{"id":747950,"date":"2026-03-17T20:39:12","date_gmt":"2026-03-17T12:39:12","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=747950"},"modified":"2026-03-17T20:39:12","modified_gmt":"2026-03-17T12:39:12","slug":"np%e5%88%8a%ef%bc%9a%e6%8a%97%e6%8a%91%e9%83%81%e8%8d%af%e8%bf%98%e8%83%bd%e6%8a%91%e5%88%b6%e6%88%90%e7%98%be%ef%bc%9f%e7%a0%94%e7%a9%b6%e6%8f%ad%e7%a4%ba%e6%b0%af%e8%83%ba%e9%85%ae%e7%a0%b4%e5%9d%8f","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=747950","title":{"rendered":"NP\u520a\uff1a\u6297\u6291\u90c1\u836f\u8fd8\u80fd\u6291\u5236\u6210\u763e\uff1f\u7814\u7a76\u63ed\u793a\u6c2f\u80fa\u916e\u7834\u574f\u53ef\u5361\u56e0\u6210\u763e\u8bb0\u5fc6\u7684\u795e\u7ecf\u673a\u5236"},"content":{"rendered":"<blockquote>\n<p>\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n<p><span><span>\u5f88\u591a\u6210\u763e\u95ee\u9898\uff0c\u6bd4\u5982\u5bf9\u53ef\u5361\u56e0\u3001\u51b0\u6bd2\u8fd9\u7c7b\u7cbe\u795e\u5174\u594b\u5242\u4e0a\u763e\uff0c\u5173\u952e\u5728\u4e8e\u5927\u8111\u91cc\u5f62\u6210\u4e86\u987d\u56fa\u7684\u6210\u763e\u8bb0\u5fc6\u3002\u4e00\u78b0\u5230\u548c\u836f\u7269\u76f8\u5173\u7684\u573a\u666f\u3001\u7ebf\u7d22\uff0c\u5c31\u5f88\u5bb9\u6613\u52fe\u8d77\u5f3a\u70c8\u7684\u6e34\u6c42\uff0c\u5bfc\u81f4\u590d\u5438\u3002<\/span><\/span><\/p>\n<p><span><span>2026\u5e743\u670814\u65e5\uff0c\u534e\u76db\u987f\u5dde\u7acb\u5927\u5b66\u6e29\u54e5\u534e\u5206\u6821Barbara A. Sorg\u56e2\u961f\u5728<span>\u300aNeuropharmacology\u300b<\/span>\u53d1\u8868Disruption of Psychostimulant-associated Memories by Single, Low Dose Ketamine in Rats\u3002<\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/768188fc33a803883be9b3a67e25b3ba_1773745205.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x426\/gravity\/center\/crop\/!1440x426&ext=.jpeg\" alt=\"NP\u520a\uff1a\u6297\u6291\u90c1\u836f\u8fd8\u80fd\u6291\u5236\u6210\u763e\uff1f\u7814\u7a76\u63ed\u793a\u6c2f\u80fa\u916e\u7834\u574f\u53ef\u5361\u56e0\u6210\u763e\u8bb0\u5fc6\u7684\u795e\u7ecf\u673a\u5236\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><span><\/span><\/p>\n<p><span><span><span><span>\u6838\u5fc3\uff1a<\/span><\/span><\/span><span><span>\u4f5c\u8005\u524d\u671f\u53d1\u73b0\uff0c\u53bb\u9664mPFC\u7684\u5468\u56f4\u795e\u7ecf\u7f51\uff08PNNs\uff09\u53ef\u6291\u5236PV\u795e\u7ecf\u5143\u653e\u7535\uff0c\u7834\u574f\u65b0\u9896\u63d0\u53d6\u4e0b\u53ef\u5361\u56e0\u8bb0\u5fc6\u7684\u91cd\u5de9\u56fa\u3002\u5355\u6b21\u4f4e\u5242\u91cf\u6c2f\u80fa\u916e\u4ec5\u5728\u65b0\u9896\u8bb0\u5fc6\u63d0\u53d6\u524d\u7ed9\u836f\u53ef\u51cf\u5c11\u5927\u9f20\u53ef\u5361\u56e0\u53ca\u7532\u57fa\u82ef\u4e19\u80fa\u7ebf\u7d22\u8bf1\u5bfc\u7684\u590d\u5438\u3002\u8fd9\u4e00\u7ed3\u679c\u8868\u660e\uff0c\u6c2f\u80fa\u916e\u8054\u5408\u65b0\u9896\u8bb0\u5fc6\u63d0\u53d6\u53ef\u9009\u62e9\u6027\u6291\u5236\u7cbe\u795e\u5174\u594b\u5242\u5bfb\u6c42\u884c\u