{"id":786885,"date":"2026-05-26T15:02:42","date_gmt":"2026-05-26T07:02:42","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=786885"},"modified":"2026-05-26T15:02:42","modified_gmt":"2026-05-26T07:02:42","slug":"%e6%89%931%e9%92%88%e7%ae%a1%e4%b8%80%e8%be%88%e5%ad%90%ef%bc%8c%e8%b6%85%e8%b6%85%e8%b6%85%e9%95%bf%e6%95%88%e9%99%8d%e8%84%82%e8%8d%af%e7%9c%9f%e7%9a%84%e6%9d%a5%e4%ba%86%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=786885","title":{"rendered":"\u62531\u9488\u7ba1\u4e00\u8f88\u5b50\uff0c\u8d85\u8d85\u8d85\u957f\u6548\u964d\u8102\u836f\u771f\u7684\u6765\u4e86\uff1f"},"content":{"rendered":"<p>\u53ea\u9700\u6253 1 \u9488\uff0c\u5c31\u80fd\u5b9e\u73b0\u7ec8\u751f\u964d\u8102\uff1f<\/p>\n<p>\u6628\u65e5\uff0cNEJM \u53d1\u5e03\u4e00\u9879\u91cd\u78c5\u7814\u7a76\uff1a\u53ea\u9700 1 \u9488\uff0c\u53ef\u6301\u4e45\u964d\u4f4e LDL-C \uff0c\u6700\u9ad8\u964d\u5e45\u8fbe 62%\u3002<\/p>\n<p><strong>\u53ea\u9700 1 \u9488\uff0c\u53ef\u6301\u4e45\u964d\u8102 62%<\/strong><\/p>\n<p>\u9ad8\u8102\u8840\u75c7\u548c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\uff08ASCVD\uff09\u60a3\u8005\uff0c\u9700\u8981\u4f9d\u8d56\u957f\u671f\u670d\u836f\u3001\u53cd\u590d\u6ce8\u5c04\u6765\u7ef4\u6301\u8840\u8102\u6c34\u5e73\u3002<\/p>\n<p>\u73b0\u9636\u6bb5\uff0c\u4ed6\u6c40\u7c7b\u836f\u7269\u662f\u964d\u8102\u6cbb\u7597\u7684\u57fa\u77f3\uff0c\u4f46\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\uff0c\u90e8\u5206\u60a3\u8005\u5373\u4fbf\u63a5\u53d7\u6700\u5927\u8010\u53d7\u5242\u91cf\u6cbb\u7597\uff0cLDL-C \u4f9d\u65e7\u96be\u4ee5\u8fbe\u6807\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u5305\u62ec PCSK9 \u6291\u5236\u5242\u5728\u5185\u7684\u964d\u8102\u836f\u7269\u7684\u6cbb\u7597\u6301\u7eed\u6027\u548c\u4f9d\u4ece\u6027\u4e0d\u7406\u60f3\uff0c12 \u4e2a\u6708\u5185\u505c\u836f\u7387\u53ef\u8fbe 30\uff5e50%\uff0c\u6cbb\u7597\u4e2d\u65ad\u66f4\u662f\u548c\u66f4\u5dee\u7684\u5fc3\u8840\u7ba1\u7ed3\u5c40\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n<p>\u5176\u4e2d\uff0c\u4ef7\u683c\u9ad8\u6602\u3001\u6ce8\u5c04\u4e0d\u4fbf\u3001\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u836f\u7269\u53ef\u53ca\u6027\uff0c\u90fd\u662f\u5bfc\u81f4\u60a3\u8005\u505c\u836f\u7684\u5e38\u89c1\u539f\u56e0\u3002<\/p>\n<p>VERVE-102 \u7684\u6838\u5fc3\u601d\u8def\uff0c\u662f\u901a\u8fc7\u4e00\u6b21\u6027\u57fa\u56e0\u7f16\u8f91\uff0c\u957f\u671f\u5173\u95ed\u809d\u810f\u4e2d\u7684 