{"id":741687,"date":"2026-03-10T20:30:00","date_gmt":"2026-03-10T12:30:00","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=741687"},"modified":"2026-03-10T20:30:00","modified_gmt":"2026-03-10T12:30:00","slug":"%e3%80%8acell%e3%80%8b%e8%82%9d-%e8%84%91%e8%bf%90%e5%8a%a8%e4%bf%a1%e5%8f%b7%e8%bd%b4%e5%8f%88%e6%9c%89%e6%96%b0%e8%a7%81%e8%a7%a3%ef%bc%81%e5%8a%a0%e5%b7%9e%e5%a4%a7%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=741687","title":{"rendered":"\u300aCell\u300b\u201c\u809d-\u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74\u201d\u53c8\u6709\u65b0\u89c1\u89e3\uff01\u52a0\u5dde\u5927\u5b66\u56e2\u961f\u53d1\u73b0\u809d\u810f\u4f1a\u5206\u6ccc\u201c\u62a4\u8111\u56e0\u5b50\u201d\uff0c\u6216\u53ef\u9006\u8f6c\u8bb0\u5fc6\u8870\u9000"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u957f\u8c08<\/p>\n<\/blockquote>\n

\u4e3a\u4ec0\u4e48\u6709\u7684\u4eba\u5e74\u7eaa\u5927\u4e86\u8bb0\u6027\u8d8a\u6765\u8d8a\u5dee\uff0c\u800c\u575a\u6301\u953b\u70bc\u7684\u8001\u4eba\u5374\u80fd\u4fdd\u6301\u6e05\u6670\u7684\u601d\u7ef4\uff1f<\/p>\n

\u6211\u4eec\u4e00\u76f4\u4ee5\u4e3a\uff0c\u8fd0\u52a8\u62a4\u8111\uff0c\u662f\u8fd0\u52a8\u76f4\u63a5“\u953b\u70bc”\u4e86\u5927\u8111\u3002<\/p>\n

\u4f46\u6700\u65b0\u7814\u7a76\u53d1\u73b0\uff0c\u771f\u76f8\u53ef\u80fd\u6070\u6070\u76f8\u53cd——\u8fd0\u52a8\u62a4\u8111\uff0c\u9760\u7684\u7adf\u7136\u662f\u809d\u810f\u3002<\/p>\n

\u8fd1\u65e5\uff0c\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684 Gregor Bieri\u6559\u6388\u56e2\u961f\u548cSaul A. Villeda\u6559\u6388\u56e2\u961f\u5728\u300aCell\u300b\u4e0a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u7ed9\u51fa\u4e86\u4e00\u4e2a\u6f02\u4eae\u7684\u7b54\u6848\uff1a\u6bcf\u4e00\u6b21\u8fc8\u5f00\u7684\u817f\uff0c\u90fd\u5728\u7ed9\u809d\u810f\u53d1\u4fe1\u53f7\uff0c\u8ba9\u5b83\u751f\u4ea7\u4e00\u79cd“\u62a4\u8111\u56e0\u5b50”\uff0c\u7136\u540e\u901a\u8fc7\u8840\u6db2\u9001\u5230\u5927\u8111\uff0c\u4fee\u590d\u90a3\u4e9b\u8870\u8001\u7684\u8840\u7ba1\u3002<\/p>\n

\u8be5\u8bba\u6587\u9898\u76ee\u4e3a\u300aLiver exerkine reverses aging- and Alzheimer’srelated memory loss via vasculature \u300b\uff0c \u672c\u7814\u7a76\u53d1\u73b0\u809d\u810f\u5206\u6ccc\u7684\u8fd0\u52a8\u56e0\u5b50 GPLD1\u662f\u8c03\u63a7\u5927\u8111\u8840\u7ba1\u529f\u80fd\u7684\u5173\u952e\uff0c\u5b83\u80fd\u4fee\u590d\u8870\u8001\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6a21\u578b\u5c0f\u9f20\u7684\u8840\u8111\u5c4f\u969c\u635f\u4f24\uff0c\u9006\u8f6c\u5176\u8bb0\u5fc6\u8870\u9000\uff1b\u540c\u65f6\u6291\u5236 TNAP \u4e5f\u80fd\u590d\u523b GPLD1 \u7684\u8ba4\u77e5\u6539\u5584\u6548\u679c\uff0c\u8bc1\u5b9e\u809d - \u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74\u901a\u8fc7\u8111\u8840\u7ba1\u4ecb\u5bfc\u8ba4\u77e5\u83b7\u76ca\uff0c\u4e3a\u8870\u8001\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u5916\u5468\u9776\u70b9\u3002<\/p>\n

