{"id":746107,"date":"2026-03-15T18:58:51","date_gmt":"2026-03-15T10:58:51","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=746107"},"modified":"2026-03-15T18:58:51","modified_gmt":"2026-03-15T10:58:51","slug":"%e5%ad%95%e6%9c%9f%e5%85%8d%e7%96%ab%e6%bf%80%e6%b4%bb%e5%bd%b1%e5%93%8d%e5%90%8e%e4%bb%a3%e5%a4%a7%e8%84%91%ef%bc%9a%e3%80%8abrain-behavior-and-immunity%e3%80%8b%e6%96%b0%e7%a0%94%e7%a9%b6%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=746107","title":{"rendered":"\u5b55\u671f\u514d\u75ab\u6fc0\u6d3b\u5f71\u54cd\u540e\u4ee3\u5927\u8111\uff1a\u300aBrain, Behavior, and Immunity\u300b\u65b0\u7814\u7a76\uff0c\u63ed\u793a3\u4e2a\u5173\u952e\u53d1\u73b0"},"content":{"rendered":"<blockquote>\n<p>\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n<p><span><span>\u9996\u5148\uff0c\u5988\u5988\u6000\u5b55\u7684\u65f6\u5019\uff0c\u8eab\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u72b6\u6001\u7279\u522b\u5173\u952e\uff0c\u5982\u679c\u5b55\u671f\u514d\u75ab\u7cfb\u7edf\u88ab\u6fc0\u6d3b\uff08\u6bd4\u5982\u611f\u5192\u3001\u611f\u67d3\u5f15\u53d1\u7684\u514d\u75ab\u53cd\u5e94\uff09\uff0c\u5c31\u53ef\u80fd\u95f4\u63a5\u5f71\u54cd\u809a\u5b50\u91cc\u5b9d\u5b9d\u7684\u5927\u8111\u53d1\u80b2\u3002\u4e4b\u524d\u79d1\u5b66\u5bb6\u5df2\u7ecf\u53d1\u73b0\uff0c\u8fd9\u79cd\u5b55\u671f\u7684\u514d\u75ab\u6fc0\u6d3b\uff0c\u662f\u5bfc\u81f4\u5b9d\u5b9d\u51fa\u751f\u540e\u53ef\u80fd\u51fa\u73b0\u81ea\u95ed\u75c7\u8fd9\u7c7b\u795e\u7ecf\u53d1\u80b2\u95ee\u9898\u7684\u4e00\u4e2a\u91cd\u8981\u73af\u5883\u539f\u56e0\u3002<\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/32d9b48acdb58aa7903c407679b47cab_1773569884.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x561\/gravity\/center\/crop\/!1440x561&ext=.jpeg\" alt=\"\u5b55\u671f\u514d\u75ab\u6fc0\u6d3b\u5f71\u54cd\u540e\u4ee3\u5927\u8111\uff1a\u300aBrain, Behavior, and Immunity\u300b\u65b0\u7814\u7a76\uff0c\u63ed\u793a3\u4e2a\u5173\u952e\u53d1\u73b0\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<p><span><span>2026\u5e743\u670812\u65e5\uff0c<span>\u4e1c\u5317\u5927\u5b66Motoko Maekawa<\/span>\u7814\u7a76\u56e2\u961f\u5728\u8457\u540d\u671f\u520a<span>\u300aBrain, Behavior, and Immunity\u300b<\/span>\u53d1\u8868\u9898\u4e3a\uff1a&ldquo;<span>Maternal granulocyte colony-stimulating factor alters synaptic maturation and social behaviors in offspring<\/span>&rdquo;\u7684\u7814\u7a76\u5de5\u4f5c\u3002<\/span><\/span><\/p>\n<p><span><span><span>\u8fd9\u9879\u7814\u7a76\u5c06\u7c92\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08G-CSF\uff09\u786e\u5b9a\u4e3a\u4ecb\u5bfc<\/span><\/span><span><span>\u6bcd\u4f53\u514d\u75ab\u6fc0\u6d3b\uff08MIA\uff09<\/span><\/span><span><span>\u5bfc\u81f4\u540e\u4ee3\u795e\u7ecf\u53d1\u80b2\u5f02\u5e38\u7684\u5173\u952e\u56e0\u5b50\u3002\u5728\u598a\u5a20\u671fMIA\u6a21\u578b\u4e2d\uff0c\u6bcd\u4f53\u4e0e\u80da\u80ce\u7684 G-CSF \u6c34\u5e73\u663e\u8457\u5347\u9ad8\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4ea7\u524d\u66b4\u9732\u4e8e