PCSK9 \u57fa\u56e0\uff0c\u4ece\u6e90\u5934\u51cf\u5c11 LDL-C\uff0c\u8fdb\u800c\u5c1d\u8bd5\u5b9e\u73b0\u300c\u6253\u4e00\u9488\u7ba1\u4e00\u8f88\u5b50\u300d\u3002<\/p>\n<p><img data-lazyload=\"https:\/\/x0.ifengimg.com\/res\/2026\/8113FDFB711752761AEE0DD44035A617E1147AEF_size638_w850_h796.png\" src=\"https:\/\/tech.ifeng.com\/c\/data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEXy8vJkA4prAAAACklEQVQI12NgAAAAAgAB4iG8MwAAAABJRU5ErkJggg==\" style=\"display:block; margin-left:auto; margin-right:auto\" alt=\"\u62531\u9488\u7ba1\u4e00\u8f88\u5b50\uff0c\u8d85\u8d85\u8d85\u957f\u6548\u964d\u8102\u836f\u771f\u7684\u6765\u4e86\uff1f\" \/><\/p>\n<p>\u56fe\u6e90\uff1a\u53c2\u8003\u8d44\u6599 1<\/p>\n<p>PCSK9 \u662f\u76ee\u524d\u8f83\u4e3a\u660e\u786e\u7684\u964d\u8102\u9776\u70b9\uff0c\u5176\u4e34\u5e8a\u4ef7\u503c\u5df2\u5728\u5355\u6297\u3001siRNA \u7b49\u6cbb\u7597\u4e2d\u5f97\u5230\u9a8c\u8bc1\u3002<\/p>\n<p>\u672c\u6b21\u516c\u5e03\u7684 Heart-2 \u7814\u7a76\uff0c\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u7684 1 \u671f\u8bd5\u9a8c\uff0c\u7eb3\u5165\u5e74\u9f84 18\uff5e70 \u5c81\u3001\u60a3\u6709\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08HeFH\uff09\u6216\u65e9\u53d1\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u3001\u4e14\u5728\u6700\u5927\u8010\u53d7\u53e3\u670d\u964d\u8102\u6cbb\u7597\u4e0b LDL-C \u4ecd \u226570 mg\/dL \u7684\u60a3\u8005\u3002<\/p>\n<p>\u53d7\u8bd5\u8005\u63a5\u53d7\u5355\u6b21\u9759\u8109\u8f93\u6ce8 VERVE-102\uff08\u5242\u91cf\u8303\u56f4 0.3\uff5e1.0 mg\/kg\uff09\u3002\u4e3a\u964d\u4f4e\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94<a href=\"https:\/\/www.alphaseek.cn\/?tag=%e9%a3%8e%e9%99%a9\" title=\"View all posts in \u98ce\u9669\" target=\"_blank\" class=\"tag_link\">\u98ce\u9669<\/a>\uff0c\u7814\u7a76\u4eba\u5458\u5728\u7ed9\u836f\u524d\u540e\u4e3a\u53d7\u8bd5\u8005\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca H1\/H2 \u53d7\u4f53\u62ee\u6297\u5242\u3002<\/p>\n<p>\u672c\u6b21\u7814\u7a76\u7eb3\u5165 35 \u540d\u53d7\u8bd5\u8005\uff0c\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u836f\u4ee3\u52a8\u529b\u5b66\u53ca PCSK9\u3001LDL-C \u6c34\u5e73\u53d8\u5316\u3002[2]<\/p>\n<p>\u7ed3\u679c\u663e\u793a\uff0c\u5355\u6b21\u7ed9\u836f\u540e\uff0cPCSK9 \u6c34\u5e73\u968f\u5242\u91cf\u9012\u589e\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u4e0b\u964d\uff1a0.3 