{"id":745554,"date":"2026-03-14T11:11:23","date_gmt":"2026-03-14T03:11:23","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=745554"},"modified":"2026-03-14T11:11:23","modified_gmt":"2026-03-14T03:11:23","slug":"%e5%8d%b1%e9%99%a9%e8%b5%b0%e4%ba%86%ef%bc%8c%e4%b8%ba%e4%bb%80%e4%b9%88%e4%bd%a0%e8%bf%98%e5%ae%b3%e6%80%95%ef%bc%9f%e7%be%8e%e5%9b%bdstephen-maren%e5%9b%a2%e9%98%9f%e6%8f%ad%e7%a4%balc-bla%e6%98%af","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=745554","title":{"rendered":"\u5371\u9669\u8d70\u4e86\uff0c\u4e3a\u4ec0\u4e48\u4f60\u8fd8\u5bb3\u6015\uff1f\u7f8e\u56fdStephen Maren\u56e2\u961f\u63ed\u793aLC-BLA\u662f\u8c03\u63a7\u6050\u60e7\u6d88\u9000\u7684\u5173\u952e\u73af\u8def"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/span><\/span><\/span><\/span><\/span><\/p>\n<\/blockquote>\n

\u4e3a\u4ec0\u4e48\u6709\u4eba\u7ecf\u5386\u8fc7\u521b\u4f24\u540e\uff0c\u5373\u4fbf\u5371\u9669\u5df2\u7ecf\u6d88\u5931\uff0c\u4f9d\u7136\u4f1a\u6df1\u9677\u6050\u60e7\u96be\u4ee5\u6446\u8131\uff1f\u5c31\u50cf\u6709\u4eba\u906d\u9047\u8fc7\u8f66\u7978\u540e\uff0c\u5373\u4fbf\u65f6\u9694\u5f88\u4e45\uff0c\u770b\u5230\u8f66\u6d41\u4ecd\u4f1a\u83ab\u540d\u6050\u614c\uff0c\u8fde\u6b63\u5e38\u7684\u51fa\u884c\u90fd\u53d7\u5f71\u54cd\uff1f\u8fd9\u80cc\u540e\u85cf\u7740\u5927\u8111\u795e\u7ecf\u73af\u8def\u7684\u8c03\u63a7\u5965\u79d8\uff0c\u800c\u8fd9\u7bc7\u7814\u7a76\u5c31\u4e3a\u6211\u4eec\u63ed\u5f00\u4e86\u5176\u4e2d\u5173\u952e\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

2026\u5e743\u670811\u65e5\uff0c<\/span>\u7f8e\u56fd<\/a>\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66Stephen Maren<\/span>\u56e2\u961f\u5728<\/span>\u300aPNAS\u300b<\/span>\u4e0a\u53d1\u8868\u7684\u7814\u7a76\uff0c\u8ffd\u8e2a\u5230\u4e86\u7b54\u6848\uff1a<\/span><\/span><\/span><\/span><\/span>\u5e94\u6fc0\u6fc0\u6d3b\u4e86\u84dd\u6591→\u674f\u4ec1\u6838\u901a\u8def\uff0c\u8ba9\u672c\u8be5\u88ab\u6291\u5236\u7684\u524d\u989d\u53f6\u76ae\u5c42\u5f7b\u5e95\u7d0a\u4e71\u4e86\u3002<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

