{"id":742574,"date":"2026-03-11T15:56:35","date_gmt":"2026-03-11T07:56:35","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=742574"},"modified":"2026-03-11T15:56:35","modified_gmt":"2026-03-11T07:56:35","slug":"%e5%9b%bd%e5%86%85%e7%ae%a1%e7%ba%bf%e5%8d%a0%e6%af%94%e8%bf%87%e5%8d%8a%ef%bc%8cmnc%e7%bc%ba%e5%b8%ad%e5%9b%9b%e4%bb%a3%e9%9d%b6%e5%90%91%e8%8d%af","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=742574","title":{"rendered":"\u56fd\u5185\u7ba1\u7ebf\u5360\u6bd4\u8fc7\u534a\uff0cMNC\u7f3a\u5e2d\u56db\u4ee3\u9776\u5411\u836f"},"content":{"rendered":"
\n

\u6587 | vb\u52a8\u8109\u7f51<\/p>\n<\/blockquote>\n

\u56db\u4ee3EGFR\u6b63\u5728\u6210\u4e3a\u80bf\u7624\u6cbb\u7597\u9886\u57df\u7684\u65b0\u7814\u53d1\u65b9\u5411\u3002<\/p>\n

\u56db\u4ee3\u9776\u5411\u836f\u662f\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u8010\u836f\u95ee\u9898\u7814\u53d1\u7684\u65b0\u4e00\u4ee3\u836f\u7269\uff0c\u76ee\u524d\u4e3b\u8981\u96c6\u4e2d\u5728EGFR\u7a81\u53d8\u578b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\u3002\u8010\u836f\u95ee\u9898\u59cb\u7ec8\u662fEGFR\u9776\u5411\u836f\u5728\u4e34\u5e8a\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u9762\u4e34\u7684\u4e3b\u8981\u95ee\u9898\uff1a\u4e00\u4ee3\/\u4e8c\u4ee3\u836f\u4e2d\u4f4d\u8010\u836f\u65f6\u95f4\u7ea6\u4e3a10-14\u4e2a\u6708\uff0c\u4e09\u4ee3\u836f\u5965\u5e0c\u66ff\u5c3c\u53ef\u5ef6\u957f\u81f318-20\u4e2a\u6708\uff0c\u4f46\u4ecd\u65e0\u6cd5\u907f\u514d\u8010\u836f\u53d1\u751f\u3002\u5728\u4f7f\u7528\u7b2c\u4e09\u4ee3EGFR-TKI\u6cbb\u759710\u4e2a\u6708\u5de6\u53f3\u540e\uff0c\u90e8\u5206\u60a3\u8005\u4f1a\u51fa\u73b0\u65b0\u7684\u8010\u836f\u6027\uff0c\u5176\u4e2dEGFR C797S\u7a81\u53d8\u662f\u6700\u5e38\u89c1\u7684\u8010\u836f\u7a81\u53d8\u4e4b\u4e00\uff0c\u53d1\u751f\u7387\u7ea6\u4e3a20%\u3002<\/p>\n

\u4e3a\u4e86\u6ee1\u8db3\u8fd9\u4e00\u4e34\u5e8a\u9700\u6c42\uff0c\u521b\u65b0<\/a>\u836f\u4f01\u6b63\u5728\u79ef\u6781\u5f00\u53d1\u7b2c\u56db\u4ee3EGFR\u9776\u5411\u836f\uff0c\u5168\u7403\u7814\u53d1\u8fdb\u5ea6\u6700\u9886\u5148\u7684\u7ba1\u7ebf\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u2161\u671f\u9636\u6bb5\u3002\u5728\u8fd9\u4e00\u524d\u6cbf\u9886\u57df\uff0c\u56fd\u5185\u9f99\u5934\u521b\u65b0\u836f\u4f01\u6b63\u5728\u8fc5\u901f\u63a8\u8fdb\u76f8\u5173\u4ea7\u54c1\u7684\u5f00\u53d1\uff0c\u76ee\u524d\u5168\u7403\u8fdb\u5165\u4e34\u5e8a\u2160\u671f\u4ee5\u540e\u7684\u56db\u4ee3EGFR\u4e2d\uff0c\u56fd\u5185\u7ba1\u7ebf\u7684\u5360\u6bd4\u5df2\u7ecf\u8d85\u8fc7\u4e00\u534a\uff0c\u800cMNC\u7684\u8fdb\u5c55\u5219\u76f8\u5bf9\u8f83\u6162\u3002<\/p>\n

