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\/ 01 \/<\/strong><\/strong><\/strong><\/strong>\u6614\u65e5\u4e4b\u661f<\/h2>\n

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\/ 02 \/<\/strong><\/strong><\/strong><\/strong>\u591a\u7c73\u8bfa\u9aa8\u724c\u7684\u5d29\u584c<\/h2>\n

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\u66f4\u65e9\u4e4b\u524d\uff0cGSK\u4f5c\u4e3a\u6700\u65e9\u5e03\u5c40RIPK1\u9886\u57df\u7684\u5de8\u5934\uff0c\u65e9\u5df2\u7387\u5148\u79bb\u573a\u30022014\u5e74\uff0cGSK\u5c06\u9996\u4e2aRIPK1\u6291\u5236\u5242GSK2982772\u63a8\u8fdb\u4e34\u5e8a\u9636\u6bb5\uff0c\u4f46\u5176\u5728\u591a\u9879\u9002\u5e94\u75c7\u4e2d\u5747\u672a\u80fd\u8fbe\u5230\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u6700\u7ec8\u88ab\u653e\u5f03\uff1b2019\u5e74\uff0cGSK\u7ec8\u6b62\u4e86\u53e6\u4e00\u6b3e\u7528\u4e8e\u6cbb\u7597\u80f0\u817a\u764c\u7684RIPK1\u836f\u7269GSK095\u4e0eK\u836f\u7684\u8054\u5408\u7597\u6cd5\u5f00\u53d1\uff0c\u6b64\u540e\u4fbf\u9010\u6e10\u6de1\u51faRIPK1\u9886\u57df\uff0c\u76ee\u524d\u5df2\u65e0\u4efb\u4f55\u76f8\u5173\u7814\u53d1\u8ba1\u5212\u3002BMS\u4e5f\u65e9\u5df2\u653e\u5f03RIPK1\u76f8\u5173\u5e03\u5c40\uff0c\u827e\u4f2f\u7ef4\u867d\u672a\u6b63\u5f0f\u5b98\u5ba3\uff0c\u4f46\u5df2\u5c06ABBV-668\u4ece\u7ba1\u7ebf\u4e2d\u6084\u7136\u79fb\u9664\u3002<\/p>\n

\u8fc7\u53bb\u51e0\u5e74\uff0cRIPK1\u6291\u5236\u5242\u5728\u4e34\u5e8a\u9636\u6bb5\u7684\u5f81\u7a0b\uff0c\u53ef\u8c13\u5c61\u6218\u5c61\u8d25\u3002MNC\u7684\u96c6\u4f53\u64a4\u9000\uff0c\u4e5f\u76f4\u63a5\u5bfc\u81f4\u5168\u7403RIPK1\u6291\u5236\u5242\u7ba1\u7ebf\u6025\u5267\u6536\u7f29\u3002\u622a\u81f3\u76ee\u524d\uff0c\u66fe\u7ecf\u5341\u4f59\u6b3e\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684RIPK1\u6291\u5236\u5242\uff0c\u5982\u4eca\u4ecd\u5728\u79ef\u6781\u63a8\u8fdb\u7684\u5df2\u5be5\u5be5\u65e0\u51e0\u3002<\/p>\n

\u6574\u4e2a\u9886\u57df\u8fdb\u5165\u4e86\u4e00\u4e2a\u7406\u6027\u53cd\u601d\u548c\u8270\u96be\u6c42\u7d22\u7684\u9636\u6bb5\u3002<\/p>\n

\/ 03 \/<\/strong><\/strong><\/strong><\/strong>\u540e\u8def\u5728\u54ea<\/h2>\n

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\u9996\u5148\uff0c\u6211\u4eec\u5fc5\u987b\u91cd\u65b0\u5ba1\u89c6\u9776\u70b9\u672c\u8eab\u7684\u590d\u6742\u673a\u5236\u3002RIPK1\u7684\u6700\u5927\u6311\u6218\uff0c\u5728\u4e8e\u5176\u529f\u80fd\u7684\u53cc\u91cd\u6027\u4e0e\u590d\u6742\u6027——\u5b83\u4e0d\u4ec5\u662f\u8c03\u63a7\u7ec6\u80de\u6b7b\u4ea1\u7684“\u5f00\u5173”\uff0c\u8fd8\u662f\u7ef4\u6301\u7ec6\u80de\u5b58\u6d3b\u7684“\u652f\u67b6”\uff0c\u5728\u4e0d\u540c\u75be\u75c5\u73af\u5883\u548c\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u4f5c\u7528\u53ef\u80fd\u5177\u6709\u5f02\u8d28\u6027\u3002<\/p>\n

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\/ 04 \/<\/strong><\/strong><\/strong><\/strong>\u603b\u7ed3<\/h2>\n

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