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\n

\u6587 | \u533b\u66dc<\/p>\n<\/blockquote>\n

5\u670831\u65e5\uff0c\u829d\u52a0\u54e5<\/a>ASCO\u5e74\u4f1a\u4e0a\uff0c\u5eb7\u65b9\u751f\u7269\u516c\u5e03\u4e86HARMONi-6\u7814\u7a76\u7684\u671f\u4e2d\u5206\u6790\u6570\u636e\u3002\u4f9d\u6c83\u897f\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0cPFS\u7684HR\u4e3a0.60\uff0cOS\u7684HR\u4e3a0.66\u3002P\u503c0.0017\u3002<\/p>\n

\u4e24\u4e2aHR\u4e4b\u95f4\u5dee\u4e860.06\u3002<\/p>\n

\u5728\u80ba\u9cde\u764c\u8fd9\u4e2a\u9002\u5e94\u75c7\u91cc\uff0c\u591a\u6570\u836f\u7269\u7684PFS\u83b7\u76ca\u4f1a\u88ab\u540e\u7ebf\u6cbb\u7597\u3001\u4ea4\u53c9\u7528\u836f\u548c\u968f\u8bbf\u6210\u719f\u5ea6\u9010\u5c42\u6d88\u89e3\u3002\u4f9d\u6c83\u897f\u6ca1\u6709\u3002\u5b83\u5728PFS\u4e0a\u7684\u4f18\u52bf\uff0c\u51e0\u4e4e\u539f\u6837\u4f20\u9012\u5230\u4e86\u6b7b\u4ea1\u98ce\u9669<\/a>\u7684\u964d\u4f4e\u4e0a\u3002<\/p>\n

\u5168\u4eba\u7fa4\u4e24\u5e74\u751f\u5b58\u7387\uff0c\u4f9d\u6c83\u897f\u7ec464.7%\uff0c\u5bf9\u7167\u7ec448.6%\uff0c\u76f8\u5dee16\u4e2a\u767e\u5206\u70b9\u3002\u591a\u5904\u8f6c\u79fb\u4e9a\u7ec4HR\u4f4e\u81f30.47\uff0cPD-L1\u9634\u6027\u4e9a\u7ec40.64\uff0c\u9ad8\u8868\u8fbe\u4e9a\u7ec4\u540c\u6837\u662f0.64\u3002\u83b7\u76ca\u65b9\u5411\u4e00\u81f4\u3002<\/p>\n

\u5982\u679c\u8bf48\u4e2a\u6708\u524dHARMONi-2\u56de\u7b54\u4e86“\u5355\u836f\u80fd\u4e0d\u80fd\u8d62K\u836f”\uff0c\u90a3\u4e48\u6628\u5929HARMONi-6\u5219\u56de\u7b54\u4e86“\u8054\u5408\u5316\u7597\u80fd\u4e0d\u80fd\u5728OS\u4e0a\u8d62\u8fc7\u4e00\u4e2a\u6210\u719f\u7684PD-1\u8054\u5408\u5316\u7597\u65b9\u6848”\u3002\u4e24\u4e2a\u95ee\u9898\u7684\u7b54\u6848\u90fd\u662f\u80af\u5b9a\u7684\u3002<\/strong><\/p>\n

\u80bf\u7624\u836f\u6700\u7ec8\u8bf4\u8bdd\u7684\u6c38\u8fdc\u662fOS\u3002\u8fd9\u4e00\u5173\uff0c\u4f9d\u6c83\u897f\u8fc7\u4e86\u3002<\/p>\n

01<\/h2>\n

\u80ba\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u5386\u53f2\u5206\u4e24\u5c42\u53f0\u9636\u3002<\/p>\n

\u7b2c\u4e00\u5c42\uff0c\u4ece\u5316\u7597\u8de8\u5230PD-1\u8054\u5408\u5316\u7597\u3002KEYNOTE-407\u9a8c\u8bc1\u4e86K\u836f\u8054\u5408\u5316\u7597\u8fd9\u6761\u8def\uff0cRATIONALE-307\u9a8c\u8bc1\u4e86\u66ff\u96f7\u5229\u73e0\u8054\u5408\u5316\u7597\u8fd9\u6761\u8def\u3002\u4e24\u9879\u7814\u7a76\u5206\u522b\u57282018\u5e74\u548c2020\u5e74\u786e\u7acb\u4e86PD-1\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\u3002\u4f46OS\u7684\u83b7\u76ca\u5e45\u5ea6\u4e00\u76f4\u4e0d\u7b97\u5927\uff0c\u4e2d\u4f4d\u503c\u5728\u5927\u591a\u6570\u7814\u7a76\u91cc\u505c\u572815\u523017\u4e2a\u6708\u4e4b\u95f4\u3002<\/p>\n

