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\u4e5f\u5c31\u662f\u8bf4\uff0c\u56fd\u5185\u4e0d\u505a\u5934\u5bf9\u5934\u7701\u4e0b\u6765\u7684\u6210\u672c\u548c\u65f6\u95f4\uff0c\u5230\u4e86\u6b27\u7f8e\u6ce8\u518c\u65f6\u5fc5\u987b\u8865\u56de\u6765\uff0c\u800c\u4e14\u4ee3\u4ef7\u66f4\u9ad8\u3002<\/p>\n

02\u3001\u88ab\u9ad8\u4f30\u7684\u7ba1\u7ebf\u7eb5\u6df1\uff1f<\/h2>\n

\u62db\u80a1\u4e66\u5f3a\u8c03\uff0c\u516c\u53f8\u4f9d\u6258\u81ea\u8eab\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u53ca\u957f\u671f\u79ef\u7d2f\u7684\u7814\u53d1\u80fd\u529b\uff0c\u7ed3\u5408\u56fd\u9645\u5316\u89c6\u91ce\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u517c\u5177\u5e7f\u5ea6\u53ca\u6df1\u5ea6\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002\u5df2\u901a\u8fc7\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u5f00\u53d1\u51fa\u591a\u4e2a\u6297\u4f53\u836f\u7269\u53ca\u5019\u9009\u836f\u7269\u6297\u4f53\u5206\u5b50\uff0c\u5305\u62ec\u5168\u7403\u540c\u7c7b\u9996\u521b\u7684\u65af\u6cf0\u5ea6\u5854\u5355\u6297\u6ce8\u5c04\u6db2\u5df2\u83b7\u6279\u4e0a\u5e02\uff0cTNM001\uff08\u6297\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2RSV\u5355\u6297\uff09\u5df2\u5728\u4e2d\u56fd\u63d0\u4ea4NDA\u5e76\u83b7\u53d7\u7406\uff0c2\u6b3e\u5019\u9009\u836f\u7269TNM009\uff08\u6297\u795e\u7ecf\u751f\u957f\u56e0\u5b50NGF\u5355\u6297\uff09\u53caTNM005\uff08\u6297\u6c34\u75d8-\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2VZV\u5355\u6297\uff09\u5df2\u5b8c\u6210\u4e34\u5e8aI\u671f\u8bd5\u9a8c\uff0c1\u6b3e\u5019\u9009\u836f\u7269TNM006\uff08\u6297\u4eba\u5de8\u7ec6\u80de\u75c5\u6bd2HCMV\u5355\u6297\uff09\u5df2\u83b7\u6279IND\uff0c\u4ee5\u53ca3\u6b3e\u5019\u9009\u836f\u7269\u5904\u4e8e\u4e34\u5e8a\u524d\u9636\u6bb5\u3002\u4e0a\u8ff0\u4ea7\u54c1\u4e2d\u65af\u6cf0\u5ea6\u5854\u5355\u6297\u6ce8\u5c04\u6db2\u3001TNM005\u4e3a\u5168\u7403\u540c\u7c7b\u9996\u521b\u6216\u5177\u6709\u5168\u7403\u540c\u7c7b\u9996\u521b\u6f5c\u529b\uff0c\u6280\u672f\u548c\u5546\u4e1a\u4ef7\u503c\u5747\u5f97\u5230\u884c\u4e1a\u8ba4\u53ef\u3002<\/p>\n