4e3a\uff0c\u4e3a\u5176\u6297\u590d\u53d1\u673a\u5236\u63d0\u4f9b\u4e86\u65b0\u7ebf\u7d22\u3002<\/span><\/span><\/span><\/p>\n<h3><span><span><span>\u6c2f\u80fa\u916e\u9884\u5904\u7406\u5bf9\u53ef\u5361\u56e0\u5bfb\u6c42\u884c\u4e3a\u7684\u521d\u6b65\u8bc4\u4f30<\/span><\/span><\/span><span><\/span><\/h3>\n<p><span><span>\u4f5c\u8005\u5728\u6b64\u8bc4\u4f30\u4e86\u5728\u8bb0\u5fc6\u63d0\u53d6\u524d\u5355\u6b21\u9884\u5904\u7406\u4f4e\u5242\u91cf\u6c2f\u80fa\u916e\uff0c\u662f\u5426\u8db3\u4ee5\u635f\u5bb3\u81ea\u6211\u7ed9\u836f\u5927\u9f20\u968f\u540e\u7684\u7ebf\u7d22\u8bf1\u5bfc\u53ef\u5361\u56e0\u5bfb\u6c42\u884c\u4e3a\u3002\u56db\u7ec4\u4e4b\u95f4\u5728\u4e3b\u52a8\u6216\u88ab\u52a8\u6760\u6746\u6309\u538b\u7684\u7d2f\u8ba1\u6b21\u6570\u3001\u53ef\u5361\u56e0\u8f93\u6ce8\u6b21\u6570\u6216\u88ab\u52a8\u6760\u6746\u6309\u538b\u6b21\u6570\u65b9\u9762\u5747\u65e0\u5dee\u5f02\u3002<\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/fedccb6cdfcd5ff476aeda57c8747e90_1773745206.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x853\/gravity\/center\/crop\/!1440x853&ext=.jpeg\" alt=\"NP\u520a\uff1a\u6297\u6291\u90c1\u836f\u8fd8\u80fd\u6291\u5236\u6210\u763e\uff1f\u7814\u7a76\u63ed\u793a\u6c2f\u80fa\u916e\u7834\u574f\u53ef\u5361\u56e0\u6210\u763e\u8bb0\u5fc6\u7684\u795e\u7ecf\u673a\u5236\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<h3><span><span><span>\u5728\u65b0\u9896\u8bb0\u5fc6\u63d0\u53d6\u524d\u7ed9\u4e88\u6c2f\u80fa\u916e\u53ef<\/span><\/span><span><span>\u635f<\/span><\/span><span><span>\u5bb3\u53ef\u5361\u56e0<\/span><\/span><span><span>\u5bfb\u6c42<\/span><\/span><span><span>\u884c\u4e3a\u7684\u91cd\u73b0<\/span><\/span><\/span><span><\/span><\/h3>\n<p><span><span><span>\u5c3d\u7ba1\u6240\u6709\u5927\u9f20\u5728\u8bad\u7ec3\u9636\u6bb5\u7684\u5b66\u4e60\u7a0b\u5ea6\u76f8\u5f53\uff0c\u4f46\u6c2f\u80fa\u916e\u5904\u7406\u4ec5\u5728\u7ed3\u5408&ldquo;\u65b0\u9896&rdquo;\u8bb0\u5fc6\u63d0\u53d6\uff08VR5\uff09\u65f6\u5c55\u73b0\u51fa\u7279\u5f02\u6027\u7597\u6548\uff1a\u7ed9\u4e88\u6c2f\u80fa\u916e\u663e\u8457\u51cf\u5c11\u4e86\u6b21<\/span><\/span><span><span>\u65e5\u7684<\/span><\/span><span><span><span>\u7ebf\u7d22\u8bf1\u5bfc\u590d\u5438\u884c\u4e3a<\/span><\/span><\/span><span><span>\uff08\u4e3b<\/span><\/span><span><span>\u52a8\u6760\u6746\u6309\u538b\u53ca\u53ef\u5361\u56e0\u8f93\u6ce8\u91cf\uff09\uff0c\u4e14\u8fd9\u79cd\u6291\u5236\u4f5c\u7528\u6bd4\u5bf9\u7167\u7ec4\u66f4\u8fc5\u901f\u3001\u66f4\u6301\u4e45\uff1b\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5728&ldquo;\u719f\u6089&rdquo;\u63d0\u53d6\u6761\u4ef6\uff08FR1\uff09\u4e0b\u6216\u4ec5\u5355\u72ec\u4f7f\u7528\u6c2f\u80fa\u916e\u5747\u65e0\u6548\u3002\u6b64\u5916\uff0c\u8be5\u7ec4\u5408\u6548\u5e94\u5728\u6807\u51c6\u5316\u5206\u6790\u4e2d\u540c\u6837\u663e\u8457\u964d\u4f4e\u4e86\u590d\u5438\u671f\u95f4\u7684\u5956\u52b1\u83b7\u53d6\