\u8be5\u7814\u7a76\u6807\u9898\u4e3a<\/span><\/span><\/span><\/span>\u300aLocus coeruleus–amygdala circuit disrupts prefrontal control to impair fear extinction\u300b<\/span><\/span><\/span><\/span><\/span>\u672c\u7814\u7a76\u53d1\u73b0<\/span><\/span><\/span><\/span>LC\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u80fd\u795e\u7ecf\u5143\u7684\u6fc0\u6d3b\u4f1a\u6a21\u62df\u5e94\u6fc0\u523a\u6fc0\uff0c\u901a\u8fc7\u6fc0\u6d3bBLA\u6295\u5c04\u81f3<\/span><\/span><\/span><\/span><\/span>vmPFC<\/span><\/span><\/span><\/span><\/span>\u7684\u901a\u8def\uff0c\u6291\u5236<\/span><\/span><\/span><\/span><\/span>vmPFC<\/span><\/span><\/span><\/span><\/span>\u7684\u795e\u7ecf\u6d3b\u52a8\uff0c\u8fdb\u800c\u635f\u5bb3\u6050\u60e7\u6d88\u9000\u5b66\u4e60\uff0c<\/span><\/span><\/span><\/span><\/span>\u800c\u5411\u57fa\u5e95\u5916\u4fa7\u674f\u4ec1\u6838\u6ce8\u5165<\/span><\/span><\/span><\/span>\u666e\u8418\u6d1b\u5c14<\/span><\/span><\/span><\/span><\/span>\u53ef\u7f13\u89e3\u8be5\u6548\u5e94\uff0c\u8bc1\u5b9e\u57fa\u5e95\u5916\u4fa7\u674f\u4ec1\u6838\u662f\u84dd\u6591\u8c03\u63a7\u524d\u989d\u53f6\u76ae\u5c42\u3001\u4ecb\u5bfc\u5e94\u6fc0\u8bf1\u5bfc\u6050\u60e7\u6d88\u9000\u969c\u788d\u7684\u5173\u952e\u8282\u70b9\u3002<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

\"\u5371\u9669\u8d70\u4e86\uff0c\u4e3a\u4ec0\u4e48\u4f60\u8fd8\u5bb3\u6015\uff1f\u7f8e\u56fdStephen<\/span><\/span><\/span><\/span><\/p>\n

\u6050\u60e7\u6d88\u9000\u5931\u8d25\uff0c\u662f\u8c01\u5728\u6363\u4e71\uff1f<\/span><\/span><\/span><\/span><\/span><\/span><\/h2>\n

\u7814\u7a76\u8005\u7528\u5316\u5b66\u9057\u4f20\u5b66\u6fc0\u6d3b\u5927\u9f20\u7684<\/span><\/span><\/span><\/span>\u84dd\u6591\u6838\uff08LC\uff09<\/span><\/span><\/span><\/span><\/span>——\u5927\u8111\u91cc\u91ca\u653e\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u3001\u8d1f\u8d23\u5e94\u6fc0\u53cd\u5e94\u7684\u6838\u5fc3\u8111\u533a\u3002\u7ed3\u679c\u5927\u9f20\u51fa\u73b0\u5f3a\u70c8\u7684\u6050\u60e7\u50f5\u4f4f\u884c\u4e3a\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

\u540c\u65f6\uff0c\u4ed6\u4eec\u7528\u9499\u6210\u50cf\u76d1\u6d4b<\/span><\/span><\/span><\/span>\u8179\u5185\u4fa7\u524d\u989d\u53f6\u76ae\u5c42\uff08vmPFC\uff09<\/span><\/span><\/span><\/span><\/span>——\u5927\u8111\u91cc\u8d1f\u8d23\u6291\u5236\u6050\u60e7\u7684\u8111\u533a\u3002\u53d1\u73b0vmPFC\u795e\u7ecf\u5143\u7684\u653e\u7535\u9891\u7387\u663e\u8457\u964d\u4f4e\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

\u800c\u4e14\uff0cvmPFC\u6d3b\u52a8\u7684\u964d\u4f4e\u51fa\u73b0\u5728\u6050\u60e7\u884c\u4e3a\u4e4b\u524d\uff0c<\/span><\/span><\/span><\/span>\u8bf4\u660e\u8fd9\u662f\u5f15\u53d1\u6050\u60e7\u7684\u795e\u7ecf\u57fa\u7840\uff0c\u800c\u975e\u6050\u60e7\u5e26\u6765\u7684\u7ed3\u679c\u3002<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

