{"id":744879,"date":"2026-03-13T15:24:32","date_gmt":"2026-03-13T07:24:32","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=744879"},"modified":"2026-03-13T15:24:32","modified_gmt":"2026-03-13T07:24:32","slug":"neurosci-bull%ef%bc%9a%e4%b8%8a%e6%b5%b7%e4%ba%a4%e9%80%9a%e5%a4%a7%e5%ad%a6%e7%a5%9d%e5%bf%a0%e7%be%a4-%e7%ab%a5%e5%b0%8f%e8%90%8d%e5%9b%a2%e9%98%9f%e6%8f%ad%e7%a4%ba%e6%96%b0%e7%94%9f%e5%84%bf","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=744879","title":{"rendered":"Neurosci Bull\uff1a\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u795d\u5fe0\u7fa4\/\u7ae5\u5c0f\u840d\u56e2\u961f\u63ed\u793a\u65b0\u751f\u513f\u5fc3\u810f\u672f\u540e\u8111\u635f\u4f24\u65b0\u673a\u5236"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

\u5bf9\u4e8e\u5f88\u591a\u6709\u5b69\u5b50\u9700\u8981\u505a\u5fc3\u810f\u7b49\u91cd\u5927\u624b\u672f\u7684\u5bb6\u5ead\u6765\u8bf4\uff0c\u6700\u62c5\u5fc3\u7684\u9664\u4e86\u624b\u672f\u672c\u8eab\u7684\u98ce\u9669<\/a>\uff0c\u8fd8\u6709\u672f\u540e\u5b69\u5b50\u7684\u5927\u8111\u53d1\u80b2\u95ee\u9898\u6bd4\u5982\u6709\u4e9b\u5b69\u5b50\u672f\u540e\u4f1a\u51fa\u73b0\u53cd\u5e94\u53d8\u6162\u3001\u6ce8\u610f\u529b\u4e0d\u96c6\u4e2d\uff0c\u751a\u81f3\u8ba4\u77e5\u53d1\u80b2\u843d\u540e\u7684\u60c5\u51b5\u3002<\/span><\/span><\/p>\n

\u5176\u5b9e\u8fd9\u80cc\u540e\uff0c\u5f88\u53ef\u80fd\u548c\u624b\u672f\u4e2d\u51fa\u73b0\u7684\u4f4e\u6e29\u7f3a\u6c27\u7f3a\u8840\u6709\u5173\u3002\u4e3a\u4e86\u4fdd\u62a4\u5b69\u5b50\u7684\u5927\u8111\uff0c\u533b\u751f\u5728\u624b\u672f\u4e2d\u5e38\u4f1a\u91c7\u7528\u4f4e\u6e29\u6280\u672f\uff0c\u4f46\u5373\u4fbf\u5982\u6b64\uff0c\u53d1\u80b2\u4e2d\u7684\u5927\u8111\uff08\u5c24\u5176\u662f\u8d1f\u8d23\u4f20\u9012\u4fe1\u53f7\u7684\u767d\u8d28\uff09\u4f9d\u7136\u5bb9\u6613\u53d7\u5230\u635f\u4f24\uff0c\u8fd9\u4e5f\u662f\u4e34\u5e8a\u4e2d\u8ba9\u533b\u751f\u548c\u5bb6\u957f\u90fd\u5934\u75bc\u7684\u96be\u9898\u3002<\/span><\/span><\/p>\n

\"Neurosci<\/span><\/span><\/p>\n

2026\u5e743\u67089\u65e5\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u4e0a\u6d77\u513f\u7ae5\u533b\u5b66\u4e2d\u5fc3\u795d\u5fe0\u7fa4<\/span>\u6559\u6388\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u57fa<\/span>\u7840<\/span>\u533b\u5b66<\/span><\/span>\u9662<\/span>\u7ae5\u5c0f\u840d<\/span>\u7814\u7a76\u5458<\/span><\/span><\/span>\u56e2\u961f\u5728<\/span>\u300a<\/span><\/span>Neuroscience Bulletin\u300b<\/span><\/span><\/span>\u53d1\u8868\u9898\u4e3a\uff1aMicr<\/span>oglia Pyroptosis\u2011Derived IL\u201118 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia\u2011Ischemia\u7684\u7814\u7a76\u5de5\u4f5c\u3002<\/span><\/span><\/p>\n