mg\/kg \u7ec4\u5e73\u5747\u4e0b\u964d 51%\uff0c1.0 mg\/kg \u7ec4\u5e73\u5747\u4e0b\u964d 88%\u3002<\/p>\n<p>LDL-C \u6c34\u5e73\u4e5f\u968f\u4e4b\u4e0b\u964d\u3002\u4e0d\u540c\u5242\u91cf\u7ec4\u7684\u964d\u5e45\u5206\u522b\u4e3a\uff1a0.3 mg\/kg \u7ec4 9%\u30010.45 mg\/kg \u7ec4 44%\u30010.6 mg\/kg \u7ec4 45%\u30010.7 mg\/kg \u7ec4 33%\u30010.8 mg\/kg \u7ec4 51%\u30011.0 mg\/kg \u7ec4 62%\u3002\u7814\u7a76\u8005\u5728\u6cbb\u7597\u540e 18 \u4e2a\u6708\u4ecd\u89c2\u5bdf\u5230\u964d\u8102\u6548\u679c\u3002<\/p>\n<p>\u5b89\u5168\u6027\u65b9\u9762\uff0cVERVE-102 \u5728\u5404\u5242\u91cf\u6c34\u5e73\u4e0b\u8010\u53d7\u6027\u826f\u597d\uff0c\u6ca1\u6709\u6cbb\u7597\u76f8\u5173\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u300235 \u540d\u53d7\u8bd5\u8005\u5747\u5b8c\u6210\u7ed9\u836f\uff0c\u65e0\u4eba\u4e2d\u9014\u9000\u51fa\u3002<\/p>\n<p>\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u5185\u5206\u6ccc\u79d1\u526f\u4e3b\u4efb\u533b\u5e08\u6881\u5fae\u5fae\u8868\u793a\uff0c\u5982\u679c\u672a\u6765\u8fdb\u5165\u4e34\u5e8a\uff0c\u8fd9\u7c7b\u6cbb\u7597\u53ef\u80fd\u4f1a\u4f18\u5148\u7528\u4e8e\u6781\u9ad8\u5371\u60a3\u8005\u3002\u6bd4\u5982\uff0c\u5df2\u7ecf\u786e\u8bca ASCVD\u3001\u5728\u4f20\u7edf\u836f\u7269\u6700\u5927\u8010\u53d7\u5242\u91cf\u4e0b LDL-C \u4ecd\u65e0\u6cd5\u8fbe\u6807\uff0c\u6216\u96be\u4ee5\u957f\u671f\u575a\u6301\u6cbb\u7597\u7684\u60a3\u8005\u3002<\/p>\n<p><strong>\u57fa\u56e0\u7f16\u8f91\u964d\u8102\uff0c\u5b89\u5168\u6027\u5b58\u5728\u8f83\u5927\u8003\u9a8c<\/strong><\/p>\n<p>\u6881\u5fae\u5fae\u8868\u793a\uff0c\u8fd9\u9879\u7814\u7a76\u4ecd\u662f\u4e00\u9879 1 \u671f\u5f00\u653e\u6807\u7b7e\u7814\u7a76\uff0c\u6837\u672c\u91cf\u8f83\u5c0f\uff0c\u6838\u5fc3\u76ee\u7684\u4e3a\u9a8c\u8bc1\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u751f\u7269\u5b66\u6709\u6548\u6027\u3002<\/p>\n<p>\u300c\u8ddd\u79bb\u771f\u6b63\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u8fd8\u9700\u8981\u66f4\u5927\u6837\u672c\u7684\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff0c\u4ee5\u53ca\u957f\u671f\u5b89\u5168\u6027\u6570\u636e\u7684\u79ef\u7d2f\u3002\u300d<\/p>\n<p>\u8bba\u6587\u4e2d\u4e5f\u6307\u51fa\uff0c\u672c\u7814\u7a76\u53d7\u8bd5\u8005\u4e0d\u80fd\u5b8c\u5168\u4ee3\u8868\u771f\u5b9e\u4e16\u754c\u4e2d\u7684\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u60a3\u8005\u3002<\/p>\n