\u57fa\u4e8e\u4f20\u7edf\u7684\u8ba4\u77e5\uff0c\u56db\u4ee3EGFR\u7528\u4e8e\u4e09\u4ee3\u836f\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u540e\u7684\u6cbb\u7597\uff0c\u5e02\u573a\u7a7a\u95f4\u6709\u9650\uff0c\u56e0\u800cMNC\u5bf9\u8fd9\u4e00\u9886\u57df\u7684\u5173\u6ce8\u5e76\u4e0d\u591a\u3002\u4f46\u968f\u7740\u56db\u4ee3EGFR\u7814\u7a76\u7684\u8fdb\u884c\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u56db\u4ee3EGFR\u5177\u5907\u4e86\u6210\u4e3a\u524d\u7ebfNSCLC\u6cbb\u7597\u836f\u7269\u7684\u53ef\u80fd\u3002MNC\u53ef\u80fd\u4f4e\u4f30\u4e86\u56db\u4ee3EGFR\u7684\u5e02\u573a\u6f5c\u529b\u3002<\/p>\n

\u5317\u5927\u533b\u5b66\u90e8\u4e91\u5f69\u7ea2\u6559\u6388\u544a\u8bc9\u52a8\u8109\u7f51\uff0c\u90e8\u5206\u56db\u4ee3\u9776\u5411\u836f\u80fd\u591f\u8986\u76d6\u591a\u79cdEGFR\u7a81\u53d8\u7c7b\u578b\uff0c\u5305\u62ec\u5355\u7a81\u53d8\u3001\u53cc\u7a81\u53d8\u548c\u4e09\u7a81\u53d8\uff08\u5373D\u3001L\u3001DT\u3001LT\u3001DC\u3001LC\u3001DTC\u3001LTC\uff09\uff0c\u56e0\u800c\u5177\u5907\u4e86\u66f4\u5927\u7684\u5e02\u573a\u7a7a\u95f4\u3002<\/p>\n

\"\u56fd\u5185\u7ba1\u7ebf\u5360\u6bd4\u8fc7\u534a\uff0cMNC\u7f3a\u5e2d\u56db\u4ee3\u9776\u5411\u836f\"<\/p>\n

\u56fe1. \u56db\u4ee3EGFR\u6709\u671b\u8986\u76d6\u516b\u79cd\u4e3b\u8981\u7a81\u53d8\uff08\u8d44\u6599\u6765\u6e90\uff1a\u5317\u5927\u533b\u5b66\u90e8\u4e91\u5f69\u7ea2\u6559\u6388\uff09<\/p>\n

\u6b64\u5916\uff0c\u5728\u7814\u7684\u56db\u4ee3EGFR\u9776\u5411\u836f\u5747\u4e3a\u53e3\u670d\u5236\u5242\uff0c\u4e0e\u9700\u8981\u6ce8\u5c04\u4f7f\u7528\u7684ADC\u3001\u53cc\u6297\u7c7b\u751f\u7269\u836f\u76f8\u6bd4\uff0c\u66f4\u52a0\u5b89\u5168\u65b9\u4fbf\uff0c\u4e5f\u66f4\u5bb9\u6613\u88ab\u60a3\u8005\u643a\u5e26\uff0c\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u660e\u663e\u63d0\u9ad8\u3002<\/p>\n

\u66f4\u5e7f\u9614\u7684\u5e02\u573a\u7a7a\u95f4\u548c\u66f4\u597d\u7684\u60a3\u8005\u4f9d\u4ece\u6027\u4f7f\u5f97\u56db\u4ee3EGFR\u6210\u4e3a\u6709\u6f5c\u529b\u7684\u7814\u53d1\u65b9\u5411\uff0c\u56fd\u5185\u5916\u521b\u65b0\u836f\u4f01\u4e5f\u5728\u8fd9\u4e00\u9886\u57df\u8fdb\u884c\u79ef\u6781\u63a2\u7d22\u3002<\/p>\n

\u6d77\u5916\u836f\u4f01\u5728\u7b2c\u56db\u4ee3EGFR\u6291\u5236\u5242\u7814\u53d1\u4e0a\u906d\u9047\u56f0\u5883<\/strong><\/h3>\n

C797S\u7a81\u53d8\u662f\u7b2c\u4e09\u4ee3EGFR-TKI\u8010\u836f\u7684\u5e38\u89c1\u539f\u56e0\u3002\u5982\u679c\u901a\u8fc7\u4f18\u5316\u5206\u5b50\u7ed3\u6784\uff0c\u80fd\u591f\u8bbe\u8ba1\u51fa\u6709\u6548\u6291\u5236C797S\u7a81\u53d8\u7684\u65b0\u578b\u6291\u5236\u5242\uff0c\u5c31\u80fd\u6709\u6548\u89e3\u51b3\u7b2c\u4e09\u4ee3\u9776\u5411\u836f\u7684\u8010\u836f\u95ee\u9898\u3002\u8fd9\u6210\u4e86\u56db\u4ee3EGFR\u9776\u5411\u836f\u7684\u4e3b\u6d41\u7814\u53d1\u7b56\u7565<\/a>\u3002\u56f4\u7ed5\u8fd9\u4e00\u601d\u8def\uff0c\u521b\u65b0\u836f\u4f01\u6b63\u5728\u5c55\u5f00\u79ef\u6781\u7814\u7a76\uff0c\u7136\u800c\u7814\u53d1\u4e4b\u8def\u5e76\u4e0d\u987a\u7545\u3002<\/p>\n