\"\u300aCell\u300b\u201c\u809d-\u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74\u201d\u53c8\u6709\u65b0\u89c1\u89e3\uff01\u52a0\u5dde\u5927\u5b66\u56e2\u961f\u53d1\u73b0\u809d\u810f\u4f1a\u5206\u6ccc\u201c\u62a4\u8111\u56e0\u5b50\u201d\uff0c\u6216\u53ef\u9006\u8f6c\u8bb0\u5fc6\u8870\u9000\"<\/p>\n

\u4e00\u4e2a\u53cd\u5e38\u8bc6\u7684\u53d1\u73b0<\/h1>\n

\u9996\u5148\uff0c\u7814\u7a76\u8005\u8ba9\u8001\u5e74\u5c0f\u9f20\u81ea\u613f\u8fd0\u52a8——\u7ed3\u679c\u548c\u9884\u671f\u4e00\u6837\uff1a\u5b83\u4eec\u8bb0\u6027\u53d8\u597d\u4e86\u3002<\/p>\n

\u4f46\u8ffd\u8e2a\u4e0b\u53bb\uff0c\u53d1\u73b0\u4e86\u4e00\u4e2a\u53cd\u5e38\u8bc6\u7684\u73b0\u8c61\uff1a<\/p>\n

\u8fd0\u52a8\u4e4b\u540e\uff0c\u5927\u8111\u672c\u8eab\u53d8\u5316\u4e0d\u5927\uff0c\u53cd\u800c\u662f\u809d\u810f\u91ccGPLD1\u86cb\u767d\u8e6d\u8e6d\u5f80\u4e0a\u6da8\u3002<\/p>\n

\u901a\u8fc7\u4f53\u5916 TNAP \u5207\u5272\u5b9e\u9a8c\u548c\u4f53\u5185\u809d\u810f\u8fc7\u8868\u8fbe GPLD1 \u5b9e\u9a8c\uff0c\u8bc1\u5b9eTNAP\u662f GPLD1 \u7684\u76f4\u63a5\u5e95\u7269\uff0cGPLD1 \u53ef\u5207\u5272\u5e76\u964d\u4f4e\u8001\u5e74\u5c0f\u9f20\u6d77\u9a6c\u8840\u7ba1\u7684 TNAP \u8868\u8fbe\u4e0e\u6d3b\u6027\uff0c\u4e5f\u5c31\u662f\u8bf4\u8fd0\u52a8\u8bf1\u5bfc\u7684\u809d\u810f GPLD1 \u80fd\u7cbe\u51c6\u4f5c\u7528\u4e8e\u8111\u8840\u7ba1\u7684 TNAP \u86cb\u767d\u3002<\/p>\n

\"\u300aCell\u300b\u201c\u809d-\u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74\u201d\u53c8\u6709\u65b0\u89c1\u89e3\uff01\u52a0\u5dde\u5927\u5b66\u56e2\u961f\u53d1\u73b0\u809d\u810f\u4f1a\u5206\u6ccc\u201c\u62a4\u8111\u56e0\u5b50\u201d\uff0c\u6216\u53ef\u9006\u8f6c\u8bb0\u5fc6\u8870\u9000\"<\/p>\n

GPLD1\u662f\u600e\u4e48\u62a4\u8111\u7684\uff1f<\/h1>\n

\u901a\u8fc7AAV \u4ecb\u5bfc\u809d\u810f\u8fc7\u8868\u8fbe\u3001\u8840\u8111\u5c4f\u969c\u6e17\u6f0f\u5b9e\u9a8c\u7b49\u53d1\u73b0\uff0cGPLD1 \u53ef\u51cf\u5c11\u8001\u5e74\u5c0f\u9f20\u6d77\u9a6c\u7684\u8840\u8111\u5c4f\u969c\u6e17\u6f0f\uff0c\u6062\u590d\u53d7\u4f53\u4ecb\u5bfc\u7684\u7269\u8d28\u8f6c\u8fd0\uff0c\u964d\u4f4e\u8840\u7ba1\u7a96\u86cb\u767d 1 \u8868\u8fbe\u3002<\/p>\n

\u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u5355\u7ec6\u80de\u6d4b\u5e8f\u663e\u793a\uff0cGPLD1 \u80fd\u9006\u8f6c\u8001\u5e74\u5c0f\u9f20\u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e2d\u7684\u8870\u8001\u76f8\u5173\u8f6c\u5f55\u53d8\u5316\uff0c\u5bcc\u96c6\u51fa\u708e\u75c7\u3001\u80fd\u91cf\u4ee3\u8c22\u7b49\u76f8\u5173\u901a\u8def\uff0c\u5373GPLD1 \u4ece\u7ed3\u6784\u548c\u5206\u5b50\u5c42\u9762\u5168\u9762\u4fee\u590d\u4e86\u8870\u8001\u7684\u8840\u8111\u5c4f\u969c\u3002<\/p>\n