\u4ece\u7eb8\u9762\u4e0a\u770b\uff0c\u8fd9\u662f\u4e00\u4e2a\u76f8\u5f53\u6709\u539a\u5ea6\u7684\u7ba1\u7ebf\u5e03\u5c40\uff0c\u8986\u76d6\u611f\u67d3\u6027\u75be\u75c5\u548c\u9547\u75db\u4e24\u5927\u9886\u57df\uff0c\u5305\u62ec\u7834\u4f24\u98ce\u3001RSV\u3001VZV\u3001HCMV\u7b49\u591a\u79cd\u611f\u67d3\u9776\u70b9\uff0c\u4ee5\u53caNGF\u9547\u75db\u9776\u70b9\u3002\u4f46\u5f53\u6211\u4eec\u9010\u4e2a\u5206\u6790\u8fd9\u4e9b\u5206\u5b50\u7684\u771f\u5b9e\u4ef7\u503c\u548c\u5151\u73b0\u8def\u5f84\u65f6\uff0c\u4f1a\u53d1\u73b0\u8fd9\u6761\"\u63a5\u529b\u68af\u961f\"\u7684\u7eb5\u6df1\u8fdc\u6bd4\u8868\u9762\u770b\u4e0a\u53bb\u8981\u8584\u3002<\/p>\n

\u6309\u4e34\u5e8a\u8fdb\u5ea6\u5206\u5c42\u6765\u770b\uff0c\u5df2\u4e0a\u5e02\u7684\u53ea\u6709TNM002\uff0cNDA\u53d7\u7406\u4e2d\u7684\u53ea\u6709TNM001\uff0cI\u671f\u5b8c\u6210\u7684\u6709TNM005\u548cTNM009\uff0cIND\u83b7\u6279\u7684\u6709TNM006\uff0c\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u6709TNM035\u3001TNM050\u3001TNM020\u4e09\u4e2a\u3002<\/p>\n

\u6211\u4eec\u4e14\u6765\u7ec6\u54c1\u3002<\/p>\n

TNM005\uff0c\u6297\u6c34\u75d8-\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\uff08VZV\uff09\u5355\u6297\u3002\u8fd9\u662f\u516c\u53f8\u5ba3\u79f0\u7684\"\u5168\u7403\u540c\u7c7b\u9996\u521b\u6f5c\u529b\"\u4ea7\u54c1\uff0c\u9002\u5e94\u75c7\u5b9a\u4f4d\u662f\u9ad8\u5371\u4eba\u7fa4\u7684VZV\u66b4\u9732\u540e\u9884\u9632\u30022023\u5e744\u6708\u5df2\u83b7FDA\u6279\u51c6IND\uff0c\u5728\u7f8e\u56fd\u5b8c\u6210\u4e86I\u671f\u4e34\u5e8a\u3002\u8fd9\u4e2a\u5206\u5b50\u503c\u5f97\u4ed4\u7ec6\u770b\uff0c\u56e0\u4e3a\u5b83\u662f\u516c\u53f8\u5168\u7403\u5316\u53d9\u4e8b\u4e2d\u9664TNM002\u4e4b\u5916\u552f\u4e00\u4e00\u4e2a\u771f\u6b63\u5728\u7f8e\u56fd\u8d70\u4e34\u5e8a\u7684\u4ea7\u54c1\u3002<\/p>\n

\u4f46VZV\u8fd9\u4e2a\u8d5b\u9053\u7684\u5e02\u573a\u524d\u666f\u9700\u8981\u5ba1\u614e\u770b\u5f85\uff0c\u5e26\u72b6\u75b1\u75b9\u7684\u5168\u7403\u9884\u9632\u4e3b\u6218\u573a\u662f\u75ab\u82d7\uff0c\u800cGSK\u7684\u6b23\u5b89\u7acb\u9002\u662f\u7edd\u5bf9\u4e3b\u5bfc\u8005\uff0c2025\u5e74\u5168\u7403\u9500\u552e\u989d36\u4ebf\u82f1\u9551\u4ee5\u4e0a\uff0c\u957f\u671f\u4fdd\u62a4\u7387\u8d85\u8fc790%\u3002\u5e26\u72b6\u75b1\u75b9\u7684\u6cbb\u7597\u4e3b\u6218\u573a\u5219\u662f\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u963f\u6614\u6d1b\u97e6\u3001\u4f10\u6614\u6d1b\u97e6\u7b49\u5df2\u7ecf\u975e\u5e38\u6210\u719f\u3002VZV\u5355\u6297\u80fd\u5207\u5165\u7684\u7ec6\u5206\u573a\u666f\u975e\u5e38\u7a84——\u4e3b\u8981\u662f\u514d\u75ab\u7f3a\u9677\u4eba\u7fa4\uff08\u9020\u8840\u5e72\u7ec6\u80de<\/a>\u79fb\u690d\u53d7\u8005\u3001\u5668\u5b98\u79fb\u690d\u53d7\u8005\u3001\u5316\u7597\u60a3\u8005\u7b49\uff09\u5728VZV\u66b4\u9732\u540e\u7684\u5e94\u6025\u9884\u9632\u3002\u8fd9\u90e8\u5206\u4eba\u7fa4\u5728\u5168\u7403\u7684\u603b\u6570\u4e0d\u5927\uff0c\u4e14\u5f88\u591a\u5df2\u7ecf\u5728\u7528VZV\u514d\u75ab\u7403\u86cb\u767d\uff08VariZIG\uff09\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\u3002<\/p>\n