\u6838\u5fc3\u53d1\u73b0\uff1a<\/span><\/span><\/span>\u4f4e\u4f53\u6e29\u6027\u7f3a\u6c27\u7f3a\u8840\u4f1a\u89e6\u53d1\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\uff0c\u91ca\u653e\u708e\u75c7\u56e0\u5b50IL-18\uff0c\u8fdb\u800c\u8fde\u9501\u5bfc\u81f4\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u6b7b\u4ea1\u3001\u8f74\u7a81\u8131\u9ad3\u9798\u53ca\u767d\u8d28\u635f\u4f24\uff1b\u800c\u5229\u7528\u53cc\u786b\u4ed1\uff08DSF\uff09\u7cbe\u51c6\u6291\u5236\u8fd9\u4e00\u7126\u4ea1\u8fc7\u7a0b\uff0c\u5728\u4f53\u5185\u5916\u5b9e\u9a8c\u4e2d\u5747\u80fd\u663e\u8457\u963b\u65ad\u8be5\u6076\u6027\u5faa\u73af\u5e76\u51cf\u8f7b\u8111\u635f\u4f24\uff0c\u8bc1\u5b9e\u4e86\u9776\u5411\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u662f\u9884\u9632\u65b0\u751f\u513f\u7f3a\u6c27\u7f3a\u8840\u6027\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u7684\u6781\u5177\u6f5c\u529b\u7684\u6cbb\u7597\u65b0\u7b56\u7565<\/a>\u3002<\/span><\/span><\/span><\/p>\n

\u4f4e\u6e29\u6c27\u7cd6\u5265\u593a\u81f4\u767d\u8d28\u635f\u4f24\u4e0e\u7ec6\u80de\u7126\u4ea1<\/span><\/span><\/span><\/span><\/h3>\n

\u4f4e\u6e29\u4fdd\u62a4\u5728\u4e34\u5e8a\u5e7f\u6cdb\u5e94\u7528\uff0c\u4f46\u65e0\u6cd5\u5b8c\u5168\u907f\u514d\u7f3a\u6c27\u7f3a\u8840\u6027\u635f\u4f24\uff0c\u53d1\u80b2\u4e2d\u5927\u8111\u7684\u9ad3\u9798\u5316\u767d\u8d28\u5bf9\u6b64\u5c24\u4e3a\u654f\u611f\u3002<\/span><\/span><\/p>\n

\u4e34\u5e8aMRI\u663e\u793a\uff0c\u63a5\u53d7\u6df1\u4f4e\u6e29\u505c\u5faa\u73af\u624b\u672f\u7684\u60a3\u513f\u5b58\u5728\u8111\u53d1\u80b2\u8fdf\u7f13\u4e0e\u767d\u8d28\u635f\u4f24\uff0c\u767d\u8d28\u7ed3\u6784\u8fde\u63a5\u53ca\u5404\u5411\u5f02\u6027\u5206\u6570\u964d\u4f4e\uff0c\u63d0\u793a\u4f4e\u6e29\u4e0b\u4ecd\u5b58\u5728\u8111\u635f\u4f24\u3002<\/span><\/span><\/p>\n

\u4f53\u5916\u5b9e\u9a8c\u663e\u793a\uff0c18\u2103\u4f4e\u6e29\u6c27\u7cd6\u5265\u593a\u4ecd\u53ef\u9020\u6210\u80fc\u80dd\u4f53\u660e\u663e\u9ad3\u9798\u635f\u4f24\uff0c\u9ad3\u9798\u7ed3\u6784\u5f02\u5e38\u4e14\u4f34\u968f\u7ec6\u80de\u7126\u4ea1\u589e\u52a0\u3002<\/span><\/span><\/p>\n

\u7efc\u4e0a\uff0c18\u2103\u4f4e\u6e29\u867d\u6709\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\uff0c\u4f46\u4e0d\u80fd\u5b8c\u5168\u9884\u9632\u6c27\u7cd6\u5265\u593a\u8bf1\u5bfc\u7684\u767d\u8d28\u635f\u4f24\uff0c\u8be5\u635f\u4f24\u81f3\u5c11\u90e8\u5206\u7531\u7ec6\u80de\u7126\u4ea1\u4ecb\u5bfc\u3002<\/span><\/span><\/p>\n

