb\u767d1\uff08URAT1\uff09\u6291\u5236\u5242\uff0c\u9002\u7528\u4e8e\u75db\u98ce\u4f34\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\uff0c\u8fd9\u6b3e\u836f\u7269\u5728\u4eac\u4e1c<\/a>\u5065\u5eb7\u4e0a\u5e02<\/a>\u4e0d\u5230\u4e00\u5e74\uff0c\u9500\u91cf\u5df2\u7ecf\u8fbe8\u4e07+\u3002<\/p>\n

\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u662f\u6211\u56fd\u57282025\u5e746\u6708\u83b7\u6279\u7684\u5168\u7403\u9996\u4e2a\u7528\u4e8e\u75db\u98ce\u6025\u6027\u53d1\u4f5c\u7684IL-1β\u5355\u514b\u9686\u6297\u4f53\uff0c\u5b83\u662f\u4e00\u79cd\u6cbb\u7597\u7528\u751f\u7269\u5236\u5242\uff0c\u7279\u70b9\u5728\u4e8e\u7cbe\u51c6\u957f\u6548\u6297\u708e\uff0c\u5b9a\u4ef79\u5343\u5143\u4e00\u9488\u3002\u91d1\u8d5b\u836f\u4e1a\u5728\u4e1a\u7ee9<\/a>\u4ea4\u6d41\u4f1a\u4e2d\u63d0\u5230\u91d1\u84d3\u6b232026Q1\u6536\u5165\u73af\u6bd4\u5927\u589e\u3002\u91d1\u8d5b\u836f\u4e1a\u9884\u671f\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u6709\u671b\u6210\u4e3a“\u4e0b\u4e00\u4e2a\u751f\u957f\u6fc0\u7d20”\uff0c\u64ac\u52a8\u767e\u4ebf\u7f8e\u5143\u7ea7\u7684\u5de8\u5927\u5e02\u573a\u3002<\/p>\n

\u4e2d\u56fd\u75db\u98ce\u60a3\u8005\u6570\u91cf\u5360\u5168\u7403\u768438%\uff0c\u662f\u75db\u98ce\u836f\u7684\u91cd\u8981\u5e02\u573a\u3002\u4f46\u75db\u98ce\u5e02\u573a\u5e76\u4e0d\u597d\u505a\uff0c\u6574\u4f53\u89c4\u6a21\u4e0d\u7b97\u5927\u4e14\u53d7\u96c6\u91c7\u964d\u4f4e\u836f\u4ef7\u5f71\u54cd\u89c4\u6a21\u88ab\u538b\u7f29\u3002\u56fd\u5185\u75db\u98ce\u836f\u5e02\u573a\u89c4\u6a21\u4ece2019\u5e74\u76845\u4ebf\u7f8e\u5143\u7f29\u51cf\u81f32024\u5e74\u76843\u4ebf\u7f8e\u5143\u3002<\/p>\n

\u56fd\u5185\u75db\u98ce\u521b\u65b0\u836f\u5e02\u573a\u7fa4\u72fc\u73af\u4f3a\uff0c\u5728URAT1\u6291\u5236\u5242\u8d5b\u9053\uff0c\u6052\u745e\u533b\u836f<\/a>\u7684 1 \u7c7b\u65b0\u836f\u9c81\u5179\u8bfa\u96f7\u94a0\u5df2\u83b7\u6279\u4e0a\u5e02\uff0c\u4e00\u54c1\u7ea2\u3001\u65b0\u5143\u7d20\u533b\u836f\u7b49\u836f\u4f01\u65b0\u4e00\u4ee3URAT1\u6291\u5236\u5242\u5df2\u7ecf\u8fdb\u5165\u540e\u671f\u9636\u6bb5\u3002\u591a\u66ff\u8bfa\u96f7\u548c\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u4e24\u6b3e\u521b\u65b0\u836f\u5982\u4f55\u5b9e\u73b0\u653e\u91cf\uff1f\u5bf9\u5e02\u573a\u6709\u54ea\u4e9b\u501f\u9274\u610f\u4e49\uff1f<\/p>\n

\u9ad8\u4ef7\u521b\u65b0\u836f\u5982\u4f55\u6253\u5f00\u75db\u98ce\u5e02\u573a<\/strong><\/h3>\n

\u8fd1\u5e74\u6765\uff0c\u4e2d\u56fd\u9ad8\u5c3f\u9178\u8840\u75c7\u4e0e\u75db\u98ce\u75be\u75c5\u8d1f\u62c5\u65e5\u76ca\u6c89\u91cd\uff0c\u5448\u73b0\u660e\u663e\u4e0a\u5347\u548c\u5e74\u8f7b\u5316\u8d8b\u52bf\uff0c\u5df2\u6210\u4e3a\u7ee7\u7cd6\u5c3f\u75c5\u4e4b\u540e\u53c8\u4e00\u5e38\u89c1\u4ee3\u8c22\u6027\u75be\u75c5\u3002<\/p>\n