\u7b2c\u4e8c\u5c42\uff0c\u4ecePD-1\u8054\u5408\u5316\u7597\u8de8\u5230PD-1\/VEGF\u53cc\u6297\u8054\u5408\u5316\u7597\u3002\u8fd9\u4e00\u6b65\u6bd4\u4e0a\u4e00\u6b65\u96be\u5f97\u591a\u3002\u4e0a\u4e00\u4e2a\u53f0\u9636\u7684\u5bf9\u624b\u662f\u5316\u7597\uff0c\u8fd9\u4e00\u6b21\u7684\u5bf9\u624b\u662f\u4e00\u4e2a\u5df2\u7ecf\u7ad9\u4f4f\u4e86\u811a\u7684\u6807\u51c6\u65b9\u6848\u3002HARMONi-6\u7684\u5bf9\u7167\u7ec4mPFS\u4e3a6.90\u4e2a\u6708\uff0c\u66ff\u96f7\u5229\u73e0\u5728RATIONALE-307\u91cc\u505a\u5230\u8fc77.6\u4e2a\u6708\uff0c\u8fd9\u662f\u88abIII\u671f\u53cd\u590d\u786e\u8ba4\u8fc7\u7684\u57fa\u51c6\u7ebf\u3002\u4f9d\u6c83\u897f\u5728\u8fd9\u6761\u7ebf\u4e0a\u6253\u51fa\u4e86PFS HR 0.60\uff0cOS HR 0.66\u3002<\/p>\n

KEYNOTE-407\u548cRATIONALE-307\u56de\u7b54\u7684\u662f\u540c\u4e00\u4e2a\u95ee\u9898\uff1a\u52a0\u4e0aPD-1\u6bd4\u4e0d\u52a0\u597d\u3002HARMONi-6\u56de\u7b54\u7684\u662f\u53e6\u4e00\u4e2a\u95ee\u9898\uff1a\u52a0\u4e0aPD-1\/VEGF\u53cc\u6297\u6bd4\u53ea\u52a0PD-1\u597d\u3002<\/strong><\/p>\n

\u4e24\u4e2a\u95ee\u9898\u7684\u91cf\u7ea7\u4e0d\u540c\u3002\u7b2c\u4e00\u4e2a\u95ee\u9898\u5df2\u7ecf\u628a\u80fd\u505a\u7684\u90fd\u505a\u4e86\uff0c\u7b2c\u4e8c\u4e2a\u95ee\u9898\u5728\u5b83\u4e4b\u4e0a\u51ff\u5f00\u4e86\u4e00\u9053\u88c2\u7f1d\u3002<\/p>\n

02<\/h2>\n

\u4f9d\u6c83\u897f\u7684\u673a\u5236\u542c\u8d77\u6765\u4e0d\u590d\u6742\u3002\u4e00\u6761\u81c2\u963b\u65adPD-1\uff0c\u6062\u590dT\u7ec6\u80de\u6740\u4f24\u80bf\u7624\u7684\u80fd\u529b\u3002\u53e6\u4e00\u6761\u81c2\u4e2d\u548cVEGF\uff0c\u62c6\u6389\u80bf\u7624\u7528\u6765\u963b\u6321\u514d\u75ab\u7ec6\u80de\u7684\u5c4f\u969c\u3002<\/p>\n

\u4f46\u673a\u5236\u53ea\u662f\u673a\u5236\u3002\u771f\u6b63\u8ba9\u884c\u4e1a\u8ba4\u771f\u5bf9\u5f85\u8fd9\u6b3e\u836f\u7684\uff0c\u4e0d\u662f\u5206\u5b50\u8bbe\u8ba1\uff0c\u662f\u5b83\u88ab\u4e24\u9879III\u671f\u8bd5\u9a8c\u53cd\u590d\u9a8c\u8bc1\u8fc7\u3002<\/strong><\/p>\n

\u4ecePFS\u5230OS\u51e0\u4e4e\u65e0\u635f\u4f20\u5bfc\uff0c\u8bf4\u660ePFS\u83b7\u76ca\u4e0d\u662f\u5f71\u50cf\u5b66\u4e0a\u7684\u77ed\u6682\u6ce2\u52a8\uff0c\u800c\u662f\u8f6c\u5316\u6210\u4e86\u6b7b\u4ea1\u98ce\u9669\u7684\u4e0b\u964d\u3002\u4f9d\u6c83\u897f\u7ec4\u7684KM\u66f2\u7ebf\u5728\u4e2d\u4f4d\u503c\u4e4b\u540e\u8d8b\u4e8e\u5e73\u7f13\uff0c\u8fd9\u662f\u514d\u75ab\u6cbb\u7597\u7684\u5178\u578b\u7279\u5f81\uff1a\u4e0d\u5e94\u7b54\u7684\u4eba\u5f88\u5feb\u8fdb\u5c55\uff0c\u5e94\u7b54\u7684\u4eba\u6d3b\u5f88\u4e45\u3002\u4f9d\u6c83\u897f\u7684\u62d6\u5c3e\u6bd4\u5bf9\u7167\u7ec4\u957f\u3002<\/p>\n

