{"id":749843,"date":"2026-03-19T16:43:55","date_gmt":"2026-03-19T08:43:55","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=749843"},"modified":"2026-03-19T16:43:55","modified_gmt":"2026-03-19T08:43:55","slug":"adv-sci%ef%bc%9a%e7%89%99%e4%b8%8d%e5%a5%bd%ef%bc%8c%e7%9c%9f%e4%bc%9a%e8%ae%a9%e4%ba%ba%e6%8a%91%e9%83%81%ef%bc%9f%e9%87%8d%e5%ba%86%e5%8c%bb%e7%a7%91%e5%a4%a7%e5%ad%a6%e5%ae%8b%e9%94%a6%e7%92%98","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=749843","title":{"rendered":"Adv Sci\uff1a\u7259\u4e0d\u597d\uff0c\u771f\u4f1a\u8ba9\u4eba\u6291\u90c1\uff1f\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u5b8b\u9526\u7498\u7b49\u9996\u6b21\u63ed\u793a\u201c\u53e3-\u8111\u201d\u708e\u75c7\u8f74\u5b8c\u6574\u901a\u8def"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

\u7cbe\u795e\u969c\u788d\uff08\u7126\u8651\/\u6291\u90c1\uff09\u662f\u5168\u7403\u4e3b\u8981\u81f4\u6b8b\u539f\u56e0\uff0c\u708e\u75c7\uff08\u5305\u62ec\u5916\u5468\u708e\u75c7\uff09\u662f\u91cd\u8981\u8bf1\u56e0\uff0c<\/span>\u6162\u6027\u7259\u5468\u708e\uff08PD\uff09<\/span><\/span>\u4f5c\u4e3a\u6162\u6027\u4e0d\u53ef\u9006\u708e\u75c7\uff0c\u88ab\u8ba4\u4e3a\u662f\u7cbe\u795e\u969c\u788d\u7684\u6f5c\u5728\u5371\u9669\u56e0\u7d20\uff0c\u4f46\u5177\u4f53\u673a\u5236\u4e0d\u660e\u3002<\/span><\/span><\/p>\n

\"Adv<\/span><\/span><\/p>\n

\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u53e3\u8154\u533b\u9662\u5b8b\u9526\u7498<\/span>\u3001\u5f90\u51cc<\/span>\u3001\u674e\u73b2\u5a55<\/span>\u5728\u300aAdvances Science\u300b<\/span>\u53d1\u8868\u9898\u4e3a\uff1a“CRP Deficiency Rescues Periodontitis-Induced Hippocampal Neurogenesis Impairment by Suppressing OPC-Derived BMP4 Signaling in Rats<\/span>”\u7684\u7814\u7a76\u5de5\u4f5c\u3002<\/span><\/span><\/p>\n

\u6838\u5fc3\uff1a<\/span><\/span><\/span>\u672c\u7814\u7a76\u805a\u7126\u6162\u6027\u7259\u5468\u708e\uff08PD\uff09\u5f15\u53d1\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u635f\u4f24\u7684\u5206\u5b50\u673a\u5236\uff0c\u4ee5SD\u5927\u9f20\u4e3a\u6a21\u578b\uff0c\u901a\u8fc7\u591a\u7ec4\u5b66\u3001\u5206\u5b50\u751f\u7269\u5b66\u548c\u884c\u4e3a\u5b66\u5b9e\u9a8c\uff0c\u63ed\u793a\u4e86CRP-BMP4 \u8f74\u5728PD\u8bf1\u5bfc\u7684\u6d77\u9a6c\u795e\u7ecf\u53d1\u751f\u53d7\u635f\u548c\u7126\u8651\/\u6291\u90c1\u6837\u884c\u4e3a\u4e2d\u7684\u6838\u5fc3\u8c03\u63a7\u4f5c\u7528\uff0c\u4e3aPD\u76f8\u5173\u795e\u7ecf\u5e76\u53d1\u75c7\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u9776\u70b9\u3002<\/span><\/span><\/span><\/p>\n

PD\u8bf1\u5bfc\u5927\u9f20\u7126\u8651\/\u6291\u90c1\u6837\u884c\u4e3a\u3001\u6d77\u9a6c\u795e\u7ecf\u53d1\u751f\u53d7\u635f\u4e14CRP\u5347\u9ad8<\/span><\/span><\/span><\/span><\/h3>\n

