{"id":745874,"date":"2026-03-15T09:53:48","date_gmt":"2026-03-15T01:53:48","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=745874"},"modified":"2026-03-15T09:53:48","modified_gmt":"2026-03-15T01:53:48","slug":"%e7%97%92%e5%88%b0%e6%8a%93%e7%8b%82%ef%bc%9f%e9%99%86%e5%86%9b%e5%8c%bb%e9%9a%8b%e5%bb%ba%e5%b3%b0-%e6%9d%8e%e7%ba%a2%e4%b8%bd-%e5%90%b4%e5%b9%bf%e5%bb%b6%e5%9b%a2%e9%98%9f%e5%8f%91%e7%8e%b0%e6%8a%91","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=745874","title":{"rendered":"\u75d2\u5230\u6293\u72c2\uff1f\u9646\u519b\u533b\u968b\u5efa\u5cf0\/\u674e\u7ea2\u4e3d\/\u5434\u5e7f\u5ef6\u56e2\u961f\u53d1\u73b0\u6291\u5236\u7619\u75d2\u7684\u5173\u952e\u795e\u7ecf\u73af\u8def\uff0c\u4e3a\u6cbb\u7597\u6162\u6027\u7619\u75d2\u63d0\u4f9b\u65b0\u9776\u70b9"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

\u4f60\u88ab\u868a\u5b50\u53ee\u4e86\u4e00\u53e3\uff0c\u624b\u521a\u8981\u6320\u3002\u7a81\u7136\uff0c\u5927\u8111\u91cc\u6709\u4e2a“\u7406\u667a\u5c0f\u4eba”\u8df3\u51fa\u6765\u558a\uff1a\u522b\u6293\uff01\u8d8a\u6293\u8d8a\u75d2\uff01<\/span><\/span><\/span><\/p>\n

\u57fa\u4e8e\u6b64\uff0c\u519b\u533b\u5927\u5b66\u57fa\u7840\u533b\u5b66\u9662\u57fa\u7840\u533b\u5b66\u5b9e\u9a8c\u4e2d\u5fc3\u968b\u5efa\u5cf0<\/span>\/\u674e\u7ea2\u4e3d<\/span>\/\u5434\u5e7f\u5ef6<\/span>\u7814\u7a76\u56e2\u961f\u5728\u300aCell Reports\u300b<\/span>\u6742\u5fd7\u53d1\u8868\u4e86“An excitatory neural circuit or descending inhibition of itch processing”\u63ed\u793a\u4e86\u4e00\u79cd\u7528\u4e8e\u4e0b\u884c\u6291\u5236\u7619\u75d2\u5904\u7406\u7684\u5174\u594b\u6027\u795e\u7ecf\u73af\u8def\u3002<\/span><\/span><\/p>\n

\"\u75d2\u5230\u6293\u72c2\uff1f\u9646\u519b\u533b\u968b\u5efa\u5cf0\/\u674e\u7ea2\u4e3d\/\u5434\u5e7f\u5ef6\u56e2\u961f\u53d1\u73b0\u6291\u5236\u7619\u75d2\u7684\u5173\u952e\u795e\u7ecf\u73af\u8def\uff0c\u4e3a\u6cbb\u7597\u6162\u6027\u7619\u75d2\u63d0\u4f9b\u65b0\u9776\u70b9\"<\/span><\/span><\/p>\n