G-CSF \u4f1a\u5bfc\u81f4\u96c4\u6027\u540e\u4ee3\u5185\u4fa7\u524d\u989d\u53f6\u76ae\u5c42\u7684\u6811\u7a81\u68d8\u5bc6\u5ea6\u5f02\u5e38\u589e\u52a0\u4e14\u6210\u719f\u5ea6\u964d\u4f4e\u5e76\u5f15\u53d1\u540e\u4ee3\u7684\u793e\u4ea4\u504f\u597d\u6539\u53d8\u3002\u8f6c\u5f55\u7ec4\u5206\u6790\u663e\u793a\uff0cG-CSF\u5f15\u8d77\u4e86\u4e24\u6027\u5728\u7a81\u89e6\u7ec4\u7ec7\u53ca\u7ebf\u7c92\u4f53\u529f\u80fd\u901a\u8def\u4e0a\u622a\u7136\u76f8\u53cd\u7684\u8868\u8fbe\u7279\u5f81\u3002\u4f53\u5916\u5b9e\u9a8c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\uff0cG-CSF\u5177\u6709\u51cf\u7f13\u7a81\u89e6\u6210\u719f\u5e76\u589e\u5f3a\u5c0f\u80f6\u8d28\u7ec6\u80de\u541e\u566c\u6d3b\u6027\u7684\u53cc\u91cd\u4f5c\u7528\u3002<\/span><\/span><\/span><\/p>\n<h3><span><span><span>MIA\u4ea7\u751f\u7684G-CSF \u80fd\u591f\u8de8\u8d8a\u5c4f\u969c\u8fdb\u5165\u80da\u80ce<\/span><\/span><\/span><span><\/span><\/h3>\n<p><span><span><span>\u5b9e\u9a8c\u663e\u793a\uff0c\u5b55\u9f20\u6ce8\u5c04 poly(I:C)\u540e\uff0c\u8840\u6d46G-CSF\u6c34\u5e73\u8fc5\u901f\u98d9\u5347\u5e76\u5728 3 \u5c0f\u65f6\u8fbe\u5cf0\uff0c\u968f\u540e\u5728 6 \u5c0f\u65f6\u8fdb\u5165\u80da\u80ce\u7ec4\u7ec7\u3002\u901a\u8fc7\u9ad8\u7075\u654f\u5ea6\u7684RNAscope\u6280\u672f\u53d1\u73b0G-CSF\u53d7\u4f53\uff08Csf3r\uff09\u5728\u80da\u80ce\u76ae\u5c42\u5e7f\u6cdb\u8868\u8fbe\uff0c\u5177\u4f53\u8986\u76d6\u4e86 Pax6+ \u653e\u5c04\u72b6\u80f6\u8d28\u7ec6\u80de\u3001Tbr2+\u4e2d\u95f4\u7956\u7ec6\u80de\u4ee5\u53ca Iba1+ \u5c0f\u80f6\u8d28\u7ec6\u80de\u3002\u5c3d\u7ba1\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e\u56e0\u6280\u672f\u7075\u654f\u5ea6\u9650\u5236\u663e\u793a\u53d7\u4f53\u4e3b\u8981\u5bcc\u96c6\u4e8e\u5c0f\u80f6\u8d28\u7ec6\u80de\uff0c\u4f46 RNAscope\u8bc1\u5b9e\u4e86\u795e\u7ecf\u7956\u7ec6\u80de\u540c\u6837\u8868\u8fbe\u8be5\u53d7\u4f53\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3a<\/span><\/span><span><span><span>G-CSF\u76f4\u63a5\u4f5c\u7528\u4e8e\u80da\u80ce\u795e\u7ecf\u524d\u4f53\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\uff0c\u8fdb\u800c\u5e72\u6270\u795e\u7ecf\u53d1\u80b2<\/span><\/span><\/span><span><span>\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u89e3\u5256\u5b66\u8bc1\u636e\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/a4555c7f177ce72153f877ff574a27ff_1773569885.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x1032&ext=.jpeg\" alt=\"\u5b55\u671f\u514d\u75ab\u6fc0\u6d3b\u5f71\u54cd\u540e\u4ee3\u5927\u8111\uff1a\u300aBrain, Behavior, and Immunity\u300b\u65b0\u7814\u7a76\uff0c\u63ed\u793a3\u4e2a\u5173\u952e\u53d1\u73b0\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<h3><span><span><span>\u6bcd\u4f53\u66b4\u9732\u4e8ehG-CSF\u4f1a\u6539\u53d8\u96c4\u6027\u540e\u4ee3\u7684\u6811\u7a81\u68d8\u5f62\u6001\uff0c\u4f46\u5bf9\u96cc\u6027\u540e\u4ee3\u65e0\u6b64\u5f71\u54cd<\/span><\/span><\/span><span><\/span><\/h3>\n<p><span><span>\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u80da\u80ce\u671f\u7b2c 