{"id":749941,"date":"2026-03-19T18:12:14","date_gmt":"2026-03-19T10:12:14","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=749941"},"modified":"2026-03-19T18:12:14","modified_gmt":"2026-03-19T10:12:14","slug":"nat-commun%ef%bc%9a%e4%b8%ba%e4%bb%80%e4%b9%88%e4%bd%a0%e8%83%bd%e6%b5%81%e7%95%85%e5%9c%b0%e8%b7%91%e3%80%81%e9%80%80%e3%80%81%e5%81%9c%e3%80%81%e8%bd%ac%e8%ba%ab%ef%bc%9f%e5%8d%97%e6%96%b9%e5%8c%bb","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=749941","title":{"rendered":"Nat Commun\uff1a\u4e3a\u4ec0\u4e48\u4f60\u80fd\u6d41\u7545\u5730\u8dd1\u3001\u9000\u3001\u505c\u3001\u8f6c\u8eab\uff1f\u5357\u65b9\u533b\u8096\u4e2d\u4e3e\u7b49\u63ed\u793a\u5c0f\u9f20\u56db\u5927\u8fd0\u52a8\u884c\u4e3a\u7684\u795e\u7ecf\u8f6c\u6362\u673a\u5236"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

\u5f80\u524d\u8dd1\uff0c\u5f80\u540e\u9000\uff0c\u6025\u505c\uff0c\u7136\u540e\u7a81\u7136\u53c8\u51b2\u51fa\u53bb\uff0c\u8fd9\u4e9b\u770b\u4f3c\u7b80\u5355\u7684\u52a8\u4f5c\uff0c\u4f60\u6bcf\u5929\u90fd\u5728\u505a\uff0c\u5374\u4ece\u6ca1\u60f3\u8fc7\u4e00\u4e2a\u95ee\u9898\uff1a\u5927\u8111\u662f\u600e\u4e48\u7cbe\u51c6\u63a7\u5236\u8fd9\u4e9b\u4e0d\u540c\u65b9\u5411\u7684\u8fd0\u52a8\u7684\uff1f\u5f80\u524d\u8dd1\u548c\u5f80\u540e\u9000\uff0c\u7528\u7684\u662f\u540c\u4e00\u5957\u795e\u7ecf\u56de\u8def\u5417\uff1f<\/span><\/span><\/span><\/p>\n

2026\u5e743\u670817\u65e5\uff0c<\/span>\u5357\u65b9\u533b\u79d1\u5927\u5b66\u8096\u4e2d\u4e3e\/Wen Zhong<\/span>\u56e2\u961f\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<\/span>\u300aNature Communications\u300b<\/span>\u4e0a\u53d1\u8868\u7684\u7814\u7a76<\/span><\/span><\/span>\u300a A shared speed encoding model for running and backing away behaviours in segregated neural circuits \u300b<\/span><\/span><\/span>\uff0c\u7ed9\u51fa\u4e86\u4e00\u4e2a\u7cbe\u5999\u7684\u7b54\u6848\uff1a<\/span><\/span><\/span><\/span><\/p>\n

\u5927\u8111\u7528\u4e86\u4e24\u5957\u72ec\u7acb\u7684\u795e\u7ecf\u56de\u8def——<\/span><\/span><\/span>\u989e\u8054\u5408\u76ae\u5c42-\u4e2d\u8111\u5bfc\u6c34\u7ba1\u5468\u56f4\u7070\u8d28\u80cc\u4fa7\uff08TeA-dPAG\uff09\u3001\u4e0a\u4e18-\u4e2d\u8111\u5bfc\u6c34\u7ba1\u5468\u56f4\u7070\u8d28\u80cc\u4fa7\uff08SC-dPAG\uff09<\/span><\/span><\/span>\uff0c\u4e00\u5957\u7ba1\u5954\u8dd1\uff0c\u4e00\u5957\u7ba1\u540e\u9000\u548c\u6025\u505c\uff0c\u4f46\u5b83\u4eec\u5171\u4eab\u540c\u4e00\u4e2a\u901f\u5ea6\u7f16\u7801\u89c4\u5219\u3002<\/span><\/span><\/span><\/span><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u9501\u5b9a\u7b2c\u4e00\u4e2a\u5173\u952e\u8111\u533a\uff1aTeA<\/span><\/span><\/span><\/span><\/h2>\n