\"\u300aCell\u300b\u201c\u809d-\u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74\u201d\u53c8\u6709\u65b0\u89c1\u89e3\uff01\u52a0\u5dde\u5927\u5b66\u56e2\u961f\u53d1\u73b0\u809d\u810f\u4f1a\u5206\u6ccc\u201c\u62a4\u8111\u56e0\u5b50\u201d\uff0c\u6216\u53ef\u9006\u8f6c\u8bb0\u5fc6\u8870\u9000\"<\/p>\n

TNAP \u5f02\u5e38\u662f\u8ba4\u77e5\u635f\u4f24\u7684\u5143\u51f6<\/h1>\n

\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u8005\u8ba9\u5e74\u8f7b\u5c0f\u9f20\u7684\u8111\u8840\u7ba1\u8fc7\u8868\u8fbeTNAP——\u7ed3\u679c\uff0c\u8fd9\u4e9b\u672c\u8be5\u8bb0\u6027\u5f88\u597d\u7684\u5c0f\u9f20\uff0c\u51fa\u73b0\u4e86\u8001\u5e74\u4e00\u6837\u7684\u8bb0\u5fc6\u8870\u9000\uff0c\u8840\u8111\u5c4f\u969c\u4e5f\u6f0f\u4e86\u3002<\/p>\n

\u800c\u4f7f\u7528CRISPR\u6280\u672f\u6572\u9664TNAP\uff0c\u6216\u8005\u53e3\u670d\u6291\u5236\u5242SBI-425\uff0c\u8001\u5e74\u5c0f\u9f20\u7684\u8bb0\u5fc6\u6062\u590d\u4e86<\/strong>\uff0c\u6548\u679c\u548c\u8fd0\u52a8\u3001\u548c\u8fc7\u8868\u8fbeGPLD1\u4e00\u6a21\u4e00\u6837\u3002<\/p>\n

\u4ee5\u4e0a\u7ed3\u679c\u8bf4\u660e TNAP \u662f\u4ecb\u5bfc\u8870\u8001\u8ba4\u77e5\u635f\u4f24\u7684\u6838\u5fc3\u9776\u70b9\uff0c\u6291\u5236\u5b83\u53ef\u590d\u523b GPLD1 \u7684\u8ba4\u77e5\u83b7\u76ca\u3002<\/p>\n

\"\u300aCell\u300b\u201c\u809d-\u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74\u201d\u53c8\u6709\u65b0\u89c1\u89e3\uff01\u52a0\u5dde\u5927\u5b66\u56e2\u961f\u53d1\u73b0\u809d\u810f\u4f1a\u5206\u6ccc\u201c\u62a4\u8111\u56e0\u5b50\u201d\uff0c\u6216\u53ef\u9006\u8f6c\u8bb0\u5fc6\u8870\u9000\"<\/p>\n

\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6709\u65b0\u5e0c\u671b<\/h1>\n

\u6700\u540e\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u5728 5xFAD \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6a21\u578b\u5c0f\u9f20\u4e2d\uff0c\u81ea\u613f\u8fd0\u52a8\uff0c\u8fc7\u8868\u8fbe GPLD1 \uff0c\u6216\u6291\u5236 TNAP \uff0c\u5747\u80fd\u51cf\u5c11\u5c0f\u9f20\u8111\u5185 β \u6dc0\u7c89\u6837\u86cb\u767d\u6c89\u79ef\uff0c\u6062\u590d\u795e\u7ecf\u53d1\u751f\u548c\u7a81\u89e6\u53ef\u5851\u6027\uff0c\u6539\u5584\u5176\u8bb0\u5fc6\u7f3a\u9677\uff1b<\/p>\n

\u540c\u65f6\u53d1\u73b0\u8001\u5e74\u4eba\u7fa4\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u8111\u5185 TNAP \u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff0c\u8bc1\u5b9e GPLD1\/TNAP \u8f74\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e2d\u540c\u6837\u5177\u6709\u8c03\u63a7\u4f5c\u7528\u3002<\/p>\n

\"\u300aCell\u300b\u201c\u809d-\u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74\u201d\u53c8\u6709\u65b0\u89c1\u89e3\uff01\u52a0\u5dde\u5927\u5b66\u56e2\u961f\u53d1\u73b0\u809d\u810f\u4f1a\u5206\u6ccc\u201c\u62a4\u8111\u56e0\u5b50\u201d\uff0c\u6216\u53ef\u9006\u8f6c\u8bb0\u5fc6\u8870\u9000\"<\/p>\n