\u4e2d\u56fd\u75db\u98ce\u60a3\u8005\u4eba\u6570\u589e\u901f\u8fdc\u9ad8\u4e8e\u5168\u7403\u5e02\u573a\u3002\u6839\u636e\u65b0\u5143\u7d20\u533b\u836f\u62db\u80a1\u4e66\uff0c2024\u5e74\u5168\u7403\u75db\u98ce\u60a3\u8005\u4eba\u6570\u4e3a6620\u4e07\u4eba\uff0c\u4e94\u5e74\u590d\u5408\u5e74\u589e\u957f\u7387\u4e3a4.4%\uff1b\u4e2d\u56fd\u75db\u98ce\u60a3\u8005\u4eba\u6570\u4e3a2530\u4e07\u4eba\uff0c\u4e94\u5e74\u590d\u5408\u5e74\u589e\u957f\u7387\u4e3a10.7%\uff0c\u5176\u4e2d\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u53ca\u75db\u98ce\u60a3\u8005\u4e2d\u8fd160%\u4e3a18\u81f335\u5c81\u4eba\u7fa4\u3002<\/p>\n

\u75db\u98ce\u6cbb\u7597\u4e2d\u6700\u5e38\u7528\u7684\u836f\u7269\u4e3b\u8981\u6839\u636e\u6cbb\u7597\u76ee\u7684\u5206\u4e3a\u4e24\u5927\u7c7b\uff1a\u2460\u6297\u708e\u6b62\u75db\u836f\uff0c\u65e8\u5728\u8fc5\u901f\u7f13\u89e3\u6025\u6027\u53d1\u4f5c\u65f6\u7684\u7ea2\u3001\u80bf\u3001\u70ed\u3001\u75db\u7b49\u75c7\u72b6\uff0c\u75db\u98ce\u6025\u6027\u53d1\u4f5c\u671f\u6709\u4e09\u79cd\u9547\u75db\u836f\u7269\uff1a\u79cb\u6c34\u4ed9\u78b1\u3001\u975e\u753e\u4f53\u836f\u3001\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff0c\u4ee5\u53ca\u65b0\u8fd1\u83b7\u6279\u7684\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u3002\u2461\u964d\u5c3f\u9178\u836f\uff0c\u65e8\u5728\u901a\u8fc7\u964d\u4f4e\u8840\u6db2\u4e2d\u5c3f\u9178\u7684\u6c34\u5e73\uff0c\u9632\u6b62\u5c3f\u9178\u7ed3\u6676\u6c89\u79ef\uff0c\u4ece\u6839\u672c\u4e0a\u51cf\u5c11\u590d\u53d1\u5e76\u6eb6\u89e3\u75db\u98ce\u77f3\u3002\u964d\u5c3f\u9178\u836f\u4e3b\u8981\u5206\u4e3a\u6291\u5236\u5c3f\u9178\u5408\u6210\u7c7b\u548c\u4fc3\u8fdb\u5c3f\u9178\u6392\u6cc4\u7c7b\u4e24\u5927\u7c7b\u3002<\/p>\n

\"13\u5e74\u65b0\u836f\u7a7a\u767d\u7ec8\u7ed3\uff0c\u75db\u98ce\u521b\u65b0\u836f\u5927\u5356\uff0c\u56fd\u4ea7\u9996\u4e2a\u521a\u83b7\u6279\"<\/p>\n

\u4e3b\u8981\u75db\u98ce\u7528\u836f<\/p>\n

\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u662f\u6025\u6027\u75db\u98ce\u6cbb\u7597\u521b\u65b0\u836f\u3002\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u5c5e\u4e8e\u6297\u708e\u6b62\u75db\u7c7b\uff0c\u662f\u56fd\u5185\u9996\u4e2a\u83b7\u6279\u7684IL-1β\u5355\u6297\uff0c\u9002\u7528\u4e8e\u5bf9\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\u548c\/\u6216\u79cb\u6c34\u4ed9\u78b1\u7981\u5fcc\u3001\u4e0d\u8010\u53d7\u6216\u7f3a\u4e4f\u7597\u6548\u7684\uff0c\u4ee5\u53ca\u4e0d\u9002\u5408\u53cd\u590d\u4f7f\u7528\u7c7b\u56fa\u9187\u6fc0\u7d20\u7684\u6210\u4eba\u75db\u98ce\u6027\u5173\u8282\u708e\u6025\u6027\u53d1\u4f5c\u3002<\/p>\n

