{"id":758731,"date":"2026-03-31T18:41:24","date_gmt":"2026-03-31T10:41:24","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=758731"},"modified":"2026-03-31T18:41:24","modified_gmt":"2026-03-31T10:41:24","slug":"pan-kras%ef%bc%8c%e8%a2%ab%e6%8f%90%e5%89%8d%e7%9a%84%e4%b8%8b%e5%8d%8a%e5%9c%ba","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=758731","title":{"rendered":"Pan-(K)RAS\uff0c\u88ab\u63d0\u524d\u7684\u4e0b\u534a\u573a"},"content":{"rendered":"
\n

\u6587 | \u6c28\u57fa\u89c2\u5bdf<\/p>\n<\/blockquote>\n

\u4e24\u5e74\u524d\uff0cPan-(K)RAS\u8d5b\u9053\u8fd8\u5728\u63a2\u7d22\u9636\u6bb5\uff0c\u4f46\u5982\u4eca\u7ade\u8d5b\u4e00\u518d\u63d0\u901f\u3002<\/p>\n

\u65e5\u524d\uff0cKestrel\u5ba3\u5e03\u5176Pan-(K)RAS\u6291\u5236\u5242KST-6051\u83b7IND\u6279\u51c6\uff0c\u7d27\u63a5\u7740\u6b63\u5927\u5929\u6674Pan-(K)RAS\u6291\u5236\u5242TQB3205\u4e5f\u83b7\u6279\u4e34\u5e8a\uff0c\u7ade\u4e89\u518d\u6b21\u5347\u6e29\u3002<\/p>\n

\u5168\u7403\u5171\u6709\u7ea620\u4f59\u6b3ePan-(K)RAS\u7ba1\u7ebf\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\uff0c\u672a\u6765\u6570\u91cf\u4ecd\u4f1a\u88ab\u6301\u7eed\u5237\u65b0\u3002<\/p>\n

\u70ed\u6f6e\u80cc\u540e\u4e00\u65b9\u9762\u662f\u5f53\u524d\u5df2\u83b7\u6279KRAS\u836f\u7269\u4ec5\u9488\u5bf9G12C\u5355\u4e00\u7a81\u53d8\uff0c\u53d7\u4f17\u7fa4\u4f53\u7a84\u4e14\u4ea7\u751f\u8010\u836f\u6027\uff0c\u4e34\u5e8a\u7f3a\u53e3\u5927\u3002\u53e6\u4e00\u65b9\u9762\u4ee5Revolution\u4e3a\u4ee3\u8868\u7684\u4f01\u4e1a\u51ed\u501fKRAS\u53d9\u4e8b\u5b9e\u73b0\u5e02\u503c\u4e00\u8def“\u98d9\u6da8”\uff0c\u4ee5\u53ca\u5e74\u521d\u4f20\u6765\u7684\u4e0e\u9ed8\u6c99\u4e1c\u7684\u91cd\u78c5\u4ea4\u6613\uff0c\u5e26\u52a8\u4e86\u7814\u53d1\u70ed\u60c5\u3002<\/p>\n

\u5f53\u7136\u4e86\uff0c\u5168\u7403\u597d\u624b\u8702\u62e5\u800c\u81f3\uff0c\u672c\u8d28\u4e0a\u4e5f\u4ee3\u8868\u4e86\u4e00\u70b9\uff1aPan-(K)RAS\u7ade\u8d5b\uff0c\u5df2\u7ecf\u63d0\u524d\u8fdb\u5165\u4e0b\u534a\u573a\uff0c\u5f88\u591a\u5206\u5b50\u53ef\u80fd\u8fd8\u6ca1\u5f00\u59cb\u5c31\u5df2\u7ecf\u88ab\u6dd8\u6c70\u4e86\u3002<\/p>\n

\u7ade\u4e89\u5df2\u7ecf\u5f00\u59cb<\/h2>\n

\u867d\u7136\u8fd8\u6ca1\u6709\u6210\u836f\uff0c\u4f46\u662fPan-(K)RAS\u7684\u7ade\u8d5b\uff0c\u5df2\u7ecf\u5f00\u59cb\u3002<\/p>\n