\u4f5c\u8005\u53d1\u73b0\u4e86\u4e00\u6761\u4ece\u543b\u4fa7\u524d\u6263\u5e26\u76ae\u5c42\u9525\u4f53\u795e\u7ecf\u5143\uff08rACC<\/span><\/span>Py<\/span><\/sup><\/span>\uff09\u5230\u4e2d\u8111\u5bfc\u6c34\u7ba1\u5468\u56f4\u7070\u8d28GABA\u80fd\u795e\u7ecf\u5143\uff08PAG<\/span><\/span>GABA<\/span><\/sup><\/span>\uff09\u7684\u5174\u594b\u6027\u4e0b\u884c\u795e\u7ecf\u73af\u8def\uff0c\u5728\u7619\u75d2\u6291\u5236\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u5728<\/span><\/span>\u7619\u75d2\u8bf1\u53d1\u6293\u6320\u884c\u4e3a<\/span><\/span><\/span>\u671f\u95f4\uff0c\u88ab\u6807\u8bb0\u4e3a“\u7619\u75d2\u76f8\u5173”\u7684rACC<\/span><\/span>Pych<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u6d3b\u52a8\u663e\u8457\u964d\u4f4e\u3002\u4eba\u4e3a\u6fc0\u6d3b\u8be5\u795e\u7ecf\u73af\u8def\u4f1a\u663e\u8457\u524a\u5f31\u7619\u75d2\u53cd\u5e94\uff0c\u800c\u6291\u5236\u8be5\u73af\u8def\u5219\u4f1a\u589e\u5f3a\u7619\u75d2\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u9274\u5b9a\u51fa\u4e00\u6761\u5174\u594b\u6027\u795e\u7ecf\u73af\u8def\u5728\u7619\u75d2\u7684\u4e0b\u884c\u8c03\u63a7\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u6291\u5236\u4f5c\u7528\uff0c\u63d0\u793a\u8be5\u73af\u8def\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597\u7619\u75d2\u7684\u6f5c\u5728\u9776\u70b9\u3002<\/span><\/span><\/span><\/p>\n

\"\u75d2\u5230\u6293\u72c2\uff1f\u9646\u519b\u533b\u968b\u5efa\u5cf0\/\u674e\u7ea2\u4e3d\/\u5434\u5e7f\u5ef6\u56e2\u961f\u53d1\u73b0\u6291\u5236\u7619\u75d2\u7684\u5173\u952e\u795e\u7ecf\u73af\u8def\uff0c\u4e3a\u6cbb\u7597\u6162\u6027\u7619\u75d2\u63d0\u4f9b\u65b0\u9776\u70b9\"<\/span><\/span><\/p>\n

\u56fe\u4e00 rACCPy\u795e\u7ecf\u5143\u4e9a\u7fa4\u901a\u8fc7\u6d3b\u52a8\u6291\u5236\u8c03\u63a7\u7619\u75d2\u884c\u4e3a<\/span><\/span><\/span><\/span><\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0crACC\u4e2d\u6709\u4e00\u7fa4\u7279\u5b9a\u7684\u795e\u7ecf\u5143\uff08rACC<\/span><\/span>Py<\/span><\/sup><\/span>\uff09\u5728\u6291\u5236\u7619\u75d2\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002\u7531\u4e8e\u53ea\u6709\u90e8\u5206rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u5728\u7619\u75d2\u65f6\u88ab\u6fc0\u6d3b\uff0c\u4f5c\u8005\u5229\u7528c-Fos Tet-Off\u7cfb\u7edf\u7279\u5f02\u6027\u6807\u8bb0\u4e86\u8fd9\u4e9b“\u7619\u75d2\u54cd\u5e94”\u795e\u7ecf\u5143\uff0c\u5e76\u8bb0\u5f55\u5b83\u4eec\u7684\u6d3b\u52a8\u3002<\/span><\/span><\/span><\/p>\n

\u7ed3\u679c\u663e\u793a\uff1a\u65e0\u8bba\u7528\u54ea\u79cd\u81f4\u75d2\u5242\uff08\u59825-HT\u3001compound 48\/80\u6216\u6c2f\u55b9\uff09<\/span><\/span>\u8bf1\u53d1\u6293\u6320\u884c\u4e3a<\/span><\/span><\/span>\uff0c\u8fd9\u4e9b\u88ab\u6807\u8bb0\u7684rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u7684\u9499\u4fe1\u53f7\u90fd\u663e\u8457\u4e0b\u964d\uff0c\u8bf4\u660e\u5b83\u4eec\u7684\u6d3b\u52a8\u51cf\u5f31\u4e0e\u6293\u6320\u884c\u4e3a\u76f4\u63a5\u76f8\u5173\u3002<\/span><\/span><\/span><\/p>\n