IL-1β\u9776\u70b9\u4ecb\u5bfc\u75be\u75c5\u4f17\u591a\uff0c\u91d1\u8d5b\u836f\u4e1a\u7387\u5148\u8bc6\u522b\u5230\u88ab\u5ffd\u7565\u7684\u75db\u98ce\u5e02\u573a\u673a\u4f1a\u3002IL-1β\u4ecb\u5bfc\u7684\u5e38\u89c1\u75be\u75c5\u5305\u62ec\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3001\u75db\u98ce\u3001\u7cd6\u5c3f\u75c5\u3001\u9aa8\u5173\u8282\u708e\u7b49\u3002\u91d1\u8d5b\u836f\u4e1a\u5f00\u53d1\u8fd9\u4e00\u9776\u70b9\u65f6\uff0c\u9996\u5148\u671d\u7740\u5168\u7403\u5171\u540c\u805a\u7126\u7684\u5e7c\u5e74\u7279\u53d1\u6027\u5173\u8282\u708e\u5f00\u53d1\u836f\u7269\u3002\u540e\u7eed\u5f00\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u91d1\u8d5b\u836f\u4e1a\u6ce8\u610f\u5230IL-1β\u662f\u5f15\u8d77\u75db\u98ce\u75bc\u75db\u7684\u6838\u5fc3\u56e0\u5b50\u3002<\/p>\n

\u6d77\u5916\u4f01\u4e1a\u5e76\u4e0d\u91cd\u89c6\u75db\u98ce\u9002\u5e94\u75c7\uff0c\u800c\u662f\u671d\u7740\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80bf\u7624\u65b9\u5411\u5f00\u53d1\u3002\u4f46\u4e2d\u56fd\u662f\u75db\u98ce\u5927\u56fd\uff0c\u4e34\u5e8a\u75db\u70b9\u5f3a\u70c8\u3002\u57fa\u4e8e\u8fd9\u4e00\u6d1e\u5bdf\uff0c\u91d1\u8d5b\u836f\u4e1a\u51b3\u5b9a\u5148\u91cd\u70b9\u5f00\u53d1\u75db\u98ce\u9002\u5e94\u75c7\uff0c\u62a2\u5148\u62ff\u4e0b\u4e86\u8fd9\u4e00\u5e02\u573a\u30022025\u5e746\u6708\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u6210\u4e3a\u9996\u4e2a\u83b7\u6279\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u7684IL-1β\u5355\u6297\u3002<\/p>\n

\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u5e76\u6ca1\u6709\u4e0a\u5e02\u5373\u7206\u53d1\uff0c\u4e0a\u5e02\u521d\u671f\uff0c\u9ad8\u6602\u4ef7\u683c\u6210\u4e3a\u5176\u5546\u4e1a\u5316\u6700\u5927\u6311\u6218\u3002\u5c3d\u7ba1\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u5355\u6b21\u7ed9\u836f\u540e12\u5468\u964d\u4f4e90%\u590d\u53d1\u98ce\u9669<\/a>\uff0c24\u5468\u540e\u964d\u4f4e87%\u590d\u53d1\u98ce\u9669\uff0c\u534a\u5e74\u624d\u7ed9\u836f\u4e00\u6b21\uff0c\u800c\u4e14\u957f\u6548\u6297\u708e\u673a\u5236\u5bf9\u5173\u8282\/\u5fc3\u8840\u7ba1\/\u80be\u810f\u7b49\u5747\u6709\u957f\u671f\u83b7\u76ca\uff0c\u4f46\u8fd1\u4e07\u5143\u4e00\u652f\u7684\u4ef7\u683c\u3001\u81f3\u5c112\u4e07\u5143\u7684\u5e74\u8d39\u7528\uff0c\u6210\u4e3a\u5176\u5546\u4e1a\u5316\u7684\u6700\u5927\u6311\u6218\u3002\u9ad8\u5b9a\u4ef7\u867d\u4e3a\u540e\u7eed\u533b\u4fdd\u8c08\u5224\u9884\u7559\u4e86\u7a7a\u95f4\uff0c\u4f46\u4e0d\u5229\u4e8e\u65e9\u671f\u63a8\u5e7f\u3002<\/p>\n

\u53e6\u4e00\u5927\u6311\u6218\u5219\u662f\u75db\u98ce\u60a3\u8005\u5bf9\u4e8e\u6297\u708e\u8ba4\u77e5\u4e0d\u8db3\u3002\u4e2d\u56fd\u75db\u98ce\u60a3\u8005\u957f\u671f\u88ab\u6559\u80b2\u4ee5“\u964d\u5c3f\u9178”\u4e3a\u6838\u5fc3\u6cbb\u7597\u76ee\u6807\uff0c\u5bf9\u6025\u6027\u671f\u7cbe\u51c6\u6297\u708e\u548c\u65e5\u5e38\u708e\u75c7\u7ba1\u7406\u7684\u8ba4\u77e5\u4e0d\u8db3\uff0c\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u4f5c\u4e3a\u6297\u708e\u6b62\u75db\u7c7b\u836f\u7269\uff0c\u9700\u8981\u7a81\u7834\u65e2\u6709\u7684\u6cbb\u7597\u8303\u5f0f\u624d\u80fd\u6253\u5f00\u5e02\u573a\u3002<\/p>\n

