{"id":747407,"date":"2026-03-17T09:29:30","date_gmt":"2026-03-17T01:29:30","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=747407"},"modified":"2026-03-17T09:29:30","modified_gmt":"2026-03-17T01:29:30","slug":"%e8%82%a0-%e8%84%91%e8%bd%b4%e6%96%b0%e5%8f%91%e7%8e%b0%ef%bc%9a%e6%98%8e%e6%98%8e%e5%be%88%e9%a5%bf%e5%8d%b4%e4%b8%8d%e6%83%b3%e5%90%83%ef%bc%9f%e5%8d%8e%e7%a7%91%e5%a4%a7%e5%88%98%e5%b9%b3%e5%9b%a2","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=747407","title":{"rendered":"\u80a0-\u8111\u8f74\u65b0\u53d1\u73b0\uff1a\u660e\u660e\u5f88\u997f\u5374\u4e0d\u60f3\u5403\uff1f\u534e\u79d1\u5927\u5218\u5e73\u56e2\u961f\u63ed\u793a\u80a0\u9053\u81f4\u75c5\u83cc\u9006\u8f6c\u9965\u997f\u9a71\u52a8\u51b3\u7b56\u7684\u795e\u7ecf\u673a\u5236"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

\u997f\u5230\u6781\u81f4\u7684\u65f6\u5019\uff0c\u4f60\u662f\u5426\u4f1a\u5192\u7740\u5927\u96e8\u51b2\u51fa\u53bb\u4e70\u5403\u7684\uff1f\u52a8\u7269\u4e5f\u4e00\u6837\uff0c\u9965\u997f\u4f1a\u538b\u8fc7\u5bf9\u5371\u9669\u7684\u6050\u60e7\uff0c\u8ba9\u5b83\u4eec\u94e4\u800c\u8d70\u9669\u53bb\u89c5\u98df\u3002\u4f46\u5982\u679c\u8fd9\u65f6\u5019\u80a0\u9053\u91cc\u85cf\u7740\u81f4\u75c5\u83cc\uff0c\u5219\u80a0\u9053\u81f4\u75c5\u83cc\u7adf\u80fd“\u5173\u6389”\u9965\u997f\u9a71\u52a8\u7684\u5192\u9669\u52c7\u6c14\u3002\u8fd9\u7a76\u7adf\u662f\u4e3a\u4ec0\u4e48\u5462\uff1f<\/span><\/span><\/span><\/span><\/p>\n

2026\u5e742\u670825\u65e5\uff0c<\/span><\/span>\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u57fa\u7840\u533b\u5b66\u9662<\/span><\/span>\u5218\u5e73<\/span>\u7814\u7a76\u5458\u56e2\u961f<\/span><\/span>\u5728<\/span>\u300aNature Communications\u300b<\/span>\u4e0a\u53d1\u8868\u7684\u7814\u7a76\u7ed9\u51fa\u4e86\u7b54\u6848\uff1a\u80a0\u9053\u91cc\u7684\u94dc<\/a>\u7eff\u5047\u5355\u80de\u83cc\uff0c\u4f1a\u901a\u8fc7\u80a0-\u8111\u8f74\uff0c\u6084\u6084\u5173\u6389\u4f60\u7684“\u89c5\u98df\u52c7\u6c14\u5f00\u5173”\u3002<\/span><\/span><\/span><\/p>\n