\u8fd9\u8868\u660e\uff0c\u8fd9\u7fa4\u7279\u5b9a\u7684<\/span><\/span>rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u53ef\u80fd\u901a\u8fc7“\u964d\u4f4e\u5174\u594b\u6027”\u6765\u53c2\u4e0e\u7619\u75d2\u8c03\u63a7\uff0c\u8fdb\u4e00\u6b65\u652f\u6301rACC\u6574\u4f53\u5728\u6291\u5236\u7619\u75d2\u4e2d\u7684\u4f5c\u7528<\/span><\/span>\u3002<\/span><\/span><\/span><\/p>\n

\"\u75d2\u5230\u6293\u72c2\uff1f\u9646\u519b\u533b\u968b\u5efa\u5cf0\/\u674e\u7ea2\u4e3d\/\u5434\u5e7f\u5ef6\u56e2\u961f\u53d1\u73b0\u6291\u5236\u7619\u75d2\u7684\u5173\u952e\u795e\u7ecf\u73af\u8def\uff0c\u4e3a\u6cbb\u7597\u6162\u6027\u7619\u75d2\u63d0\u4f9b\u65b0\u9776\u70b9\"<\/span><\/span><\/p>\n

\u56fe\u4e8c \u5316\u5b66\u9057\u4f20\u5b66\u91cd\u65b0\u6fc0\u6d3b\u7619\u75d2\u6807\u8bb0\u7684rACCPy\u795e\u7ecf\u5143\u53ef\u6291\u5236\u7619\u75d2\u5904\u7406<\/span><\/span><\/span><\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u63a2\u7a76\u4e86\u7619\u75d2\u6807\u8bb0\u7684rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u662f\u5426\u4e5f\u5728\u7619\u75d2\u5904\u7406\u4e2d\u53d1\u6325\u91cd\u8981\u7684\u6291\u5236\u4f5c\u7528\u3002<\/span><\/span><\/span><\/p>\n

\u4e3a\u63a2\u7a76\u88ab\u7619\u75d2\u6fc0\u6d3b\u7684rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u662f\u5426\u5177\u6709\u529f\u80fd\u6027\u6291\u5236\u4f5c\u7528\uff0c\u7814\u7a76\u4eba\u5458\u5229\u7528c-Fos Tet-Off\u7cfb\u7edf\u5728\u5927\u9f20\u53cc\u4fa7rACC\u4e2d\u7279\u5f02\u6027\u5730\u5728“\u7619\u75d2\u6807\u8bb0”\u795e\u7ecf\u5143\u4e2d\u8868\u8fbehM3Dq-mCherry\u6216\u4ec5\u8868\u8fbemCherry\u4f5c\u4e3a\u5bf9\u7167\u3002\u5728\u505c\u7528\u5f3a\u529b\u9709\u7d20\u540e\uff0c\u901a\u8fc7<\/span><\/span>\u9762\u988a\u6ce8\u5c045-HT\u8bf1\u53d1\u7619\u75d2<\/span><\/span><\/span>\uff0c\u4f7f\u8fd9\u4e9b\u795e\u7ecf\u5143\u88ab\u6807\u8bb0\u5e76\u8868\u8fbe\u76f8\u5e94\u86cb\u767d\u3002\u968f\u540e\u7ed9\u4e88CNO\u4ee5\u6fc0\u6d3bhM3Dq\uff0c\u7ed3\u679c\u53d1\u73b0\uff1a\u91cd\u65b0\u6fc0\u6d3b\u8fd9\u7fa4\u539f\u672c\u5728\u7619\u75d2\u65f6\u6d3b\u52a8\u4e0b\u964d\u7684\u795e\u7ecf\u5143\uff0c\u53ef\u663e\u8457\u51cf\u5c11\u75315-HT\u3001compound 48\/80\u548c\u6c2f\u55b9\u4e09\u79cd\u4e0d\u540c\u81f4\u75d2\u5242\u8bf1\u53d1\u7684<\/span><\/span>\u6293\u6320\u53d1\u4f5c\u6b21\u6570<\/span><\/span><\/span>\u53ca<\/span><\/span>\u603b\u6293\u6320\u65f6\u95f4<\/span><\/span><\/span>\u3002\u800c\u5728\u672a\u7ed9\u4e88CNO\u65f6\uff0chM3Dq\u7ec4\u4e0e\u5bf9\u7167\u7ec4\u65e0\u5dee\u5f02\uff0c\u6392\u9664\u4e86\u53d7\u4f53\u8868\u8fbe\u672c\u8eab\u7684\u5f71\u54cd\u3002<\/span><\/span><\/span><\/p>\n

