{"id":744633,"date":"2026-03-13T10:23:47","date_gmt":"2026-03-13T02:23:47","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=744633"},"modified":"2026-03-13T10:23:47","modified_gmt":"2026-03-13T02:23:47","slug":"%e7%97%92%e5%88%b0%e7%9d%a1%e4%b8%8d%e7%9d%80%e8%bf%98%e5%bf%83%e7%83%a6%ef%bc%9f%e7%be%8e%e5%9b%bd%e7%a7%91%e5%ad%a6%e5%ae%b6%e5%8f%91%e7%8e%b0%e6%ad%a2%e7%97%92%e6%8a%97%e7%84%a6%e8%99%91","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=744633","title":{"rendered":"\u75d2\u5230\u7761\u4e0d\u7740\u8fd8\u5fc3\u70e6\uff1f\u7f8e\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u201c\u6b62\u75d2\u6297\u7126\u8651\u201d\u65b0\u901a\u8def\uff0c\u4e00\u4e3e\u4e24\u5f97"},"content":{"rendered":"<blockquote>\n<p>\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n<p><span><span>\u60f3\u8c61\u4e00\u4e0b\uff0c\u4f60\u88ab\u4e25\u91cd\u7684\u76ae\u80a4\u7619\u75d2\u6298\u78e8\u5f97\u5750\u7acb\u96be\u5b89\u6216\u8005\u56e0\u4e3a\u7126\u8651\u800c\u5fc3\u70e6\u610f\u4e71\u3002\u4f20\u7edf\u7684\u6b62\u75d2\u836f\u5f80\u5f80\u50cf\u4e00\u8bb0&ldquo;\u95f7\u68cd&rdquo;\uff0c\u867d\u7136\u80fd\u6b62\u75d2\uff0c\u4f46\u526f\u4f5c\u7528\u5f88\u5927\uff1a\u8981\u4e48\u8ba9\u4f60\u660f\u660f\u6b32\u7761\u3001\u6d51\u8eab\u65e0\u529b\uff08\u9547\u9759\uff09\uff0c\u8981\u4e48\u8ba9\u4f60\u8dd1\u5395\u6240\u8dd1\u4e2a\u4e0d\u505c\uff08\u5229\u5c3f\uff09\uff0c\u6839\u672c\u6ca1\u6cd5\u6b63\u5e38\u751f\u6d3b\u6216\u5de5\u4f5c&hellip;&hellip;<\/span><\/span><\/p>\n<p><span><span>\u57fa\u4e8e\u6b64\uff0c2026\u5e743\u67089\u65e5\uff0c<span>\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240Laura M. Bohn<\/span>\u7814\u7a76\u56e2\u961f\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<span>\u300aNeuropsychopharmacology\u300b<\/span>\u6742\u5fd7\u53d1\u8868\u4e86&ldquo;Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice&rdquo;\u63ed\u793a\u4e86\u4e09\u5511187\u662f\u4e00\u79cd\u504f\u5411\u6027&kappa;\u963f\u7247\u53d7\u4f53\uff08KOR\uff09\u6fc0\u52a8\u5242\uff0c\u80fd\u5728\u4e0d\u5f15\u8d77\u9547\u9759\u4f5c\u7528\u7684\u60c5\u51b5\u4e0b\u6291\u5236\u5c0f\u9f20\u7619\u75d2\u5e76\u8bf1\u5bfc\u6297\u7126\u8651\u6837\u884c\u4e3a\u3002<\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/fd0d6a88dad11550ee6a8bb6f26b906c_1773370939.