\u4e3a\u4e86\u7834\u5c40\u8fd9\u4e00\u96be\u70b9\uff0c\u91d1\u8d5b\u836f\u4e1a\u52a0\u5927\u4e86\u63a8\u5e7f\u548c\u5e02\u573a\u6559\u80b2\u529b\u5ea6\u3002\u5728\u6218\u7565\u4e0a\u91d1\u8d5b\u836f\u4e1a\u5c06\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u4f5c\u4e3a\u7a81\u7834\u5bf9\u751f\u957f\u6fc0\u7d20\u5355\u4e00\u7206\u6b3e\u4f9d\u8d56\u7684\u91cd\u70b9\u4ea7\u54c1\uff0c\u4f5c\u4e3a\u6218\u7565\u8f6c\u578b\u7684\u5173\u952e\u843d\u5b50\uff0c\u6295\u5165\u4e86\u5927\u91cf\u8d44\u6e90<\/a>\u63a8\u5e7f\u3002<\/p>\n

\u5728\u5e02\u573a\u6559\u80b2\u65b9\u9762\uff0c\u91d1\u8d5b\u836f\u4e1a\u91cd\u70b9\u5f3a\u8c03\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u6b62\u75db\u3001\u9632\u590d\u53d1\u7684\u7279\u70b9\uff0c\u51fb\u4e2d\u6025\u6027\u53d1\u4f5c\u671f\u60a3\u8005\u75db\u70b9\uff0c\u4ee5\u53ca\u5f3a\u8c03\u7cbe\u51c6\u6297\u708e\u7684\u83b7\u76ca\u3002<\/p>\n

\u5728\u5b9a\u4ef7\u4e0e\u51c6\u5165\u5c42\u9762\uff0c\u91d1\u8d5b\u836f\u4e1a\u91c7\u53d6\u4e86\u67d4\u6027\u7b56\u7565<\/a>\u4ee5\u5bf9\u51b2\u9ad8\u4ef7\u5e26\u6765\u7684\u5e02\u573a\u963b\u529b\uff1a\u4e0a\u5e02\u521d\u671f\u63a8\u51fa“\u65e9\u9e1f\u8865\u8d34\u4ef7”\u964d\u4f4e\u9996\u6b21\u8d2d\u4e70\u95e8\u69db\uff1b\u4e3a\u4e86\u964d\u4f4e\u60a3\u8005\u4e4b\u95f4\u7597\u6548\u5dee\u5f02\u5e26\u6765\u7684\u8d2d\u4e70\u987e\u8651\uff0c\u91d1\u8d5b\u836f\u4e1a\u4e5f\u66fe\u63a8\u51fa\u534a\u5e74\u590d\u53d1\u514d\u8d39\u9001\u4e00\u9488\u7684\u6d3b\u52a8\uff0c\u8ba9\u66f4\u591a\u60a3\u8005\u613f\u610f\u5c1d\u8bd5\u65b0\u836f\u7269\u3002\u540c\u65f6\uff0c\u91d1\u8d5b\u836f\u4e1a\u4e5f\u5728\u79ef\u6781\u63a8\u52a8\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u7eb3\u5165\u533b\u4fdd\u62a5\u9500\u3002<\/p>\n

\u5728\u6e20\u9053\u5e03\u5c40\u5c42\u9762\uff0c\u91d1\u8d5b\u836f\u4e1a\u540c\u6b65\u63a8\u8fdb\u7ebf\u4e0b\u533b\u9662\u8986\u76d6\u4e0e\u7ebf\u4e0a\u6570\u5b57\u5316\u8425\u9500\uff0c\u5df2\u4e0e\u4eac\u4e1c\u5065\u5eb7\u3001\u963f\u91cc\u5065\u5eb7\u7b49\u5e73\u53f0\u8fbe\u6210\u6df1\u5ea6\u5408\u4f5c\uff0c\u501f\u52a9\u9662\u5916\u6e20\u9053\u89e6\u8fbe\u5e74\u8f7b\u60a3\u8005\u7fa4\u4f53\uff0c\u5f62\u6210\u5168\u6e20\u9053\u8986\u76d6\u7f51\u7edc\u3002<\/p>\n