\u4e3a\u8fdb\u4e00\u6b65\u9a8c\u8bc1\uff0c\u7814\u7a76\u8005\u901a\u8fc7\u5316\u5b66\u9057\u4f20\u6291\u5236\u8fd9\u4e9b\u795e\u7ecf\u5143\u540e\uff0c\u6293\u6320\u884c\u4e3a\u663e\u8457\u589e\u5f3a\uff1b\u540c\u6837\uff0c\u5728\u65e0CNO\u6761\u4ef6\u4e0b\uff0c\u4e24\u7ec4\u884c\u4e3a\u65e0\u5dee\u522b\u3002<\/span><\/span><\/p>\n

\u8fd9\u4e9b\u53cc\u5411\u64cd\u63a7\u5b9e\u9a8c\u4e00\u81f4\u8868\u660e\uff1a<\/span><\/span>\u8fd9\u7fa4\u5728\u7619\u75d2\u8fc7\u7a0b\u4e2d\u88ab\u7279\u5f02\u6027\u6fc0\u6d3b\uff08\u5e76\u968f\u540e\u6291\u5236\uff09\u7684rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u5e76\u975e\u88ab\u52a8\u54cd\u5e94\u7619\u75d2\uff0c\u800c\u662f\u4e3b\u52a8\u53d1\u6325\u6291\u5236\u6027\u8c03\u63a7\u4f5c\u7528\uff0c\u6d3b\u52a8\u589e\u5f3a\u53ef\u7f13\u89e3\u7619\u75d2\uff0c\u6d3b\u52a8\u51cf\u5f31\u5219\u52a0\u5267\u7619\u75d2\u3002<\/span><\/span><\/span><\/p>\n

\"\u75d2\u5230\u6293\u72c2\uff1f\u9646\u519b\u533b\u968b\u5efa\u5cf0\/\u674e\u7ea2\u4e3d\/\u5434\u5e7f\u5ef6\u56e2\u961f\u53d1\u73b0\u6291\u5236\u7619\u75d2\u7684\u5173\u952e\u795e\u7ecf\u73af\u8def\uff0c\u4e3a\u6cbb\u7597\u6162\u6027\u7619\u75d2\u63d0\u4f9b\u65b0\u9776\u70b9\"<\/span><\/span><\/p>\n

\u56fe\u4e09 \u5316\u5b66\u9057\u4f20\u5b66\u6fc0\u6d3b\u7619\u75d2\u6807\u8bb0\u7684\u6295\u5c04\u81f3PAG\u7684rACCPy\u795e\u7ecf\u5143\u53ef\u6291\u5236\u7619\u75d2<\/span><\/span><\/span><\/p>\n