\u6700\u5148\u88ab\u5bc4\u4e88\u539a\u671b\u7684\u7ba1\u7ebf\u662fBLU-945\uff0c\u7531Blueprint\u7814\u53d1\u30022023\u5e74ASCO\u4f1a\u8bae\u4e0a\u516c\u5e03\u7684\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cBLU-945\u5355\u836f\u5728≥400 mg\/d\u7ec4\u4e2d\u670948%\u7684\u60a3\u8005\u80bf\u7624\u7f29\u5c0f\uff0c\u5305\u62ec\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u3002\u7136\u800c\u9ad8\u5242\u91cfBLU-945\u7ec4\uff08400-600mg\/\u5929\uff09\u60a3\u8005\u4e2d\u51fa\u73b0\u4e86\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u4e3b\u8981\u662f\u809d\u529f\u80fd\u5f02\u5e38\uff0c\u8fd9\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u4f7f\u7528\u3002<\/p>\n

BLU-945\u7684\u4e34\u5e8a\u6570\u636e\u8868\u73b0\u51fa\u7597\u6548\u672a\u8fbe\u9884\u671f\u4ee5\u53ca\u6cbb\u7597\u7a97\u53e3\u72ed\u7a84\u7684\u95ee\u9898\uff0c\u8fd9\u5bfc\u81f4\u8be5\u4ea7\u54c1\u7684\u98ce\u9669<\/a>\u83b7\u76ca\u6bd4\u4e0d\u8db3\u3002\u57fa\u4e8e\u8fd9\u4e00\u4e34\u5e8a\u8868\u73b0\uff0cBlueprint\u5ba3\u5e03\u4e0d\u518d\u6295\u8d44<\/a>BLU-945\uff0cBLU-945\u7684\u4e34\u5e8a\u7814\u7a76\u56e0\u800c\u9677\u5165\u4e86\u957f\u65f6\u95f4\u505c\u6ede\u72b6\u6001\u3002<\/p>\n

BLU-945\u7684\u4e34\u5e8a\u56f0\u5883\u53cd\u6620\u4e86\u56db\u4ee3EGFR\u5728\u7814\u53d1\u4e2d\u9762\u4e34\u7684\u4e00\u5927\u96be\u9898\uff1a\u5982\u4f55\u6709\u6548\u5e73\u8861\u5bf9\u590d\u6742\u7a81\u53d8\u7684\u6709\u6548\u6291\u5236\u4e0e\u4eba\u4f53\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n

Black Diamond\u5f00\u53d1\u7684BDTX-1535\u662f\u53e6\u4e00\u4e2a\u88ab\u5e02\u573a\u5bc4\u4e88\u539a\u671b\u7684\u4ea7\u54c1\u30022025\u5e7412\u67083\u65e5\uff0cBlack Diamond\u516c\u5e03\u4e86BDTX-1535\u7528\u4e8e\u4e00\u7ebf\u643a\u5e26\u975e\u7ecf\u5178EGFR\u7a81\u53d8\u7684NSCLC\u60a3\u8005\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u3002\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5171\u5165\u7ec443\u4f8b\u643a\u5e2635\u79cd\u4e0d\u540c\u975e\u7ecf\u5178EGFR\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u76ee\u524d\u7814\u7a76\u4ecd\u5728\u8fdb\u884c\u4e2d\u3002\u521d\u6b65\u7597\u6548\u6570\u636e\u663e\u793a\uff1a25\u4f8b\u786e\u8ba4\u90e8\u5206\u7f13\u89e3\uff0c1\u4f8b\u786e\u8ba4\u5b8c\u5168\u7f13\u89e3\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08\u6309RECIST 1.1\u6807\u51c6\uff09\u4e3a60%\uff1b\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edfORR\uff08\u6309RANO-BM\u6807\u51c6\uff09\u4e3a86%\uff1b\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a91%\u3002\u4f46\u662f\u4ee4\u4eba\u5931\u671b\u7684\u662f\uff0c\u8be5\u6570\u636e\u662f\u9488\u5bf9\u975e\u7ecf\u5178EGFR\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u4e5f\u5c31\u662f\u8bf4\u4e0d\u5305\u62ecEGFR C797S\u7a81\u53d8\u7684\u60a3\u8005\u3002<\/p>\n