\u524d\u671f\u7684\u5e02\u573a\u6559\u80b2\u548c\u6e20\u9053\u94fa\u8bbe\u521d\u89c1\u6210\u6548\uff0c\u57282026\u5e74Q1\uff0c\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u5546\u4e1a\u5316\u5f00\u59cb\u589e\u957f\u3002\u91d1\u8d5b\u836f\u4e1a\u4e1a\u7ee9\u4ea4\u6d41\u4f1a\u4e0a\u63d0\u5230\u91d1\u84d3\u6b23\u4e00\u5b63\u5ea6\u6536\u5165\u73af\u6bd4\u56db\u5b63\u5ea6\u6709\u8f83\u5927\u589e\u957f\uff0c\u524d\u671f\u5e02\u573a\u6559\u80b2\u5df2\u4e3a\u4ea7\u54c1\u63a8\u5e7f\u6253\u4e0b\u4e00\u5b9a\u57fa\u7840\uff0c\u4ea7\u54c1\u7597\u6548\u5f97\u5230\u66f4\u591a\u533b\u751f\u3001\u60a3\u8005\u8ba4\u53ef\u3002<\/p>\n

\u4ee5\u4ef7\u6362\u91cf\uff0c\u72ec\u5360\u671f\u62ff\u4e0b\u66f4\u5927\u5e02\u573a\u4efd\u989d<\/strong><\/h3>\n

\u591a\u66ff\u8bfa\u96f7\u662f\u6162\u6027\u75db\u98ce\u6cbb\u7597\u521b\u65b0\u836f\u3002\u591a\u66ff\u8bfa\u96f7\u5219\u662f\u51ed\u501f\u5b89\u5168\u6027\u4f18\u52bf\u3001\u5e7f\u6cdb\u7684\u53ef\u53ca\u6027\u4f18\u52bf\u5feb\u901f\u63a8\u5f00\u3002\u536b\u6750\u5bf9\u591a\u66ff\u8bfa\u96f7\u7684\u63a8\u5e7f\u7b56\u7565\u53ef\u6982\u62ec\u4e3a“\u4e34\u5e8a\u5dee\u5f02\u5316\u5b9a\u4f4d+\u6781\u901f\u5546\u4e1a\u5316\u843d\u5730+\u533b\u4fdd\u5feb\u901f\u51c6\u5165”\u7684\u7ec4\u5408\u62f3\uff0c\u6838\u5fc3\u76ee\u6807\u662f\u5728\u56fd\u4ea7\u7ade\u54c1\u4e0a\u5e02\u524d\u5c3d\u53ef\u80fd\u62a2\u5360\u5e02\u573a\u4efd\u989d\uff0c\u5efa\u7acb\u54c1\u724c\u58c1\u5792\u3002<\/p>\n

\u4e34\u5e8a\u5b9a\u4f4d\u4e0a\uff0c\u591a\u66ff\u8bfa\u96f7\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u7684\u9ad8\u9009\u62e9\u6027URAT1\u6291\u5236\u5242\uff0c\u536b\u6750\u5c06\u5176\u5b9a\u4f4d\u4e3a\u7ee7\u82ef\u6eb4\u9a6c\u9686\u540e\u7684\u65b0\u4e00\u4ee3\u4fc3\u5c3f\u9178\u6392\u6cc4\u836f\u7269\u3002\u6838\u5fc3\u5356\u70b9\u662f\u66f4\u597d\u7684\u7597\u6548\uff0c\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u7814\u7a76\u663e\u793a\u5176\u5bf9\u809d\u529f\u80fd\u5f71\u54cd\u8f83\u5c0f\uff0c\u65e0\u663e\u8457\u809d\u635f\u5bb3\u526f\u4f5c\u7528\u3002\u4ece\u4e34\u5e8a\u6570\u636e\u4e0a\u770b\uff0c\u4e2d\u56fd\u2162\u671f\u7814\u7a76\u663e\u793a\uff0c4mg\u591a\u66ff\u8bfa\u96f7\u6cbb\u759724\u5468\u540e\u8840\u5c3f\u9178\u8fbe\u6807\u7387\uff08≤360μmol\/L\uff09\u8fbe73.6%\uff0c\u663e\u8457\u4f18\u4e8e40mg\u975e\u5e03\u53f8\u4ed6\u7ec4\u768438.1%\u3002<\/p>\n