\u9996\u5148\uff0c\u7814\u7a76\u8005\u5728\u5c0f\u9f20\u5927\u8111\u7684<\/span><\/span>\u989e\u8054\u5408\u76ae\u5c42\uff08TeA\uff09<\/span><\/span>\u91cc\u53d1\u73b0\u4e86\u4e00\u7c7b\u7279\u6b8a\u7684\u795e\u7ecf\u5143\uff1a\u53ea\u8981\u5c0f\u9f20\u4e00\u8dd1\uff0c\u5b83\u4eec\u5c31\u6d3b\u8dc3\uff0c\u800c\u4e14\u8dd1\u5f97\u8d8a\u5feb\uff0c\u5b83\u4eec\u653e\u7535\u8d8a\u9891\u7e41\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5b83\u4eec\u7684\u653e\u7535\u5148\u4e8e\u5954\u8dd1\u884c\u4e3a\u53d1\u751f——<\/span><\/span>\u8bf4\u660e\u5b83\u4eec\u662f\u53d1\u4ee4\u8005\uff0c\u4e0d\u662f\u8ddf\u968f\u8005<\/span><\/span>\u3002<\/span><\/span>\u653e\u7535\u9891\u7387\u548c\u5954\u8dd1\u901f\u5ea6\u7684\u5173\u7cfb\uff0c\u53ef\u4ee5\u7528\u4e00\u4e2a<\/span><\/span>\u5355\u76f8\u7f14\u5408\u65b9\u7a0b<\/span><\/strong>\u5b8c\u7f8e\u62df\u5408\u3002<\/span><\/span><\/span><\/span><\/p>\n

\u987a\u7740\u8fd9\u6761\u7ebf\u7d22\u5f80\u4e0b\u627e\uff0c\u53d1\u73b0\u5b83\u4eec\u4e3b\u8981\u6295\u5c04\u5230<\/span><\/span>\u4e2d\u8111\u5bfc\u6c34\u7ba1\u5468\u56f4\u7070\u8d28\u80cc\u4fa7\uff08dPAG\uff09<\/span><\/span>\uff0c\u800cdPAG\u91cc\u4e5f\u6709\u540c\u7c7b\u795e\u7ecf\u5143\uff0c\u5bf9\u901f\u5ea6\u7684\u54cd\u5e94\u66f4\u654f\u611f\u3001\u5ef6\u8fdf\u66f4\u77ed\u3002<\/span><\/span><\/span><\/p>\n

\u56e0\u6b64\uff0cTeA\u548cdPAG\u91cc\u90fd\u6709\u80fd\u5bf9\u5954\u8dd1\u901f\u5ea6\u54cd\u5e94\u7684\u795e\u7ecf\u5143\u3002<\/span><\/span><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u7528\u5149\u6fc0\u6d3bTeA-dPAG\u901a\u8def\uff0c\u5c0f\u9f20\u5c31\u5954\u8dd1<\/span><\/span><\/span><\/h2>\n

\u7814\u7a76\u8005\u7528\u5149\u9057\u4f20\u5b66\u76f4\u63a5\u6fc0\u6d3b<\/span><\/span>TeA-dPAG<\/span><\/span>\u8fd9\u6761\u901a\u8def\u3002\u7ed3\u679c\u548c\u9884\u60f3\u7684\u4e00\u6837\uff1a<\/span><\/span>\u523a\u6fc0\u9891\u7387\u8d8a\u9ad8\uff0c\u5c0f\u9f20\u8dd1\u5f97\u8d8a\u5feb<\/span><\/span>\uff0c\u800c\u4e14\u523a\u6fc0\u9891\u7387\u548c\u5954\u8dd1\u901f\u5ea6\u7684\u5173\u7cfb\uff0c\u6b63\u597d\u7b26\u5408\u90a3\u4e2a\u5355\u76f8\u7f14\u5408\u65b9\u7a0b\u3002<\/span><\/span>\u8fd9\u5c31\u8bc1\u660e\u4e86\u8fd9\u6761\u901a\u8def\u4e0d\u4ec5\u662f\u8868\u89c2\u901f\u5ea6\u53d8\u5316\uff0c\u800c\u662f\u56e0\u679c\u6027\u5730\u9a71\u52a8\u5954\u8dd1\u884c\u4e3a\u3002<\/span><\/span><\/span><\/p>\n