\u5168\u6587\u603b\u7ed3<\/h1>\n

\u672c\u7814\u7a76\u8bc1\u5b9e\u809d\u810f\u5206\u6ccc\u7684\u8fd0\u52a8\u56e0\u5b50 GPLD1 \u662f\u809d - \u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74\u7684\u6838\u5fc3\u5206\u5b50\uff0c\u5176\u901a\u8fc7\u5207\u5272\u8111\u8840\u7ba1\u7684 TNAP \u86cb\u767d\uff0c\u4fee\u590d\u8840\u8111\u5c4f\u969c\u529f\u80fd\u3001\u9006\u8f6c\u8870\u8001\u76f8\u5173\u7684\u8f6c\u5f55\u7d0a\u4e71\uff0c\u8fdb\u800c\u6539\u5584\u8870\u8001\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6a21\u578b\u5c0f\u9f20\u7684\u8ba4\u77e5\u635f\u4f24\uff1b\u660e\u786e\u4e86\u8111\u8840\u7ba1\u662f\u8fd0\u52a8\u548c GPLD1 \u53d1\u6325\u8ba4\u77e5\u4fdd\u62a4\u4f5c\u7528\u7684\u5173\u952e\u9776\u70b9\uff0c\u4e3a\u4ece\u5916\u5468\u5668\u5b98\u5e72\u9884\u4e2d\u67a2\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u63d0\u4f9b\u4e86\u65b0\u65b9\u5411\u3002<\/p>\n

\u7814\u7a76\u610f\u4e49<\/h1>\n

\u7406\u8bba\u610f\u4e49<\/strong>\uff1a\u9996\u6b21\u8bc1\u5b9e\u809d\u810f\u5206\u6ccc\u7684\u8fd0\u52a8\u56e0\u5b50\u80fd\u76f4\u63a5\u8c03\u63a7\u8111\u8840\u7ba1\u529f\u80fd\uff0c\u63ed\u793a\u4e86\u4e00\u6761\u5b8c\u6574\u7684“\u809d-\u8111\u8fd0\u52a8\u4fe1\u53f7\u8f74”\u3002<\/p>\n

\u5e94\u7528\u610f\u4e49<\/strong>\uff1a\u7ed5\u5f00\u4e86\u8840\u8111\u5c4f\u969c\u8fd9\u4e2a\u836f\u7269\u7814\u53d1\u7684\u6700\u5927\u969c\u788d\u3002\u9776\u70b9\u5728\u8840\u7ba1\u4e0a\uff0c\u836f\u7269\u4e0d\u7528\u8fdb\u8111\u5b50\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u7814\u53d1\u96be\u5ea6\u548c\u526f\u4f5c\u7528\u98ce\u9669<\/a>\uff0c\u4e3a\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u6cbb\u7597\u6253\u5f00\u4e86\u65b0\u65b9\u5411\u3002<\/p>\n

\u5c0f\u7f16\u5bc4\u8bed<\/h1>\n

\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u836f\u7269\u7814\u53d1\uff0c\u4e3a\u4ec0\u4e48\u8fd9\u4e48\u96be\uff1f\u4e00\u4e2a\u6838\u5fc3\u539f\u56e0\u662f\uff1a\u8840\u8111\u5c4f\u969c\u3002\u5f88\u591a\u80fd\u6cbb\u75c5\u7684\u5206\u5b50\uff0c\u6839\u672c\u8fdb\u4e0d\u53bb\u5927\u8111\u3002\u5f3a\u884c\u8fdb\u53bb\uff0c\u53ef\u80fd\u5e26\u6765\u526f\u4f5c\u7528\u3002\u4f46GPLD1\/TNAP\u8fd9\u4e2a\u9776\u70b9\uff0c\u5999\u5c31\u5999\u5728\uff1a\u5b83\u5c31\u5728\u8111\u8840\u7ba1\u4e0a\uff0c\u4e0d\u7528\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u3002\u53e3\u670dTNAP\u6291\u5236\u5242SBI-425\uff0c\u5df2\u7ecf\u5728\u5c0f\u9f20\u8eab\u4e0a\u9a8c\u8bc1\u4e86\u6548\u679c\u3002<\/p>\n

\u8fd9\u8ba9\u6211\u4eec\u91cd\u65b0\u601d\u8003\uff1a\u62a4\u8111\uff0c\u53ef\u80fd\u8981\u4ece\u62a4“\u809d”\u5f00\u59cb\u3002\u672a\u6765\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u53ef\u80fd\u53ea\u9700\u8981\u5403\u4e00\u7247\u836f\uff0c\u5c31\u80fd\u5ef6\u7f13\u8bb0\u5fc6\u8870\u9000\u3002<\/p>\n

\u867d\u7136\u8def\u8fd8\u5f88\u957f\uff0c\u4f46\u65b9\u5411\u5df2\u7ecf\u4eae\u4e86\u3002<\/p>\n

\u539f\u6587\u94fe\u63a5\uff1a<\/span><\/span><\/span><\/span><\/span>
<\/span><\/span>https:\/\/doi.org\/10.1016\/j.cell.2026.01.024<\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n","protected":false},"excerpt":{"rendered":"

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