\u8be5\u7814\u7a76\u6807\u9898\u4e3a<\/span><\/span>\u300a Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans \u300b\uff0c\u672c\u7814\u7a76\u4ee5\u79c0\u4e3d\u9690\u6746\u7ebf\u866b\u4e3a\u6a21\u578b\uff0c\u53d1\u73b0<\/span>\u80a0\u9053\u81f4\u75c5\u83cc\u94dc\u7eff\u5047\u5355\u80de\u83cc\u4f1a\u98a0\u8986\u7ebf\u866b\u56e0\u9965\u997f\u4ea7\u751f\u7684\u5192\u9669\u89c5\u98df\u51b3\u7b56<\/span>\uff1b\u800c\u9965\u997f\u5219\u9002\u5ea6\u6fc0\u6d3b\u8be5\u795e\u7ecf\u5143\u4fc3\u8fdb\u5192\u9669\uff0c<\/span><\/span><\/span>\u63ed\u793a\u4e86\u80a0\u9053\u4ee3\u8c22\u548c\u514d\u75ab\u4fe1\u53f7\u901a\u8fc7\u4e2d\u67a2 5 - \u7f9f\u8272\u80fa\u91cd\u5851\u884c\u4e3a\u7684\u80a0 - \u8111\u8c03\u63a7\u673a\u5236\u3002<\/span><\/span><\/span><\/span><\/p>\n

\"\u80a0-\u8111\u8f74\u65b0\u53d1\u73b0\uff1a\u660e\u660e\u5f88\u997f\u5374\u4e0d\u60f3\u5403\uff1f\u534e\u79d1\u5927\u5218\u5e73\u56e2\u961f\u63ed\u793a\u80a0\u9053\u81f4\u75c5\u83cc\u9006\u8f6c\u9965\u997f\u9a71\u52a8\u51b3\u7b56\u7684\u795e\u7ecf\u673a\u5236\"<\/span><\/span><\/p>\n

\u4e00\u4e2a\u5947\u602a\u7684\u73b0\u8c61——\u997f\u574f\u4e86\uff0c\u4f46\u4e0d\u6562\u53bb\u89c5\u98df<\/span><\/span><\/span><\/span><\/h2>\n

\u7814\u7a76\u8005\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u7cbe\u5de7\u7684\u5b9e\u9a8c\uff1a\u8ba9\u7ebf\u866b\u997f\u7740\u809a\u5b50\uff0c\u9762\u524d\u6709\u4e00\u9053\u5c4f\u969c——\u9ad8\u6e17\u7518\u6cb9\uff0c\u5bf9\u7ebf\u866b\u6765\u8bf4\u662f\u4e00\u79cd\u5371\u9669\u3002<\/span><\/span><\/p>\n

\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u9965\u997f\u4f1a\u8ba9\u7ebf\u866b\u7518\u613f\u5192\u9669\uff0c\u8de8\u8fc7\u5c4f\u969c\u53bb\u89c5\u98df\u3002\u4f46\u5982\u679c\u7ebf\u866b\u88ab\u94dc\u7eff\u5047\u5355\u80de\u83cc\u611f\u67d3\uff0c\u5219\u51fa\u73b0\u5947\u602a\u7684\u73b0\u8c61\uff1a<\/span><\/span>\u997f\u5f52\u997f\uff0c\u4f46\u5b83\u4eec\u4e0d\u6562\u5192\u9669\u4e86<\/span><\/span>\u3002\u5176\u4ed6\u81f4\u75c5\u83cc\uff08\u6bd4\u5982\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\uff09\u6ca1\u6709\u8fd9\u4e2a\u6548\u679c\uff0c\u800c\u4e14\u5fc5\u987b\u662f\u5728\u80a0\u9053\u5b9a\u6b96\u7684\u6d3b\u83cc\u624d\u884c\u3002\u901a\u8fc7<\/span><\/span>\u795e\u7ecf\u5143\u6c89\u9ed8\u5b9e\u9a8c<\/span><\/strong>\u548c\u57fa\u56e0\u6572\u9664\uff0c\u8bc1\u5b9e\u8fd9\u4e00\u8fc7\u7a0b\u7531<\/span><\/span>ADF 5 - \u7f9f\u8272\u80fa\u795e\u7ecf\u5143<\/span><\/span>\u4ecb\u5bfc\uff0c\u591a\u5df4\u80fa\u4fe1\u53f7\u65e0\u53c2\u4e0e\uff0c<\/span><\/span><\/span><\/p>\n