\u4e3a\u63a2\u7a76rACCPy→PAG\u73af\u8def\u662f\u5426\u53c2\u4e0e\u7619\u75d2\u6291\u5236\uff0c\u7814\u7a76\u4eba\u5458\u91c7\u7528\u5316\u5b66\u9057\u4f20\u5b66\u65b9\u6cd5\u8fdb\u884c\u53cc\u5411\u64cd\u63a7\u3002<\/span><\/span><\/span><\/span><\/p>\n

\u9996\u5148\uff0c\u4ed6\u4eec\u7279\u5f02\u6027\u6fc0\u6d3b\u8fd9\u4e00\u901a\u8def\uff1a\u5728rACC\u6ce8\u5c04Cre\u4f9d\u8d56\u7684hM3Dq\u75c5\u6bd2\uff0c\u540c\u65f6\u5728PAG\u6ce8\u5c04\u9006\u884c\u6027Cre\u75c5\u6bd2\uff0c\u4f7f\u4ec5\u6295\u5c04\u5230PAG\u7684rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u8868\u8fbe\u5174\u594b\u6027\u53d7\u4f53\u3002\u6fc0\u6d3b\u540e\uff0c\u65e0\u8bba\u5728<\/span><\/span>\u9888\u80cc\u90e8\u8fd8\u662f\u9762\u988a\u7619\u75d2\u6a21\u578b<\/span><\/span><\/span>\u4e2d\uff0c\u75315-HT\u3001compound 48\/80\u6216<\/span><\/span>\u6c2f\u55b9\u8bf1\u53d1\u7684\u6293\u6320\u884c\u4e3a<\/span><\/span><\/span>\u5747\u663e\u8457\u51cf\u5c11\u3002\u53cd\u4e4b\uff0c\u5f53\u9009\u62e9\u6027\u6291\u5236\u8be5\u901a\u8def\u65f6\uff0c\u6293\u6320\u884c\u4e3a\u660e\u663e\u52a0\u91cd\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u805a\u7126\u4e8e\u771f\u6b63\u88ab\u7619\u75d2\u6fc0\u6d3b\u7684\u90a3\u90e8\u5206rACC<\/span><\/span>Py<\/span><\/sup><\/span>→PAG\u795e\u7ecf\u5143\uff08\u5373“\u7619\u75d2\u6807\u8bb0”\u4e9a\u7fa4\uff09\u3002\u901a\u8fc7c-Fos\u4f9d\u8d56\u7cfb\u7edf\uff0c\u4ec5\u8ba9\u8fd9\u7fa4\u7ec6\u80de\u8868\u8fbehM3Dq\u6216hM4Di\u3002\u7ed3\u679c\u53d1\u73b0\uff1a<\/span><\/span>\u91cd\u65b0\u6fc0\u6d3b\u5b83\u4eec\u53ef\u5f3a\u529b\u6291\u5236\u591a\u79cd\u81f4\u75d2\u5242\u5f15\u8d77\u7684\u6293\u6320\uff0c\u800c\u6291\u5236\u5b83\u4eec\u5219\u52a0\u5267\u6293\u6320\uff1b\u4e14\u5728\u4e0d\u7ed9\u4e88CNO\u65f6\uff0c\u5404\u7ec4\u65e0\u5dee\u5f02\uff0c\u6392\u9664\u975e\u7279\u5f02\u6027\u6548\u5e94\u3002<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff1a\u5e76\u975e\u6240\u6709rACC<\/span><\/span>Py<\/span><\/sup><\/span>→PAG\u795e\u7ecf\u5143\u90fd\u53c2\u4e0e\u8c03\u63a7\uff0c\u800c\u662f\u5176\u4e2d\u88ab\u7619\u75d2\u7279\u5f02\u6027\u62db\u52df\u7684\u4e9a\u7fa4\u53d1\u6325\u5173\u952e\u6291\u5236\u4f5c\u7528\u3002\u8be5\u73af\u8def\u6784\u6210\u4e86\u5927\u8111\u4e0b\u884c\u6291\u5236\u7619\u75d2\u7684\u91cd\u8981\u901a\u8def\uff0c\u4e3a\u7406\u89e3\u6162\u6027\u7619\u75d2\u7684\u4e2d\u67a2\u673a\u5236\u548c\u5f00\u53d1\u9776\u5411\u5e72\u9884\u7b56\u7565<\/a>\u63d0\u4f9b\u4e86\u65b0\u9776\u70b9\u3002<\/span><\/span><\/span><\/p>\n