\"\u5371\u9669\u8d70\u4e86\uff0c\u4e3a\u4ec0\u4e48\u4f60\u8fd8\u5bb3\u6015\uff1f\u7f8e\u56fdStephen<\/span><\/span><\/span><\/span><\/p>\n

\u84dd\u6591\u6fc0\u6d3b\uff0c\u771f\u7684\u80fd\u6a21\u62df\u5e94\u6fc0\u5417\uff1f<\/span><\/span><\/span><\/h2>\n

\u7814\u7a76\u8005\u8981\u786e\u8ba4\uff1a\u7528\u4eba\u5de5\u624b\u6bb5\u6fc0\u6d3b\u84dd\u6591\uff0c\u548c\u771f\u5b9e\u5e94\u6fc0\u662f\u4e0d\u662f\u4e00\u56de\u4e8b\uff1f<\/span><\/span><\/span><\/span><\/p>\n

\u4ed6\u4eec\u5bf9\u6bd4\u4e86\u84dd\u6591\u6fc0\u6d3b\u548c\u8db3\u5e95\u7535\u51fb\uff08\u7ecf\u5178\u5e94\u6fc0\u6e90\uff09\u7684\u6548\u679c\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e24\u8005\u90fd\u8ba9\u5927\u9f20\u4ea7\u751f\u5f3a\u70c8\u7684\u6050\u60e7\u50f5\u76f4\u884c\u4e3a\uff1b\u4e24\u8005\u90fd\u6291\u5236\u4e86vmPFC\u7684\u795e\u7ecf\u6d3b\u52a8\uff1b\u5927\u90e8\u5206vmPFC\u795e\u7ecf\u5143\u5bf9\u4e24\u79cd\u523a\u6fc0\u7684\u53cd\u5e94\u4e00\u81f4\uff0c\u5747\u8868\u73b0\u4e3a\u653e\u7535\u51cf\u5c11\u3002<\/span><\/span><\/span><\/span><\/p>\n

\u8fd9\u8868\u660e\u4eba\u5de5\u6fc0\u6d3b\u84dd\u6591\u80fd\u7cbe\u51c6\u6a21\u62df\u81ea\u7136\u5e94\u6fc0\u7684\u795e\u7ecf\u548c\u884c\u4e3a\u6548\u5e94\uff0c\u8bc1\u5b9e\u84dd\u6591\u662f\u5e94\u6fc0\u5f15\u53d1\u6050\u60e7\u7684\u6838\u5fc3\u9776\u70b9\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

\"\u5371\u9669\u8d70\u4e86\uff0c\u4e3a\u4ec0\u4e48\u4f60\u8fd8\u5bb3\u6015\uff1f\u7f8e\u56fdStephen<\/span><\/span><\/span><\/span><\/p>\n

\u84dd\u6591\u662f\u5982\u4f55\u6291\u5236vmPFC\u7684\uff1f<\/span><\/span><\/span><\/h2>\n

\u84dd\u6591\u4e0d\u76f4\u63a5\u8fde\u63a5vmPFC\u3002\u90a3\u4fe1\u53f7\u662f\u600e\u4e48\u4f20\u8fc7\u53bb\u7684\uff1f<\/span><\/span><\/span><\/span><\/p>\n

\u7814\u7a76\u8005\u9501\u5b9a\u4e86<\/span><\/span><\/span><\/span>\u57fa\u5e95\u5916\u4fa7\u674f\u4ec1\u6838\uff08BLA\uff09<\/span><\/span><\/span><\/span><\/span>——\u4e00\u4e2a\u4e0e\u60c5\u7eea\u8bb0\u5fc6\u5bc6\u5207\u76f8\u5173\u7684\u8111\u533a\u3002\u7136\u540e\u4ed6\u4eec\u5728BLA\u6ce8\u5165<\/span><\/span><\/span><\/span>\u666e\u8418\u6d1b\u5c14<\/span><\/span><\/span><\/span><\/span>——\u4e00\u79cdβ\u80be\u4e0a\u817a\u7d20\u80fd\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u76f8\u5f53\u4e8e\u5728\u674f\u4ec1\u6838\u62e6\u622a\u84dd\u6591\u4f20\u6765\u7684\u4fe1\u53f7\u3002\u7ed3\u679c\u663e\u793a\uff0cvmPFC\u7684\u795e\u7ecf\u6d3b\u52a8\u548c\u7fa4\u4f53\u52a8\u6001\u6062\u590d\u4e86\u6b63\u5e38\uff0c\u867d\u7136\u6ca1\u80fd\u5b8c\u5168\u6d88\u9664\u6050\u60e7\u884c\u4e3a\uff0c\u4f46\u663e\u8457\u7f13\u89e3\u4e86\u6050\u60e7\u6d88\u9000\u969c\u788d\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