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><span>\u7efc\u4e0a\u6240\u8ff0\uff0c<\/span><\/span><span><span><span>\u6c2f\u80fa\u916e\u5fc5\u987b\u5728\u8bb0\u5fc6\u91cd\u5de9\u56fa\u7684\u5173\u952e\u7a97\u53e3\u671f\u4e0e\u65b0\u9896\u6027\u4f53\u9a8c\u76f8\u7ed3\u5408\uff0c\u624d\u80fd\u6709\u6548\u7834\u574f\u53ef\u5361\u56e0\u7ebf\u7d22\u8bb0\u5fc6\u5e76\u6291\u5236\u590d\u5438\u3002<\/span><\/span><\/span><\/span><\/p>\n<p><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/79decad12d88ebc16102c5f79fcc18ed_1773745206.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x1850\/gravity\/center\/crop\/!1440x1850&ext=.jpeg\" alt=\"NP\u520a\uff1a\u6297\u6291\u90c1\u836f\u8fd8\u80fd\u6291\u5236\u6210\u763e\uff1f\u7814\u7a76\u63ed\u793a\u6c2f\u80fa\u916e\u7834\u574f\u53ef\u5361\u56e0\u6210\u763e\u8bb0\u5fc6\u7684\u795e\u7ecf\u673a\u5236\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/p>\n<h3><span><span><span><span>\u65b0\u9896\u8bb0\u5fc6\u63d0\u53d6\u8054\u5408\u6c2f\u80fa\u916e\u5bf9 mPFC\u8111\u533aPNNs\u4e0ePV\u795e\u7ecf\u5143\u7684\u5f71\u54cd<\/span><\/span><\/span><\/span><span><\/span><\/h3>\n<p><span><span>PNNs\u5305\u56f4\u7740\u5185\u4fa7\u524d\u989d\u53f6\u76ae\u5c42\uff08mPFC\uff09\u4e2d\u591a\u6570PV\u4e2d\u95f4\u795e\u7ecf\u5143\uff0c\u800c\u4f4e\u5242\u91cf\u6c2f\u80fa\u916e\u53ef\u9009\u62e9\u6027\u9776\u5411PV\u7ec6\u80de\u3002\u5927\u591a\u6570mPFC PV\u795e\u7ecf\u5143\u542b\u6709NMDA\u53d7\u4f53\uff0c\u6025\u6027\u6c2f\u80fa\u916e\u901a\u8fc7\u963b\u65ad\u8be5\u53d7\u4f53\u8fc5\u901f\u964d\u4f4ePV\u7ec6\u80de\u6d3b\u6027\u53caPV\u6c34\u5e73\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u68c0\u6d4b\u4e86\u7ebf\u7d22\u590d\u5438\u540e1.5\u5c0f\u65f6mPFC\u4e2dPNNs\u3001PV\u7684\u8868\u8fbe\uff0c\u5e76\u8bc4\u4f30\u4e86\u7ec6\u80de\u6fc0\u6d3b\u6807\u5fd7\u7269c-Fos\u548cNpas4\u3002<\/span><\/span><\/p>\n<p><span><span><span>\u7814\u7a76\u663e\u793a\uff0c\u4f4e\u5242\u91cf\u6c2f\u80fa\u916e\u7ed3\u5408\u65b0\u9896\u8bb0\u5fc6\u63d0\u53d6\uff08VR5\uff09\u867d\u672a\u6539\u53d8\u6574\u4f53PNN\u5f3a\u5ea6\uff0c\u4f46\u663e\u8457\u964d\u4f4e\u4e86\u6fc0\u6d3b\u6001\uff08c-Fos\u9633\u6027\uff09PV\u795e\u7ecf\u5143\u5468\u56f4\u7684PNN\u5f3a\u5ea6\uff0c\u5e76\u6291\u5236\u4e86PV\u7ec6\u80de\u5185\u7684Npas4\u8868\u8fbe\u3002\u7ed9\u4e88\u6c2f\u80fa\u916e\u540emPFC\u4e2d\u88ab\u6fc0\u6d3b\u7684PV\u795e\u7ecf\u5143\u6570\u91cf\u51cf\u5c11\uff0c\u5e76\u4e14\u8be5\u6548\u5e94\u4e0e\u7ed9\u836f\u65f6\u95f4\uff08\u63d0\u53d6\u524d\u6216\u540e\uff09\u65e0\u5173\uff0c\u8868\u660e\u5176\u80fd\u8fc5\u901f\u6291\u5236PV\u7ec6\u80de\u7684\u529f\u80fd\u6027\u6fc0\u6d3b\u3002\u8fd9\u4e9b\u7ed3\u679c\u63d0\u793a\uff0c<\/span><\/span><span><span><span>\u6c2f\u80fa\u916e\u901a\u8fc7\u5728\u8bb0\u5fc6\u91cd\u5de9\u56fa\u7a97\u53e3\u671f\u7279\u5f02\u6027\u524a\u5f31PV\u795e\u7ecf\u5143\u7684\u6d3b\u52a8\uff0c\u53ef\u80fd\u5e72\u6270\u4e86\u8bb0\u5fc6\u7684\u7cbe\u786e\u6027\u6216\u52a8\u673a\u9a71\u52a8\uff0c\u8fdb\u800c\u5bfc\u81f4\u968f\u540e\u89c2\u5bdf\u5230\u7684PNN\u7ed3\u6784\u6539\u53d8\u53ca\u590d\u5438\u884c\u4e3a\u7684\u51cf\u5c11<\/span><\/span><\/span><span><span>\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/2f108f1dbacc241b0cc0ed004b3aa91e_1773745206.