{"id":745871,"date":"2026-03-15T09:42:16","date_gmt":"2026-03-15T01:42:16","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=745871"},"modified":"2026-03-15T09:42:16","modified_gmt":"2026-03-15T01:42:16","slug":"elife%ef%bc%9a%e9%87%8d%e5%ba%86%e8%84%91%e4%b8%ad%e5%bf%83han-qin-%e9%99%86%e5%86%9b%e5%8c%bb%e8%b0%8c%e5%b0%8f%e7%bb%b4%e7%ad%89%e6%8f%ad%e7%a4%barem%e6%9c%9f%e9%97%b4%e5%b7%a9%e5%9b%ba%e7%a4%be","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=745871","title":{"rendered":"eLife\uff1a\u91cd\u5e86\u8111\u4e2d\u5fc3Han Qin\/\u9646\u519b\u533b\u8c0c\u5c0f\u7ef4\u7b49\u63ed\u793aREM\u671f\u95f4\u5de9\u56fa\u793e\u4ea4\u8bb0\u5fc6\u7684\u795e\u7ecf\u56de\u8def"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08\"eLife\uff1a\u91cd\u5e86\u8111\u4e2d\u5fc3Han<\/span><\/a><\/p>\n<\/blockquote>\n

\u6211\u4eec\u90fd\u77e5\u9053\u7761\u7720\u5f88\u91cd\u8981\uff0c\u7279\u522b\u662f\u5feb\u901f\u773c\u52a8\u7761\u7720\uff08REM\uff09\u3002\u79d1\u5b66\u5bb6\u65e9\u5c31\u53d1\u73b0\uff0cREM\u7761\u7720\u5bf9\u5de9\u56fa\u8bb0\u5fc6\u5f88\u5173\u952e\u3002<\/span><\/span><\/p>\n

\u6bd4\u5982\u4f60\u6628\u5929\u5728\u805a\u4f1a\u4e0a\u8ba4\u8bc6\u7684\u65b0\u670b\u53cb\u957f\u4ec0\u4e48\u6837\u3001\u53eb\u4ec0\u4e48\u540d\u5b57\u3001\u6027\u683c\u5982\u4f55\u3002\u8fd9\u79cd“\u8c01\u662f\u8c01”\u7684\u8bb0\u5fc6\u975e\u5e38\u7279\u6b8a\uff0c\u5982\u679c\u53d7\u635f\uff0c\u4eba<\/span>\u5c31\u4f1a\u53d8\u5f97<\/span>\u793e\u6050\u6216\u8005\u8ba4\u4e0d\u51fa\u719f\u4eba\u3002<\/span><\/span><\/p>\n

\u57fa\u4e8e\u6b64\uff0c2026\u5e743\u670812\u65e5\uff0c<\/span>\u91cd\u5e86\u8111\u4e0e\u667a\u80fd\u79d1\u5b66\u4e2d\u5fc3<\/span>Han Qin<\/span><\/span>\/<\/span><\/span>\u9646\u519b\u519b\u533b\u5927\u5b66<\/span>\u8c0c<\/span><\/span>\u5c0f\u7ef4<\/span>\/\u5927\u576a\u533b\u9662\u97e9\u5065<\/span>\u7b49\u5728\u300aeLife\u300b<\/span>\u6742\u5fd7\u53d1\u8868\u4e86“A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memory”\u63ed\u793a\u4e86\u4e0b\u4e18\u8111-\u9694\u6838-\u6d77\u9a6c\u56de\u8def\u4ecb\u5bfc\u4f9d\u8d56\u5feb\u901f\u773c\u52a8\u7761\u7720\u7684\u793e\u4ea4\u8bb0\u5fc6\u5de9\u56fa\u3002<\/span><\/span><\/p>\n