\u591a\u66ff\u8bfa\u96f7\u63a8\u5e7f\u8fc7\u7a0b\u4e2d\u4e00\u5927\u7b56\u7565\u662f\u4ee5\u4ef7\u6362\u91cf\uff0c\u5feb\u901f\u5360\u9886\u5e02\u573a\u3002\u57fa\u4e8e\u536b\u6750\u79ef\u7d2f\u7684\u5f3a\u5927\u6e20\u9053\u3002\u591a\u66ff\u8bfa\u96f7\u83b7\u6279\u540e\u9996\u65e5\u4eac\u6caa\u540c\u6b65\u5f00\u65b9\u300172\u5c0f\u65f6\u5185\u5168\u56fd\u591a\u5730\u4e0a\u67b6\u5b9e\u73b0\u9ad8\u6548\u7387\u843d\u5730\u3002\u5728\u5b9a\u4ef7\u7b56\u7565\u4e0a\uff0c\u536b\u6750\u5feb\u901f\u63a8\u8fdb\u591a\u66ff\u8bfa\u96f7\u533b\u4fdd\u51c6\u5165\u3002\u83b7\u6279\u4e00\u5e74\u540e\uff0c\u591a\u66ff\u8bfa\u96f7\u5c31\u5df2\u7eb3\u5165\u533b\u4fdd\u8986\u76d6\uff0c\u5927\u5e45\u964d\u4f4e\u4e86\u60a3\u8005\u81ea\u4ed8\u6bd4\u4f8b\u30022026\u5e74\u533b\u4fdd\u62a5\u9500\u6267\u884c\u4ee5\u6765\uff0c\u636e\u60a3\u8005\u900f\u9732\uff0c\u533b\u4fdd\u62a5\u9500\u540e\u7684\u591a\u66ff\u8bfa\u96f7\u81ea\u4ed8\u8d39\u752820mg×14\u7247\/\u76d2\u4ec5\u970023.36\u5143\u3002<\/p>\n

\u9009\u62e9\u5e73\u4ef7\u8def\u7ebf\u7684\u80cc\u540e\uff0c\u4e00\u65b9\u9762\u662f\u56e0\u4e3a\u536b\u6750\u8ba4\u4e3a\uff0c\u6211\u56fd\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u57fa\u6570\u5de8\u5927\uff0c\u5e76\u5448\u73b0\u9ad8\u5c3f\u9178\u8840\u75c7\u548c\u75db\u98ce\u4eba\u7fa4\u6301\u7eed\u589e\u957f\u548c\u53d1\u75c5\u5e74\u8f7b\u5316\u7684\u8d8b\u52bf\uff0c\u957f\u671f\u89c4\u8303\u6cbb\u7597\u7684\u7ecf\u6d4e\u8d1f\u62c5\u662f\u5236\u7ea6\u60a3\u8005\u83b7\u76ca\u7684\u5173\u952e\u74f6\u9888\u3002\u4ee5\u4ef7\u6362\u91cf\u53ef\u4ee5\u66f4\u5feb\u6253\u5f00\u5e02\u573a\uff0c\u8986\u76d6\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0cURAT1\u6291\u5236\u5242\u8d5b\u9053\u6b63\u88ab\u56fd\u4ea7\u7ba1\u7ebf\u6b65\u6b65\u7d27\u903c\uff0c\u76ee\u524d\u81f3\u5c11\u6709\u5341\u6761\u7ba1\u7ebf\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\uff0c\u6052\u745e\u533b\u836f\u7684 1 \u7c7b\u65b0\u836f\u300c\u9c81\u5179\u8bfa\u96f7\u94a0\u300d\u65b0\u8fd1\u83b7\u6279\uff0c\u521b\u65b0\u836f\u7684\u751f\u547d\u5468\u671f\u88ab\u538b\u7f29\u3002\u591a\u66ff\u8bfa\u96f7\u7684\u5e02\u573a\u72ec\u5360\u7a97\u53e3\u6b63\u5728\u6536\u7a84\uff0c\u5fc5\u987b\u4e89\u5206\u593a\u79d2\uff0c\u5728\u6709\u9650\u7684\u5e02\u573a\u72ec\u5360\u671f\u5185\u53d1\u6325\u6700\u5927\u7684\u52bf\u80fd\u3002<\/p>\n

\u4ee5\u4ef7\u6362\u91cf\u7684\u7b56\u7565\u5f97\u5230\u4e86\u5e02\u573a\u4e0d\u9519\u7684\u53cd\u9988\uff0c\u4ece\u7ebf\u4e0a\u6e20\u9053\u8868\u73b0\u6765\u770b\uff0c\u591a\u66ff\u8bfa\u96f7\u589e\u957f\u8fc5\u901f\u30022026\u5e745\u6708\uff0c\u591a\u66ff\u8bfa\u96f7\u4eac\u4e1c\u5065\u5eb7\u9500\u91cf\u73af\u6bd4\u589e\u957f\u4e86\u7ea633%\u3002<\/p>\n

\u591a\u5bb6\u56fd\u4ea7\u4f01\u4e1a\u7b49\u5f85\u52a0\u5165\u6218\u5c40<\/strong><\/h3>\n

\u4f0f\u6b23\u5947\u62dc\u5355\u6297\u548c\u591a\u66ff\u8bfa\u96f7\u6253\u54cd\u5934\u9635\uff0c\u75db\u98ce\u521b\u65b0\u836f\u5e02\u573a\u8fd8\u6709\u591a\u4e2a\u79cd\u5b50\u9009\u624b\u84c4\u52bf\u5f85\u53d1\u3002\u75db\u98ce\u5e02\u573a\u5c06\u6b63\u8fce\u6765\u6700\u6fc0\u70c8\u7684\u53d8\u9769\u671f\u3002<\/p>\n