12.5 \u5929\u66b4\u9732\u4e8e\u9ad8\u5242\u91cfhG-CSF\uff08800 &micro;g\/kg\uff09\u4f1a\u5bfc\u81f4\u96c4\u6027\u540e\u4ee3\u6210\u5e74\u540e\u524d\u989d\u53f6\u76ae\u5c42\u7684\u795e\u7ecf\u5143\u7ed3\u6784\u5f02\u5e38\uff0c\u5177\u4f53\u8868\u73b0\u4e3a\u6811\u7a81\u68d8\u5bc6\u5ea6\u663e\u8457\u589e\u52a0\uff0c\u4e14\u4f34\u6709\u660e\u663e\u7684\u53d1\u80b2\u5ef6\u8fdf\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u96cc\u6027\u540e\u4ee3\u867d\u6709\u5bc6\u5ea6\u589e\u52a0\u7684\u8d8b\u52bf\u3002<\/span><\/span><\/p>\n<p><span><span><span>\u6b64\u5916\uff0c\u4f4e\u5242\u91cf\u7ec4\u672a\u89c1\u660e\u663e\u6539\u53d8\uff0c\u4e14\u8be5\u5904\u7406\u5e76\u4e0d\u5f71\u54cd\u5b58\u6d3b\u7387\u6216\u751f\u957f\u7b49\u57fa\u672c\u751f\u7406\u6307\u6807\u3002\u7ed3\u679c\u8868\u660e\uff0c<\/span><\/span><span><span><span>G-CSF \u5bf9\u7a81\u89e6\u6784\u5efa\u7684\u5f71\u54cd\u5177\u6709\u660e\u663e\u7684\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u4e14\u521d\u6b65\u663e\u73b0\u51fa\u6027\u522b\u5dee\u5f02\u7684\u503e\u5411\uff08\u96c4\u6027\u66f4\u654f\u611f\uff09<\/span><\/span><\/span><span><span>\uff0c\u8fd9\u4e3a MIA \u76f8\u5173\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u63d0\u4f9b\u4e86\u76f4\u63a5\u7684\u75c5\u7406\u8bc1\u636e\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/66bf37f24acb06789056ea9a7a7b72ea_1773569885.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x1206\/gravity\/center\/crop\/!1440x1206&ext=.jpeg\" alt=\"\u5b55\u671f\u514d\u75ab\u6fc0\u6d3b\u5f71\u54cd\u540e\u4ee3\u5927\u8111\uff1a\u300aBrain, Behavior, and Immunity\u300b\u65b0\u7814\u7a76\uff0c\u63ed\u793a3\u4e2a\u5173\u952e\u53d1\u73b0\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<h3><span><span><span>\u6bcd\u4f53\u66b4\u9732\u4e8ehG-CSF\u4f1a\u6539\u53d8\u96c4\u6027\u548c\u96cc\u6027\u540e\u4ee3\u7684\u793e\u4ea4\u884c\u4e3a<\/span><\/span><\/span><span><\/span><\/h3>\n<p><span><span><span>\u4f5c\u8005\u63a5\u4e0b\u6765\u8003\u5bdf\u4e86\u6bcd\u4f53\u66b4\u9732\u4e8ehG-CSF\u662f\u5426\u5f71\u54cd\u540e\u4ee3\u7684\u884c\u4e3a\u3002\u5728<\/span><\/span><span><span><span>\u793e\u4ea4\u504f\u597d\u6d4b\u8bd5<\/span><\/span><\/span><span><span>\u4e2d\uff0c\u63a5\u53d7\u9ad8\u5242\u91cfhG-CSF\u5904\u7406\u7684\u96c4\u6027\u540e\u4ee3\u8868\u73b0\u51fa\u793e\u4ea4\u504f\u597d\u964d\u4f4e\uff0c\u800c\u540c\u7b49\u5904\u7406\u7684\u96cc\u6027\u540e\u4ee3\u5219\u663e\u793a\u51fa\u793e\u4ea4\u504f\u597d\u589e\u52a0\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><span>\u5728\u540c\u6027\u522b\u7684\u6240\u6709\u52a8\u7269\u4e2d\uff0c\u793e\u4ea4\u6307\u6570\u4e0e\u6811\u7a81\u68d8\u5bc6\u5ea6\u5728\u96cc\u6027\u4e2d\u5448\u6b63\u76f8\u5173\uff0c\u800c\u5728\u96c4\u6027\u4e2d\u5219\u65e0\u6b64\u5173\u8054\u3002\u5728\u4e24\u79cd\u6027\u522b\u7684\u4f4e\u5242\u91cfhG-CSF\u540e\u4ee3\u4e2d\u5747\u672a\u89c2\u5bdf\u5230\u5dee\u5f02\u3002\u5728\u5176\u4ed6\u884c\u4e3a\u5b66\u6d4b\u8bd5\u4e2d\uff0c\u9ad8\u5242\u91cfhG-CSF\u5904\u7