\u4e5f\u5c31\u662f\u8bf4\uff0c\u80a0\u9053\u91cc\u7684\u94dc\u7eff\u5047\u5355\u80de\u83cc\uff0c\u901a\u8fc75-\u7f9f\u8272\u80fa\u901a\u8def\uff0c\u5173\u6389\u4e86\u7ebf\u866b\u7684“\u89c5\u98df\u52c7\u6c14”\u3002<\/span><\/span><\/p>\n

\"\u80a0-\u8111\u8f74\u65b0\u53d1\u73b0\uff1a\u660e\u660e\u5f88\u997f\u5374\u4e0d\u60f3\u5403\uff1f\u534e\u79d1\u5927\u5218\u5e73\u56e2\u961f\u63ed\u793a\u80a0\u9053\u81f4\u75c5\u83cc\u9006\u8f6c\u9965\u997f\u9a71\u52a8\u51b3\u7b56\u7684\u795e\u7ecf\u673a\u5236\"<\/span><\/span><\/p>\n

ADF\u795e\u7ecf\u5143\u600e\u4e48\u611f\u77e5\u98df\u7269\uff1f<\/span><\/span><\/span><\/h2>\n

ADF\u795e\u7ecf\u5143\u539f\u672c\u88ab\u8ba4\u4e3a\u4e3b\u8981\u8c03\u8282\u60c5\u7eea\u548c\u884c\u4e3a\uff0c\u4f46\u8fd9\u6b21\u7814\u7a76\u53d1\u73b0\u5b83\u80fd\u76f4\u63a5\u611f\u77e5\u98df\u7269\u6c14\u5473——<\/span><\/strong>\u4e8c\u4e59\u9170<\/span><\/span><\/strong>\u3002<\/span><\/strong><\/span><\/p>\n

\u7528\u9499\u6210\u50cf\u8bb0\u5f55ADF\u795e\u7ecf\u5143\u7684\u6d3b\u52a8\uff1a\u9965\u997f\u65f6\uff0c\u5b83\u5bf9\u4e8c\u4e59\u9170\u7684\u54cd\u5e94\u589e\u5f3a\uff1b\u611f\u67d3\u65f6\uff0c\u54cd\u5e94\u8fdb\u4e00\u6b65\u589e\u5f3a\u3002<\/span><\/strong>\u901a\u8fc7<\/span><\/span>\u57fa\u56e0\u7b5b\u9009\u548c CRISPR \u57fa\u56e0\u7f16\u8f91\uff0c\u9274\u5b9a\u51fa<\/span><\/strong>SRI-36<\/span><\/span>\u662f ADF \u4e2d\u611f\u77e5\u4e8c\u4e59\u9170\u7684\u53d7\u4f53\uff0cSRI-36\u7684\u8868\u8fbe\u91cf\u8d8a\u9ad8\uff0cADF\u795e\u7ecf\u5143\u5bf9\u98df\u7269\u6c14\u5473\u5c31\u8d8a\u654f\u611f\uff0c\u7ebf\u866b\u4e5f\u5c31\u8d8a“\u7ea0\u7ed3”\u3002<\/span><\/span><\/span><\/p>\n

\u56e0\u6b64\uff0c<\/span><\/strong>SRI-36 \u662f\u7ebf\u866b\u611f\u77e5\u98df\u7269\u6c14\u5473\u5e76\u8c03\u63a7\u51b3\u7b56\u7684\u5173\u952e\u53d7\u4f53\u3002<\/span><\/span><\/span><\/p>\n

\"\u80a0-\u8111\u8f74\u65b0\u53d1\u73b0\uff1a\u660e\u660e\u5f88\u997f\u5374\u4e0d\u60f3\u5403\uff1f\u534e\u79d1\u5927\u5218\u5e73\u56e2\u961f\u63ed\u793a\u80a0\u9053\u81f4\u75c5\u83cc\u9006\u8f6c\u9965\u997f\u9a71\u52a8\u51b3\u7b56\u7684\u795e\u7ecf\u673a\u5236\"<\/span><\/span><\/p>\n