\u4eceBlack Diamond\u5173\u4e8eBDTX-1535\u7684\u4e34\u5e8a\u6570\u636e\u62ab\u9732\u65b9\u5f0f\u63a8\u6d4b\uff0c\u8fd9\u6b3e\u5728\u7814\u4ea7\u54c1\u9488\u5bf9EGFR C797S\u7a81\u53d8\u60a3\u8005\u7684\u6cbb\u7597\u6570\u636e\u4f30\u8ba1\u4e0d\u4f1a\u592a\u7406\u60f3\u3002<\/p>\n

BLU-945\u548cBDTX-1535\u8fd9\u4e24\u6b3e\u6f5c\u529b\u4ea7\u54c1\u906d\u9047\u7684\u7814\u53d1\u96be\u9898\u8868\u660e\u5e02\u573a\u9700\u8981\u9488\u5bf9\u65b0\u578b\u56db\u4ee3EGFR\u6291\u5236\u5242\u3002\u76ee\u524d\u5168\u7403\u521b\u65b0\u836f\u4f01\u6b63\u5728\u6301\u7eed\u5f00\u53d1\u65b0\u7684EGFR\u9776\u5411\u836f\u3002\u636e\u52a8\u8109\u7f51\u4e0d\u5b8c\u5168\u7edf\u8ba1\uff0c\u5168\u7403\u7814\u53d1\u8fdb\u5c55\u8fdb\u5165\u4e34\u5e8a\u2160\u671f\u9636\u6bb5\u4ee5\u540e\u7684\u7ba1\u7ebf\u8d85\u8fc710\u6761\u3002<\/p>\n

\"\u56fd\u5185\u7ba1\u7ebf\u5360\u6bd4\u8fc7\u534a\uff0cMNC\u7f3a\u5e2d\u56db\u4ee3\u9776\u5411\u836f\"<\/p>\n

\u56fe2. \u5168\u7403\u5728\u7814\u7684\u7b2c\u56db\u4ee3EGFR\u6291\u5236\u5242\uff08\u8d44\u6599\u6765\u6e90\uff1a\u52a8\u8109\u7f51\u6574\u7406\uff09<\/p>\n

\u56fd\u5185\u836f\u4f01\u5728\u7b2c\u56db\u4ee3EGFR\u6291\u5236\u5242\u7814\u53d1\u4e0a\u8fdb\u5c55\u8fc5\u901f<\/strong><\/h3>\n

\u5728\u56db\u4ee3EGFR\u6291\u5236\u5242\u7684\u7814\u53d1\u4e2d\uff0c\u4e2d\u56fd\u521b\u65b0\u836f\u4f01\u8fdb\u5c55\u8fc5\u901f\uff0c\u5728\u7814\u7ba1\u7ebf\u5c55\u73b0\u51fa\u5f3a\u52b2\u7684\u5b9e\u529b\u3002<\/p>\n

1\uff09\u8c6a\u68ee\u836f\u4e1aHS-10375\u5b9e\u73b0\u4e86\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u517c\u987e<\/strong><\/p>\n

HS-10375\u7531\u6c5f\u82cf\u8c6a\u68ee\u836f\u4e1a\u81ea\u4e3b\u7814\u53d1\uff0c\u662f\u4e00\u79cd\u53e3\u670d\u3001\u9ad8\u9009\u62e9\u6027\u7684\u7b2c\u56db\u4ee3EGFR\u6291\u5236\u5242\uff0c\u8be5\u4ea7\u54c1\u7684\u6838\u5fc3\u7814\u53d1\u76ee\u6807\u975e\u5e38\u660e\u786e\uff1a\u9776\u5411C797S\u7a81\u53d8\uff0c\u89e3\u51b3\u7b2c\u4e09\u4ee3EGFR-TKI\uff08\u5965\u5e0c\u66ff\u5c3c\uff09\u8010\u836f\u540e\u6700\u5e38\u89c1\u7684\u9776\u5185\u8010\u836f\u7a81\u53d8\u3002HS-10375\u80fd\u591f\u517c\u987e\u4e09\u91cd\u7a81\u53d8\uff0c\u5bf9Del19\/T790M\/C797S\u7b49\u9ad8\u96be\u5ea6\u7684\u4e09\u91cd\u7a81\u53d8\u540c\u65f6\u6709\u6548\u3002<\/p>\n