\u56e0\u6b64\uff0c\u84dd\u6591\u5bf9vmPFC\u7684\u6291\u5236\uff0c\u9700\u8981\u901a\u8fc7\u674f\u4ec1\u6838\u7684β\u53d7\u4f53\u6765\u4f20\u9012\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

\"\u5371\u9669\u8d70\u4e86\uff0c\u4e3a\u4ec0\u4e48\u4f60\u8fd8\u5bb3\u6015\uff1f\u7f8e\u56fdStephen<\/span><\/span><\/span><\/span><\/p>\n

\u84dd\u6591→\u674f\u4ec1\u6838\uff0c\u5c31\u662f\u90a3\u6761<\/span><\/span>“\u574f\u56de\u8def”<\/span><\/span><\/strong><\/span><\/h2>\n

\u5229\u7528<\/span><\/span><\/span><\/span>\u7ea4\u7ef4\u5149\u5ea6\u6cd5<\/span><\/strong><\/span><\/span>\u548c\u9006\u884c\u75c5\u6bd2\u6807\u8bb0\u6280\u672f\uff0c\u53d1\u73b0\u5355\u72ec\u6fc0\u6d3b\u84dd\u6591\u5411\u57fa\u5e95\u5916\u4fa7\u674f\u4ec1\u6838\u7684\u6295\u5c04\u901a\u8def\uff0c\u8db3\u4ee5\u8bf1\u53d1\u5927\u9f20\u7684\u6050\u60e7\u6d88\u9000\u969c\u788d\uff0c\u800c\u4e14\u6548\u679c\u4f1a\u6301\u7eed\u5230\u6d88\u9000\u63d0\u53d6\u9636\u6bb5\uff0c\u540c\u65f6\u6392\u9664\u4e86\u84dd\u6591\u6fc0\u6d3b\u589e\u5f3a\u6050\u60e7\u8bb0\u5fc6\u5de9\u56fa\u7684\u53ef\u80fd\u6027\u3002<\/span><\/span><\/span><\/span>\u8fd9\u8bc1\u5b9e\u84dd\u6591 - \u57fa\u5e95\u5916\u4fa7\u674f\u4ec1\u6838\u7684\u76f4\u63a5\u901a\u8def\uff0c\u662f\u5e94\u6fc0\u5bfc\u81f4\u6050\u60e7\u6d88\u9000\u969c\u788d\u7684\u6838\u5fc3\u73af\u8def\u3002<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

\"\u5371\u9669\u8d70\u4e86\uff0c\u4e3a\u4ec0\u4e48\u4f60\u8fd8\u5bb3\u6015\uff1f\u7f8e\u56fdStephen<\/span><\/span><\/span><\/span><\/p>\n

