{"id":747954,"date":"2026-03-17T20:51:41","date_gmt":"2026-03-17T12:51:41","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=747954"},"modified":"2026-03-17T20:51:41","modified_gmt":"2026-03-17T12:51:41","slug":"nat-commun%ef%bc%9a%e4%bb%a5%e8%89%b2%e5%88%97%e7%a7%91%e5%ad%a6%e5%ae%b6%e6%8f%ad%e7%a4%ba%e7%ba%b9%e7%8a%b6%e4%bd%93%e5%86%85%e8%b0%83%e6%8e%a75-%e7%be%9f%e8%89%b2%e8%83%ba%e4%ba%a7%e7%94%9f","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=747954","title":{"rendered":"Nat Commun\uff1a\u4ee5\u8272\u5217\u79d1\u5b66\u5bb6\u63ed\u793a\u7eb9\u72b6\u4f53\u5185\u8c03\u63a75-\u7f9f\u8272\u80fa\u4ea7\u751f\u201c\u6109\u60a6\u611f\u201d\u7684\u65b0\u795e\u7ecf\u901a\u8def"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

\u6b63\u8d70\u5728\u4e00\u6761\u719f\u6089\u7684\u4e0b\u73ed\u8def\u4e0a\uff0c\u8111\u5b50\u91cc\u76d8\u7b97\u7740\u665a\u996d\u5403\u4ec0\u4e48\u3002\u7a81\u7136\uff0c\u8def\u8fb9\u4e00\u5bb6\u4ece\u672a\u6ce8\u610f\u8fc7\u7684\u5c0f\u5e97\u98d8\u51fa\u4e86\u4f60\u6700\u7231\u5403\u7684\u7ea2\u70e7\u8089\u9999\u5473\uff0c\u6216\u8005\u4f60\u610f\u5916\u5730\u5728\u53e3\u888b\u91cc\u6478\u5230\u4e86\u4e00\u5f20\u9057\u5fd8\u7684\u767e\u5143\u5927\u949e\u3002\u5728\u90a3\u4e00\u77ac\u95f4\uff0c\u4f60\u7684\u811a\u6b65\u8f7b\u5feb\u4e86\uff0c\u5fc3\u60c5\u77ac\u95f4\u70b9\u4eae\uff0c\u751a\u81f3\u5fcd\u4e0d\u4f4f\u54fc\u8d77\u4e86\u6b4c\u3002\u8fd9\u79cd“\u7a81\u5982\u5176\u6765\u7684\u5c0f\u786e\u5e78”\u8ba9\u5927\u8111\u77ac\u95f4\u505a\u51fa\u7684\u79ef\u6781\u53cd\u5e94\u3002<\/span><\/span><\/p>\n

\u57fa\u4e8e\u6b64\uff0c2026\u5e743\u670816\u65e5\uff0c\u5e0c\u4f2f\u6765\u5927\u5b66Joshua A. Goldberg\u7814\u7a76\u56e2\u961f\u5728\u300aNature communications\u300b<\/span>\u6742\u5fd7\u53d1\u8868\u4e86“Synchronous activation of striatal cholinergic interneurons induces local serotonin release<\/span>”\u63ed\u793a\u4e86\u7eb9\u72b6\u4f53\u80c6\u78b1\u80fd\u4e2d\u95f4\u795e\u7ecf\u5143\u7684\u540c\u6b65\u6fc0\u6d3b\u8bf1\u5bfc\u5c40\u90e85-\u7f9f\u8272\u80fa\u91ca\u653e\u3002<\/span><\/span><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u8fd9\u9879\u7814\u7a76\u63ed\u793a\u4e86\u7eb9\u72b6\u4f53\u5185\u4e00\u79cd\u533a\u57df\u7279\u5f02\u6027\u7684\u795e\u7ecf\u9012\u8d28\u4ea4\u4e92\u673a\u5236\uff1a\u5728\u80cc\u4fa7\u7eb9\u72b6\u4f53\u4e2d\uff0c\u80c6\u78b1\u80fd\u4e2d\u95f4\u795e\u7ecf\u5143\uff08CINs\uff09\u7684\u540c\u6b65\u6fc0\u6d3b\u80fd\u76f4\u63a5\u901a\u8fc75-\u7f9f\u8272\u80fa\u80fd\u8f74\u7a81\u4e0a\u7684\u70df\u78b1\u578b\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\uff08nAChRs\uff09\uff0c\u89e6\u53d1\u5c40\u90e85-\u7f9f\u8272\u80fa\uff085-HT\uff09\u7684\u5feb\u901f\u91ca\u653e\u5e76\u6269\u5927\u5176\u4fe1\u53f7\u8303\u56f4\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u79cd\u8026\u5408\u6548\u5e94\u57285-HT\u652f\u914d\u66f4\u5bc6\u7684\u8179\u4fa7\u7eb9\u72b6\u4f53\u4e2d\u53cd\u800c\u4e0d\u5b58\u5728\u3002\u5728<\/span><\/span>\u5f3a\u8feb\u75c7\uff08OCD\uff09\u6a21\u578b\u5c0f\u9f20<\/span><\/span><\/span>\u4e2d\uff0c\u8fd9\u79cd\u673a\u5236\u56e0\u9ad8\u80c6\u78b1\u80fd\u72b6\u6001\u800c\u88ab\u75c5\u7406\u6027\u653e\u5927\uff0c\u5bfc\u81f45-HT\u52a8\u529b\u5b66\u5f02\u5e38\u3002\u8fd9\u4e00\u53d1\u73b0\u786e\u7acb\u4e86CINs\u4f5c\u4e3a5-HT\u8c03\u8282\u8005\u7684\u8eab\u4efd\u5e76\u4e3a\u5f3a\u8feb\u75c7\u7b49\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u63d0\u4f9b\u4e86\u65b0\u7684\u75c5\u7406\u89c6\u89d2\u3002<\/span><\/span><\/span><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u56fe\u4e00 nAChRs\u589e\u5f3aDS\u533a5-HT\u91ca\u653e\u4e0e\u6269\u6563<\/p>\n