\u4f5c\u8005\u9996\u5148\u68c0\u6d4b\u8bc4\u4f30\u4e86\u52a8\u7269\u884c\u4e3a\u53d8\u5316\uff0cPD\u5927\u9f20\u5728<\/span><\/span>\u65f7\u573a\u5b9e\u9a8c\uff08OFT\uff09<\/span><\/span><\/span>\u4e2d\u884c\u8d70\u8ddd\u79bb\u7f29\u77ed\u3001<\/span><\/span>\u9ad8\u67b6\u5341\u5b57\u8ff7\u5bab\u5b9e\u9a8c\uff08EPM\uff09<\/span><\/span><\/span>\u4e2d\u5f00\u653e\u81c2\u505c\u7559\u65f6\u95f4\u51cf\u5c11\uff0c\u8868\u73b0\u51fa\u4e0e\u5e94\u6fc0\u5927\u9f20\u76f8\u4f3c\u7684\u7126\u8651\/\u6291\u90c1\u6837\u884c\u4e3a\uff0c\u4f46PD\u672a\u52a0\u91cd\u5e94\u6fc0\u5927\u9f20\u7684\u884c\u4e3a\u5f02\u5e38\u3002<\/span><\/span><\/span><\/p>\n

\u795e\u7ecf\u53d1\u751f\uff1a<\/span><\/span>PD\u5bfc\u81f4\u5927\u9f20\u6d77\u9a6c DG\u3001CA1\u3001CA3\u533a\u795e\u7ecf\u5143\u6392\u5217\u7d0a\u4e71<\/span><\/span><\/span>\uff0cDCX +\u672a\u6210\u719f\u795e\u7ecf\u5143\u6570\u91cf\u51cf\u5c11\u7ea650%\uff0c\u4f46\u672a\u52a0\u91cd\u5e94\u6fc0\u8bf1\u5bfc\u7684\u795e\u7ecf\u5143\u635f\u4f24\u3002<\/span><\/span><\/span><\/p>\n

\u708e\u75c7\u56e0\u5b50\uff1aPD \u672a\u663e\u8457\u4e0a\u8c03\u6d77\u9a6c\u533aTnf−α\u3001Il−1β mRNA<\/a> \u8868\u8fbe\uff08\u4e0e\u5e94\u6fc0\u6a21\u578b\u4e0d\u540c\uff09\uff0c\u4f46\u708e\u75c7\u6297\u4f53\u82af\u7247<\/a>\u548cWestern blot \u8bc1\u5b9e\u6d77\u9a6c CRP \u86cb\u767d\u6c34\u5e73\u663e\u8457\u5347\u9ad8\u3002<\/span><\/span><\/p>\n

\"Adv<\/span><\/span><\/p>\n

Crp KO\u7f13\u89e3PD\u8bf1\u5bfc\u7684\u635f\u4f24<\/p>\n

snRNA-seq\u663e\u793a\u6d77\u9a6c\u7ec6\u80de\u5e76\u975e CRP \u4e3b\u8981\u4ea7\u751f\u8005\uff0cELISA \u8bc1\u5b9ePD\u5927\u9f20\u5916\u5468\u8840\u548c\u7259\u9f88 CRP \u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff0c\u4e14 PD \u672a\u6539\u53d8\u6d77\u9a6c\u8840\u8111\u5c4f\u969c\uff08BBB\uff09\u76f8\u5173\u6807\u5fd7\u7269 ZO-1\u3001CAV-1 \u7684\u8868\u8fbe\uff0c\u63d0\u793a\u6d77\u9a6c CRP \u5347\u9ad8\u975eBBB\u7ed3\u6784\u6539\u53d8\u4ecb\u5bfc\u3002<\/span><\/span><\/p>\n

Crp KO\u7684\u4fdd\u62a4\u4f5c\u7528\uff1a<\/span><\/span><\/p>\n

Crp KO \u6291\u5236PD\u8bf1\u5bfc\u7684\u7259\u5468\u708e\u75c7\uff0c\u4e14\u672a\u68c0\u6d4b\u5230\u6d77\u9a6cTnf−α\u3001Il−1β\u7684\u5f02\u5e38\u4e0a\u8c03\uff1bCrp KO \u5927\u9f20\u5728 PD\/\u5e94\u6fc0\u4e0b\uff0c\u6d77\u9a6c\u795e\u7ecf\u5143\u6392\u5217\u6b63\u5e38\uff0cDCX +\u672a\u6210\u719f\u795e\u7ecf\u5143\u6570\u91cf\u65e0\u663e\u8457\u51cf\u5c11\uff0c\u4ec5PD +\u5e94\u6fc0\u4e0b\u4fdd\u62a4\u4f5c\u7528\u51cf\u5f31\uff1b<\/span><\/span>Crp KO\u5927\u9f20\u5728PD\/\u5e94\u6fc0\u4e0b\uff0cOFT \u548c EPM \u68c0\u6d4b\u65e0\u663e\u8457\u7126\u8651\/\u6291\u90c1\u6837\u884c\u4e3a\u3002<\/span><\/span><\/span><\/span><\/p>\n

\"Adv<\/span><\/span><\/p>\n

\u6162\u6027\u7259\u5468\u708e\u5927\u9f20\u6a21\u578b\u4e2dCRP-BMP4\u4fe1\u53f7\u8f74\u53c2\u4e0e\u6d77\u9a6c\u635f\u4f24\u53ca\u884c\u4e3a\u5f02\u5e38<\/p>\n