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x438\/gravity\/center\/crop\/!1440x438&ext=.jpeg\" alt=\"\u75d2\u5230\u7761\u4e0d\u7740\u8fd8\u5fc3\u70e6\uff1f\u7f8e\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u201c\u6b62\u75d2\u6297\u7126\u8651\u201d\u65b0\u901a\u8def\uff0c\u4e00\u4e3e\u4e24\u5f97\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<p><span><span>\u4f5c\u8005\u63ed\u793a\u4e86\u4e00\u79cd\u5f3a\u6548\u4e14\u5177\u6709G\u86cb\u767d\u4fe1\u53f7\u504f\u5411\u6027\u7684\u65b0\u578b&kappa;-\u963f\u7247\u53d7\u4f53\u6fc0\u52a8\u5242\u4e09\u5511187\uff0c\u8be5\u5316\u5408\u7269\u4e0d\u4ec5\u5c55\u73b0\u51fa\u5353\u8d8a\u7684\u6297\u7619\u75d2\u6d3b\u6027\uff0c\u8fd8\u80fd\u8bf1\u5bfc\u72ec\u7279\u7684\u6297\u7126\u8651\u6837\u884c\u4e3a\uff08\u8fd9\u662f\u7c7b\u4f3c\u7269\u4e09\u55111.1\u6240\u4e0d\u5177\u5907\u7684\uff09\uff1b\u5176\u663e\u8457\u4f18\u52bf\u5728\u4e8e\u514b\u670d\u4e86\u4f20\u7edfKOR\u6fc0\u52a8\u5242\u7684\u5e38\u89c1\u526f\u4f5c\u7528\uff0c\u5373\u5728\u4fdd\u6301\u6297\u7619\u75d2\u7597\u6548\u7684\u540c\u65f6\u4e0d\u5f15\u8d77\u9547\u9759\u4f5c\u7528\uff08\u4e0d\u5f71\u54cd\u81ea\u53d1\u6027\u8fd0\u52a8\u6d3b\u6027\uff09\u4e14\u5229\u5c3f\u6548\u5e94\u6781\u5fae\uff08\u5728\u8d85\u6709\u6548\u5242\u91cf100\u500d\u65f6\uff0c\u5c3f\u91cf\u4ec5\u4e3a\u7ecf\u5178\u836f\u7269U50,488H\u768430%\uff09\uff0c\u56e0\u6b64\u4e3a\u6cbb\u7597\u4f34\u6709\u6301\u7eed\u6027\u6162\u6027\u7619\u75d2\u7684\u7126\u8651\u75c7\u63d0\u4f9b\u4e86\u4e00\u6761\u907f\u514d\u9547\u9759\u548c\u4e25\u91cd\u5229\u5c3f\u526f\u4f5c\u7528\u7684\u5168\u65b0\u9014\u5f84\u3002<\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/96e8b8f2e007e7570ea494067fdf34b7_1773370939.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x1174\/gravity\/center\/crop\/!1440x1174&ext=.jpeg\" alt=\"\u75d2\u5230\u7761\u4e0d\u7740\u8fd8\u5fc3\u70e6\uff1f\u7f8e\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u201c\u6b62\u75d2\u6297\u7126\u8651\u201d\u65b0\u901a\u8def\uff0c\u4e00\u4e3e\u4e24\u5f97\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<p><span><span><span>\u56fe\u4e00 \u4e09\u5511187\u7684\u53d7\u4f53\u4eb2\u548c\u529b\u4e0e\u4fe1\u53f7\u504f\u5411\u6027\u8bc4\u4ef7<\/span><\/span><\/span><\/p>\n<p><span><span>\u4e3a\u6bd4\u8f83\u4e09\u5511187\u4e0e\u4e09\u55111.1\u3001U50,488H\u3001U69,593\uff0c\u7814\u7a76\u8fdb\u884c\u4e86\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u5b9e\u9a8c\uff0c\u4ee5U69,593\u4e3a\u53c2\u8003\u6fc0\u52a8\u5242\u3002<\/span><\/span><\/p>\n<p><span><span>\u4e09\u5511187\u5bf9&kappa;\u963f\u7247\u53d7\u4f53\u4eb2\u548c\u529b\u66f4\u9ad8\uff0c\u5728\u591a\u9879\u4fe1\u53f7\u901a\u8def\u4e2d\u6548\u529b\u66f4\u5f3a\uff0c\u4f46ERK1\/2\u78f7\u9178\u5316\u6548\u529b