<p>\u9996\u5148\uff0c\u672c\u7814\u7a76\u7eb3\u5165\u7684\u662f\u7ecf\u8fc7\u4e25\u683c\u7b5b\u9009\u3001\u75c5\u60c5\u76f8\u5bf9\u7a33\u5b9a\u7684\u60a3\u8005\uff0c\u4e0e\u771f\u5b9e\u4e34\u5e8a\u4e2d\u66f4\u590d\u6742\u7684\u4eba\u7fa4\u5b58\u5728\u5dee\u5f02\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u65e9\u671f\u5b89\u5168\u6027\u7ed3\u679c\u4e0d\u80fd\u7b80\u5355\u5916\u63a8\u81f3\u66f4\u5e7f\u6cdb\u4eba\u7fa4\uff0c\u5c24\u5176\u662f\u5408\u5e76\u75c7\u66f4\u591a\u3001\u75c5\u60c5\u66f4\u590d\u6742\uff0c\u6216\u6b63\u5728\u63a5\u53d7\u591a\u79cd\u836f\u7269\u6cbb\u7597\u7684\u60a3\u8005\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u53d7\u7814\u7a76\u5730\u70b9\u5f71\u54cd\uff0c\u672c\u7814\u7a76\u53d7\u8bd5\u8005\u4ee5\u767d\u4eba\u4e3a\u4e3b\uff0c\u975e\u4e34\u5e8a\u8131\u9776\u7b5b\u67e5\u4e5f\u4e3b\u8981\u57fa\u4e8e\u767d\u4eba\u4f9b\u4f53\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u4e0d\u540c\u9057\u4f20\u80cc\u666f\u4eba\u7fa4\uff0cVERVE-102 \u7684\u5b89\u5168\u6027\u3001\u7f16\u8f91\u7279\u5f02\u6027\u548c\u7597\u6548\u80fd\u5426\u5b8c\u5168\u5916\u63a8\uff0c\u9700\u8981\u66f4\u591a\u6570\u636e\u9a8c\u8bc1\u3002<\/p>\n<p><img data-lazyload=\"https:\/\/x0.ifengimg.com\/res\/2026\/0BFC98B470B51C6603DF92A02576FFB948FC7BE3_size46_w1080_h720.jpg\" src=\"https:\/\/tech.ifeng.com\/c\/data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA1BMVEXy8vJkA4prAAAACklEQVQI12NgAAAAAgAB4iG8MwAAAABJRU5ErkJggg==\" style=\"display:block; margin-left:auto; margin-right:auto\" alt=\"\u62531\u9488\u7ba1\u4e00\u8f88\u5b50\uff0c\u8d85\u8d85\u8d85\u957f\u6548\u964d\u8102\u836f\u771f\u7684\u6765\u4e86\uff1f\" \/><\/p>\n<p>\u56fe\u6e90\uff1a\u56fe\u866b\u521b\u610f<\/p>\n<p>\u4e0e\u4f20\u7edf\u964d\u8102\u836f\u3001PCSK9 \u5355\u6297\u6216 siRNA \u836f\u7269\u4e0d\u540c\uff0c\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u4e00\u65e6\u53d1\u6325\u4f5c\u7528\uff0c\u5e26\u6765\u7684\u53ef\u80fd\u662f\u957f\u671f\u751a\u81f3\u6c38\u4e45\u6027\u7684\u6539\u53d8\u3002\u524d\u8005\u5982\u679c\u51fa\u73b0\u95ee\u9898\uff0c\u901a\u5e38\u8fd8\u53ef\u4ee5\u505c\u836f\u6216\u7b49\u5f85\u836f\u6548\u6d88\u9000\uff1b\u800c\u540e\u8005\u7684\u53ef\u9006\u6027\u660e\u663e\u66f4\u4f4e\u3002<\/p>\n<p>\u300cVERVE-102 \u4e0e\u4ed6\u6c40\u7c7b\u836f\u7269\u3001PCSK9 \u6291\u5236\u5242\u7684\u672c\u8d28\u533a\u522b\u5728\u4e8e\uff0c\u5b83\u662f\u4e00\u79cd\u4f53\u5185\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u3002\u300d\u6881\u5fae\u5fae\u5f3a\u8c03\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u5373\u4fbf PCSK9 \u8fd9\u4e00\u9776\u70b9\u5df2\u6709\u8f83\u5f3a\u7684\u9057\u4f20\u5b66\u8bc1\u636e\u652f\u6301\uff0c\u4ecd\u7136\u9700\u5173\u6ce8\u4e0d\u53ef\u9006\u7f16\u8f91\u53ef\u80fd\u5e26\u6765\u7684\u98ce\u9669\u3001\u9002\u7528\u4eba\u7fa4\u8fb9\u754c\uff0c\u4ee5\u53ca\u957f\u671f\u76d1\u6d4b\u8981\u6c42\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u73b0\u6709\u6cbb\u7597\u624b\u6bb5\u5df2\u7ecf\u80fd\u5e2e\u52a9\u8bb8\u591a\u60a3\u8005\u964d\u4f4e LDL-C\uff0c\u5305\u62ec\u4ed6\u6c40\u3001\u4f9d\u6298\u9ea6\u5e03\u3001PCSK9 \u5355\u6297\u548c siRNA \u836f\u7269\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4f53\u5185\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u672a\u6765\u53ef\u80fd\u9762\u4e34\u4ef7\u683c\u66f4\u9ad8\u3001\u76d1\u7ba1\u66f4\u4e25\u683c\uff0c\u4ee5\u53ca\u957f\u671f\u968f\u8bbf\u7684\u8d1f\u62c5\u3002<\/p>\n<p>\u300c\u672a\u6765\u5728\u76d1\u7ba1\u5c42\u9762\u5982\u4f55\u754c\u5b9a\uff0c\u957f\u671f\u968f\u8bbf\u4e2d\u9700\u8981\u91cd\u70b9\u5173\u6ce8\u54ea\u4e9b\u5b89\u5168\u6027\u7ef4\u5ea6\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u6210\u719f\u7b54\u6848\uff0c\u9700\u8981\u7b49\u5f85\u66f4\u591a\u6570\u636e\u6765\u56de\u7b54\u3002\u300d\u6881\u5fae\u5fae\u8bf4\u9053\u3002<\/p>\n<p><strong>\u957f\u6548\u964d\u8102\uff0c\u5df2\u7ecf\u6210\u4e3a\u65b0\u4e00\u4ee3\u7597\u6cd5\u7684\u5171\u540c\u65b9\u5411<\/strong><\/p>\n<p>\u4e8b\u5b9e\u4e0a\uff0cVERVE-102 \u4e0d\u662f\u5b64\u4f8b\u3002<\/p>\n<p>\u8fc7\u53bb\u51e0\u5e74\uff0c\u964d\u8102\u6cbb\u7597\u7684\u4e00\u4e2a\u91cd\u8981\u65b9\u5411\uff0c\u662f\u51cf\u5c11\u7ed9\u836f\u6b21\u6570\u3001\u5ef6\u957f\u836f\u7269\u4f5c\u7528\u65f6\u95f4\u3002\u5176\u4e2d\uff0c\u6700\u6210\u719f\u7684\u4ee3\u8868\u4e4b\u4e00\u662f PCSK9 siRNA \u836f\u7269\u82f1\u514b\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\uff08Inclisran\uff09\u3002<\/p>\n<p>\u82f1\u514b\u53f8\u5170\u94a0\u901a\u8fc7 RNA \u5e72\u6270\u673a\u5236\u6291\u5236\u809d\u7ec6\u80de\u5185 PCSK9 \u7684\u5408\u6210\uff0c\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\uff0c\u9996\u5242\u540e 3 \u4e2a\u6708\u52a0\u5f3a\u4e00\u6b21\uff0c\u6b64\u540e\u6bcf\u534a\u5e74\u4e00\u6b21\u3002\uff08\u4e01\u9999\u56ed\u66fe\u8fdb\u884c\u6df1\u5ea6\u62a5\u9053\uff0c\u70b9\u51fb\u67e5\u770b\uff1a\u5168\u7403\u552f\u4e00\uff01\u6253 