{"id":750459,"date":"2026-03-20T10:55:57","date_gmt":"2026-03-20T02:55:57","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=750459"},"modified":"2026-03-20T10:55:57","modified_gmt":"2026-03-20T02:55:57","slug":"lag-3%e5%8f%88%e5%a1%8c%e6%88%bf%e4%ba%86","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=750459","title":{"rendered":"LAG-3\u53c8\u584c\u623f\u4e86"},"content":{"rendered":"<blockquote>\n<p>\u6587 | \u6c28\u57fa\u89c2\u5bdf<\/p>\n<\/blockquote>\n<p>LAG-3\u53c8\u584c\u623f\u4e86\u3002<\/p>\n<p>3\u670813\u65e5\uff0cImmutep\u5ba3\u5e03\uff0c\u5176\u53ef\u6eb6\u6027LAG-3\u86cb\u767defti\u8054\u5408K\u836f\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u2162\u671f\u7814\u7a76\u56e0\u7597\u6548\u4e0d\u4f73\u63d0\u524d\u7ec8\u6b62\uff0c\u516c\u53f8\u80a1\u4ef7\u5355\u65e5\u66b4\u8dcc\u8fd190%\u3002<\/p>\n<p>\u5e02\u573a\u53cd\u5e94\u5982\u6b64\u5267\u70c8\uff0c\u539f\u56e0\u5728\u4e8e\u8fd9\u4e0d\u4ec5\u662f\u4e00\u9879\u4e34\u5e8a\u5931\u8d25\uff0c\u66f4\u662f\u4e00\u6b21\u9884\u671f\u5d29\u584c\u3002<\/p>\n<p>\u5355\u4ece\u9776\u70b9\u6765\u770b\uff0cLAG-3\u5e76\u4e0d\u7b97\u5931\u8d25\u3002\u81f3\u5c11\uff0c\u8be5\u9776\u70b9\u5df2\u8bde\u751f\u91cd\u78c5\u836f\u7269\u3002BMS\u7684LAG-3\/PD-1\u53cc\u6297\u7ec4\u5408Opdualag\uff08Relatlimab+Nivolumab\uff09\u5df2\u5728\u4e00\u7ebf\u9ed1\u8272\u7d20\u7624\u9002\u5e94\u75c7\u83b7\u6279<a href=\"https:\/\/www.alphaseek.cn\/?tag=%e4%b8%8a%e5%b8%82\" title=\"View all posts in \u4e0a\u5e02\" target=\"_blank\" class=\"tag_link\">\u4e0a\u5e02<\/a>\uff0c2025\u5e74\u5176\u5168\u7403\u9500\u552e\u989d\u8fbe\u523011.85\u4ebf\u7f8e\u5143\u3002<\/p>\n<p>\u53ea\u662f\uff0c\u514d\u75ab\u7597\u6cd5\u7684\u5149\u73af\uff0c\u6ce8\u5b9a\u8fd9\u6837\u7684\u9500\u552e\u989d\u8fdc\u4e0d\u8db3\u4ee5\u6ee1\u8db3\u5e02\u573a\u671f\u5f85\u3002\u5e02\u573a\u5e0c\u671bLAG-3\u80fd\u633a\u8fdb\u66f4\u5927\u7684\u6cbb\u7597\u9886\u57df\u3002<\/p>\n<p>\u4e5f\u6b63\u56e0\u6b64\uff0c\u5e02\u573a\u5bf9Immutep\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\u7684\u63a2\u7d22\u5bc4\u4e88\u539a\u671b\u3002<\/p>\n<p>\u4f46\u968f\u7740\u6b64\u6b21\u4e34\u5e8a\u9879\u76ee\u5ba3\u544a\u7ec8\u6b62\uff0c\u5e02\u573a\u4e0d\u53ea\u662f\u5bf9efti\u611f\u5230\u5931\u671b\uff0cLAG-3\u9776\u70b9\u7684\u672a\u6765\u6216\u8bb8\u4e5f\u9700\u8981\u91cd\u65b0\u5ba1\u89c6\u3002<\/p>\n<h2><strong><strong><strong><strong>\/ 01 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margin-right:auto\" \/><\/p>\n<p>\u4e0e\u4f20\u7edf\u7684LAG-3\u6297\u4f53\u4e0d\u540c\uff0cefti\u662f\u4e00\u79cd\u53ef\u6eb6\u6027LAG-3\u86cb\u767d\uff0c\u901a\u8fc7\u4e0eMHCII\u7ed3\u5408\u6765\u4e3b\u52a8\u6fc0\u6d3b\u6297\u539f\u9012\u5448\u7ec6\u80de\uff0c\u4ece\u800c\u589e\u5f3aT\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\uff0c\u7406\u8bba\u4e0a\uff0c\u8fd9\u79cd\u673a\u5236\u80fd\u591f\u653e\u5927\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n<