\u5728\u8be5\u8d5b\u9053\u4e0a\uff0cRevolution Medicines\u662f\u7edd\u5bf9\u7684\u9886\u8dd1\u8005\u3002\u5176\u6838\u5fc3\u7ba1\u7ebfDaraxonrasib (RMC-6236)\u662f\u8fdb\u5ea6\u6700\u5feb\u7684Pan-RAS\u6291\u5236\u5242\u3002<\/p>\n

\u65e9\u671f\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff1a\u5728\u9488\u5bf9\u4e8c\u7ebf\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u7684\u6cbb\u7597\u4e2d\uff0cRMC-6236\u6cbb\u7597KRAS G12X\u7a81\u53d8\u60a3\u8005\u76846\u4e2a\u6708\u751f\u5b58\u7387\u8fbe\u5230100%\uff0c\u4efb\u610fRAS\u7a81\u53d8\u60a3\u800597%\u3002\u8be5\u7ed3\u679c\u4f7f\u5176\u83b7\u5f97FDA\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u6cbb\u7597\u7684PDAC\u60a3\u8005\u3002<\/p>\n

\u540c\u65f6\uff0cRevolution\u6b63\u5728\u52a0\u901f\u633a\u8fdb\u4e00\u7ebf\u6cbb\u7597\uff0cRMC-9805\u8054\u5408mFOLFIRINOX\u5316\u7597\u65b9\u6848\u5728\u4e00\u7ebf\u6cbb\u7597\u80f0\u817a\u764c\u60a3\u80051\u671f\u6570\u636e\u663e\u793aORR\u4e3a53%\u3002\u5c3d\u7ba1\u662f\u65e9\u671f\u4e34\u5e8a\uff0c\u4f46\u5df2\u4e3aRevolution\u589e\u6dfb\u4e86\u4fe1\u5fc3\u3002JPM\u5927\u4f1a\u4e0a\uff0c\u516c\u53f8\u8ba1\u52122026\u5f00\u5c55\u9488\u5bf9\u4e00\u7ebf\u80ba\u764c\u3001\u80f0\u817a\u764c\u76843\u671f\u4e34\u5e8a\u3002<\/p>\n

\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c2026\u5e74\u521d\u5e02\u573a\u66fe\u4f20\u51fa\u9ed8\u6c99\u4e1c\u62df\u4ee5\u7ea6300\u4ebf\u7f8e\u5143\u6536\u8d2d<\/a>Revolution\u7684\u6d88\u606f\u3002\u867d\u7136\u6700\u7ec8\u53cc\u65b9\u56e0\u4f30\u503c\u5206\u6b67\u672a\u8fbe\u6210\u4ea4\u6613\uff0c\u4f46\u8fd9\u5e76\u6ca1\u6709\u91cd\u632b\u5e02\u573a\u4fe1\u5fc3\uff0c\u53cd\u800c\u6210\u4e3a\u4e86\u884c\u4e1a\u80cc\u4e66\u3002<\/p>\n

\u4f46Revolution\u5e76\u4e0d\u662f\u5b89\u6795\u65e0\u5fe7\uff0c\u7d27\u968f\u5176\u540e\u7684\u52a0\u79d1\u601d\uff0c\u5c31\u5e0c\u671b\u53d1\u8d77\u6311\u6218\u3002<\/p>\n

\u4e0eRMC-6236\u9488\u5bf9KRAS\u3001HRAS\u3001NRAS\u4e0d\u540c\uff0cJAB\u201123E73\u662f\u5c0f\u5206\u5b50\u6291\u5236\u5242\u53ea\u6291\u5236KRAS\u3002\u8fd9\u4e5f\u88ab\u8ba4\u4e3a\u662f\u7ade\u4e89\u4f18\u52bf\uff0c\u56e0\u4e3a\u76f8\u5173\u7814\u7a76\u63d0\u793a\u6291\u5236HRAS\u3001NRAS\u53cd\u800c\u4f1a\u5f71\u54cd\u80bf\u7624\u6740\u4f24\u4f5c\u7528\uff0c\u8fd8\u4f1a\u8bf1\u53d1\u6f5c\u5728\u6bd2\u6027\u3002<\/p>\n