\u7814\u7a76\u63ed\u793a\u4e86PD\u8bf1\u5bfc\u6d77\u9a6c\u635f\u4f24\u548c\u7126\u8651\/\u6291\u90c1\u6837\u884c\u4e3a\u7684\u65b0\u901a\u8def\uff1a\u5916\u5468CRP\u8fdb\u5165\u6d77\u9a6c→\u8c03\u63a7 OPCs\uff08\u4e3b\u8981\u662fOPCs_4\uff09\u8868\u8fbeBMP4→\u6291\u5236NPC\u7684\u795e\u7ecf\u5143\u5206\u5316\uff08\u4e0b\u8c03 NeuroD1\uff09→\u6d77\u9a6c\u795e\u7ecf\u53d1\u751f\u53d7\u635f→\u7126\u8651\/\u6291\u90c1\u6837\u884c\u4e3a\u3002\u7814\u7a76\u8bc1\u5b9e<\/span><\/span>CRP-BMP4 \u8f74\u662f PD \u76f8\u5173\u795e\u7ecf\u5e76\u53d1\u75c7\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\uff0c\u6291\u5236\u8be5\u8f74\u53ef\u6062\u590dPD\u8bf1\u5bfc\u7684\u795e\u7ecf\u5143\u5206\u5316\u635f\u4f24\u3001\u6539\u5584\u884c\u4e3a\u5f02\u5e38<\/span><\/span><\/span>\u3002CRP \u7f3a\u5931\u53ef\u589e\u5f3aOPCs\u7684\u529f\u80fd\u9002\u5e94\u6027\uff0c\u5373\u4f7f OPCs \u6570\u91cf\u51cf\u5c11\uff0c\u4ecd\u80fd\u7ef4\u6301\u9ad3\u9798\u7a33\u6001\u548c\u795e\u7ecf\u5143\u5206\u5316<\/span><\/span><\/span><\/p>\n

\"Adv<\/span><\/span><\/p>\n

\u7814\u7a76\u610f\u4e49<\/span><\/span><\/span><\/h3>\n

\u8fd9\u9879\u7814\u7a76\u63ed\u793a\u4e86\u5916\u5468\u708e\u75c7\uff08\u7259\u5468\u708e\uff09\u8bf1\u53d1\u4e2d\u67a2\u8ba4\u77e5\u53d7\u635f\u7684\u5168\u65b0\u5206\u5b50\u673a\u5236\uff0c\u786e\u7acb\u4e86CRP\u5728\u4ecb\u5bfc“\u53e3-\u8111\u8f74”\u901a\u8baf<\/a>\u4e2d\u7684\u6838\u5fc3\u5730\u4f4d\u3002\u9996\u6b21\u8bc1\u5b9e\u4e86 CRP \u7f3a\u5931\u80fd\u663e\u8457\u9006\u8f6c\u7259\u5468\u708e\u5f15\u8d77\u7684\u6d77\u9a6c\u795e\u7ecf\u53d1\u751f\u969c\u788d\u5e76\u89e3\u6790\u4e86\u5176\u80cc\u540e\u7684\u7ec6\u80de\u7ea7\u8054\u53cd\u5e94\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0d\u4ec5\u6253\u7834\u4e86 CRP \u4ec5\u4f5c\u4e3a\u708e\u75c7\u6807\u8bb0\u7269\u7684\u4f20\u7edf\u8ba4\u77e5\uff0c\u5c06\u5176\u5b9a\u4e49\u4e3a\u5e72\u9884\u8ba4\u77e5\u9000\u5316\u7684\u529f\u80fd\u6027\u9776\u70b9\uff0c\u4e5f\u4e3a\u4e34\u5e8a\u4e0a\u901a\u8fc7\u63a7\u5236\u7259\u5468\u5065\u5eb7\u6216\u9776\u5411 CRP\/BMP4 \u901a\u8def\u6765\u9632\u6cbb\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u76f8\u5173\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u5b9e\u9a8c\u4f9d\u636e\u3002<\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587 | \u8111\u58f0\u5e38\u8c08 \u7cbe\u795e\u969c\u788d\uff08\u7126\u8651\/\u6291\u90c1\uff09\u662f\u5168\u7403\u4e3b\u8981\u81f4\u6b8b\u539f\u56e0\uff0c\u708e\u75c7\uff08\u5305\u62ec\u5916\u5468\u708e\u75c7\uff09\u662f\u91cd\u8981\u8bf1\u56e0\uff0c\u6162\u6027\u7259\u5468\u708e\uff08PD\uff09 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[344,339,24],"views":19,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/749843"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=749843"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/749843\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=749843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=749843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=749843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}