\u9488\u5bf9BLU-945\u5728\u4e34\u5e8a\u9636\u6bb5\u66b4\u9732\u51fa\u7684\u6cbb\u7597\u7a97\u53e3\u72ed\u7a84\u3001\u6bd2\u6027\u7a81\u51fa\u7684\u95ee\u9898\uff0cHS-10375\u5728\u65e9\u671f\u4e34\u5e8a\u8bbe\u8ba1\u4e2d\u66f4\u52a0\u6ce8\u91cd\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\uff0c\u4e0d\u518d\u5355\u7eaf\u8ffd\u6c42“\u6700\u5f3a\u7684\u9776\u70b9\u6291\u5236\u529b”\uff0c\u800c\u662f\u5bfb\u6c42\u6709\u6548\u6291\u5236\u4e0e\u53ef\u8010\u53d7\u6bd2\u6027\u4e4b\u95f4\u7684\u5e73\u8861\u3002\u8fd9\u4e00\u7b56\u7565\u8c03\u6574\u7684\u6548\u679c\u5728\u76ee\u524d\u5df2\u62ab\u9732\u7684\u6570\u636e\u4e2d\u5f97\u5230\u4e86\u4f53\u73b0\u3002<\/p>\n

HS-10375\u7684\u4e34\u5e8a\u2160\u671f\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u4ea7\u54c1\u7684\u5b89\u5168\u6027\u826f\u597d\uff1a81.5%\u7684\u60a3\u8005\u53d1\u751f\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\uff0c\u6700\u5e38\u89c1\u4e3a\u6076\u5fc3\uff0837%\uff09\u3001\u98df\u6b32\u4e0b\u964d\uff0833%\uff09\u3001AST\u5347\u9ad8\uff0833%\uff09\uff0c\u5747\u4e3a\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u3002\u867d\u7136\u6cbb\u7597\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4f46\u67091\u540d\u4e94\u7ebf\u6cbb\u7597\u5931\u8d25\u540e\u643a\u5e26EGFR C797S\u7a81\u53d8\u7684\u60a3\u8005\u5728HS-10375\u6cbb\u75976\u5468\u540e\u9776\u75c5\u7076\u7f29\u5c0f39.3%\u3002HS-10375\u5728EGFR C797S\u7a81\u53d8\u60a3\u8005\u4e2d\u521d\u6b65\u663e\u793a\u51fa\u6709\u6548\u6027\u3002\u5c3d\u7ba1\u8be5\u6570\u636e\u6837\u672c\u91cf\u6709\u9650\uff0c\u4ec5\u5305\u542b1\u4f8b\u786e\u8bca\u4e3aC797S\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u4f46\u4e3a\u7b2c\u56db\u4ee3EGFR-TKI\u836f\u7269HS-10375\u7684\u540e\u7eed\u5f00\u53d1\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n

C797S\u867d\u662f\u56db\u4ee3\u836f\u7684\u6838\u5fc3\u9776\u70b9\uff0c\u4f46\u4e34\u5e8a\u4e0a\u4ec5\u5360\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u768420%\u5de6\u53f3\u3002HS-10375\u7684\u4e34\u5e8a\u8bbe\u8ba1\u6ca1\u6709\u5b8c\u5168\u9501\u5b9aC797S\u9633\u6027\u4eba\u7fa4\uff0c\u800c\u662f\u5728\u6269\u5c55\u961f\u5217\u4e2d\u7eb3\u5165\u4e86\u591a\u79cd\u8010\u836f\u673a\u5236\u60a3\u8005\uff0c\u975eC797S\u4eba\u7fa4\u4e2d\u4e5f\u89c2\u5bdf\u5230\u90e8\u5206\u7f13\u89e3\u3002\u8fd9\u4e00\u73b0\u8c61\u8868\u660e\u8be5\u5316\u5408\u7269\u53ef\u80fd\u5bf9\u67d0\u4e9b\u65c1\u8def\u8010\u836f\u673a\u5236\u4e5f\u6709\u6291\u5236\u6548\u5e94\uff0c\u8fd9\u5c06\u6781\u5927\u62d3\u5c55\u5176\u672a\u6765\u7684\u4e34\u5e8a\u9002\u7528\u573a\u666f\u3002<\/p>\n

2\uff09\u7ea2\u4e91\u5236\u836fH002\u6709\u671b\u5b9e\u73b0\u516b\u79cdEGFR\u4e3b\u8981\u7a81\u53d8\u5168\u8986\u76d6<\/strong><\/p>\n