1 \u9488\u7ba1\u534a\u5e74\uff0c\u8fd9\u6b3e\u836f\u8fdb\u533b\u4fdd\u4e86\uff09<\/p>\n<p>\u82f1\u514b\u53f8\u5170\u94a0\u53ef\u4f7f LDL-C \u964d\u4f4e\u7ea6 50\uff5e60%\uff0c\u5176\u957f\u671f\u7597\u6548\u548c\u5b89\u5168\u6027\u4e5f\u5df2\u6709\u6570\u636e\u652f\u6301\u3002<\/p>\n<p>\u4e0d\u8fc7\uff0c\u82f1\u514b\u53f8\u5170\u94a0\u4ecd\u662f\u9700\u8981\u91cd\u590d\u7ed9\u836f\u7684 RNA \u836f\u7269\u3002\u5b83\u7684\u4f18\u52bf\u5728\u4e8e\u7ed9\u836f\u95f4\u9694\u957f\u3001\u4fbf\u4e8e\u7ba1\u7406\uff0c\u4f46\u4e0d\u4f1a\u6539\u53d8 DNA\uff0c\u4e5f\u65e0\u6cd5\u5b9e\u73b0\u4e00\u6b21\u6cbb\u7597\u540e\u6c38\u4e45\u751f\u6548\u3002<\/p>\n<p>PCSK9 \u5355\u6297\u4e5f\u5df2\u7ecf\u5728\u4e34\u5e8a\u4e2d\u5e7f\u6cdb\u5e94\u7528\u3002\u4f9d\u6d1b\u5c24\u5355\u6297\u3001\u963f\u5229\u897f\u5c24\u5355\u6297\u3001\u745e\u5361\u897f\u5355\u6297\u7b49\u836f\u7269\u6bcf 2 \u5468\u6216\u6bcf\u6708\u7ed9\u836f\u4e00\u6b21\uff0cLDL-C \u964d\u5e45\u7ea6 60%\uff0c\u76f8\u6bd4\u53e3\u670d\u836f\u663e\u8457\u5ef6\u957f\u4e86\u7ed9\u836f\u95f4\u9694\uff0c\u4f46\u60a3\u8005\u4ecd\u9700\u957f\u671f\u89c4\u5f8b\u6ce8\u5c04\u3002[3]<\/p>\n<p>\u4e0e\u6b64\u540c\u65f6\uff0c\u53e3\u670d PCSK9 \u6291\u5236\u5242\u4e5f\u5728\u63a8\u8fdb\u4e2d\u3002\u90e8\u5206\u5728\u7814\u53e3\u670d\u836f\u7269\u8bd5\u56fe\u7528\u6bcf\u5929\u53e3\u670d\u7684\u65b9\u5f0f\u8fbe\u5230\u63a5\u8fd1\u6ce8\u5c04\u7c7b PCSK9 \u836f\u7269\u7684\u964d\u8102\u5e45\u5ea6\u3002\u4f8b\u5982\uff0c\u53e3\u670d PCSK9 \u6291\u5236\u5242 enlicitide decanoate \u5728 HeFH \u60a3\u8005\u7684 3 \u671f\u7814\u7a76\u4e2d\u663e\u793a\uff0c24 \u5468\u65f6 LDL-C \u964d\u5e45\u53ef\u8fbe 58.2%\u3002[4]<\/p>\n<\/p>\n<p>\u56fe\u6e90\uff1a\u56fe\u866b\u521b\u610f<\/p>\n<p>\u6bcf\u65e5\u53e3\u670d\u867d\u7136\u66f4\u65b9\u4fbf\uff0c\u4f46\u4ecd\u65e7\u96be\u4ee5\u5f7b\u5e95\u89e3\u51b3\u957f\u671f\u6cbb\u7597\u4e2d\u7684\u4f9d\u4ece\u6027\u95ee\u9898\u3002<\/p>\n<p>\u9664\u4e86 PCSK9\uff0c\u7814\u7a76\u8005\u4e5f\u5728\u63a2\u7d22\u5176\u4ed6\u8102\u8d28\u4ee3\u8c22\u9776\u70b9\u7684\u957f\u6548\u6cbb\u7597\u65b9\u6848\u3002ANGPTL3 \u6291\u5236\u5242\u53ef\u540c\u65f6\u5f71\u54cd LDL-C\u3001\u7518\u6cb9\u4e09\u916f\u7b49\u591a\u79cd\u8840\u8102\u6307\u6807\u3002<\/p>\n<p>\u5176\u4e2d\uff0c\u5355\u6297\u836f\u7269 