\"Neurosci<\/span><\/span><\/p>\n

NF-κB\/GSDMD \u4ecb\u5bfc\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1<\/p>\n

\u5728\u786e\u5b9a\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u662f\u5173\u952e\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86\u5177\u4f53\u901a\u8def\u3002<\/span><\/span><\/p>\n

\u4f4e\u6e29\u6c27\u7cd6\u5265\u593a\u4f1a\u6fc0\u6d3b\u5c0f\u80f6\u8d28\u7ec6\u80de\u5e76\u901a\u8fc7\u4e0a\u8c03 Nlrp3\u3001Gsdmd\u3001Casp1\u5f15\u53d1GSDMD \u4f9d\u8d56\u7684\u7ec6\u80de\u7126\u4ea1\u3002\u901a\u8def\u5206\u6790\u663e\u793a\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de\u5185\u4e3b\u8981\u662fNF\u2011κB \u901a\u8def\u88ab\u6fc0\u6d3b\uff0c\u6291\u5236NF\u2011κB\u53ef\u660e\u663e\u51cf\u8f7b\u7126\u4ea1\u3002\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u4f4e\u6e29\u6c27\u7cd6\u5265\u593a\u4f1a\u8ba9\u5c0f\u80f6\u8d28\u7ec6\u80de\u91ca\u653eIL\u201118\u548cIL\u20111β\uff0c\u5176\u4e2d\u53eaIL\u20111\u5728\u8111\u810a\u6db2\u4e2d\u663e\u8457\u5347\u9ad8\u3002<\/span><\/span><\/p>\n

\u603b\u4f53\u8bf4\u660e\uff1aNF\u2011κB\/GSDMD\u901a\u8def\u4ecb\u5bfc\u4e86\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\uff0c\u80fc\u80dd\u4f53\u7684\u708e\u75c7\u53cd\u5e94\u5f88\u53ef\u80fd\u7531IL\u201118\u4ecb\u5bfc\u3002<\/span><\/span><\/p>\n

\"Neurosci<\/span><\/span><\/p>\n

DSF\u51cf\u8f7b\u65ad\u5976\u5927\u9f20DHCA\u540e\u7126\u4ea1\u9a71\u52a8\u7684\u767d\u8d28\u635f\u4f24<\/p>\n

\u5728\u8bc1\u5b9e\u5c0f\u80f6\u8d28\u7ec6\u80deNF-κB\/GSDMD\/IL-18\u8f74\u53c2\u4e0e\u8f74\u7a81\u8131\u9ad3\u9798\u540e\uff0c\u4f5c\u8005\u91c7\u7528GSDMD\u5b54\u5f62\u6210\u6291\u5236\u5242\u53cc\u786b\u4ed1\u8fdb\u884c\u5e72\u9884\u3002\u4f53\u5916\u5b9e\u9a8c\u663e\u793a\uff0c\u53cc\u786b\u4ed1\u53ef\u964d\u4f4e\u80fc\u80dd\u4f53\u4e2dNLRP3\u3001c-CASP1\u3001GSDMD\u3001IL-1β\u3001IL-18\u7b49\u7126\u4ea1\u76f8\u5173\u86cb\u767d\uff0c\u5347\u9ad8\u9ad3\u9798\u78b1\u6027\u86cb\u767d\u5e76\u51cf\u5c11\u5c0f\u80f6\u8d28\u7ec6\u80deGSDMD\u8868\u8fbe\uff0c\u4ece\u800c\u51cf\u8f7b\u6c27\u7cd6\u5265\u593a\u6240\u81f4\u767d\u8d28\u635f\u4f24\u3002<\/span><\/span><\/p>\n