\u7814\u7a76\u56e2\u961f\u5229\u7528\u53cc\u5149\u5b50\u6210\u50cf\u4e0eGRAB-5HT\u4f20\u611f\u5668\uff0c\u5728\u6025\u6027\u8111\u5207\u7247\u4e2d\u89c2\u5bdf\u5230\u80cc\u4fa7\u7eb9\u72b6\u4f53\u5185\u7684\u7535\u523a\u6fc0\u80fd\u8bf1\u53d1\u663e\u8457\u76845-HT\u91ca\u653e\uff0c\u4e14\u8fd9\u79cd\u91ca\u653e\u9ad8\u5ea6\u4f9d\u8d56\u4e8enAChRs\u7684\u6fc0\u6d3b\u3002<\/span><\/span><\/p>\n

\u5b9e\u9a8c\u8bc1\u5b9e\uff0cnAChR\u4e0d\u4ec5\u80fd\u901a\u8fc7\u7f8e\u52a0\u660e\u654f\u611f\u7684\u673a\u5236\u63d0\u53475-HT\u91ca\u653e\u5e45\u5ea6\uff0c\u8fd8\u4f7f\u5176\u6269\u6563\u7684\u7a7a\u95f4\u8303\u56f4\u6269\u5927\u4e86\u7ea645%\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u7531\u4e59\u9170\u80c6\u78b1“\u95e8\u63a7”\u7684\u8c03\u8282\u673a\u5236\u57285-HT\u652f\u914d\u66f4\u5bc6\u7684\u8179\u4fa7\u7eb9\u72b6\u4f53\u4e2d\u5e76\u672a\u53d1\u73b0\u3002<\/span><\/span><\/p>\n

\u6b64\u5916\uff0c\u901a\u8fc7\u62ee\u6297\u5242<\/span><\/span>RS 23597-190\u53caSSRI\u7c7b\u836f\u7269\u897f\u915e\u666e\u5170\u7684\u6d4b\u8bd5\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8be5\u4f20\u611f\u5668\u5bf95-HT\u4fe1\u53f7\u6355\u83b7\u7684\u7279\u5f02\u6027\u53ca\u53d7\u7a81\u89e6\u524d\u81ea\u8eab\u53d7\u4f53\u8c03\u63a7\u7684\u52a8\u529b\u5b66\u7279\u5f81<\/span><\/span>\u3002<\/span><\/span><\/span><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u56fe\u4e8c CINs\u6fc0\u6d3b\u72ec\u7acb\u9a71\u52a8DS\u51855-HT\u91ca\u653e<\/p>\n

\u7814\u7a76\u8005\u5229\u7528\u5149\u9057\u4f20\u5b66\u7ed3\u5408GRAB-5HT\u4f20\u611f\u5668\u8bc1\u5b9e\uff0c\u80c6\u78b1\u80fd\u4e2d\u95f4\u795e\u7ecf\u5143\uff08CINs\uff09\u7684\u540c\u6b65\u6fc0\u6d3b\u8db3\u4ee5\u72ec\u7acb\u9a71\u52a8\u80cc\u4fa7\u7eb9\u72b6\u4f53\u5185\u76845-HT\u91ca\u653e\u3002\u8fd9\u4e00\u8fc7\u7a0b\u7531α4β2\u578b\u70df\u78b1\u578b\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\uff08nAChRs\uff09\u76f4\u63a5\u4ecb\u5bfc\uff0c\u4e14\u4e59\u9170\u80c6\u78b1\u76f4\u63a5\u4f5c\u7528\u4e8e5-HT\u795e\u7ecf\u7ea4\u7ef4\uff0c\u65e0\u9700\u7ecf\u8fc7GABA\u3001\u8c37\u6c28\u9178\u6216\u591a\u5df4\u80fa\u7cfb\u7edf\u7684\u4e2d\u8f6c\u3002<\/span><\/span><\/p>\n