\"eLife\uff1a\u91cd\u5e86\u8111\u4e2d\u5fc3Han<\/span><\/span><\/p>\n

\u8fd9\u9879\u7814\u7a76\u9274\u5b9a\u51fa\u4e00\u6761\u4ece\u5916\u4fa7\u4e73\u5934\u4e0a\u6838\uff08SuM\uff09\u7ecf\u5185\u4fa7\u9694\u6838\uff08MS\uff09\u81f3\u6d77\u9a6c CA2 \u7684“\u4e0b\u4e18\u8111-\u9694\u6838-\u6d77\u9a6c”\u7279\u5f02\u6027\u73af\u8def\uff0c\u8bc1\u660e\u5176\u662f REM\u671f\u95f4\u5de9\u56fa\u793e\u4ea4\u8bb0\u5fc6\u7684\u5173\u952e\u901a\u8def\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u6295\u5c04\u81f3MS\u7684SuM\u795e\u7ecf\u5143\u4ec5\u5728REM\u7761\u7720\u671f\u7279\u5f02\u6027\u6fc0\u6d3b\uff0c\u901a\u8fc7\u5149\u9057\u4f20\u5b66\u624b\u6bb5\u6291\u5236\u8be5\u6295\u5c04\u6216\u5176\u4e0b\u6e38\u7684MS-CA2\u8def\u5f84\u4f1a\u9009\u62e9\u6027\u7834\u574f\u793e\u4ea4\u8bb0\u5fc6\u7684\u5de9\u56fa\uff0c\u800c\u4e0d\u5f71\u54cd\u6050\u60e7\u8bb0\u5fc6\u3002\u8fd9\u4e00\u53d1\u73b0\u5c06 SuM\u5b9a\u4f4d\u4e3aREM\u7761\u7720\u4e2d\u7684“\u8bb0\u5fc6\u5206\u6d41\u67a2\u7ebd”\uff0c\u5b83\u901a\u8fc7\u5e73\u884c\u7684\u795e\u7ecf\u901a\u8def\uff0c\u5c06\u4e0d\u540c\u6a21\u6001\u7684\u8bb0\u5fc6\u4fe1\u606f\u7cbe\u51c6\u8def\u7531\u81f3\u6d77\u9a6c\uff0c\u4e3a\u7406\u89e3\u7761\u7720\u5982\u4f55\u52a0\u5de5\u7279\u5b9a\u7c7b\u578b\u7684\u793e\u4f1a\u8ba4\u77e5\u63d0\u4f9b\u4e86\u91cd\u8981\u673a\u5236\u3002<\/span><\/span><\/p>\n

\"eLife\uff1a\u91cd\u5e86\u8111\u4e2d\u5fc3Han<\/span><\/span><\/p>\n

\u56fe\u4e00 MS\u6295\u5c04\u6027SuM\u795e\u7ecf\u5143\u7684\u9006\u884c\u6807\u8bb0<\/span><\/span><\/span><\/p>\n

\u4f5c\u8005\u5206\u522b\u5411MS\u6ce8\u5c04\u8868\u8fbe\u589e\u5f3a\u578b\u7eff\u8272\u8367\u5149\u86cb\u767d\uff08EGFP\uff09\u7684\u9006\u884c\u817a\u76f8\u5173\u75c5\u6bd2\u8f7d\u4f53\u5e76\u5411\u6d77\u9a6c\u9f7f\u72b6\u56de\uff08DG\uff09\u6ce8\u5c04\u8868\u8fbe\u7ea2\u8272\u8367\u5149\u86cb\u767dmCherry\u7684\u9006\u884c\u817a\u76f8\u5173\u75c5\u6bd2\u8f7d\u4f53\uff0c\u4ece\u800c\u6807\u8bb0\u4e86\u6295\u5c04\u81f3MS\u548c\u6295\u5c04\u81f3\u6d77\u9a6c\u7684SuM\u795e\u7ecf\u5143\u3002<\/span><\/span><\/p>\n

\u901a\u8fc7\u4e8b\u540e\u7ec4\u7ec7\u5b66\u9a8c\u8bc1\u4e86EGFP\u5728MS\u4e2d\u7684\u8868\u8fbe\u533a\u57df\u4ee5\u53camCherry\u5728\u6d77\u9a6c\u4e2d\u7684\u8868\u8fbe\u533a\u57df\u3002\u5728\u8fde\u7eed\u5207\u7247\u4e2d\u89c2\u5bdf\u5230SuM\u5185\u5b58\u5728EGFP\u548cmCherry\u6807\u8bb0\u7684\u80de\u4f53\u3002mCherry\u6807\u8bb0\u7684\u795e\u7ecf\u5143\u4e3b\u8981\u4f4d\u4e8e\u5916\u4fa7SuM\uff0c\u800cEGFP\u6807\u8bb0\u7684\u795e\u7ecf\u5143\u5219\u5206\u5e03\u5728\u5185\u4fa7\u548c\u5916\u4fa7SuM\u3002EGFP\u4e0emCherry\u795e\u7ecf\u5143\u7684\u5171\u6807\u8bb0\u7387\u8f83\u4f4e\uff0c\u4e0d\u8db35%\u3002<\/span><\/span><\/p>\n