\u80a0\u9053\u600e\u4e48\u7ed9ADF\u795e\u7ecf\u5143\u53d1\u6307\u4ee4\uff1f<\/span><\/span><\/span><\/h2>\n

RNAi \u6572\u4f4e<\/span><\/strong>\u548c<\/span><\/span>\u7ec4\u7ec7\u7279\u5f02\u6027\u8868\u8fbe\u5b9e\u9a8c<\/span><\/strong>\u8bc1\u5b9e\uff0c<\/span><\/span>\u9965\u997f<\/span><\/span>\u6fc0\u6d3b\u80a0\u9053 AAK-2\/AMPK \u80fd\u91cf\u901a\u8def\uff0c\u901a\u8fc7 DAF-16\/FOXO \u8bf1\u5bfc INS-37 \u91ca\u653e\uff0c\u7ecf\u80f0\u5c9b\u7d20\u901a\u8def\u8c03\u63a7 ADF \u7684 SRI-36 \u8868\u8fbe\uff1b<\/span><\/span>\u611f\u67d3<\/span><\/span>\u5219\u6fc0\u6d3b\u80a0\u9053 PMK-2\/p38 MAPK \u514d\u75ab\u901a\u8def\uff0c\u6291\u5236 DAF-16 \u5e76\u8bf1\u5bfc INS-7 \u91ca\u653e\uff0c\u8fdb\u4e00\u6b65\u653e\u5927 SRI-36 \u8868\u8fbe\u3002<\/span><\/span><\/span><\/p>\n

\u56e0\u6b64\uff0c\u80a0\u9053\u901a\u8fc7\u4e24\u6761\u4e0d\u540c\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u5206\u522b\u54cd\u5e94\u9965\u997f\u548c\u611f\u67d3\uff0c\u8fdc\u7a0b\u8c03\u63a7\u5927\u8111\u795e\u7ecf\u5143\u7684\u53d7\u4f53\u8868\u8fbe\u3002<\/span><\/span><\/p>\n

\"\u80a0-\u8111\u8f74\u65b0\u53d1\u73b0\uff1a\u660e\u660e\u5f88\u997f\u5374\u4e0d\u60f3\u5403\uff1f\u534e\u79d1\u5927\u5218\u5e73\u56e2\u961f\u63ed\u793a\u80a0\u9053\u81f4\u75c5\u83cc\u9006\u8f6c\u9965\u997f\u9a71\u52a8\u51b3\u7b56\u7684\u795e\u7ecf\u673a\u5236\"<\/span><\/span><\/p>\n

ADF\u795e\u7ecf\u5143\u6536\u5230\u4fe1\u53f7\u540e\uff0c\u600e\u4e48\u6539\u53d8\u884c\u4e3a\uff1f<\/span><\/span><\/span><\/h2>\n

ADF\u795e\u7ecf\u5143\u662f5-\u7f9f\u8272\u80fa\u80fd\u795e\u7ecf\u5143<\/span><\/span><\/strong>\uff0c\u5b83\u901a\u8fc7\u91ca\u653e5-\u7f9f\u8272\u80fa\u6765\u5f71\u54cd\u884c\u4e3a\uff0c\u7814\u7a76\u8005\u53d1\u73b0<\/span><\/strong>5-\u7f9f\u8272\u80fa\u7684\u91ca\u653e\u91cf<\/span><\/span><\/strong>\u51b3\u5b9a\u4e86\u7ebf\u866b\u662f“\u5192\u9669”\u8fd8\u662f“\u907f\u9669”\u3002<\/span><\/strong><\/span><\/p>\n