H002\u662f\u7ea2\u4e91\u5236\u836f\uff08\u539f\u540d\u7ea2\u4e91\u751f\u7269\uff09\u81ea\u4e3b\u5f00\u53d1\u7684\u7b2c\u56db\u4ee3 EGFR \u6291\u5236\u5242\u3002\u5f53EGFR\u4ea7\u751fC797S\u7a81\u53d8\uff0cC797S\u4f1a\u963b\u6b62EGFR\u7a81\u53d8\u4f53\u4e0e\u7b2c\u4e09\u4ee3TKI\uff08\u5305\u62ec\u5965\u5e0c\u66ff\u5c3c\uff09\u4e4b\u95f4\u5f62\u6210\u5171\u4ef7\u952e\uff0c\u56e0\u800c\u4ea7\u751f\u80bf\u7624\u8010\u836f\u3002<\/p>\n

\u7ea2\u4e91\u5236\u836f\u7684H002\u91c7\u7528\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u8bf1\u5bfc\u53d8\u6784\u8bbe\u8ba1\u3002\u7ea2\u4e91\u5236\u836f\u521b\u59cb\u4eba\u4e91\u5f69\u7ea2\u6559\u6388\u544a\u8bc9\u52a8\u8109\u7f51\uff0cH002\u80fd\u591f\u8986\u76d6L858R\u3001Del-19\u3001L858R\/T790M\u3001Del-19\/T790M\u3001L858R\/C797S\u3001Del-19\/C797S\u3001L858R\/T790M\/C797S\u3001Del-19\/T790M\/C797S\u516b\u79cd\u4e3b\u8981\u7a81\u53d8\uff0c\u53ef\u4ee5\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u7684\u4e34\u5e8a\u9009\u62e9\u3002<\/p>\n

\u76ee\u524dH002\u5728\u56fd\u5185\u6b63\u5904\u4e8e\u4e34\u5e8a\u2161\u671f\u9636\u6bb5\uff0c\u7528\u4e8e\u6cbb\u7597\u9488\u5bf9\u7ecf\u4e09\u4ee3EGFR-TKI\u4e00\u7ebf\u6216\u4e8c\u7ebf\u6cbb\u7597\u540e\u8010\u836f\u7684\u591a\u79cd\u542bC797S\u7a81\u53d8\u7ec4\u5408\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002\u6b64\u524d\u7684\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0cH002\u5b89\u5168\u6027\u826f\u597d\uff0c\u5373\u4f7f\u5728\u6700\u9ad8\u5242\u91cf\u4e0b\uff0c\u8be5\u4ea7\u54c1\u4f9d\u7136\u6709\u8f83\u597d\u7684\u5b89\u5168\u6027\u3002\u6b64\u5916\u636e\u52a8\u8109\u7f51\u4e86\u89e3\uff0cH002\u7528\u4e8e\u6cbb\u7597\u65e9\u671fEGFR\u7a81\u53d8\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5df2\u83b7\u5f97IND\u6279\u51c6\u3002<\/p>\n

H002\u7684\u8bbe\u8ba1\u8fc7\u7a0b\u4e2d\u517c\u987e\u4e86\u9009\u62e9\u6027\u3001\u5206\u5b50\u548c\u9776\u6807\u7684\u7ed3\u5408\u53ca\u6210\u836f\u6027\uff0c\u6709\u671b\u6210\u4e3a\u5168\u65b0\u7684\u7b2c\u56db\u4ee3EGFR\u9776\u5411\u836f\u3002<\/p>\n

3\uff09\u6d66\u5408\u533b\u836f<\/a>PH009-1 \u5177\u6709\u7a81\u53d8\u8986\u76d6\u5e7f\u6cdb\u548c\u9776\u5411\u9009\u62e9\u6027\u9ad8\u7684\u7279\u70b9<\/strong><\/p>\n

PH009-1 \u662f\u82cf\u5dde\u6d66\u5408\u533b\u836f\u5728\u7814\u7684\u7b2c\u56db\u4ee3EGFR\u6291\u5236\u5242\uff0c\u8be5\u4ea7\u54c1\u5177\u6709\u7a81\u53d8\u8986\u76d6\u5e7f\u6cdb\u548c\u9776\u5411\u9009\u62e9\u6027\u9ad8\u4e24\u5927\u7a81\u51fa\u7279\u70b9\u3002<\/p>\n

PH009-1 \u7684\u7a81\u53d8\u8986\u76d6\u5e7f\u6cdb\uff0c\u5bf9 EGFR \u7684\u5355\u7a81\u53d8\uff08L858R\u6216Del19\uff09\u3001\u53cc\u7a81\u53d8\uff08Del19\/C797S\u6216L858R\/C797S\uff09\u548c\u4e09\u7a81\u53d8\uff08Del19\/T790M\/C797S\u6216L858R\/T790M\/C797S\uff09\u5747\u5177\u6709\u5f3a\u6291\u5236\u6d3b\u6027\u3002PH009-1\u80fd\u591f\u540c\u65f6\u6291\u5236\u8fd9\u4e09\u7c7b\u7a81\u53d8\uff0c\u56e0\u800c\u80fd\u4e3a\u66f4\u591a\u56e0 EGFR \u7a81\u53d8\u800c\u8010\u836f\u7684\u60a3\u8005\u63d0\u4f9b\u6cbb\u7597\u673a\u4f1a\u3002<\/p>\n