\u8fd1\u671fJAB\u201123E73\u516c\u5e03\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u6570\u636e\u4f3c\u4e4e\u9a8c\u8bc1\u4e86\u8fd9\u4e00\u70b9\u3002\u540c\u6837\u662f\u80f0\u817a\u764c\u60a3\u8005\uff0cJAB-23E73\u5f15\u53d1\u7684≥3\u7ea7TRAEs\u53d1\u751f\u7387\u4e3a14.4%\uff0c\u975e\u5934\u5bf9\u5934\u4e34\u5e8aRMC-6236\u4e3a34%\u3002\u5728RMC-6236\u5f15\u53d1\u7684\u9ad8\u8fbe91%\u7684\u76ae\u80a4\u6bd2\u6027\u95ee\u9898\u4e0a\uff0cJAB-23E73\u8bf1\u53d1\u7387\u4ec5\u4e3a8%\uff0c\u6574\u4f53\u5b89\u5168\u6027\u53ef\u63a7\u3002<\/p>\n

\u5f53\u7136\u4e86\uff0c\u8be5\u7ed3\u679c\u53ea\u662f1\u671f\u7814\u7a76\u7ed3\u679c\u800c\u4e14\u662f\u722c\u5761\u8bd5\u9a8c\u6570\u636e\uff0c\u7597\u6548\u4e0e\u5b89\u5168\u6027\u7684\u7ade\u4e89\u4f18\u52bf\u4ecd\u9700\u66f4\u5927\u7684\u6837\u672c\u91cf\u8fdb\u884c\u518d\u5206\u6790\u3002<\/p>\n

\u53ea\u662f\uff0cRMC-6236\u4e0eJAB-23E73\u7684\u4e89\u593a\uff0c\u672c\u8d28\u4e0a\u53cd\u6620\u4e86\u8be5\u9886\u57df\u6fc0\u70c8\u7ade\u4e89\u7684\u5f00\u59cb\u3002<\/p>\n

\u88ab\u63d0\u524d\u7684\u4e0b\u534a\u573a<\/h2>\n

\u968f\u7740\u5165\u5c40\u8005\u589e\u591a\uff0c\u7ade\u4e89\u4e5f\u5728\u7ee7\u7eed\u5347\u7ea7\u3002<\/p>\n

\u867d\u7136\u65b0\u8fdb\u5165\u4e34\u5e8a\u6216IND\u9636\u6bb5\u7684\u5206\u5b50\u672c\u8d28\u4e0a\u4ecd\u5c5e\u4e8ePan-RAS\u5e7f\u8c31\u6291\u5236\u6216Pan-(K)RAS\u9009\u62e9\u6027\u6291\u5236\u4e24\u5927\u6846\u67b6\uff0c\u4f46\u5206\u5b50\u5c42\u9762\u521b\u65b0<\/a>\u4e0d\u65ad\u3002<\/p>\n

\"Pan-(K)RAS\uff0c\u88ab\u63d0\u524d\u7684\u4e0b\u534a\u573a\"<\/p>\n

RMC-6236\u5728\u65e9\u671f\u4e34\u5e8a\u4e2d\uff0c\u76ae\u80a4\u6bd2\u6027\u548c\u80c3\u80a0\u9053\u6bd2\u6027\u8f83\u4e3a\u663e\u8457\uff0c\u9700\u8981\u901a\u8fc7\u5242\u91cf\u4f18\u5316\u5e73\u8861\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u6311\u6218\uff0c\u4e5f\u6210\u4e3a\u540e\u7eed\u7ade\u4e89\u8005\u6539\u8fdb\u8bbe\u8ba1\u548c\u7b56\u7565<\/a>\u7684\u91cd\u8981\u53c2\u8003\u3002<\/p>\n