p>\u8fd9\u4e00\u673a\u5236\u5dee\u5f02\u4e5f\u88ab\u8ba4\u4e3a\u53ef\u80fd\u7ed5\u5f00\u6b64\u524dLAG-3\u6297\u4f53\u5728\u5b9e\u4f53\u7624\u4e2d\u7684\u74f6\u9888\uff0c\u5176\u65e9\u671f\u4e34\u5e8a\u6570\u636e\u8868\u73b0\u4e5f\u786e\u5b9e\u4e89\u6c14\u3002<\/p>\n<p><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/wx\/2026\/03\/20260320095804083776.jpg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x808\/gravity\/center\/crop\/!1440x808&ext=.jpg\" alt=\"LAG-3\u53c8\u584c\u623f\u4e86\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/p>\n<p>\u4eceTACTI-002\u8bd5\u9a8c\u4e2d\u62c6\u5206\u7684\u4e00\u7ec4\u6570\u636e\u663e\u793a\uff0cefti\u8054\u5408K\u836f\u5728\u672a\u7ecf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u4e2d\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u7597\u6548\u3002\u5728114\u540d\u60a3\u8005\u7684\u6cbb\u7597\u4e2d\uff0cORR\u8fbe\u523040.4%\uff0c\u5bf9\u6bd4K\u836f\u63d0\u5347\u4e86\u8fd11\u500d\u3002<\/p>\n<p>\u66f4\u5173\u952e\u7684\u662f\uff0c\u8be5\u8bd5\u9a8c\u60a3\u8005\u5165\u7ec4\u672a\u6309\u7167PD-L1\u8868\u8fbe\u6c34\u5e73\u7b5b\u9009\uff0c\u7ea675%\u7684\u5165\u7ec4\u60a3\u8005PD-L1\u8bc4\u5206\u4f4e\u4e8e50%\u3002\u5bf9\u4e8ePD-L1\u8868\u8fbe\u8f83\u4f4e\u751a\u81f3\u9634\u6027\uff08CPS&lt;1\uff09\u7684\u60a3\u8005\u800c\u8a00\uff0c\u8fd9\u4e00\u7ed3\u679c\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\uff0c\u56e0\u4e3a\u8fd9\u7c7b\u60a3\u8005\u901a\u5e38\u96be\u4ee5\u4ecePD-1\u5355\u836f\u6cbb\u7597\u4e2d\u83b7\u76ca\uff0c\u4e00\u76f4\u88ab\u89c6\u4e3a\u514d\u75ab\u6cbb\u7597\u7684\u76f8\u5bf9\u7a7a\u767d\u4eba\u7fa4\u3002<\/p>\n<p>\u5728\u9488\u5bf9\u5934\u9888\u9cde\u72b6\u7ec6\u80de\u764c\u7684TACTI-003\u7814\u7a76\u4e2d\uff0cefti\u5728PD-L1\u9634\u6027\u60a3\u8005\u7684\u6cbb\u7597\u6f5c\u529b\u518d\u6b21\u88ab\u9a8c\u8bc1\u3002\u6574\u4f53\u4e0a\uff0cefti\u8054\u5408K\u836f\u7ec4\u5408ORR\u8fbe\u523032.8%\uff0c\u5bf9\u6bd4K\u836f\u5355\u836f26.7%\u663e\u8457\u63d0\u9ad8\uff0c\u800c\u5728K\u836f\u4e0d\u9002\u7528\u7684\u9634\u6027\u60a3\u8005\u4eba\u7fa4\uff0c\u8054\u5408\u7528\u836fORR\u4e5f\u8fbe\u5230\u4e8626.9%\u3002<\/p>\n<p>\u5728\u8fd9\u6837\u7684\u80cc\u666f\u4e0b\uff0c\u5173\u952e\u6027TACTI-004\u7814\u7a76\u88ab\u5bc4\u4e88\u539a\u671b\u3002\u5728\u5408\u4f5c\u65b9\u963f\u65af\u5229\u5eb7\u7684\u534f\u52a9\u4e0b\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8fdb\u901f\u5ea6\u4e5f\u76f8\u5f53\u8fc5\u901f\u3002\u53d1\u5e03\u7ec8\u6b62\u516c\u544a\u4e4b\u524d\uff0c756\u540d\u76ee\u6807\u60a3\u8005\u7684\u5165\u7ec4\u8fdb\u5ea6\u5df2\u7ecf\u8fc7\u534a\u3002<\/p>\n<p>\u53ef\u4ee5\u8bf4\uff0cTACTI-004\u7814\u7a76\u7684\u9884\u671f\u88ab\u62c9\u6ee1\u4e86\uff0c\u4f46\u73b0\u5b9e\u5f88\u6b8b\u9177\u3002<\/p>\n<p>&ldquo;\u6839\u636e\u5bf9\u73b0\u6709\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u7684\u5ba1\u67e5\uff0c\u72ec\u7acb\u6570\u636e\u76d1\u5bdf\u59d4\u5458\u4f1a\u5efa\u8bae\u56e0\u8bd5\u9a8c\u65e0\u6548\u800c\u7ec8\u6b62\u8bd5\u9a8c&rdquo;\u3002<\/p>\n<p>TACTI-004\u7814\u7a76\u7eb3\u5165\u7684\u662fPD-L1\u8868\u8fbe0%&mdash;100%\u7684\u5168\u4eba\u7fa4\u60a3\u8005\uff0c\u4f46\u5728\u5df2\u5165\u7ec4\u534a\u6570\u7684\u60c5\u51b5\u4e0b\u4ecd\u5efa\u8bae\u7ec8\u6b62\u8bd5\u9a8c\uff0c\u57fa\u672c\u5ba3\u544aefti\u4e00\u7ebf\u6cbb\u7597NSCLC\u5df2\u65e0\u53ef\u80fd\u3002<\/p>\n<p>\u5c3d\u7ba1NSCLC\u53d7\u9650\uff0c\u516c\u53f8\u4e5f\u5e76\u6ca1\u6709\u653e\u5f03\u8be5\u836f\uff0cHR+\/HER2-\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u548c\u4e09\u9634\u6027\u4e73\u817a\u764c\u76843\u671f\u4e34\u5e8a\u4ecd\u5728\u8fdb\u884c\u3002\u4f46\u5931\u53bb\u4e86\u80ba\u764c\u8fd9\u4e2a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5927\u5e02\u573a\uff0cefti\u7684\u6f5c\u529b\u53d7\u9650\u3002<\/p>\n<p>\u66f4\u96be\u4ee5\u63a5\u53d7\u7684\u662f\uff0c\u5e02\u573a\u5bf9efti\u7684\u7597\u6548\u63d0\u51fa\u4e86\u8d28\u7591\u3002GlobalData\u7684\u80bf\u7624\u548c\u8840\u6db2\u5b66\u5206\u6790\u5e08BiswajitPodder\u8868\u793a\uff0c\u5728NSCLC\u8bd5\u9a8c\u4e2d\u505c\u6b62\u8bd5\u9a8c\u5bf9Immutep\u6765\u8bf4\u662f\u4e00\u4e2a&ldquo;\u91cd\u5927\u632b\u6298&rdquo;\u3002<\/p>\n<h2><strong><strong><strong><strong>\/ 02 \/<\/strong><\/strong><\/strong><\/strong>\u8d70\u4e0d\u51fa\u9ed1\u8272\u7d20\u7624<\/h2>\n<p>\u4e00\u5ea6\uff0cLAG-3\u88ab\u5bc4\u4e88\u539a\u671b\u3002<\/p>\n<p>LAG-3\u9776\u70b9\u65e9\u57281990\u5e74\u4fbf\u5df2\u7ecf\u88ab\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u8ddd\u79bb\u73b0\u5728\u5df2\u7ecf\u8fc7\u53bb30\u5e74\u3002\u8fd9\u4e5f\u4f7f\u5f97\uff0c\u533b\u5b66\u754c\u5bf9\u4e8eLAG-3\u6709\u4e86\u4e00\u4e9b\u5171\u8bc6\u3002<\/p>\n<p>\u9996\u5148\uff0cLAG-3\u4f5c\u4e3a\u4e00\u79cd\u514d\u75ab\u53cd\u5e94\u7684\u8d1f\u8c03\u8282\u56e0\u5b50\uff0c\u5b83\u4e0e\u6291\u5236T\u7ec6\u80de\u6d3b\u5316\u548c\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\u6709\u5173\uff0c\u8bf1\u5bfc\u514d\u75ab\u7a33\u6001;\u56e0\u6b64\uff0c\u5b83\u6709\u53ef\u80fd\u6210\u4e3a\u4e00\u4e2a\u6709\u524d\u9014\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u3002<\/p>\n<p>\u5176\u6b21\uff0cLAG-3\u8868\u8fbe\u5df2\u5728\u591a\u79cd\u7c7b\u578b\u7684\u764c\u75c7\u4e2d\u5f97\u5230\u8bc1\u5b9e\uff0c\u5373\u7ed3\u76f4\u80a0\u764c\u3001\u80c3\u764c\u3001\u4e73\u817a\u764c\uff0c\u751a\u81f3\u80f0\u817a\u764c\uff0c\u8fd9\u4e0e\u5b83\u4eec\u7684\u9884\u540e\u5bc6\u5207\u76f8\u5173\u3002\u8fd9\u610f\u5473\u7740\uff0cLAG-3\u7684\u5e94\u7528\u8303\u56f4\u6bd4\u8f83\u5e7f\u3002<\/p>\n<p>\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bc1\u636e\u5f3a\u8c03\u4e86LAG-3\u963b\u65ad\u4f5c\u4e3a\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u53ef\u884c<a href=\"https:\/\/www.alphaseek.cn\/?tag=%e7%ad%96%e7%95%a5\" title=\"View all posts in \u7b56\u7565\" target=\"_blank\" 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