evinacumab \u5df2\u83b7\u6279\u7528\u4e8e\u7eaf\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u9488\u5bf9 ANGPTL3 \u7684 RNA \u836f\u7269\u548c\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u4e5f\u5728\u7814\u53d1\u4e2d\u3002\u5df2\u6709\u65e9\u671f\u4eba\u4f53\u7814\u7a76\u663e\u793a\uff0c\u4e00\u6b21\u6027 CRISPR \u7f16\u8f91\u9776\u5411 ANGPTL3 \u540e\uff0c\u53ef\u964d\u4f4e LDL-C \u548c\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\uff0c\u4f46\u76ee\u524d\u4ecd\u5904\u4e8e\u975e\u5e38\u65e9\u671f\u7684\u9636\u6bb5\u3002[5]<\/p>\n<p>\u7eb5\u89c2\u5f53\u524d\u683c\u5c40\uff0c\u957f\u6548\u964d\u8102\u7597\u6cd5\u5927\u81f4\u53ef\u5206\u4e3a\u4e09\u4e2a\u68af\u961f\uff1a<\/p>\n<p>1\u3001\u5df2\u8f83\u6210\u719f\u7684\u957f\u6548\u6ce8\u5c04\u836f\u7269\uff0c\u4ee5 PCSK9 \u5355\u6297\u548c\u82f1\u514b\u53f8\u5170\u94a0\u4e3a\u4ee3\u8868\uff0c\u7597\u6548\u660e\u786e\u3001\u53ef\u6309\u9700\u8c03\u6574\uff0c\u4f46\u4ecd\u4f9d\u8d56\u957f\u671f\u6cbb\u7597\uff1b<\/p>\n<p>2\u3001\u5728\u7814\u7684\u53e3\u670d\u65b0\u836f\uff0c\u4ee5\u66f4\u4fbf\u6377\u7684\u670d\u836f\u65b9\u5f0f\u63d0\u5347\u60a3\u8005\u63a5\u53d7\u5ea6\uff1b<\/p>\n<p>3\u3001\u4ee5 VERVE-102 \u4e3a\u4ee3\u8868\u7684\u4f53\u5185\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\uff0c\u5219\u5e0c\u671b\u901a\u8fc7\u4e00\u6b21\u7ed9\u836f\uff0c\u957f\u671f\u751a\u81f3\u6c38\u4e45\u6539\u53d8\u9776\u57fa\u56e0\u8868\u8fbe\uff0c\u4ece\u800c\u51cf\u5c11\u751a\u81f3\u6446\u8131\u53cd\u590d\u7528\u836f\u3002<\/p>\n<p>\u4e5f\u6b63\u56e0\u5982\u6b64\uff0cVERVE-102 \u7684\u6f5c\u529b\u66f4\u5927\uff0c\u4f46\u5b89\u5168\u6027\u98ce\u9669\u548c\u76d1\u7ba1\u6311\u6218\u4e5f\u66f4\u9ad8\u3002<\/p>\n<p><strong>\u3010\u7814\u7a76\u70b9\u8bc4\u3011<\/strong><\/p>\n<p><strong>\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u5fc3\u5185\u79d1\u6559\u6388\u3001\u4e3b\u4efb\u533b\u5e08 \u674e\u52c7\uff1a<\/strong><\/p>\n<p>HEART-2 \u8bd5\u9a8c\u662f\u57fa\u56e0\u5de5\u7a0b\u6cbb\u7597\u591a\u57fa\u56e0\/\u6162\u6027\u75be\u75c5\u8fdb\u5165\u4e34\u5e8a\u5e94\u7528\u7684\u91cd\u8981\u4e00\u6b65\uff0c\u5177\u6709\u533b\u5b66\u53f2\u610f\u4e49\u3002<\/p>\n<p>\u5176\u9776\u70b9\u9009\u62e9\u660e\u786e\uff1a\u901a\u8fc7\u6291\u5236 PCSK9 \u57fa\u56e0\u8f6c\u5f55\uff0cVERVE-102 \u4e00\u6b21\u7528\u836f\u5373\u53ef\u957f\u671f\u51cf\u5c11 PCSK9 \u86cb\u767d\u751f\u6210\uff0c\u4f7f\u8840\u6d46 