\u540c\u6837\u662f\u5206\u5b50\u80f6\u8bbe\u8ba1\uff0c\u52b2\u65b9\u533b\u836f<\/a>\u7684GFH276\u901a\u8fc7\u5f62\u6210CypA\u2011GFH276\u2011RAS\u4e09\u5143\u590d\u5408\u7269\u91cd\u5851RAS\u4fe1\u53f7\uff0c\u8be5\u590d\u5408\u7269\u80fd\u6291\u5236\u591a\u6570\u7a81\u53d8\u578bRAS\u3002\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c0.3–3\u202fmg\/kg\u53e3\u670d\u5242\u91cf\u5373\u53ef\u663e\u8457\u6291\u5236\u80bf\u7624\uff0c\u76f8\u6bd4RMC\u20116236 10\u202fmg\/kg\uff0c\u8d77\u6548\u5242\u91cf\u66f4\u4f4e\uff0c\u4e14\u5728\u591a\u91cd\u8010\u836f\u7ec6\u80de\u7cfb\u663e\u793a\u6df1\u5ea6MAPK\u901a\u8def\u6291\u5236\u3002\u76ee\u524dGFH276\u5df2\u8fdb\u51651\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7d27\u8ddfRevolution\u811a\u6b65\u3002<\/p>\n

\u7531\u5609\u8d8a\u533b\u836f\u6388\u6743\u7ed9Erasca\u516c\u53f8\u7684JYP0015\u540c\u6837\u91c7\u7528\u5206\u5b50\u80f6\u7b56\u7565\uff0c\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0cJYP0015\u5bf9CypA\u7684\u4eb2\u548c\u529b\u8f83RMC\u20116236\u9ad8\u51fa8–21\u500d\uff0c\u4e14\u534a\u8870\u671f\u66f4\u957f\uff0c\u662f“\u540c\u7c7b\u6700\u4f73”\u3002\u5176\u7528\u4e8ePDAC\u7684\u521d\u6b65\u4e34\u5e8a\u7597\u6548\u6570\u636e\u9884\u8ba1\u5c06\u5728\u4eca\u5e74\u53d1\u5e03\u3002<\/p>\n

\u963f\u8bfa\u533b\u836f\u7684AN9025\u4e5f\u662fPan-RAS\u6291\u5236\u5242\uff0c\u4e5f\u58f0\u79f0\u5177\u6709“BIC”\u6f5c\u529b\u3002\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0cAN9025\u5728\u6291\u5236RAS\u7a81\u53d8\u7ec6\u80de\u7cfb\u7ec6\u80de\u6d3b\u529b\u65b9\u9762\u6548\u529b\u7ea6\u4e3aRMC-6236\u7684100\u500d\uff0c\u836f\u6548\u7a7a\u95f4\u8fdb\u4e00\u6b65\u62d3\u5bbd\u3002<\/p>\n

\u7531\u4e8e\u4e13\u5229\u58c1\u5792\u548c\u6280\u672f\u95e8\u69db\uff0cPan-RAS\u6291\u5236\u5242\u7684\u7814\u53d1\u6570\u91cf\u76f8\u5bf9\u6709\u9650\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0cPan-(K)RAS\u6291\u5236\u5242\u7814\u53d1\u8282\u594f\u660e\u663e\u52a0\u5feb\uff0c\u5404\u5bb6\u516c\u53f8\u7eb7\u7eb7\u5728\u4e34\u5e8a\u524d\u548c\u65e9\u671f\u4e34\u5e8a\u9636\u6bb5\u5f62\u6210\u4e86\u5404\u81ea\u72ec\u7279\u7684“BIC”\u4f18\u52bf\uff0c\u7ade\u4e89\u9010\u6b65\u8fdb\u5165\u4e0b\u534a\u573a\u3002<\/p>\n

\u5728\u8fd9\u4e00\u8d5b\u9053\u4e2d\uff0c“ON\/OFF”\u72b6\u6001\u53cc\u91cd\u6291\u5236\u5df2\u662f\u6807\u914d\u3002<\/p>\n

