{"id":739789,"date":"2026-03-08T19:52:33","date_gmt":"2026-03-08T11:52:33","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=739789"},"modified":"2026-03-08T19:52:33","modified_gmt":"2026-03-08T11:52:33","slug":"science%ef%bd%9c%e6%94%bb%e5%85%8bad%e7%8e%b0%e6%9b%99%e5%85%89%ef%bc%81%e7%be%8e%e5%9b%bd%e7%a7%91%e5%ad%a6%e5%ae%b6%e5%bc%80%e5%8f%91%e6%96%b0%e5%9e%8bcar-a%e7%96%97%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=739789","title":{"rendered":"Science\uff5c\u653b\u514bAD\u73b0\u66d9\u5149\uff01\u7f8e\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u65b0\u578bCAR-A\u7597\u6cd5"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u662f\u8001\u5e74\u4eba\u6700\u5e38\u89c1\u7684\u75f4\u5446\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u8bb0\u6027\u8d8a\u6765\u8d8a\u5dee\u3001\u8ba4\u4e0d\u51fa\u5bb6\u4eba\u3001\u751f\u6d3b\u6162\u6162\u4e0d\u80fd\u81ea\u7406\uff0c\u7ed9\u60a3\u8005\u548c\u5bb6\u5ead\u90fd\u5e26\u6765\u6c89\u91cd\u8d1f\u62c5\u3002\u8fd9\u79cd\u75c5\u5728\u5927\u8111\u91cc\u5148\u51fa\u73b0\u5f02\u5e38\u86cb\u767d\u5806\u79ef\uff0c\u518d\u5f15\u53d1\u795e\u7ecf\u635f\u4f24\uff0c\u5bfc\u81f4\u8ba4\u77e5\u529f\u80fd\u6301\u7eed\u4e0b\u964d\u3002<\/p>\n

\u57fa\u4e8e\u6b64\uff0c2026\u5e743\u67085\u65e5\uff0c\u534e\u76db\u987f\u5927\u5b66Marco Colonna\u7814\u7a76\u56e2\u961f\u5728Science\u6742\u5fd7\u53d1\u8868\u4e86“Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy”\u63ed\u793a\u4e86\u901a\u8fc7\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\uff08CAR-A\uff09\u7597\u6cd5\u9776\u5411β-\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u7406\u3002<\/p>\n

\"Science\uff5c\u653b\u514bAD\u73b0\u66d9\u5149\uff01\u7f8e\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u65b0\u578bCAR-A\u7597\u6cd5\"<\/p>\n

\u5728\u6b64\uff0c\u4f5c\u8005\u4ecb\u7ecd\u4e86\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\u8868\u8fbe\u7684\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR-A\uff09\u5e76\u5728\u4f53\u5916\u9a8c\u8bc1\u4e86\u5176\u529f\u80fd\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e24\u79cdCAR-A\u8bbe\u8ba1\u4e0d\u4ec5\u80fd\u51cf\u5c11\u6591\u5757\u5f62\u6210\u540e\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u53ca\u76f8\u5173\u75c5\u7406\u6539\u53d8\uff0c\u8fd8\u80fd\u5728\u4f53\u5185\u9884\u9632\u65e9\u671f\u6591\u5757\u7684\u6c89\u79ef\u3002\u5355\u6838RNA\u6d4b\u5e8f\u663e\u793a\uff0cCAR-A\u6cbb\u7597\u8bf1\u5bfc\u4e86\u4e00\u79cd\u9488\u5bf9\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u7406\u7684\u72ec\u7279\u80f6\u8d28\u7ec6\u80de\u53cd\u5e94\uff0c\u6d89\u53ca\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e0e\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u534f\u540c\u6d3b\u52a8\u3002\u6b64\u5916\uff0c\u6bcf\u79cd\u6784\u5efa\u4f53\u8fd8\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6216\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d\u5f15\u53d1\u4e86\u72ec\u7279\u7684\u3001\u53d7\u4f53\u7279\u5f02\u6027\u7684\u6548\u5e94\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u4e86CAR-A\u4f5c\u4e3aAD\u75be\u75c5\u4fee\u9970\u7b56\u7565<\/a>\u7684\u6cbb\u7597\u6f5c\u529b\u3002<\/p>\n

\"Science\uff5c\u653b\u514bAD\u73b0\u66d9\u5149\uff01\u7f8e\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u65b0\u578bCAR-A\u7597\u6cd5\"<\/p>\n

\u56fe\u4e00 \u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u4f53\u5916Aβ\u7279\u5f02\u6027CAR\u8bbe\u8ba1\u4e0e\u9a8c\u8bc1<\/span><\/span><\/p>\n

\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u91cc\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u90fd\u6709\u541e\u566c\u6e05\u7406\u4f5c\u7528\uff0c\u80fd\u5403\u6389\u7ec6\u80de\u788e\u7247\u7b49\u7269\u8d28\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de\u8fd8\u53ef\u901a\u8fc7\u6297\u4f53\u76f8\u5173\u53d7\u4f53\u541e\u566c\u76ee\u6807\u3002<\/p>\n