LDL-C \u7a33\u5b9a\u964d\u4f4e &gt;60%\u3002\u5176\u673a\u5236\u662f\u5728\u7ec6\u80de\u6838\u5185\u501f\u52a9 DNA \u4fee\u590d\u673a\u5236\u5b8c\u6210 A&middot;T \u5230 G&middot;C \u7684\u5355\u78b1\u57fa\u66ff\u6362\uff0c\u4f7f PCSK9 \u57fa\u56e0\u8f6c\u5f55\u63d0\u524d\u7ec8\u6b62\uff0c\u4ece\u800c\u963b\u65ad <a href=\"https:\/\/www.alphaseek.cn\/?tag=mrna\" title=\"View all posts in mRNA\" target=\"_blank\" class=\"tag_link\">mRNA<\/a> \u8868\u8fbe\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u809d\u7ec6\u80de\u9776\u5411\u7eb3\u7c73\u9897\u7c92\u9012\u9001\u7cfb\u7edf\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u5df2\u5728\u4eba\u4f53\u4e2d\u5f97\u5230\u521d\u6b65\u9a8c\u8bc1\uff0c\u6807\u5fd7\u7740 PCSK9 \u964d\u8102\u6cbb\u7597\u4ece\u5355\u6297\u3001\u5c0f\u5e72\u6270 RNA \u8fdb\u4e00\u6b65\u8fc8\u5411\u57fa\u56e0\u7f16\u8f91\u3002<\/p>\n<p>\u4f46 VERVE-102 \u9700\u8fdb\u5165\u809d\u7ec6\u80de\u6838\u53d1\u6325\u4f5c\u7528\uff0c\u4ecd\u6709\u5173\u952e\u95ee\u9898\u5f85\u660e\u786e\uff1a\u4e00\u662f\u8131\u9776\u98ce\u9669\uff0c\u5305\u62ec\u662f\u5426\u8fdb\u5165\u809d\u5916\u7ec4\u7ec7\u6216\u751f\u6b96\u7ec6\u80de\uff0c\u662f\u5426\u5f15\u53d1\u4ee3\u9645\u9057\u4f20\u53d8\u5f02\uff0c\u4ee5\u53ca\u662f\u5426\u7f16\u8f91 PCSK9 \u4ee5\u5916\u7684\u57fa\u56e0\uff1b\u4e8c\u662f\u57fa\u56e0\u7f16\u8f91\u540e\u7684\u957f\u671f\u98ce\u9669\uff0c\u5305\u62ec\u6f5c\u5728\u81f4\u764c\u6027\u3001\u514d\u75ab\u53cd\u5e94\u3001\u809d\u810f\u5b89\u5168\u6027\u548c\u4e0d\u53ef\u9006\u7f16\u8f91\u98ce\u9669\u3002<\/p>\n<p>(\u6765\u6e90\uff1a\u65b0\u6d6a\u79d1\u6280)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u53ea\u9700\u6253 1 \u9488\uff0c\u5c31\u80fd\u5b9e\u73b0\u7ec8\u751f\u964d\u8102\uff1f \u6628\u65e5\uff0cNEJM \u53d1\u5e03\u4e00\u9879\u91cd\u78c5\u7814\u7a76\uff1a\u53ea\u9700 1 \u9488\uff0c\u53ef\u6301\u4e45\u964d\u4f4e LDL-C \uff0c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[344,192],"views":9,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/786885"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=786885"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/786885\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=786885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=786885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=786885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}