\u5b9e\u9a8c\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u8fd9\u79cd\u7531CINs\u89e6\u53d1\u76845-HT\u91ca\u653e\u4ec5\u5b58\u5728\u4e8e\u80cc\u4fa7\u7eb9\u72b6\u4f53\uff0c\u800c\u5728\u8179\u4fa7\u7eb9\u72b6\u4f53\u4e2d\u5e76\u672a\u68c0\u6d4b\u5230\uff0c\u6697\u793a<\/span><\/span>CINs\u53ef\u80fd\u662f\u80cc\u4fa7\u533a\u57df\u5185\u8c03\u63a75-HT\u91ca\u653e\u7684\u552f\u4e00\u5185\u6e90\u6027\u4e59\u9170\u80c6\u78b1\u6765\u6e90\u3002<\/span><\/span><\/span><\/p>\n

\"Nat<\/span><\/span><\/p>\n

\u56fe\u4e09 Sapap3\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u4e2d\u80c6\u78b1\u80fd\u4ecb\u5bfc\u7684\u7eb9\u72b6\u4f535-\u7f9f\u8272\u80fa\u91ca\u653e\u589e\u52a0<\/p>\n

\u5728Sapap3\u57fa\u56e0\u6572\u9664\u7684<\/span><\/span>\u5f3a\u8feb\u75c7\u6a21\u578b\u5c0f\u9f20<\/span><\/span><\/span>\u4e2d\uff0c\u7eb9\u72b6\u4f53\u7684“\u9ad8\u80c6\u78b1\u80fd\u72b6\u6001”\u663e\u8457\u653e\u5927\u4e86\u8fd9\u4e00\u4ea4\u4e92\u673a\u5236\u3002<\/span><\/span><\/span><\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u867d\u7136\u6b64\u7c7b\u5c0f\u9f20\u7684\u57fa\u78405-HT\u91ca\u653e\u80fd\u529b\u5e76\u672a\u6539\u53d8\uff0c\u4f46\u7531\u4e8eCINs\u5bc6\u5ea6\u548c\u6d3b\u6027\u66f4\u9ad8\uff0c\u5bfc\u81f4\u7535\u523a\u6fc0\u8bf1\u53d1\u76845-HT\u4fe1\u53f7\u4e2d\u7f8e\u52a0\u660e\u654f\u611f\u6210\u5206\uff08\u5373\u4f9d\u8d56\u4e59\u9170\u80c6\u78b1\u7684\u90e8\u5206\uff09\u663e\u8457\u589e\u5f3a\u3002<\/span><\/span><\/p>\n

\u8fd9\u79cd\u75c5\u7406\u6027\u653e\u5927\u4e0e\u591a\u5df4\u80fa\u7cfb\u7edf\u7684\u53d8\u5316\u7c7b\u4f3c\uff0c\u5171\u540c\u89e3\u91ca\u4e86\u5f3a\u8feb\u75c7\u6a21\u578b\u4e2d\u5355\u80fa\u7c7b\u7269\u8d28\u5468\u8f6c\u7387\u5347\u9ad8\u7684\u73b0\u8c61\uff0c\u8868\u660e<\/span><\/span>\u80c6\u78b1\u80fd\u7cfb\u7edf\u7684\u5f02\u5e38\u6d3b\u8dc3\u662f\u9a71\u52a8\u5f3a\u8feb\u75c7\u6837\u884c\u4e3a\u4e2d5-HT\u52a8\u529b\u5b66\u7d0a\u4e71\u7684\u6838\u5fc3\u56e0\u7d20\u3002<\/span><\/span><\/span><\/p>\n

\u603b\u7ed3<\/span><\/span><\/span><\/h3>\n

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(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n

    \n
  • \u6587\u7ae0\u6765\u6e90\uff1a<\/strong>https:\/\/doi.org\/10.1038\/s41467-026-70359-6<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    \u6587 | \u8111\u58f0\u5e38\u8c08 \u6b63\u8d70\u5728\u4e00\u6761\u719f\u6089\u7684\u4e0b\u73ed\u8def\u4e0a\uff0c\u8111\u5b50\u91cc\u76d8\u7b97\u7740\u665a\u996d\u5403\u4ec0\u4e48\u3002\u7a81\u7136\uff0c\u8def\u8fb9\u4e00\u5bb6\u4ece\u672a\u6ce8\u610f\u8fc7\u7684\u5c0f\u5e97\u98d8\u51fa\u4e86\u4f60\u6700\u7231 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[],"views":33,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/747954"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=747954"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/747954\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=747954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=747954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=747954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}