\"\u75d2\u5230\u6293\u72c2\uff1f\u9646\u519b\u533b\u968b\u5efa\u5cf0\/\u674e\u7ea2\u4e3d\/\u5434\u5e7f\u5ef6\u56e2\u961f\u53d1\u73b0\u6291\u5236\u7619\u75d2\u7684\u5173\u952e\u795e\u7ecf\u73af\u8def\uff0c\u4e3a\u6cbb\u7597\u6162\u6027\u7619\u75d2\u63d0\u4f9b\u65b0\u9776\u70b9\"<\/span><\/span><\/p>\n

\u56fe\u56db \u5316\u5b66\u9057\u4f20\u5b66\u6fc0\u6d3brACCPy\u795e\u7ecf\u5143\u6240\u652f\u914d\u7684PAGGABA\u80fd\u795e\u7ecf\u5143\u53ef\u6291\u5236\u7619\u75d2\u5904\u7406<\/span><\/span><\/span><\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u7619\u75d2\u6807\u8bb0\u7684rACCPy\u795e\u7ecf\u5143\u901a\u8fc7\u6fc0\u6d3bPAG\u4e2d\u7684GABA\u80fd\u795e\u7ecf\u5143\u6765\u6291\u5236\u7619\u75d2\u3002\u4e3a\u9a8c\u8bc1\u8fd9\u4e00\u673a\u5236\uff0c\u4f5c\u8005\u5229\u7528\u8de8\u7a81\u89e6\u75c5\u6bd2\u8ffd\u8e2a\u7ed3\u5408\u5316\u5b66\u9057\u4f20\u5b66\u6280\u672f\uff0c\u7279\u5f02\u6027\u64cd\u63a7\u88abrACCPy\u652f\u914d\u7684PAG GABA\u80fd\u795e\u7ecf\u5143\u3002<\/span><\/span><\/p>\n

\u7ed3\u679c\u663e\u793a\uff1a\u6fc0\u6d3b\u8fd9\u4e9bPAG<\/span><\/span>GABA<\/span><\/sup><\/span>\u80fd\u795e\u7ecf\u5143\u540e\uff0c\u65e0\u8bba\u5728<\/span><\/span>\u9888\u80cc\u90e8\u8fd8\u662f\u9762\u988a\u7619\u75d2\u6a21\u578b<\/span><\/span><\/span>\u4e2d\uff0c\u75315-HT\u3001compound 48\/80\u6216<\/span><\/span>\u6c2f\u55b9\u8bf1\u53d1\u7684\u6293\u6320\u884c\u4e3a<\/span><\/span><\/span>\u5747\u663e\u8457\u51cf\u5c11\uff1b\u6291\u5236\u5b83\u4eec\u5219\u5bfc\u81f4\u6293\u6320\u660e\u663e\u52a0\u91cd\u3002<\/span><\/span><\/span><\/p>\n

\u8fd9\u8868\u660e\uff0c<\/span><\/span>rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u5e76\u975e\u76f4\u63a5\u6291\u5236\u7619\u75d2\uff0c\u800c\u662f\u901a\u8fc7rACC<\/span><\/span>Py<\/span><\/sup><\/span>→ PAG<\/span><\/span>GABA<\/span><\/sup><\/span>\u80fd\u795e\u7ecf\u5143\u8fd9\u4e00\u4e0b\u884c\u901a\u8def\u53d1\u6325\u6291\u5236\u4f5c\u7528<\/span><\/span>\uff0c\u8be5\u73af\u8def\u7684\u6fc0\u6d3b\u53ef\u6709\u6548“\u8e29\u4e0b\u7619\u75d2\u7684\u5239\u8f66”\uff0c\u800c\u5176\u529f\u80fd\u51cf\u5f31\u5219\u4f1a\u52a0\u5267\u7619\u75d2\u53cd\u5e94\u3002<\/span><\/span><\/span><\/p>\n