\u800c\u4e14dPAG\u795e\u7ecf\u5143\u7684\u7f16\u7801\u6548\u7387\uff0c\u6bd4TeA\u9ad8\u51fa\u4e00\u500d——<\/span><\/span>\u8bf4\u660e\u4fe1\u53f7\u8d8a\u5f80\u4e0b\u6e38\uff0c\u5904\u7406\u8d8a\u9ad8\u6548<\/span><\/span>\u3002<\/span><\/span><\/span><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u627e\u5230\u7b2c\u4e8c\u6761\u901a\u8def\uff1aSC-dPAG<\/span><\/span><\/strong><\/span><\/h2>\n

\u7528\u795e\u7ecf\u793a\u8e2a\u53d1\u73b0\uff0c\u8fd8\u6709\u53e6\u4e00\u6761\u901a\u8def\u4e5f\u6295\u5c04\u5230dPAG\uff0c\u4f46\u6765\u6e90\u4e8e\u4e0d\u540c\u8111\u533a——<\/span><\/span>\u4e0a\u4e18\uff08SC\uff09<\/span><\/span>\u3002<\/span><\/span><\/span><\/p>\n

\u800c\u4e14SC-dPAG\u548cTeA-dPAG\u7684\u795e\u7ecf\u5143\u7fa4\u4f53\uff0c\u51e0\u4e4e\u6ca1\u6709\u91cd\u53e0\uff0c<\/span><\/span>\u8bf4\u660e\u5b83\u4eec\u662f\u4e24\u6761\u72ec\u7acb\u7684\u901a\u8def<\/span><\/span>\u3002\u7528\u5149\u6fc0\u6d3bSC-dPAG\uff0c\u5c0f\u9f20\u7684\u53cd\u5e94\u5b8c\u5168\u4e0d\u4e00\u6837\uff1a\u6709\u7684\u505c\u4f4f\uff0c\u6709\u7684\u5f80\u540e\u9000\uff0c\u6709\u7684\u9000\u4e00\u6b65\u540e\u53c8\u51b2\u51fa\u53bb\uff08\u53cd\u5f39\u5954\u8dd1\uff09\u3002\u4f46\u6709\u610f\u601d\u7684\u662f\uff0c\u540e\u9000\u548c\u53cd\u5f39\u5954\u8dd1\u7684\u901f\u5ea6\uff0c\u548c\u523a\u6fc0\u9891\u7387\u7684\u5173\u7cfb\uff0c<\/span><\/span>\u5c45\u7136\u4e5f\u7b26\u5408\u5355\u76f8\u7f14\u5408\u65b9\u7a0b\u3002<\/span><\/span><\/span><\/span><\/p>\n

\u4e5f\u5c31\u662f\u8bf4\uff0cSC-dPAG\u662f\u540e\u9000\u548c\u6025\u505c\u7684\u53e6\u4e00\u5957\u7cfb\u7edf\uff0c\u4e0e TeA-dPAG \u901a\u8def\u5171\u4eab\u901f\u5ea6\u7f16\u7801\u6a21\u578b\uff0c\u53ea\u662f\u4ecb\u5bfc\u7684\u884c\u4e3a\u7c7b\u578b\u4e0d\u540c\u3002<\/span><\/strong><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u4e24\u6761\u8def\u600e\u4e48\u5207\u6362\uff1f<\/span><\/span><\/strong><\/span><\/h2>\n

\u4e24\u6761\u901a\u8def\u90fd\u6c47\u5165dPAG\uff0c\u90a3\u5b83\u4eec\u662f\u600e\u4e48\u534f\u8c03\u7684\uff1f\u7814\u7a76\u8005\u53d1\u73b0\uff0c<\/span><\/span>dPAG\u91cc\u751f\u957f\u6291\u7d20\uff08SOM\uff09\u795e\u7ecf\u5143<\/span><\/span>\u662f\u5173\u952e\u8c03\u63a7\u8005\uff0c\u5b83\u901a\u8fc7\u5355\u5411\u6291\u5236\u5b9e\u73b0\u884c\u4e3a\u5207\u6362\uff1a<\/span><\/span><\/span><\/p>\n