\u521a\u83b7\u6279\u4e34\u5e8a\u7684KST-6051\u662f\u4e00\u79cd\u5f3a\u6548\u4e14\u9009\u62e9\u6027\u7684KRAS\u6291\u5236\u5242\uff0c\u5bf9\u5904\u4e8e\u6d3b\u6027\uff08GTP\u7ed3\u5408\uff09\u548c\u975e\u6d3b\u6027\uff08GDP\u7ed3\u5408\uff09\u72b6\u6001\u7684KRAS\u5747\u5177\u6709\u6d3b\u6027\u3002\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0cKST-6051\u5728\u591a\u79cd\u4eba\u7c7bKRAS\u7a81\u53d8\u80bf\u7624\u6a21\u578b\u4e2d\u5747\u8868\u73b0\u51fa\u5f3a\u5927\u7684\u9776\u5411\u901a\u8def\u8c03\u63a7\u80fd\u529b\u3001\u6297\u589e\u6b96\u6d3b\u6027\u4ee5\u53ca\u826f\u597d\u7684\u8010\u53d7\u5242\u91cf\u3002<\/p>\n

\u6b63\u5927\u5929\u6674\u7684TQB3205\u540c\u6837\u8986\u76d6\u4e24\u79cd\u72b6\u6001\uff0c\u4f46\u5176\u673a\u5236\u4e0d\u540c\uff1a\u901a\u8fc7\u9776\u5411KRAS\u4e0a\u6e38\u8c03\u63a7\u56e0\u5b50SOS1\u5b9e\u73b0\u5e7f\u8c31\u6291\u5236\u3002SOS1\u662f\u4e00\u79cd\u9e1f\u560c\u5464\u6838\u82f7\u9178\u4ea4\u6362\u56e0\u5b50\uff0c\u50ac\u5316KRAS\u7531GDP\u7ed3\u5408\u7684\u5931\u6d3b\u72b6\u6001\u5411GTP\u7ed3\u5408\u7684\u6fc0\u6d3b\u72b6\u6001\u8f6c\u53d8\u3002TQB3205\u901a\u8fc7\u9ad8\u4eb2\u548c\u529b\u7ed3\u5408SOS1\uff0c\u963b\u65ad\u5176\u4e0eKRAS\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6291\u5236\u4e0b\u6e38ERK\u78f7\u9178\u5316\u4fe1\u53f7\uff0c\u6700\u7ec8\u6291\u5236\u591a\u79cdKRAS\u7a81\u53d8\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3002<\/p>\n

\u53e6\u4e00\u7c7b\u7ade\u4e89\u7b56\u7565\u662f\u7ec4\u5408\u7528\u836f\uff0c\u4f8b\u5982\u767e\u6d4e\u795e\u5dde\u7684BGB-53038\u5728\u5df2\u5f00\u5c55\u76841\u671f\u5b89\u5168\u6027\u8bd5\u9a8c\u4e2d\uff0c\u5df2\u521d\u6b65\u9a8c\u8bc1\u4e86\u4e0e\u6297PD-1\u6297\u4f53\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u4ee5\u53ca\u4e0e\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u7684\u7597\u6548\u3002<\/p>\n

\u5728Pan-(K)RAS\u7b56\u7565\u4e2d\uff0c\u66f4\u6fc0\u8fdb\u7684\u65b9\u5f0f\u662f\u86cb\u767d\u964d\u89e3\uff0cAstellas Pharma\u7684ASP5834\u5c31\u662f\u9996\u6b3e\u9776\u5411Pan-(K)RAS\u7684\u86cb\u767d\u964d\u89e3\u5242\uff0c\u53ef\u8986\u76d6KRAS G12V\/D\/C\/R\/A\u548cG13D\u7a81\u53d8\uff0c\u4ee5\u53caKRAS\u91ce\u751f\u578b\u57fa\u56e0\u6269\u589e\u3002\u901a\u8fc7\u76f4\u63a5\u964d\u89e3KRAS\u86cb\u767d\uff0c\u8be5\u836f\u7269\u5b9e\u73b0\u4e86\u66f4\u5f7b\u5e95\u7684\u4fe1\u53f7\u5173\u95ed\u3002<\/p>\n

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