\"\u75d2\u5230\u6293\u72c2\uff1f\u9646\u519b\u533b\u968b\u5efa\u5cf0\/\u674e\u7ea2\u4e3d\/\u5434\u5e7f\u5ef6\u56e2\u961f\u53d1\u73b0\u6291\u5236\u7619\u75d2\u7684\u5173\u952e\u795e\u7ecf\u73af\u8def\uff0c\u4e3a\u6cbb\u7597\u6162\u6027\u7619\u75d2\u63d0\u4f9b\u65b0\u9776\u70b9\"<\/span><\/span><\/p>\n

\u56fe\u4e94 \u5168\u6587\u6458\u8981\u56fe<\/span><\/span><\/span><\/p>\n

\u603b\u7ed3<\/span><\/span><\/span><\/h3>\n

\u4f5c\u8005\u8bc1\u5b9e\u4e86rACC<\/span><\/span>Py<\/span><\/sup><\/span>→PAG<\/span><\/span>GABA<\/span><\/sup><\/span>\u795e\u7ecf\u73af\u8def\u5728\u7619\u75d2\u7684\u4e0b\u884c\u8c03\u63a7\u4e2d\u53d1\u6325\u5173\u952e\u7684\u6291\u5236\u4f5c\u7528\u3002rACC<\/span><\/span>Py<\/span><\/sup><\/span>\u795e\u7ecf\u5143\u5174\u594b\u6027\u7684\u589e\u5f3a\u53ef\u6fc0\u6d3b\u4e0b\u6e38\u7684\u6291\u5236\u6027PAG<\/span><\/span>GABA<\/span><\/sup><\/span>\u80fd\u795e\u7ecf\u5143\uff0c\u8fdb\u800c\u6291\u5236\u4e0b\u6e38\u7684PAG\u8c37\u6c28\u9178\u80fd\u795e\u7ecf\u5143\uff0c\u4ece\u800c\u6709\u6548\u6291\u5236\u7619\u75d2\u8bf1\u53d1\u7684\u6293\u6320\u884c\u4e3a\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u66f4\u5168\u9762\u3001\u6df1\u5165\u5730\u7406\u89e3\u7619\u75d2\u7684\u4e2d\u67a2\u8c03\u63a7\u673a\u5236\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u5b9e\u9a8c\u57fa\u7840\u548c\u65b0\u7684\u89c6\u89d2\uff0c\u540c\u65f6\u4e5f\u4e3a\u5bfb\u627e\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\u4ee5\u53ca\u5f00\u53d1\u9488\u5bf9\u7619\u75d2\u7684\u65b0\u578b\u836f\u7269\u548c\u6cbb\u7597\u65b9\u6cd5\u5960\u5b9a\u4e86\u91cd\u8981\u7684\u7406\u8bba\u57fa\u7840\u3002<\/span><\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n

    \n
  • \u6587\u7ae0\u6765\u6e90\uff1a<\/strong>https:\/\/doi.org\/10.1016\/j.celrep.2024.115062<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    \u6587 | \u8111\u58f0\u5e38\u8c08 \u4f60\u88ab\u868a\u5b50\u53ee\u4e86\u4e00\u53e3\uff0c\u624b\u521a\u8981\u6320\u3002\u7a81\u7136\uff0c\u5927\u8111\u91cc\u6709\u4e2a“\u7406\u667a\u5c0f\u4eba”\u8df3\u51fa\u6765\u558a\uff1a\u522b […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[88],"views":24,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/745874"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=745874"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/745874\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=745874"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=745874"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=745874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}