\u4e3a\u4e86\u505a\u51fa\u80fd\u6e05\u9664Aβ\u7684CAR\uff0c\u7814\u7a76\u8005\u628a\u6297Aβ\u6297\u4f53\u7247\u6bb5\u5206\u522b\u8fde\u63a5\u5230\u4e0d\u540c\u53d7\u4f53\u548c\u4fe1\u53f7\u533a\u57df\uff0c\u5b9e\u9a8c\u53d1\u73b0\u6539\u9020\u540e\u7684\u7ec6\u80de\u80fd\u4e13\u95e8\u541e\u566c\u964d\u89e3Aβ\uff0c\u4e0d\u4f1a\u4e71\u541e\u566c\u5176\u4ed6\u86cb\u767d\uff0c\u5728\u539f\u4ee3\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u91cc\u4e5f\u80fd\u660e\u663e\u589e\u5f3aAβ\u6e05\u7406\u3002\u7528\u4e24\u79cd\u6297\u4f53\u7247\u6bb5\u4f18\u5316\u540e\uff0cCre-Megf10\u6548\u679c\u6700\u597d\uff0cCre-Dectin1\u548cAdu-Dectin1\u6548\u679c\u76f8\u8fd1\uff0c\u4e8e\u662f\u9009\u7528\u8fd9\u4e24\u79cd\u6784\u5efa\u8f7d\u4f53\u505a\u52a8\u7269\u5b9e\u9a8c\u3002<\/p>\n

\u7ec6\u80de\u5b9e\u9a8c\u663e\u793a\u8fd9\u4e24\u79cdCAR\u90fd\u80fd\u63d0\u9ad8\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6444\u53d6Aβ\u7684\u80fd\u529b\uff0cCre-Megf10\u66f4\u7a81\u51fa\uff0cAdu-Dectin1\u8fd8\u80fd\u4fc3\u8fdb\u5c0f\u80f6\u8d28\u7ec6\u80de\u541e\u566c\uff1b\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c\u8868\u660eAdu-Dectin1\u53ef\u660e\u663e\u63d0\u5347\u8111\u5185\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5bf9Aβ\u7684\u6444\u53d6\uff0c\u4e24\u79cdCAR\u5728AD\u6a21\u578b\u5c0f\u9f20\u8111\u4e2d\u80fd\u7a33\u5b9a\u8868\u8fbe\u8f83\u957f\u65f6\u95f4\uff0c\u9633\u6027\u7ec6\u80de\u4f1a\u805a\u96c6\u5728\u6dc0\u7c89\u6837\u6591\u5757\u5468\u56f4\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8bf4\u660eCre-Megf10\u548cAdu-Dectin1\u8fd9\u4e24\u79cdCAR\u7597\u6cd5\u503c\u5f97\u8fdb\u4e00\u6b65\u5f00\u5c55\u66f4\u5927\u89c4\u6a21\u7684\u4f53\u5185\u7814\u7a76\u3002<\/p>\n

\"Science\uff5c\u653b\u514bAD\u73b0\u66d9\u5149\uff01\u7f8e\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u65b0\u578bCAR-A\u7597\u6cd5\"<\/p>\n

\u56fe\u4e8c \u5355\u6b21\u665a\u671fAAV-CAR-A\u6cbb\u7597\u5728\u4f53\u5185\u51cf\u5c11\u4e86\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u53d8\u53ca\u5176\u76f8\u5173\u75c5\u7406\u6539\u53d8<\/span><\/span><\/p>\n

\u8fd9\u9879\u7814\u7a76\u8bc4\u4f30\u4e86\u5355\u6b21\u9759\u8109\u6ce8\u5c04AAV-PHP.eB\u9012\u9001\u7684CAR-A\u7597\u6cd5\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6a21\u578b\u5c0f\u9f20\u7684\u7597\u6548\uff1a<\/p>\n