\u8f83\u4f4e\uff0c\u4ecd\u8868\u73b0\u51fa\u4e00\u5b9a\u901a\u8def\u504f\u5411\u6027\u3002<\/span><\/span><\/p>\n<p><span><span>\u8131\u9776\u7b5b\u9009\u663e\u793a\u5176\u5bf9&kappa;\u963f\u7247\u53d7\u4f53\u9009\u62e9\u6027\u9ad8\uff0c\u65e0\u660e\u663e\u5176\u4ed6\u9776\u70b9\u4f5c\u7528\u3002<\/span><\/span><\/p>\n<p><span><span><span>\u52a8\u7269\u5b9e\u9a8c\u8868\u660e<\/span><\/span><span><span>\u4e09\u5511187\u53ef\u900f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u8111\u4e2d\u4f5c\u7528\u7ef4\u6301\u65f6\u95f4\u8f83\u957f<\/span><\/span><span><span>\uff0c\u4e0e\u4e09\u55111.1\u76f8\u8fd1\uff1b\u5bf9\u7167\u836f\u7269\u5728\u8111\u5185\u4e5f\u53ef\u5feb\u901f\u8fbe\u5230\u8f83\u9ad8\u6d53\u5ea6\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/1625ac97927a33fc84e4206e7008879b_1773370940.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x1780\/gravity\/center\/crop\/!1440x1780&ext=.jpeg\" alt=\"\u75d2\u5230\u7761\u4e0d\u7740\u8fd8\u5fc3\u70e6\uff1f\u7f8e\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u201c\u6b62\u75d2\u6297\u7126\u8651\u201d\u65b0\u901a\u8def\uff0c\u4e00\u4e3e\u4e24\u5f97\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<p><span><span><span>\u56fe\u4e8c &kappa;\u963f\u7247\u53d7\u4f53\u6fc0\u52a8\u5242\u5bf9\u5c0f\u9f20\u7619\u75d2\u3001\u5229\u5c3f\u53ca\u884c\u4e3a\u5f71\u54cd\u7684\u8bc4\u4f30<\/span><\/span><\/span><\/p>\n<p><span><span>\u8fd9\u9879\u7814\u7a76\u5bf9\u6bd4\u4e86\u7ecf\u5178\u836f\u7269U50,488H\u4e0e\u4e24\u79cd\u65b0\u578b\u4e09\u5511\u5316\u5408\u7269\uff081.1\u548c187\uff09\u5728\u6b62\u75d2\u53ca\u526f\u4f5c\u7528\u65b9\u9762\u7684\u8868\u73b0\uff0c\u7ed3\u679c\u663e\u793a\u65b0\u578b\u5316\u5408\u7269\u66f4\u5177\u4f18\u52bf\uff1a\u5728\u6b62\u75d2\u7597\u6548\u4e0a\uff0c\u4e09\u5511187\u4ec5\u97000.3\u6beb\u514b\/\u5343\u514b\u7684\u4f4e\u5242\u91cf\u5373\u53ef\u8d77\u6548\uff0c\u6548\u529b\u4e0eU50,488H\u76f8\u5f53\u4e14\u663e\u8457\u4f18\u4e8e\u9700\u9ad8\u5242\u91cf\u624d\u89c1\u6548\u7684\u4e09\u55111.1\uff1b<\/span><\/span><\/p>\n<p><span><span><span>\u5728\u526f\u4f5c\u7528\u65b9\u9762\uff0c\u867d\u7136\u4e09\u8005\u5747\u6709\u5229\u5c3f\u3001\u5f15\u53d1<\/span><\/span><span><span><span>\u6500\u722c<\/span><\/span><\/span><span><span>\u53ca<\/span><\/span><span><span><span>\u7834\u574f\u7b51\u5de2<\/span><\/span><\/span><span><span>\u672c\u80fd\u7684\u4f5c\u7528\uff0c\u4f46\u65b0\u578b\u4e09\u5511\u5316\u5408\u7269\u7684\u5f71\u54cd\u8fdc\u5c0f\u4e8eU50,488H\uff1a\u5176\u9ad8\u5242\u91cf\u4e