406\u7684\u96cc\u6027\u540e\u4ee3\u5728<\/span><\/span><span><span><span>\u65f7\u573a<\/span><\/span><\/span><span><span>\u4e2d\u5fc3\u533a\u57df\u505c\u7559\u65f6\u95f4\u66f4\u957f\uff0c\u800c\u4f4e\u5242\u91cfhG-CSF\u5904\u7406\u7684\u96cc\u6027\u540e\u4ee3\u5728\u51fa\u751f\u540e\u7b2c8\u5929\u548c\u7b2c10\u5929\u53d1\u51fa\u7684<\/span><\/span><span><span><span>\u8d85\u58f0\u6ce2\u53eb\u58f0<\/span><\/span><\/span><span><span>\u8f83\u5c11\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/b231b151629f3a8e1685307382fc3412_1773569885.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x990\/gravity\/center\/crop\/!1440x990&ext=.jpeg\" alt=\"\u5b55\u671f\u514d\u75ab\u6fc0\u6d3b\u5f71\u54cd\u540e\u4ee3\u5927\u8111\uff1a\u300aBrain, Behavior, and Immunity\u300b\u65b0\u7814\u7a76\uff0c\u63ed\u793a3\u4e2a\u5173\u952e\u53d1\u73b0\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<h3><span><span><span>\u7814\u7a76\u610f\u4e49<\/span><\/span><\/span><\/h3>\n<p><span><span>\u8fd9\u4e9b\u53d1\u73b0\u62d3\u5c55\u4e86MIA\u7814\u7a76\u7684\u6982\u5ff5\u6846\u67b6\uff0c\u5e76\u5f3a\u8c03\u4e86\u63a2\u7d22\u9664\u7ecf\u5178\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u4e4b\u5916\u7684\u975e\u4f20\u7edf\u514d\u75ab\u4ecb\u8d28\u7684\u91cd\u8981\u6027\u3002<\/span><\/span><\/p>\n<p><span><span>\u8fd9\u4e9b\u53d1\u73b0\u63ed\u793a\u4e86G-CSF\u5728\u5851\u9020\u795e\u7ecf\u53d1\u80b2\u4e2d\u6b64\u524d\u672a\u88ab\u8ba4\u8bc6\u7684\u4f5c\u7528\uff0c\u5e76\u4e3a\u7406\u89e3\u6bcd\u4f53\u708e\u75c7\u5982\u4f55\u4fc3\u6210\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u548c\u7cbe\u795e\u75be\u75c5\uff08\u5305\u62ec\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff0cASD\uff09\u7684<a href=\"https:\/\/www.alphaseek.cn\/?tag=%e9%a3%8e%e9%99%a9\" title=\"View all posts in \u98ce\u9669\" target=\"_blank\" class=\"tag_link\">\u98ce\u9669<\/a>\u63d0\u4f9b\u4e86\u673a\u5236\u5c42\u9762\u7684\u89c1\u89e3\u3002<\/span><\/span><\/p>\n<p>(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n<ul>\n<li><strong>\u6587\u7ae0\u6765\u6e90\uff1a<\/strong>https:\/\/doi.org\/10.1016\/j.bbi.2026.106534<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u6587 | \u8111\u58f0\u5e38\u8c08 \u9996\u5148\uff0c\u5988\u5988\u6000\u5b55\u7684\u65f6\u5019\uff0c\u8eab\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u72b6\u6001\u7279\u522b\u5173\u952e\uff0c\u5982\u679c\u5b55\u671f\u514d\u75ab\u7cfb\u7edf\u88ab\u6fc0\u6d3b\uff08\u6bd4\u5982\u611f\u5192\u3001\u611f\u67d3\u5f15\u53d1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[192],"views":32,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/746107"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=746107"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/746107\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=746107"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=746107"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=746107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}