BLU-945\u7684\u5f00\u53d1\u7ecf\u9a8c\u8868\u660e\uff0c\u56db\u4ee3EGFR\u4e0d\u4ec5\u8981\u6709\u6548\uff0c\u8fd8\u8981\u5b89\u5168\u3002PH009-1\u7684\u5206\u5b50\u7ed3\u6784\u5bf9\u542b\u6709C797S\u7b49\u7a81\u53d8\u578b\u7684EGFR\u5177\u6709\u6781\u9ad8\u7684\u4eb2\u548c\u529b\uff0c\u800c\u5bf9\u91ce\u751f\u578bEGFR\u7684\u4eb2\u548c\u529b\u663e\u8457\u964d\u4f4e\uff0c\u8fd9\u4f7f\u5f97PH009-1 \u7684\u9776\u5411\u9009\u62e9\u6027\u9ad8\u3002PH009-1 \u7684\u9ad8\u9009\u62e9\u6027\uff0c\u4f7f\u5176\u80fd\u66f4\u7cbe\u786e\u5730\u9776\u5411\u7a81\u53d8\u578b EGFR\uff0c\u51cf\u5c11\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u5f71\u54cd\uff0c\u964d\u4f4e\u526f\u4f5c\u7528\u7684\u53d1\u751f\u3002<\/p>\n

\u7cbe\u51c6\u6291\u5236\u590d\u6742\u7a81\u53d8\u4e0e\u9ad8\u5b89\u5168\u6027\u7684\u7ec4\u5408\u4f7fPH009-1\u6210\u4e3a\u4e00\u6b3e\u6709\u6f5c\u529b\u7684\u7b2c\u56db\u4ee3EGFR\u6291\u5236\u5242\u3002<\/p>\n

4\uff09\u5a01\u5c1a\u751f\u7269WSD0922-Fu\u88ab\u7eb3\u5165\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a<\/strong><\/p>\n

WSD0922-FU\u662f\u4e00\u79cd\u80fd\u591f\u7a7f\u900f\u8840\u8111\u5c4f\u969c\u7684\u9009\u62e9\u6027EGFR\u6291\u5236\u5242\uff0c\u9488\u5bf9EGFR\u53ca\u5176\u591a\u79cd\u7a81\u53d8\u4f53\uff08\u5305\u62ecEGFRv\u2162\uff09\u5177\u6709\u6291\u5236\u4f5c\u7528\u3002<\/p>\n

\u57282025\u5e74WCLC\u5927\u4f1a\u4e0a\uff0c\u5a01\u5c1a\u751f\u7269\u516c\u5e03\u4e86\u7b2c\u56db\u4ee3EGFR\u6291\u5236\u5242WSD0922-FU\u6cbb\u7597EGFR C797S\u7a81\u53d8\u665a\u671fNSCLC\u60a3\u8005\u7684I\/\u2161\u671f\u4e34\u5e8a\u6570\u636e\uff0c\u8be5\u4ea7\u54c1\u8868\u73b0\u51fa\u8f83\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002\u670942\u4f8b\u60a3\u8005\u63a5\u53d7\u4e86WSD0922-FU\u6cbb\u7597\uff0c\u8fd9\u4e9b\u60a3\u8005\u4e4b\u524d\u63a5\u53d7\u8fc7\u7b2c\u4e09\u4ee3EGFR-TKI\u6cbb\u7597\u3002\u5728\u53ef\u8bc4\u4f30\u7597\u6548\u7684\u60a3\u8005\u4e2d\uff08n=33\uff09\uff0cORR\u4e3a60.6%\uff0820\/33\uff09\uff0cDCR\u4e3a100%\u3002mPFS\u5c1a\u672a\u8fbe\u5230\u3002<\/p>\n

\u7531\u4e8e\u5a01\u5c1a\u751f\u7269\u7684WSD0922-FU\u5177\u6709\u8f83\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08>60%\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\u8fbe\u5230\u4e86100%\uff0c2026\u5e742\u67083\u65e5\uff0c\u8be5\u4ea7\u54c1\u88ab\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u7a0b\u5e8f\uff0c\u7528\u4e8e\u4e00\u7ebf\u7ecf\u7b2c\u4e09\u4ee3EGFR-TKI\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u3001\u5177\u6709EGFR C797S \u57fa\u56e0\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u3002<\/p>\n