\u5b89\u5168\u6027\u540c\u6837\u8d8a\u8fc7\u4e86\u9cde\u764c\u7ed9VEGF\u9776\u5411\u836f\u57cb\u4e0b\u7684\u9677\u9631\u3002\u8d1d\u4f10\u73e0\u5355\u6297\u5f53\u5e74\u6b63\u662f\u56e0\u4e3a\u51fa\u8840\u98ce\u9669\u88ab\u6321\u5728\u4e86\u9cde\u764c\u95e8\u5916\u3002\u4f9d\u6c83\u897f\u5728HARMONi-6\u91cc\u6574\u4f53\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5bf9\u7167\u7ec4\u76f8\u5f53\uff0c\u6ca1\u6709\u65b0\u4fe1\u53f7\u3002<\/p>\n

\u5728\u9cde\u764c\u91cc\u540c\u65f6\u62ff\u5230OS\u83b7\u76ca\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u8fd9\u662f\u7b2c\u4e00\u6b21\u3002<\/strong><\/p>\n

\u8fd8\u6709\u4e00\u4e2a\u9690\u542b\u7684\u5546\u4e1a\u903b\u8f91\u3002\u4f9d\u6c83\u897f\u8054\u5408\u5316\u7597mPFS\u4e3a11.14\u4e2a\u6708\uff0c\u6bd4\u5bf9\u7167\u7ec4\u957f\u4e86\u56db\u4e2a\u591a\u6708\u3002\u6cbb\u7597\u7a97\u53e3\u7684\u5ef6\u957f\u76f4\u63a5\u653e\u5927\u4e86\u5355\u60a3\u8005\u836f\u8d39\u6536\u5165\u3002\u5f53PFS\u83b7\u76ca\u53ef\u4ee5\u51e0\u4e4e\u65e0\u635f\u5730\u4f20\u5bfc\u81f3OS\uff0c\u8fd9\u6b3e\u5206\u5b50\u7684\u4e34\u5e8a\u4ef7\u503c\u548c\u5546\u4e1a\u4ef7\u503c\u5c31\u4e0d\u518d\u662f\u4e24\u6761\u9700\u8981\u5206\u522b\u8bba\u8bc1\u7684\u66f2\u7ebf\u3002<\/p>\n

03<\/h2>\n

\u4f9d\u6c83\u897f\u624b\u91cc\u5df2\u7ecf\u6709\u4e86\u4e24\u4efdIII\u671f\u6570\u636e\u3002HARMONi-2\u7684\u5355\u836fPFS\u83b7\u76ca\u548cOS\u8d8b\u52bf\u3002HARMONi-6\u7684\u8054\u5408\u5316\u7597PFS\u548cOS\u53cc\u786e\u8ba4\u3002\u4e00\u6b3e\u836f\u5728\u4e0d\u540c\u6cbb\u7597\u573a\u666f\u3001\u4e0d\u540c\u4eba\u7fa4\u3001\u4e0d\u540c\u7ec8\u70b9\u4e0a\u53cd\u590d\u9a8c\u8bc1\u540c\u4e00\u5957\u673a\u5236\uff0c\u8fd9\u4e0d\u5e38\u89c1\u3002<\/p>\n

\u63a5\u4e0b\u6765\u8981\u770b\u7684\u662fHARMONi-3\u3002<\/strong><\/p>\n

Summit Therapeutics\u8d1f\u8d23\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u6ce8\u518c\u7814\u7a76\uff0c\u4f9d\u6c83\u897f\u8054\u5408\u5316\u7597\u5bf9\u6bd4K\u836f\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027NSCLC\u3002\u8fd9\u662f\u51b3\u5b9a\u4f9d\u6c83\u897f\u80fd\u4e0d\u80fd\u8fdb\u5165\u5168\u7403PD-1\u66ff\u4ee3\u65b9\u6848\u7684\u90a3\u573a\u8003\u8bd5\u3002<\/p>\n