\u75db\u98ce\u521b\u65b0\u836f\u5e02\u573a\u5343\u5e06\u7ade\u53d1\uff0c\u96c6\u4e2d\u4e8eURAT1\u6291\u5236\u5242\u3002\u56fd\u4ea7\u75db\u98ce\u6cbb\u7597\u65b0\u836f\u805a\u7126\u4e8e\u4e0b\u4e00\u4ee3URAT1\u6291\u5236\u5242\u7684\u7814\u53d1\uff0c\u901a\u8fc7\u4f18\u5316\u5206\u5b50\u7ed3\u6784\u3001\u5f00\u53d1\u957f\u6548\u5236\u5242\u7b49\u7b56\u7565\uff0c\u65e8\u5728\u63d0\u5347\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002<\/p>\n

\u591a\u6761\u56fd\u4ea7\u75db\u98ce\u6cbb\u7597\u7ba1\u7ebf\u8fdb\u5165\u540e\u671f\u3002\u6052\u745e\u533b\u836f\u9c81\u5179\u8bfa\u96f7\u94a0\u4f5c\u4e3a\u9996\u4e2a\u83b7\u6279\u7684\u56fd\u4ea7URAT1\u521b\u65b0\u836f\uff0c\u5176III \u671f\u4e34\u5e8a\u6570\u636e\u663e\u793asUA\u8fbe\u6807\u7387\u4e3a56.9%\uff0c\u57282026\u5e745\u670828\u65e5\u83b7\u6279\u4e0a\u5e02\uff0c\u62a2\u5230\u5148\u53d1\u4f18\u52bf\u3002\u6052\u745e\u533b\u836f\u5728\u75db\u98ce\u5e02\u573a\u6709\u7740\u5f3a\u5927\u7684\u6e20\u9053\u5f71\u54cd\u529b\uff0c\u6052\u745e\u975e\u5e03\u53f8\u4ed6\u4e8e2013\u5e74\u5728\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\uff0c\u5e02\u573a\u4efd\u989d\u9886\u5148\uff0c\u5f3a\u6709\u529b\u7684\u6e20\u9053\u628a\u63a7\u529b\u65e0\u7591\u5c06\u52a9\u529b\u6052\u745e\u75db\u98ce\u65b0\u836f\u5546\u4e1a\u5316\u3002<\/p>\n

\u4e00\u54c1\u7ea2\u7684AR882 12\u4e2a\u6708\u8fbe\u6807\u7387\u9ad8\u8fbe89%\uff0c\u53ef\u6709\u6548\u6eb6\u89e3\u75db\u98ce\u77f3\uff0c\u8ba9\u5176\u5907\u53d7\u5173\u6ce8\u3002\u4e00\u54c1\u7ea2\u900f\u9732AR882\u5728\u56fd\u5185\u8bbe\u8ba1\u4e86\u9488\u5bf9\u4e34\u5e8a\u4e00\u7ebf\u7528\u836f\u975e\u5e03\u53f8\u4ed6\u7684\u4f18\u6548\u5bf9\u6bd4\u8bd5\u9a8c\uff0c\u4ece\u76ee\u524d\u638c\u63e1\u7684\u8bd5\u9a8c\u770b\uff0c\u4ea7\u54c1\u6548\u679c\u4f18\u4e8e\u540c\u7c7b\u7ade\u54c1\u3002\u5168\u7403\u591a\u4e2d\u5fc3\u53ca\u56fd\u5185\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u7a33\u6b65\u63a8\u8fdb\u4e2d\u3002\u9884\u8ba1AR882\u4e34\u5e8a\u9636\u6bb5\u5c06\u57282026\u5e74\u5e74\u4e2d\u7ed3\u675f\uff0c\u5b8c\u6210\u6570\u636e\u6574\u7406\u53ca\u62a5\u544a\u540e\uff0c\u5c06\u7533\u62a5\u63d0\u4ea4\u81f3NDA\uff0c\u7533\u62a5\u6210\u529f\u540eNDA\u5ba1\u6279\u9884\u8ba1\u9700\u8981\u7ea612-15\u4e2a\u6708\u7684\u65f6\u95f4\u3002\u6700\u5feb\u53ef\u80fd\u57282027\u5e74\u5e95\u62162028\u5e74\u521d\u5728\u4e2d\u56fd\u4e0a\u5e02\u3002<\/p>\n