0b\u7684\u5229\u5c3f\u91cf\u4ec5\u4e3a\u7ecf\u5178\u836f\u7269\u7684\u7ea6\u56db\u5206\u4e4b\u4e00\uff0c\u4e14\u9700\u8981\u66f4\u9ad8\u5242\u91cf\u624d\u4f1a\u5f15\u53d1\u5c0f\u9f20\u8e81\u52a8<\/span><\/span><span><span><span>\u6500\u722c\u6216\u5e72\u6270\u7b51\u5de2\u884c\u4e3a<\/span><\/span><\/span><span><span>\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><span>\u7efc\u4e0a\u6240\u8ff0\uff0c<\/span><\/span><span><span>\u4ee5\u4e09\u5511187\u4e3a\u4ee3\u8868\u7684\u65b0\u578b\u5316\u5408\u7269\u5728\u4fdd\u6301\u5f3a\u6548\u6b62\u75d2\u7684\u540c\u65f6\uff0c\u5927\u5e45\u964d\u4f4e\u4e86\u5229\u5c3f\u53ca\u884c\u4e3a\u5e72\u6270\u7b49\u526f\u4f5c\u7528\uff0c\u8868\u73b0\u51fa\u6bd4\u7ecf\u5178\u836f\u7269\u66f4\u5b89\u5168\u3001\u66f4\u6e29\u548c\u7684\u7279\u6027\u3002<\/span><\/span><\/span><\/p>\n<p><span><span><img src=\"https:\/\/images.tmtpost.com\/uploads\/images\/2026\/03\/1db2dbab5186ed39beab8c1a6617c775_1773370940.jpeg?imageMogr2\/auto-orient\/strip\/interlace\/1\/quality\/85\/thumbnail\/1440x1258\/gravity\/center\/crop\/!1440x1258&ext=.jpeg\" alt=\"\u75d2\u5230\u7761\u4e0d\u7740\u8fd8\u5fc3\u70e6\uff1f\u7f8e\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u201c\u6b62\u75d2\u6297\u7126\u8651\u201d\u65b0\u901a\u8def\uff0c\u4e00\u4e3e\u4e24\u5f97\" style=\"display:block; margin-left:auto; margin-right:auto\" \/><\/span><\/span><\/p>\n<p><span><span><span>\u56fe\u4e09 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1.1\uff0c\u4ee5\u671f\u5728\u65e0\u660e\u663e\u9547\u9759\u7684\u524d\u63d0\u4e0b\u53d1\u6325\u4f5c\u7528\u3002<\/span><\/span><\/span><\/p>\n<p><span><span>\u5728\u96c4\u6027\u5c0f\u9f20\u4e2d\uff0cU50,488H 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| \u8111\u58f0\u5e38\u8c08 \u60f3\u8c61\u4e00\u4e0b\uff0c\u4f60\u88ab\u4e25\u91cd\u7684\u76ae\u80a4\u7619\u75d2\u6298\u78e8\u5f97\u5750\u7acb\u96be\u5b89\u6216\u8005\u56e0\u4e3a\u7126\u8651\u800c\u5fc3\u70e6\u610f\u4e71\u3002\u4f20\u7edf\u7684\u6b62\u75d2\u836f\u5f80\u5f80\u50cf\u4e00\u8bb0&#038;l [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[367],"views":25,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/744633"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=744633"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/744633\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=744633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=744633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=744633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}