{"id":745865,"date":"2026-03-15T09:20:32","date_gmt":"2026-03-15T01:20:32","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=745865"},"modified":"2026-03-15T09:20:32","modified_gmt":"2026-03-15T01:20:32","slug":"%e5%8c%97%e5%a4%a7%e6%9d%8e%e6%af%93%e9%be%99%e5%9b%a2%e9%98%9f%e5%86%8d%e5%87%ba%e5%88%a9%e5%99%a8%ef%bc%8c%e6%96%b0%e5%9e%8b%e6%8e%a2%e9%92%88%e5%ae%9e%e6%97%b6%e8%bf%bd%e8%b8%aa%e8%84%91%e5%86%85","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=745865","title":{"rendered":"\u5317\u5927\u674e\u6bd3\u9f99\u56e2\u961f\u518d\u51fa\u5229\u5668\uff0c\u65b0\u578b\u63a2\u9488\u5b9e\u65f6\u8ffd\u8e2a\u8111\u5185\u708e\u75c7\u4fe1\u53f7"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

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\u8be5\u7814\u7a76\u6807\u9898\u4e3a<\/span><\/span>\u300a A genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 dynamics in vivo<\/a> \u300b<\/span>\uff0c\u5f00\u53d1\u51fa\u7684 PGE2 \u8367\u5149\u4f20\u611f\u5668 GRABPGE2-1.0\u5bf9 PGE2 \u5177\u6709\u9ad8\u7279\u5f02\u6027\u3001\u7eb3\u6469\u5c14\u7ea7\u4eb2\u548c\u529b\u548c\u5feb\u901f\u52a8\u529b\u5b66\u7279\u5f81\uff0c<\/span><\/span><\/span>\u5b9e\u73b0\u5728\u4f53\u76d1\u6d4b\u5c0f\u9f20\u708e\u75c7\u3001\u766b\u75eb\u72b6\u6001\u4e0b\u8111\u5185 PGE2 \u7684\u65f6\u7a7a\u52a8\u6001\uff0c\u4e3a PGE2 \u76f8\u5173\u751f\u7406\u75c5\u7406\u7814\u7a76\u63d0\u4f9b\u4e86\u5168\u65b0\u5de5\u5177\u3002<\/span><\/span><\/span><\/span><\/p>\n

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\"\u5317\u5927\u674e\u6bd3\u9f99\u56e2\u961f\u518d\u51fa\u5229\u5668\uff0c\u65b0\u578b\u63a2\u9488\u5b9e\u65f6\u8ffd\u8e2a\u8111\u5185\u708e\u75c7\u4fe1\u53f7\"<\/span><\/span><\/p>\n

\u6d3b\u4f53\u5c0f\u9f20\u7684\u5728\u4f53 PGE2 \u52a8\u6001\u76d1\u6d4b<\/span><\/span><\/span><\/h2>\n

\u628a\u4f20\u611f\u5668\u653e\u8fdb\u6d3b\u4f53\u5c0f\u9f20\u7684\u5927\u8111\u91cc\uff0c\u7814\u7a76\u8005\u770b\u5230\u4e86\u4ee5\u524d\u4ece\u672a\u89c1\u8fc7\u7684\u4e1c\u897f\u3002<\/span><\/span><\/p>\n

\u708e\u75c7\u65f6\uff1a<\/span><\/span>PGE2\u5728\u4e0b\u4e18\u8111\u89c6\u524d\u533a\u7f13\u6162\u5347\u9ad8\uff1b\u5728\u76ae\u5c42\uff0c\u5347\u9ad8\u96c6\u4e2d\u5728\u5916\u5468\u5c0f\u8840\u7ba1\u9644\u8fd1\uff1b\u5347\u5f97\u6162\u3001\u964d\u5f97\u6162\u3001\u5cf0\u503c\u4f4e\u3002<\/span><\/span><\/span><\/p>\n

\u766b\u75eb\u65f6\uff1a<\/span><\/span>PGE2\u5728\u76ae\u5c42\u524d\u90e8\u5feb\u901f\u7206\u53d1\uff1b\u548c\u8840\u7ba1\u65e0\u5173\uff0c\u662f\u795e\u7ecf\u5143\u81ea\u5df1\u91ca\u653e\u7684\uff1b\u5347\u5f97\u5feb\u3001\u964d\u5f97\u5feb\u3001\u5cf0\u503c\u9ad8\u3002<\/span><\/span><\/span><\/p>\n