\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c<\/span><\/span>\u5916\u4fa7SuM\u795e\u7ecf\u5143\u540c\u65f6\u5411MS\u548c\u6d77\u9a6c\u63d0\u4f9b\u6295\u5c04\u3002<\/span><\/span><\/span><\/p>\n

\"eLife\uff1a\u91cd\u5e86\u8111\u4e2d\u5fc3Han<\/span><\/span><\/p>\n

\u56fe\u4e8c \u7761\u7720-\u89c9\u9192\u5468\u671f\u4e2d\u5916\u4fa7SuM\u81f3MS\u6295\u5c04\u795e\u7ecf\u5143\u7684\u9499\u4fe1\u53f7\u8bb0\u5f55<\/span><\/span><\/span><\/p>\n

\u7814\u7a76\u4eba\u5458\u5229\u7528\u9006\u884c\u75c5\u6bd2\u6807\u8bb0\u6280\u672f\u7279\u5f02\u6027\u5730\u5728\u8be5\u901a\u8def\u795e\u7ecf\u5143\u4e2d\u8868\u8fbe\u9499\u6307\u793a\u5242\uff0c\u5e76\u7ed3\u5408\u5149\u7ea4\u8bb0\u5f55\u4e0e\u8111\u7535\/\u808c\u7535\u8bb0\u5f55\uff0c\u9996\u6b21\u5728<\/span><\/span>\u81ea\u7531\u79fb\u52a8\u7684\u5c0f\u9f20<\/span><\/span><\/span>\u4e2d\u53d1\u73b0\uff1a\u8be5\u795e\u7ecf\u901a\u8def\u5728\u5feb\u901f\u773c\u52a8\u7761\u7720\u671f\uff08\u5373\u505a\u68a6\u9636\u6bb5\uff09\u7684\u9499\u6d3b\u6027\u663e\u8457\u9ad8\u4e8e\u6162\u6ce2\u7761\u7720\u548c\u5b89\u9759\u89c9\u9192\u671f\uff0c\u4e14\u5176\u6d3b\u6027\u5728\u8fdb\u5165\u68a6\u5883\u65f6\u6025\u5267\u98d9\u5347\u3001\u5728\u68a6\u9192\u77ac\u95f4\u8fc5\u901f\u4e0b\u964d\uff0c\u8868\u73b0\u51fa\u9c9c\u660e\u7684“\u68a6\u5883\u7279\u5f02\u6027”\uff1b<\/span><\/span><\/span><\/p>\n

\u968f\u540e\uff0c\u56e2\u961f\u8fdb\u4e00\u6b65\u901a\u8fc7\u5149\u9057\u4f20\u5b66\u7ed3\u5408\u5728\u4f53\u7535\u751f\u7406\u8bb0\u5f55\uff0c\u5229\u7528\u84dd\u5149\u8109\u51b2\u7cbe\u51c6\u8bc6\u522b\u5e76\u9a8c\u8bc1\u4e86\u5355\u4e2a\u6295\u5c04\u795e\u7ecf\u5143\u7684\u653e\u7535\u7279\u5f81\uff0c\u786e\u8bc1\u4e86\u8fd9<\/span><\/span>\u7fa4\u795e\u7ecf\u5143\u662f\u8c03\u63a7\u7761\u7720\u72b6\u6001\u8f6c\u6362\u3001\u7279\u522b\u662f\u7ef4\u6301\u5feb\u901f\u773c\u52a8\u7761\u7720\u7684\u5173\u952e\u8282\u70b9\u3002<\/span><\/span><\/span><\/p>\n

\"eLife\uff1a\u91cd\u5e86\u8111\u4e2d\u5fc3Han<\/span><\/span><\/p>\n

\u56fe\u4e09 REM\u671fSuM-MS\u901a\u8def\u6c89\u9ed8\u635f\u6bc1\u8bb0\u5fc6\u5de9\u56fa<\/span><\/span><\/span><\/p>\n