HARMONi-6\u7ed9HARMONi-3\u7559\u4e0b\u4e86\u4e00\u4e2a\u5f88\u5f3a\u7684\u5148\u9a8c\u3002HARMONi-6\u6253\u8d62\u7684\u662f\u66ff\u96f7\u5229\u73e0\u8054\u5408\u5316\u7597\uff0cHARMONi-3\u9cde\u764c\u961f\u5217\u8981\u6253\u7684\u662fK\u836f\u8054\u5408\u5316\u7597\u3002\u4ece\u65e2\u5f80III\u671fmPFS\u770b\uff0cK\u836f\u8054\u5408\u5316\u7597\u5e76\u4e0d\u6bd4\u66ff\u96f7\u5229\u73e0\u8054\u5408\u5316\u7597\u66f4\u5f3a\uff1aKEYNOTE-407 mPFS 6.4\u4e2a\u6708\uff0cRATIONALE-307 mPFS 7.6\u4e2a\u6708\u3002HARMONi-6\u7684\u5bf9\u7167\u7ec4mPFS 6.90\u4e2a\u6708\uff0c\u8fd9\u4e2a\u5bf9\u7167\u6c34\u51c6\u662f\u624e\u5b9e\u7684\u3002\u4f9d\u6c83\u897f\u5df2\u7ecf\u5728\u8fd9\u4e2a\u6c34\u51c6\u7684\u5bf9\u7167\u4e0a\u62ff\u5230\u4e86PFS HR 0.60\u548cOS HR 0.66\u3002HARMONi-3\u9cde\u764c\u961f\u5217\u81f3\u5c11\u4e0d\u662f\u4e00\u4e2a\u66f4\u96be\u6253\u7684\u4ed7\u3002<\/p>\n

HARMONi-3\u771f\u6b63\u8981\u56de\u7b54\u7684\u95ee\u9898\uff0c\u4ece“\u80fd\u4e0d\u80fd\u8d62”\u53d8\u6210\u4e86“\u80fd\u4ee5\u591a\u5927\u4f18\u52bf\u8d62\uff0cOS\u80fd\u4e0d\u80fd\u518d\u8d62\u4e00\u6b21”\u3002<\/strong>\u4e24\u4e2a\u95ee\u9898\u7684\u6027\u8d28\u5b8c\u5168\u4e0d\u540c\u3002<\/p>\n

HARMONi-6\u7684\u610f\u4e49\u4e0d\u6b62\u4e8e\u4e00\u6b3e\u836f\u7684\u6210\u529f\u3002PFS\u5230OS\u51e0\u4e4e\u65e0\u635f\u4f20\u5bfc\uff0c\u8bf4\u660e\u8fd9\u4e0d\u662f\u4e00\u6b21\u4fa5\u5e78\uff0c\u662f\u4e00\u4e2a\u673a\u5236\u88ab\u4e34\u5e8a\u5b8c\u6574\u9a8c\u8bc1\u7684\u7ed3\u679c\u3002\u5b83\u8bc1\u660e\u4e2d\u56fd\u516c\u53f8\u53ef\u4ee5\u5728\u5168\u7403\u6700\u4e3b\u6d41\u7684\u80bf\u7624\u9002\u5e94\u75c7\u4e0a\uff0c\u7528\u6700\u9ad8\u7b49\u7ea7\u7684III\u671f\u5934\u5bf9\u5934\u8bc1\u636e\uff0c\u628a\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u5f80\u524d\u63a8\u4e00\u6b65\u3002<\/p>\n

\u80bf\u7624\u836f\u6700\u7ec8\u8bf4\u8bdd\u7684\u662fOS\uff0c\u56e0\u4e3a\u4e00\u4e2a\u836f\u7269\u7684\u610f\u4e49\u662f\u771f\u6b63\u5ef6\u957f\u60a3\u8005\u6d3b\u7740\u7684\u65f6\u95f4\u3002\u4f9d\u6c83\u897f\u75280.60\u548c0.66\u8fd9\u4e24\u4e2a\u6570\u5b57\uff0c\u628a\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u5750\u6807\u7cfb\u5f80\u524d\u79fb\u4e86\u4e00\u683c\u3002ASCO2026\u76845\u670831\u65e5\u8fd9\u4e00\u5929\uff0c\u5c5e\u4e8e\u4e2d\u56fd\u3002<\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587 | \u533b\u66dc 5\u670831\u65e5\uff0c\u829d\u52a0\u54e5ASCO\u5e74\u4f1a\u4e0a\uff0c\u5eb7\u65b9\u751f\u7269\u516c\u5e03\u4e86HARMONi-6\u7814\u7a76\u7684\u671f\u4e2d\u5206\u6790\u6570\u636e\u3002\u4f9d\u6c83\u897f\u8054\u5408 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"aside","meta":[],"categories":[6],"tags":[70,192],"views":60,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/790572"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=790572"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/790572\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=790572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=790572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=790572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}