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x2354\/gravity\/center\/crop\/!1440x2354&ext=.jpeg\" alt=\"NP\u520a\uff1a\u6297\u6291\u90c1\u836f\u8fd8\u80fd\u6291\u5236\u6210\u763e\uff1f\u7814\u7a76\u63ed\u793a\u6c2f\u80fa\u916e\u7834\u574f\u53ef\u5361\u56e0\u6210\u763e\u8bb0\u5fc6\u7684\u795e\u7ecf\u673a\u5236\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><span><\/span><\/p>\n<p><span><span>\u8be5\u7814\u7a76\u63ed\u793a\u4e86\u4f4e\u5242\u91cf\u6c2f\u80fa\u916e\u8054\u5408\u7279\u5b9a\u8bb0\u5fc6\u63d0\u53d6<a href=\"https:\/\/www.alphaseek.cn\/?tag=%e7%ad%96%e7%95%a5\" title=\"View all posts in \u7b56\u7565\" target=\"_blank\" class=\"tag_link\">\u7b56\u7565<\/a>\u5728\u963b\u65ad\u53ef\u5361\u56e0\u6210\u763e\u8bb0\u5fc6\u91cd\u5de9\u56fa\u65b9\u9762\u7684\u72ec\u7279\u6f5c\u529b\uff0c\u4e3a\u6cbb\u7597\u836f\u7269\u6210\u763e\u63d0\u4f9b\u4e86\u65b0\u7684\u795e\u7ecf\u751f\u7269\u5b66\u673a\u5236\u548c\u4e34\u5e8a\u8f6c\u5316\u601d\u8def\uff1a\u8bc1\u660e\u4e86\u5355\u6b21\u4f4e\u5242\u91cf\u6c2f\u80fa\u916e\u672c\u8eab\u4e0d\u8db3\u4ee5\u6291\u5236\u590d\u5438\uff0c\u5fc5\u987b\u4e0e\u5f15\u5165\u65b0\u9896\u5956\u52b1\u6761\u4ef6\u7684\u8bb0\u5fc6\u63d0\u53d6\u76f8\u7ed3\u5408\u624d\u6709\u6548\u3002\u672c\u6587\u5f3a\u8c03\u4e86\u884c\u4e3a\u5e72\u9884\u4e0e\u836f\u7406\u5b66\u6cbb\u7597\u534f\u540c\u7684\u91cd\u8981\u6027\uff0c\u4e3a\u4f18\u5316\u73b0\u6709\u66b4\u9732\u7597\u6cd5\u63d0\u4f9b\u4e86\u5173\u952e\u4f9d\u636e\u3002<\/span><\/span><\/p>\n<p>(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n<ul>\n<li><strong>\u6587\u7ae0\u6765\u6e90\uff1a<\/strong>https:\/\/doi.org\/10.1016\/j.neuropharm.2026.110912<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u6587 | \u8111\u58f0\u5e38\u8c08 \u5f88\u591a\u6210\u763e\u95ee\u9898\uff0c\u6bd4\u5982\u5bf9\u53ef\u5361\u56e0\u3001\u51b0\u6bd2\u8fd9\u7c7b\u7cbe\u795e\u5174\u594b\u5242\u4e0a\u763e\uff0c\u5173\u952e\u5728\u4e8e\u5927\u8111\u91cc\u5f62\u6210\u4e86\u987d\u56fa\u7684\u6210\u763e\u8bb0\u5fc6\u3002\u4e00\u78b0 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[88],"views":22,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/747950"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=747950"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/747950\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=747950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=747950"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=747950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}