\u5954\u8dd1\uff1a<\/span><\/span>TeA-dPAG\u6fc0\u6d3b\uff0cSC-dPAG\u88ab\u6291\u5236<\/span><\/span><\/span><\/p>\n

\u540e\u9000\/\u505c\u6b62\uff1a<\/span><\/span>SC-dPAG\u6fc0\u6d3b\uff0cSOM\u6291\u5236TeA-dPAG<\/span><\/span><\/span><\/p>\n

\u53cd\u5f39\u5954\u8dd1\uff1a<\/span><\/span>SC-dPAG\u5148\u6fc0\u6d3b\uff0c\u7136\u540eSOM\u6291\u5236\u6d88\u9000\uff0cTeA-dPAG\u53cd\u5f39<\/span><\/span><\/span><\/p>\n

\u56e0\u6b64\uff0cSOM\u795e\u7ecf\u5143\u5c31\u50cf\u4e2a\u4ea4\u901a\u6307\u6325\u5458\uff0c\u8ba9\u4e24\u6761\u8def\u4e0d\u540c\u65f6\u5f00\u7eff\u706f\uff0c\u4ece\u800c\u5b9e\u73b0\u5954\u8dd1\u3001\u540e\u9000\u3001\u505c\u6b62\u3001\u53cd\u5f39\u5954\u8dd1\u56db\u79cd\u884c\u4e3a\u72b6\u6001\u7684\u8f6c\u6362\u3002<\/span><\/span><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u5168\u6587\u603b\u7ed3<\/span><\/span><\/span><\/h2>\n

\u8be5\u7814\u7a76\u89e3\u6790\u4e86<\/span><\/span>TeA-dPAG\u3001SC-dPAG<\/span><\/span>\u4e24\u6761\u5206\u79bb\u795e\u7ecf\u56de\u8def\u7684\u529f\u80fd\uff0c\u53d1\u73b0\u5176\u867d\u5206\u522b\u8c03\u63a7\u5954\u8dd1\u548c\u540e\u9000\uff0c\u5374\u5171\u4eab\u5355\u76f8\u7f14\u5408\u65b9\u7a0b\u7684\u901f\u5ea6\u7f16\u7801\u6a21\u578b\uff1b\u660e\u786e\u4e86 dPAG \u5185 CaMKIIα \u795e\u7ecf\u5143\u4e3a\u6838\u5fc3\u884c\u4e3a\u5355\u5143\u3001SOM \u795e\u7ecf\u5143\u4e3a\u6291\u5236\u8c03\u63a7\u5355\u5143\uff0c\u4ecb\u5bfc\u56db\u79cd\u8fd0\u52a8\u884c\u4e3a\u72b6\u6001\u8f6c\u6362\uff0c\u8fd8\u9a8c\u8bc1\u4e86\u7f16\u7801\u6a21\u578b\u7684\u56e0\u679c\u6027\uff0c<\/span><\/span>\u63ed\u793a\u4e86\u5927\u8111\u8fd0\u52a8\u4e2d\u67a2\u7684\u884c\u4e3a\u8c03\u63a7\u903b\u8f91\u3002<\/span><\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n

    \n
  • \u539f\u6587\u94fe\u63a5\uff1a<\/strong>https:\/\/doi.org\/10.1038\/s41467-026-70755-y<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    \u6587 | \u8111\u58f0\u5e38\u8c08 \u5f80\u524d\u8dd1\uff0c\u5f80\u540e\u9000\uff0c\u6025\u505c\uff0c\u7136\u540e\u7a81\u7136\u53c8\u51b2\u51fa\u53bb\uff0c\u8fd9\u4e9b\u770b\u4f3c\u7b80\u5355\u7684\u52a8\u4f5c\uff0c\u4f60\u6bcf\u5929\u90fd\u5728\u505a\uff0c\u5374\u4ece\u6ca1\u60f3\u8fc7\u4e00\u4e2a\u95ee\u9898 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[],"views":18,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/749941"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=749941"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/749941\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=749941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=749941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=749941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}