\u4f53\u5185\u5b9e\u9a8c\u91c7\u7528<\/span><\/span>\u65ad\u5976\u5927\u9f20\u6df1\u4f4e\u6e29\u505c\u5faa\u73af\u6a21\u578b<\/span><\/span>\uff0c\u672f\u524d4\u5c0f\u65f6\u7ed9\u4e88\u53cc\u786b\u4ed1\u8179\u8154\u6ce8\u5c04\u3002\u7ed3\u679c\u663e\u793a\uff0c\u53cc\u786b\u4ed1\u53ef\u964d\u4f4e\u5927\u9f20GSDMD\u6c34\u5e73\u3001\u63d0\u9ad8\u9ad3\u9798\u78b1\u6027\u86cb\u767d\uff0c\u51cf\u5c11\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u5e76\u964d\u4f4e\u8840\u6e05IL-18\u548cIL-1β\uff0c\u660e\u663e\u7f13\u89e3\u8f74\u7a81\u8131\u9ad3\u9798\u53ca\u767d\u8d28\u635f\u4f24\u3002<\/span><\/span><\/span><\/p>\n

\u7efc\u4e0a\uff0c<\/span><\/span>\u53cc\u786b\u4ed1\u53ef\u6291\u5236\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\uff0c\u5bf9\u53d1\u80b2\u5927\u8111\u4f4e\u6e29\u7f3a\u6c27\u7f3a\u8840\u540e\u7684\u767d\u8d28\u635f\u4f24\u5177\u6709\u4fdd\u62a4\u4f5c\u7528<\/span><\/span><\/span>\uff0c\u6709\u671b\u6210\u4e3a\u6f5c\u5728\u6cbb\u7597\u624b\u6bb5\u3002<\/span><\/span><\/span><\/p>\n

\"Neurosci<\/span><\/span><\/p>\n

\u7814\u7a76\u610f\u4e49<\/span><\/span><\/span><\/h3>\n

\u672c\u7814\u7a76\u9996\u6b21\u5efa\u7acb\u5f00\u80f8\u5f0f\u65ad\u5976\u5927\u9f20\u6df1\u4f4e\u6e29\u505c\u5faa\u73af\u6a21\u578b\uff0c\u66f4\u8d34\u8fd1\u513f\u79d1\u624b\u672f\u4e34\u5e8a\u573a\u666f\uff0c\u53ef\u7528\u4e8e\u6a21\u62df\u53d1\u80b2\u5927\u8111\u767d\u8d28\u635f\u4f24\uff0c\u4e3a\u7814\u7a76\u4f4e\u6e29\u7f3a\u6c27\u7f3a\u8840\u8111\u635f\u4f24\u673a\u5236\u4e0e\u795e\u7ecf\u4fdd\u62a4\u7b56\u7565\u63d0\u4f9b\u4e86\u53ef\u9760\u52a8\u7269\u6a21\u578b\u3002<\/span><\/span><\/p>\n

\u8be5\u6a21\u578b\u660e\u786e\u4e86\u4f4e\u6e29\u4e0b\u8111\u635f\u4f24\u7684\u5173\u952e\u673a\u5236\uff0c\u4e3a\u5236\u5b9a\u7cbe\u51c6\u5e72\u9884\u3001\u5f3a\u5316\u8111\u4fdd\u62a4\u63d0\u4f9b\u4e86\u7406\u8bba\u4f9d\u636e\u3002\u8be5\u7814\u7a76\u4e3a\u8001\u836f\u65b0\u7528\u63d0\u4f9b\u4e86\u8f6c\u5316\u524d\u666f\uff0c\u4e5f\u4e3a\u4f4e\u6e29\u8111\u635f\u4f24\u63d0\u4f9b\u4e86\u5b89\u5168\u3001\u53ef\u5feb\u901f\u4e34\u5e8a\u8f6c\u5316\u7684\u5e72\u9884\u65b0\u601d\u8def\u3002<\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n

    \n
  • \u6587\u7ae0\u6765\u6e90\uff1a<\/strong>https:\/\/doi.org\/10.1007\/s12264-026-01602-9<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    \u6587 | \u8111\u58f0\u5e38\u8c08 \u5bf9\u4e8e\u5f88\u591a\u6709\u5b69\u5b50\u9700\u8981\u505a\u5fc3\u810f\u7b49\u91cd\u5927\u624b\u672f\u7684\u5bb6\u5ead\u6765\u8bf4\uff0c\u6700\u62c5\u5fc3\u7684\u9664\u4e86\u624b\u672f\u672c\u8eab\u7684\u98ce\u9669\uff0c\u8fd8\u6709\u672f\u540e\u5b69\u5b50\u7684\u5927\u8111 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[88,192],"views":24,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/744879"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=744879"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/744879\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=744879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=744879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=744879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}