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\u7b2c\u4e00\u6b21\uff0c\u4eba\u4eec\u770b\u6e05\u4e86\u540c\u4e00\u4e2a\u5206\u5b50\uff0c\u5728\u4e24\u79cd\u75be\u75c5\u91cc\uff0c\u626e\u6f14\u7740\u5b8c\u5168\u4e0d\u540c\u7684\u89d2\u8272\u3002\u4f20\u611f\u5668\u80fd\u5728\u6d3b\u4f53\u5c0f\u9f20\u8111\u4e2d\uff0c\u7cbe\u51c6\u6355\u6349\u4e0d\u540c\u75c5\u7406\u72b6\u6001\u4e0b PGE2 \u7684\u52a8\u6001\u53d8\u5316\u3002<\/span><\/span><\/p>\n

\"\u5317\u5927\u674e\u6bd3\u9f99\u56e2\u961f\u518d\u51fa\u5229\u5668\uff0c\u65b0\u578b\u63a2\u9488\u5b9e\u65f6\u8ffd\u8e2a\u8111\u5185\u708e\u75c7\u4fe1\u53f7\"<\/span><\/span><\/p>\n

\u603b\u7ed3\u5168\u6587<\/span><\/span><\/strong><\/span><\/h2>\n

\u674e\u6bd3\u9f99\u56e2\u961f\u57fa\u4e8e GRAB \u7b56\u7565<\/a>\u5f00\u53d1\u51fa\u57fa\u56e0\u7f16\u7801\u7684<\/span><\/span>\u524d\u5217\u817a\u7d20 E2 \u8367\u5149\u4f20\u611f\u5668 PGE2-1.0<\/span>\uff0c\u8bc1\u5b9e\u5176\u9ad8\u7279\u5f02\u6027\u3001\u9ad8\u7075\u654f\u5ea6\u548c\u4f18\u5f02\u7684\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u4e14\u4e0d\u5e72\u6270\u5185\u6e90\u4fe1\u53f7\u901a\u8def<\/span><\/span>\u3002\u968f\u540e\u6210\u529f\u76d1\u6d4b\u5230\u5c0f\u9f20\u708e\u75c7\u3001\u766b\u75eb\u72b6\u6001\u4e0b\u8111\u5185\u4e0d\u540c\u533a\u57df PGE2 \u7684\u65f6\u7a7a\u52a8\u6001\u53d8\u5316\uff0c\u5e76\u9996\u6b21\u53d1\u73b0 PGE2 \u5728\u4e24\u79cd\u75c5\u7406\u72b6\u6001\u4e0b\u5177\u6709\u622a\u7136\u4e0d\u540c\u7684\u65f6\u7a7a\u5206\u5e03\u548c\u52a8\u529b\u5b66\u7279\u5f81\uff0c<\/span><\/span>\u8be5\u4f20\u611f\u5668\u4e3a\u6df1\u5165\u7814\u7a76 PGE2 \u7684\u751f\u7406\u75c5\u7406\u529f\u80fd\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u9ad8\u65f6\u7a7a\u5206\u8fa8\u7387\u5de5\u5177\u3002<\/span><\/span><\/span><\/p>\n

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\u7814\u7a76\u610f\u4e49<\/span><\/span><\/span><\/h2>\n

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\u5e94\u7528\u610f\u4e49<\/span><\/strong>\uff1a<\/span><\/span>\u8be5\u4f20\u611f\u5668\u4e3a\u7814\u7a76 PGE2 \u76f8\u5173\u7684\u708e\u75c7\u3001\u75bc\u75db\u3001\u766b\u75eb\u7b49\u75be\u75c5\u63d0\u4f9b\u4e86\u6838\u5fc3\u5de5\u5177<\/span><\/span>\uff0c\u4e5f\u4e3a\u5f00\u53d1\u9776\u5411 PGE2 \u7684\u75be\u75c5\u6cbb\u7597\u65b9\u6848\u63d0\u4f9b\u4e86\u7cbe\u51c6\u7684\u68c0\u6d4b\u624b\u6bb5\uff0c\u6709\u671b\u63a8\u52a8\u795e\u7ecf\u708e\u75c7\u548c\u766b\u75eb\u7b49\u75be\u75c5\u7684\u673a\u5236\u7814\u7a76\u4e0e\u836f\u7269\u7814\u53d1\u3002<\/span><\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n

    \n
  • \u539f\u6587\u94fe\u63a5\uff1a<\/strong>https:\/\/doi.org\/10.1016\/j.neuron.2026.01.030<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    \u6587 | \u8111\u58f0\u5e38\u8c08 \u53d1\u70e7\u3001\u766b\u75eb\u53d1\u4f5c\u65f6\u6211\u4eec\u7684\u5927\u8111\u91cc\u5230\u5e95\u53d1\u751f\u4e86\u4ec0\u4e48\uff1f\u8eab\u4f53\u7684\u708e\u75c7\u53cd\u5e94\u548c\u795e\u7ecf\u5f02\u5e38\u80cc\u540e\uff0c\u603b\u6709\u524d\u5217\u817a\u7d20 E2 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[60,88],"views":27,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/745865"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=745865"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/745865\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=745865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=745865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=745865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}