\u9002\u5ea6\u91ca\u653e\u65f6\uff08\u9965\u997f\u72b6\u6001\uff09<\/span><\/span><\/strong>\uff1a\u901a\u8fc7SER-4\/LGC-50\u53d7\u4f53\u6291\u5236AIB\u4e2d\u95f4\u795e\u7ecf\u5143\u3001\u6fc0\u6d3bAUA\u4e2d\u95f4\u795e\u7ecf\u5143 → \u4fc3\u8fdb\u5192\u9669\u89c5\u98df\uff1b<\/span><\/strong>\u8fc7\u91cf\u91ca\u653e\u65f6\uff08\u611f\u67d3\u72b6\u6001\uff09<\/span><\/span><\/strong>\uff1a\u901a\u8fc7MOD-1\u53d7\u4f53\u6291\u5236AIA\/AIY\u4e2d\u95f4\u795e\u7ecf\u5143 → \u6291\u5236\u89c5\u98df\u3001\u4f18\u5148\u907f\u9669\u3002<\/span><\/strong><\/span><\/p>\n

\u56e0\u6b64\uff0c<\/span><\/strong>5 - \u7f9f\u8272\u80fa\u7684\u91ca\u653e\u91cf\u51b3\u5b9a\u4e86\u7ebf\u866b\u662f “\u5192\u9669\u89c5\u98df” \u8fd8\u662f “\u907f\u9669\u4fdd\u547d”\u3002<\/span><\/span><\/span><\/p>\n

\"\u80a0-\u8111\u8f74\u65b0\u53d1\u73b0\uff1a\u660e\u660e\u5f88\u997f\u5374\u4e0d\u60f3\u5403\uff1f\u534e\u79d1\u5927\u5218\u5e73\u56e2\u961f\u63ed\u793a\u80a0\u9053\u81f4\u75c5\u83cc\u9006\u8f6c\u9965\u997f\u9a71\u52a8\u51b3\u7b56\u7684\u795e\u7ecf\u673a\u5236\"<\/span><\/span><\/p>\n

\u5168\u6587\u603b\u7ed3<\/span><\/span><\/span><\/h2>\n

\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u63ed\u793a\u4e86<\/span><\/span>\u4e00\u6761\u4ece\u80a0\u9053\u5230\u884c\u4e3a\u7684\u5b8c\u6574\u901a\u8def\uff1a<\/span><\/span><\/strong><\/span><\/p>\n

\u9965\u997f → \u80a0\u9053\u80fd\u91cf\u901a\u8def\u6fc0\u6d3b\uff08AAK-2\/AMPK\uff09 → \u91ca\u653eINS-37 → \u9002\u5ea6\u4e0a\u8c03ADF\u795e\u7ecf\u5143\u7684SRI-36\u53d7\u4f53 → \u9002\u5ea6\u91ca\u653e5-\u7f9f\u8272\u80fa → \u6fc0\u6d3bAUA\u3001\u6291\u5236AIB → \u5192\u9669\u89c5\u98df\u3002<\/span><\/span><\/p>\n

\u611f\u67d3 → \u80a0\u9053\u514d\u75ab\u901a\u8def\u6fc0\u6d3b\uff08PMK-2\/p38 MAPK\uff09 → \u91ca\u653eINS-7 → \u5927\u5e45\u4e0a\u8c03SRI-36\u53d7\u4f53 → \u8fc7\u91cf\u91ca\u653e5-\u7f9f\u8272\u80fa → \u6291\u5236AIA\/AIY → \u4f18\u5148\u907f\u9669\u3002<\/span><\/span><\/p>\n

\u8fd9\u6761\u901a\u8def\u9996\u6b21\u9610\u660e\u80a0\u9053\u4ee3\u8c22\u3001\u514d\u75ab\u4fe1\u53f7\u901a\u8fc7\u80a0 - \u8111\u8f74\u6c47\u805a\u4e8e\u4e2d\u67a2 5 - \u7f9f\u8272\u80fa\uff0c\u8c03\u63a7\u5bbf\u4e3b\u51b3\u7b56\u884c\u4e3a\u7684\u5206\u5b50\u795e\u7ecf\u673a\u5236\uff0c\u5b8c\u5584\u4e86\u80a0\u8111\u6c9f\u901a\u7684\u7406\u8bba\u4f53\u7cfb\u3002<\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n

    \n
  • \u539f\u6587\u94fe\u63a5<\/strong>\uff1ahttps:\/\/doi.org\/10.1038\/s41467-026-69924-w<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

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