\u66f4\u5173\u952e\u7684\u662f\u7814\u53d1\u8282\u594f\u3002\u4e00\u4e2a2023\u5e74\u624d\u83b7\u6279IND\u3001\u76ee\u524d\u521a\u5b8c\u6210I\u671f\u7684\u5206\u5b50\uff0c\u6309\u6b63\u5e38\u8282\u594f\u63a8\u8fdbII\u671fIII\u671f\u5230\u4e0a\u5e02\uff0c\u6700\u5c11\u9700\u89815\u52307\u5e74\u3002\u4e5f\u5c31\u662f\u8bf4\uff0cTNM005\u5373\u4fbf\u987a\u5229\uff0c\u4e5f\u8981\u52302028\u52302030\u5e74\u624d\u80fd\u8d21\u732e\u6536\u5165\u3002\u6b64\u5916\uff0c\u6cf0\u8bfa\u9ea6\u535a\u8ba1\u5212\u4e2d\u7684\u7814\u53d1\u52df\u8d44\u5e76\u6ca1\u6709\u4e13\u95e8\u7528\u4e8eTNM005\u63a8\u8fdb\u7684\u9884\u7b97\uff0c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u5173\u952e\u7684\u4fe1\u53f7\uff0c\u610f\u5473\u7740\u516c\u53f8\u7ba1\u7406\u5c42\u5b9e\u9645\u4e0a\u5e76\u6ca1\u6709\u628aTNM005\u5f53\u4f5c\u8fd1\u671f\u7684\u4f18\u5148\u9879\u76ee\u3002<\/p>\n

\"\u5168\u7403\u540c\u7c7b\u9996\u521b\u6f5c\u529b\"\u8fd9\u4e2a\u6807\u7b7e\u542c\u8d77\u6765\u5f88\u7f8e\uff0c\u4f46\u6ca1\u6709\u5339\u914d\u7684\u8d44\u91d1\u6295\u5165\uff0c\u5b83\u5c31\u53ea\u662f\u4e00\u4e2a\u6807\u7b7e\u3002<\/p>\n

TNM006\uff0c\u6297\u4eba\u5de8\u7ec6\u80de\u75c5\u6bd2\uff08HCMV\uff09\u5355\u6297\u30022023\u5e745\u6708CDE\u6279\u51c6IND\uff0c\u516c\u53f8\u5ba3\u79f0\"\u6709\u671b\u586b\u8865\u4eba\u5de8\u7ec6\u80de\u75c5\u6bd2\u611f\u67d3\u9884\u9632\u9886\u57df\u7684\u56fd\u4ea7\u9884\u9632\u7528\u6297\u4f53\u751f\u7269\u836f\u7a7a\u767d\"\u3002<\/p>\n