\u65b0\u5143\u7d20\u533b\u836f\u7684ABP-671\u5b89\u5168\u6027\u8868\u73b0\u7a81\u51fa\u3002ABP-671\u5177\u6709\u72ec\u7279\u7684\u5316\u5b66\u7ed3\u6784\uff0c\u907f\u514d\u4e86\u4f20\u7edf\u836f\u7269\uff08\u5982\u82ef\u6eb4\u9a6c\u9686\uff09\u4e2d\u5e38\u89c1\u7684\u82ef\u5e76\u544b\u5583\u9aa8\u67b6\uff0c\u4ece\u800c\u9632\u6b62\u5f62\u6210\u4e0e\u809d\u635f\u4f24\u76f8\u5173\u7684\u6709\u6bd2\u4ee3\u8c22\u7269\uff0c\u964d\u4f4e\u809d\u6bd2\u98ce\u9669\uff0c\u4ece\u5b89\u5168\u6027\u4e0a\u770b\uff0c\u672a\u62a5\u544a\u4efb\u4f55\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6(\u300cSAE\u300d)\u4e14\u51e0\u4e4e\u6ca1\u67093\u7ea7\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6(\u300cTEAE\u300d)\uff0c\u666e\u904d\u8f7b\u5fae\u4e14\u5404\u7ec4\u4e4b\u95f4\u76f8\u4f3c\uff0c\u5e76\u672a\u89c2\u5bdf\u5230\u809d\u810f\u6216\u5fc3\u8840\u7ba1\u5b89\u5168\u4fe1\u53f7\u3002\u7597\u6548\u4e0a\u770b\uff0c\u4e34\u5e8a\u6570\u636e\u663e\u793a\u5728\u7ed9\u836f\u4ec54\u5468\u65f6\uff0c\u65e0\u8bba\u662fBID\uff0c\u6bcf\u6b214 mg\uff0c\u8fd8\u662fQD\uff0c\u6bcf\u6b218 mg\uff0c\u5747\u6709100%\u7684\u53d7\u8bd5\u8005\u8fbe\u5230\u4e86\u76ee\u6807sUA\u6c34\u5e73\uff08\uff1c6.0 mg\/dL\uff09\u3002<\/p>\n

ABP-671\u4e5f\u662f\u65b0\u5143\u7d20\u533b\u836f\u51b2\u51fbIPO<\/a>\u7684\u6838\u5fc3\u4ea7\u54c1\uff0c\u8fd9\u6b3e\u836f\u7269\u5df2\u4e0e\u5eb7\u54f2\u836f\u4e1a\u8fbe\u6210\u5408\u4f5c\uff0c\u5eb7\u54f2\u836f\u4e1a\u5c06\u652f\u4ed8\u9996\u4ed8\u6b3e\u53ca\u91cc\u7a0b\u7891\u6b3e\u9879\uff0c\u4ee5\u83b7\u5f97\u8be5\u4ea7\u54c1\u5728\u4e2d\u56fd\u5e02\u573a\u7684\u72ec\u5bb6CSO\u5546\u4e1a\u5316\u6743\u5229\u3002<\/p>\n

\u591a\u4e2a\u540c\u9002\u5e94\u75c7\u3001\u540c\u9776\u70b9\u836f\u7269\u4e0a\u5e02\uff0c\u53ef\u4ee5\u9884\u89c1\u75db\u98ce\u521b\u65b0\u836f\u65e0\u7591\u662f\u672a\u6765\u4e24\u5e74\u9ad8\u5ea6\u7ade\u4e89\u7684\u5e02\u573a\uff0c\u4e14\u536b\u6750\u591a\u66ff\u8bfa\u96f7\u5df2\u7eb3\u5165\u533b\u4fdd\uff0c\u5176\u63d0\u4f9b\u7684\u4ef7\u683c\u951a\u70b9\u5c06\u4e3a\u56fd\u4ea7\u4f01\u4e1a\u5e26\u6765\u5b9a\u4ef7\u538b\u529b\uff0c\u5728\u5b89\u5168\u6027\u548c\u4e34\u5e8a\u4ef7\u503c\u4e0a\u6709\u5f3a\u6709\u529b\u5dee\u5f02\u70b9\u7684\u4ea7\u54c1\u66f4\u5bb9\u6613\u62ff\u4e0b\u66f4\u5927\u5e02\u573a\u3002<\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587 | vb\u52a8\u8109\u7f51 \u75db\u98ce\u521b\u65b0\u836f\u5e02\u573a\u5f00\u59cb\u5546\u4e1a\u5316\u5151\u73b0\uff0c\u5e76\u4ea4\u51fa\u9996\u5f20\u5546\u4e1a\u5316\u6210\u7ee9\u5355\u3002 \u4ece\u5e02\u573a\u53cd\u9988\u4e0a\u770b\uff0c\u4e24\u6b3e\u5df2\u83b7\u6279\u75db\u98ce\u521b\u65b0 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[57,195,266,124,252,275,88,238,192],"views":27,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/792336"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=792336"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/792336\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=792336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=792336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=792336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}