\u5168\u6587\u603b\u7ed3<\/span><\/span><\/strong><\/span><\/h2>\n

\u8be5\u7814\u7a76\u4ee5\u5927\u9f20\u4e3a\u6a21\u578b\uff0c\u8fd0\u7528\u5316\u5b66\u9057\u4f20\u5b66\u3001\u9499\u6210\u50cf\u3001\u7ea4\u7ef4\u5149\u5ea6\u6cd5<\/span>\u7b49\u6280\u672f\uff0c\u7cfb\u7edf\u89e3\u6790\u4e86\u5e94\u6fc0\u635f\u5bb3\u6050\u60e7\u6d88\u9000\u7684\u795e\u7ecf\u73af\u8def\u673a\u5236\uff0c<\/span><\/span><\/span><\/span>\u8bc1\u5b9e\u84dd\u6591\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u7cfb\u7edf\u662f\u6838\u5fc3\u8c03\u63a7\u8005<\/span><\/span><\/span><\/span><\/span>\uff0c\u5176\u901a\u8fc7\u6fc0\u6d3b\u57fa\u5e95\u5916\u4fa7\u674f\u4ec1\u6838\uff0c\u6291\u5236\u8179\u5185\u4fa7\u524d\u989d\u53f6\u76ae\u5c42\u7684\u6b63\u5e38\u529f\u80fd\uff0c\u7834\u574f\u5176\u795e\u7ecf\u6d3b\u52a8\u548c\u7fa4\u4f53\u52a8\u6001\uff0c\u8fdb\u800c\u5f15\u53d1\u6050\u60e7\u6d88\u9000\u969c\u788d\uff1b<\/span><\/span><\/span><\/span>\u800c\u963b\u65ad\u674f\u4ec1\u6838\u7684 β \u80be\u4e0a\u817a\u7d20\u80fd\u53d7\u4f53\uff0c\u53ef\u6062\u590d\u524d\u989d\u53f6\u7684\u8c03\u63a7\u529f\u80fd\uff0c\u7f13\u89e3\u8be5\u969c\u788d\uff0c\u660e\u786e\u4e86\u57fa\u5e95\u5916\u4fa7\u674f\u4ec1\u6838\u5728\u84dd\u6591\u4e0e\u524d\u989d\u53f6\u4e4b\u95f4\u7684\u5173\u952e\u4e2d\u4ecb\u4f5c\u7528\u3002<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

\u7814\u7a76\u5c55\u671b<\/span><\/span><\/span><\/h2>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u5728<\/span><\/span><\/span><\/span>\u57fa\u5e95\u5916\u4fa7\u674f\u4ec1\u6838\u6ce8\u5165\u666e\u8418\u6d1b\u5c14\uff08β\u53d7\u4f53\u62ee\u6297\u5242\uff09<\/span><\/span><\/span><\/span><\/span>\uff0c\u80fd\u6062\u590dvmPFC\u7684\u529f\u80fd\uff0c\u7f13\u89e3\u6050\u60e7\u6d88\u9000\u969c\u788d\u3002\u8fd9\u610f\u5473\u7740\uff1a\u672a\u6765\uff0c\u6216\u8bb8\u53ef\u4ee5\u901a\u8fc7\u9776\u5411\u674f\u4ec1\u6838\u7684β\u53d7\u4f53\uff0c\u5e2e\u52a9\u90a3\u4e9b\u88ab\u6050\u60e7\u56f0\u4f4f\u7684\u4eba——\u5728\u66b4\u9732\u7597\u6cd5\u4e2d\uff0c\u8ba9\u5927\u8111\u91cd\u65b0\u5b66\u4f1a“\u5173\u6389”\u6050\u60e7\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

\u539f\u6587\u94fe\u63a5\uff1a<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>
<\/span><\/span>https:\/\/doi.org\/10.1073\/pnas.2528250123<\/span><\/span><\/span><\/p>\n<\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587 | \u8111\u58f0\u5e38\u8c08 \u4e3a\u4ec0\u4e48\u6709\u4eba\u7ecf\u5386\u8fc7\u521b\u4f24\u540e\uff0c\u5373\u4fbf\u5371\u9669\u5df2\u7ecf\u6d88\u5931\uff0c\u4f9d\u7136\u4f1a\u6df1\u9677\u6050\u60e7\u96be\u4ee5\u6446\u8131\uff1f\u5c31\u50cf\u6709\u4eba\u906d\u9047\u8fc7\u8f66\u7978\u540e\uff0c\u5373\u4fbf […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[367],"views":17,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/745554"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=745554"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/745554\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=745554"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=745554"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=745554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}