\u8fd9\u9879\u7814\u7a76\u63ed\u793a\uff0c\u5728\u5feb\u901f\u773c\u52a8\u7761\u7720\uff08REM\uff0c\u5373\u505a\u68a6\u9636\u6bb5\uff09\u671f\u95f4\uff0c\u5927\u8111\u4e2d\u4ece“\u5916\u4fa7\u4e0a\u4e73\u5934\u6838”\u6295\u5c04\u5230“\u5185\u4fa7\u9694\u6838”\u7684\u795e\u7ecf\u901a\u8def\u5bf9\u8bb0\u5fc6\u5de9\u56fa\u81f3\u5173\u91cd\u8981\u3002<\/span><\/span><\/p>\n

\u7814\u7a76\u4eba\u5458\u5229\u7528\u5149\u9057\u4f20\u6280\u672f\u5728\u5c0f\u9f20REM\u7761\u7720\u671f\u7279\u5f02\u6027\u6291\u5236\u8be5\u901a\u8def\uff0c\u53d1\u73b0\u867d\u7136\u8fd9\u672a\u6270\u4e71\u5e38\u89c4\u7684\u8111\u7535\u8282\u5f8b\uff0c\u5374\u5bfc\u81f4\u5c0f\u9f20\u9192\u6765\u540e\u51fa\u73b0\u660e\u663e\u7684\u8bb0\u5fc6\u7f3a\u9677\uff1a\u5b83\u4eec\u65e2\u65e0\u6cd5\u533a\u5206\u719f\u6089\u4e0e\u964c\u751f\u7684\u540c\u7c7b\uff08<\/span><\/span>\u793e\u4ea4\u8bb0\u5fc6<\/span><\/span><\/span>\u4e27\u5931\uff09\uff0c\u4e5f\u8bb0\u4e0d\u4f4f\u66fe\u7ecf\u53d7\u8fc7\u60ca\u5413\u7684\u5177\u4f53\u573a\u666f\uff08<\/span><\/span>\u60c5\u5883\u8bb0\u5fc6<\/span><\/span><\/span>\u53d7\u635f\uff09\u3002<\/span><\/span><\/span><\/p>\n

\u8fd9\u8868\u660e\uff0c<\/span><\/span>\u8be5\u795e\u7ecf\u901a\u8def\u662fREM\u7761\u7720\u671f\u95f4\u5c06\u793e\u4ea4\u7ecf\u5386\u548c\u60c5\u5883\u6050\u60e7\u8f6c\u5316\u4e3a\u957f\u671f\u8bb0\u5fc6\u7684\u5173\u952e“\u5b58\u76d8”\u673a\u5236\u3002<\/span><\/span><\/span><\/span><\/p>\n

\u603b\u7ed3<\/span><\/span><\/span><\/h3>\n

\u8be5\u53d1\u73b0\u6700\u4eae\u773c\u7684\u5730\u65b9\u5728\u4e8e\u8bc1\u660e\u4e86\u5927\u8111\u5728\u7761\u89c9\u65f6\u5e76\u4e0d\u662f“\u4e00\u9505\u7096”\uff0c\u800c\u662f\u901a\u8fc7\u50cfSuM-MS-CA2\u8fd9\u6837\u7684“\u4e13\u7528\u5feb\u9012<\/a>\u7ebf”\uff0c\u628a\u767d\u5929\u7684\u793e\u4ea4\u77ac\u95f4\u7cbe\u51c6\u5b58\u5165\u5927\u8111\u3002<\/span><\/span><\/p>\n

\u603b\u4e4b\uff0c\u4f5c\u8005\u63ed\u793a\u4e86\u4e00\u6761\u4e0a\u4e73\u5934\u6838-\u9694\u6838-\u6d77\u9a6c\u73af\u8def\uff0c\u8be5\u73af\u8def\u5728\u5feb\u901f\u773c\u52a8\u7761\u7720\u671f\u95f4\u9009\u62e9\u6027\u6fc0\u6d3b\uff0c\u4e14\u5bf9\u793e\u4f1a\u8bb0\u5fc6\u5de9\u56fa\u81f3\u5173\u91cd\u8981\u3002\u8fd9\u4e3a\u7406\u89e3\u5feb\u901f\u773c\u52a8\u7761\u7720\u671f\u95f4\u76ae\u5c42\u4e0b\u7ed3\u6784\u4e0e\u6d77\u9a6c\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5982\u4f55\u8c03\u63a7\u8bb0\u5fc6\u5de9\u56fa\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u6846\u67b6\u3002<\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n