HCMV\u5728\u4e2d\u56fd\u662f\u5668\u5b98\u79fb\u690d\u548c\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u611f\u67d3\u7ba1\u7406\u7684\u91cd\u8981\u9632\u8303\u5bf9\u8c61\uff0c\u5e02\u573a\u9700\u6c42\u662f\u771f\u5b9e\u5b58\u5728\u7684\uff0c\u4f46HCMV\u8fd9\u4e2a\u8d5b\u9053\u7684\u56fd\u9645\u7ade\u4e89\u975e\u5e38\u6fc0\u70c8\u3002\u9ed8\u6c99\u4e1c\u7684\u6765\u7279\u83ab\u97e6\u5df2\u7ecf\u6210\u4e3a\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690dHCMV\u9884\u9632\u7684\u6807\u51c6\u6cbb\u7597\uff0c\u6b66\u7530\u5236\u836f\u7684\u9a6c\u7acb\u5df4\u97e6\u4e5f\u57282021\u5e74\u83b7\u6279\u7528\u4e8e\u96be\u6cbb\u6027HCMV\u611f\u67d3\u3002\u8fd9\u4e24\u4e2a\u836f\u7269\u76f8\u6bd4\u5355\u6297\u6709\u53e3\u670d\u4fbf\u5229\u6027\u7684\u5de8\u5927\u4f18\u52bf\uff0c\u5355\u6297\u5728HCMV\u6cbb\u7597\u9886\u57df\u8981\u627e\u5230\u81ea\u5df1\u7684\u5dee\u5f02\u5316\u5b9a\u4f4d\u5e76\u4e0d\u5bb9\u6613\u3002\u6b64\u5916\uff0c\u4f20\u7edf\u7684HCMV\u9ad8\u514d\u75ab\u7403\u86cb\u767d\uff08CytoGam\uff09\u5df2\u7ecf\u5b58\u5728\uff0c\u4e14\u8fd9\u4e2a\u9886\u57df\u771f\u6b63\u7684\u4e34\u5e8a\u75db\u70b9\u662f\u8010\u836f\u75c5\u6bd2\uff0c\u9700\u8981\u7684\u662f\u65b0\u673a\u5236\u836f\u7269\u800c\u4e0d\u662f\u53e6\u4e00\u4e2a\u88ab\u52a8\u514d\u75ab\u5236\u5242\u3002<\/p>\n

\u66f4\u4f55\u51b5\uff0cTNM006\u76ee\u524d\u53ea\u662fIND\u9636\u6bb5\uff0c\u8ddd\u79bb\u4e0a\u5e02\u8fd8\u6709\u81f3\u5c116\u52308\u5e74\u5468\u671f\u3002<\/p>\n

TNM009\uff0c\u6297\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff08NGF\uff09\u5355\u6297\uff0c\u7528\u4e8e\u9aa8\u8f6c\u79fb\u7b49\u764c\u75db\u9547\u75db\u3002\u4f46\u9700\u8981\u7279\u522b\u6307\u51fa\u7684\u662f\uff0cNGF\u6291\u5236\u5242\u7814\u7a76\u662f\u6781\u9ad8\u98ce\u9669\u7684\u9886\u57df\u3002<\/p>\n

\u65e9\u57282011\u5e74\uff0c\u7f8e\u56fdFDA\u5c31\u66fe\u5c06NGF\u7c7b\u522b\u8fdb\u884c\u4e86\u4e34\u5e8a\u6401\u7f6e\uff0c\u56e0\u6709\u8bc1\u636e\u8868\u660e\u8be5\u7c7b\u836f\u7269\u4e0e\u5173\u8282\u635f\u4f24\u548c\u5176\u4ed6\u4e0d\u826f\u4e8b\u4ef6\u6709\u5173\u3002\u5305\u62ec\u827e\u4f2f\u7ef4\u3001\u963f\u65af\u5229\u5eb7\u3001\u5f3a\u751f\u3001\u793c\u6765\u3001\u8f89\u745e\u3001\u518d\u751f\u5143\u3001\u68af\u74e6\u7b49\u516c\u53f8\u76f8\u7ee7\u6298\u621f\uff0c\u582a\u79f0\u836f\u7269\u5de8\u5934\u7684\u575f\u573a\u3002NGF\u6297\u4f53\u7684\u5b89\u5168\u6027\u7a97\u53e3\u975e\u5e38\u7a84\uff0c\u5173\u8282\u5feb\u901f\u8fdb\u5c55\u6027\u9aa8\u5173\u8282\u708e\u662f\u53cd\u590d\u51fa\u73b0\u7684\u526f\u4f5c\u7528\u3002<\/p>\n