\u76ee\u524d\u5728\u56db\u4ee3EGFR\u9776\u5411\u836f\u7684\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u56fd\u5185\u4f01\u4e1a\u5df2\u7ecf\u5177\u5907\u4e86\u9886\u5148\u4f18\u52bf\u3002<\/p>\n

\u56db\u4ee3EGFR\u8fdc\u975e\u7ec8\u5c40<\/strong><\/h3>\n

\u5c3d\u7ba1\u5e02\u573a\u5bf9\u56db\u4ee3EGFR\u9776\u5411\u836f\u5bc4\u4e88\u539a\u671b\uff0c\u4f46\u4e0d\u53ef\u5ffd\u7565\u7684\u662f\uff0c\u56db\u4ee3EGFR\u9776\u5411\u836f\u7684\u5f00\u53d1\u4ecd\u9762\u4e34\u6f5c\u5728\u6311\u6218\uff1a1\uff09\u9009\u62e9\u6027\u95ee\u9898\uff1a\u56db\u4ee3EGFR\u9776\u5411\u836f\u9700\u8981\u5bf9\u7a81\u53d8\u578bEGFR\u6709\u9ad8\u9009\u62e9\u6027\uff0c\u5e76\u964d\u4f4e\u5bf9\u91ce\u751f\u578bEGFR\u7684\u5f71\u54cd\uff0c\u4ece\u800c\u51cf\u5c11\u76ae\u75b9\u3001\u8179\u6cfb\u7b49\u526f\u4f5c\u7528\u3002\u5982\u679c\u8fd9\u4e9b\u95ee\u9898\u65e0\u6cd5\u6709\u6548\u907f\u514d\uff0c\u4f1a\u5f71\u54cd\u5230\u60a3\u8005\u7684\u4f9d\u4ece\u6027\u30022\uff09\u8010\u836f\u6027\u95ee\u9898\uff1a\u5c3d\u7ba1\u7b2c\u56db\u4ee3EGFR\u9776\u5411\u836f\u6709\u671b\u89e3\u51b3\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u95ee\u9898\uff0c\u4f46\u80bf\u7624\u5b58\u5728\u9002\u5e94\u6027\u8fdb\u5316\u7684\u80fd\u529b\uff0c\u5728\u63a5\u53d7\u56db\u4ee3\u836f\u6cbb\u7597\u540e\uff0c\u80bf\u7624\u7ec6\u80de\u4ecd\u6709\u53ef\u80fd\u901a\u8fc7\u65b0\u7684\u673a\u5236\u4ea7\u751f\u8010\u836f\u3002<\/p>\n

\u8fd9\u9700\u8981\u7814\u53d1\u4eba\u5458\u63a2\u7d22\u66f4\u591a\u7684\u6cbb\u7597\u53ef\u80fd\u6027\uff1a\u6bd4\u5982\u4e0e\u4f5c\u7528\u4e8e\u5176\u4ed6\u9776\u70b9\u7684\u836f\u7269\u6216\u8005\u514d\u75ab\u7597\u6cd5\u8054\u5408\u4f7f\u7528\uff1b\u6216\u8005\u5f00\u53d1\u51fa\u66f4\u597d\u7684\u56db\u4ee3EGFR\u9776\u5411\u836f\u4ea7\u54c1\uff0c\u4ece\u800c\u7531\u540e\u7ebf\u6551\u6025\u836f\u7269\u8f6c\u53d8\u4e3a\u524d\u7ebf\u6cbb\u7597\u836f\u7269\u3002\u76ee\u524d\u56db\u4ee3EGFR\u9776\u5411\u836f\u7684\u7814\u53d1\u8fd8\u5904\u4e8e\u65e9\u671f\u9636\u6bb5\uff0c\u6211\u4eec\u671f\u5f85\u8fd9\u4e00\u9886\u57df\u7684\u65b0\u4ea7\u54c1\u548c\u65b0\u7597\u6cd5\u80fd\u4e3a\u80bf\u7624\u60a3\u8005\u5e26\u6765\u66f4\u5927\u7684\u4e34\u5e8a\u83b7\u76ca\u3002<\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587 | vb\u52a8\u8109\u7f51 \u56db\u4ee3EGFR\u6b63\u5728\u6210\u4e3a\u80bf\u7624\u6cbb\u7597\u9886\u57df\u7684\u65b0\u7814\u53d1\u65b9\u5411\u3002 \u56db\u4ee3\u9776\u5411\u836f\u662f\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u8010\u836f\u95ee\u9898\u7814\u53d1\u7684\u65b0 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[252,275,241,88,192],"views":26,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/742574"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=742574"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/742574\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=742574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=742574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=742574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}