TNM009\u9009\u62e9\u9aa8\u8f6c\u79fb\u764c\u75db\u4f5c\u4e3a\u5207\u5165\u9002\u5e94\u75c7\u662f\u4e00\u4e2a\u806a\u660e\u7684\u7b56\u7565<\/a>\uff0c\u764c\u75db\u60a3\u8005\u9884\u671f\u5bff\u547d\u77ed\uff0c\u5173\u8282\u5b89\u5168\u6027\u7684\u957f\u671f\u98ce\u9669\u76f8\u5bf9\u4e0d\u90a3\u4e48\u81f4\u547d\u3002\u4f46\u8fd9\u540c\u65f6\u4e5f\u610f\u5473\u7740TNM009\u7684\u5e02\u573a\u5929\u82b1\u677f\u88ab\u8fd9\u4e2a\u9009\u62e9\u9650\u5236\u4e86\u3002\u9aa8\u8f6c\u79fb\u764c\u75db\u662f\u963f\u7247\u7c7b\u836f\u7269\u7684\u4f20\u7edf\u9002\u5e94\u75c7\uff0c\u5e02\u573a\u867d\u7136\u4e0d\u5c0f\uff0c\u4f46\u5355\u6297\u7684\u9ad8\u5b9a\u4ef7\u80fd\u5426\u88ab\u764c\u75db\u60a3\u8005\u63a5\u53d7\u662f\u4e2a\u95ee\u9898\u3002NGF\u5355\u6297\u5728\u9547\u75db\u9886\u57df\u771f\u6b63\u7684\u5e02\u573a\u60f3\u8c61\u7a7a\u95f4\u662f\u6162\u6027\u75bc\u75db\uff08\u9aa8\u5173\u8282\u708e\u3001\u6162\u6027\u4e0b\u80cc\u75db\u7b49\uff09\uff0c\u4f46\u5de8\u5934\u4eec\u5728\u8fd9\u4e9b\u9002\u5e94\u75c7\u4e0a\u7684\u5931\u8d25\u5df2\u7ecf\u8bc1\u660e\u8fd9\u6761\u8def\u975e\u5e38\u96be\u8d70\u3002<\/p>\n

\u516c\u53f8\u8fd9\u6b21\u52df\u8d44\u8ba1\u5212\u628a2.4\u4ebf\u5143\u62bc\u5728TNM009\u4e0a\uff0c\u662f\u4e00\u4e2a\u76f8\u5f53\u6fc0\u8fdb\u7684\u8d44\u6e90\u914d\u7f6e\uff0c\u6bd4TNM001\u57282027\u5e74\u540e\u7684\u6240\u6709\u7814\u53d1\u9884\u7b97\u52a0\u8d77\u6765\u8fd8\u591a\u3002\u8fd9\u53cd\u6620\u51fa\u516c\u53f8\u7ba1\u7406\u5c42\u628aTNM009\u4f5c\u4e3a\"TNM001\u4e4b\u540e\u7684\u4e0b\u4e00\u4e2a\u6545\u4e8b\"\u6765\u63a8\u8fdb\u3002\u4f46\u8003\u8651\u5230NGF\u9776\u70b9\u7684\u5931\u8d25\u7387\uff0c\u8fd9\u662f\u4e00\u7b14\u98ce\u9669\u5f88\u5927\u7684\u6295\u5165\uff0c\u5728II\u671f\u6216III\u671f\u9047\u5230\u5b89\u5168\u6027\u95ee\u9898\u9700\u8981\u7ec8\u6b62\u7684\u6982\u7387\u4e0d\u5bb9\u5ffd\u89c6\u3002<\/p>\n

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04\u3001First-in-Class\u4e4b\u540e<\/h2>\n

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