\u7814\u7a76\u4eba\u5458\u57286\u6708\u9f84\u5c0f\u9f20\u53d1\u75c5\u5e73\u53f0\u671f\u6ce8\u5165\uff08Cre-Megf10\u6216Adu-Dectin1\uff09\u75c5\u6bd2\uff0c3\u4e2a\u6708\u540e\u53d1\u73b0\u4e24\u79cd\u7597\u6cd5\u5747\u4f7f\u5927\u8111\u76ae\u5c42\u548c\u6d77\u9a6c\u533a\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u8d1f\u8377\u663e\u8457\u964d\u4f4e\u7ea650%\u5e76\u6709\u6548\u6e05\u9664\u4e86\u6bd2\u6027\u8f83\u5f3a\u7684\u4e0d\u6eb6\u6027Aβ42\u805a\u96c6\u4f53\uff0c\u8fdb\u800c\u5927\u5e45\u51cf\u5c11\u4e86\u6591\u5757\u5468\u56f4\u7684\u795e\u7ecf\u7ea4\u7ef4\u635f\u4f24\uff1b<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u867d\u7136\u4e24\u79cd\u7597\u6cd5\u90fd\u80fd\u6e05\u9664\u6591\u5757\uff0c\u4f46\u53ea\u6709Cre-Megf10\u6cbb\u7597\u7ec4\u989d\u5916\u5b9e\u73b0\u4e86\u7a81\u89e6\u540e\u7ed3\u6784\u7684\u4fee\u590d\uff0c\u90e8\u5206\u6062\u590d\u4e86\u795e\u7ecf\u5143\u95f4\u7684\u8fde\u63a5\u5b8c\u6574\u6027\uff0c\u8bc1\u660e\u8be5\u7597\u6cd5\u5c24\u5176\u662fCre-Megf10\u65b9\u6848\u5728\u6e05\u9664\u75c5\u7406\u86cb\u767d\u548c\u6539\u5584\u795e\u7ecf\u529f\u80fd\u65b9\u9762\u5177\u6709\u663e\u8457\u7684\u4f53\u5185\u6cbb\u7597\u6f5c\u529b\u3002<\/p>\n

\"Science\uff5c\u653b\u514bAD\u73b0\u66d9\u5149\uff01\u7f8e\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u65b0\u578bCAR-A\u7597\u6cd5\"<\/p>\n

\u56fe\u4e09 \u4e24\u79cdCAR-A\u6cbb\u7597\u53ef\u8bf1\u5bfc\u51fa\u4e0d\u540c\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u53cd\u5e94<\/span><\/span><\/p>\n

\u8fd9\u9879\u7814\u7a76\u63ed\u793a\uff0c\u4e24\u79cdCAR-A\u7597\u6cd5\u901a\u8fc7\u964d\u4f4eAD\u5c0f\u9f20\u8111\u5185\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u8d1f\u8377\uff0c\u663e\u8457\u6539\u53d8\u4e86\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u751f\u5b58\u72b6\u6001\uff1a\u5b83\u4eec\u6210\u529f\u6291\u5236\u4e86\u4ee3\u8868\u7ec6\u80de\u9ad8\u538b\u4e0e\u8017\u7aed\u7684\u7ecf\u5178“\u75be\u75c5\u76f8\u5173\u5c0f\u80f6\u8d28\u7ec6\u80de”\uff08DAM1\/DAM2\u578b\uff09\uff0c\u8f6c\u800c\u4fc3\u8fdb\u4e86\u4e00\u79cd\u72ec\u7279\u7684“CSF1R\u9ad8\/CD68\u9ad8”\u6df7\u5408\u4e9a\u7fa4\u7684\u5f62\u6210\u3002<\/p>\n

\u8fd9\u79cd\u65b0\u578b\u7ec6\u80de\u65e2\u4fdd\u7559\u4e86\u5065\u5eb7\u7a33\u6001\u7279\u5f81\uff0c\u53c8\u5177\u5907\u9ad8\u6548\u7684\u6e05\u7406\u80fd\u529b\uff0c\u7279\u522b\u662f\u5728Adu-Dectin1\u6cbb\u7597\u7ec4\u4e2d\uff0c\u8fd8\u89c2\u5bdf\u5230\u66f4\u5f3a\u7684\u6297\u539f\u5448\u9012\uff08MHC-II\uff09\u6d3b\u6027\u53ca\u6591\u5757\u541e\u566c\u73b0\u8c61\uff1b<\/p>\n

\u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u79cd\u4ece“\u8fc7\u5ea6\u6fc0\u6d3b\u8017\u7aed”\u5411“\u6e29\u548c\u9ad8\u6548\u5b88\u62a4”\u7684\u8868\u578b\u8f6c\u53d8\uff0c\u53cd\u6620\u4e86\u5c0f\u80f6\u8d28\u7ec6\u80de\u56e0\u75c5\u7406\u8d1f\u62c5\u51cf\u8f7b\u800c\u83b7\u5f97\u7684\u538b\u529b\u91ca\u653e\u4e0e\u529f\u80fd\u6062\u590d\uff0c\u53ef\u80fd\u662f\u6cbb\u7597\u8d77\u6548\u7684\u5173\u952e\u673a\u5236\u3002<\/p>\n

\u603b\u7ed3<\/p>\n

CAR-A\u7597\u6cd5\u901a\u8fc7\u6e05\u9664\u90e8\u5206\u6dc0\u7c89\u6837\u86cb\u767d\uff0c\u8ba9\u539f\u672c\u56e0\u8fc7\u5ea6\u5de5\u4f5c\u800c“\u7cbe\u75b2\u529b\u7aed”\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\uff0c\u6062\u590d\u6210\u4e86\u4e00\u79cd\u65e2\u80fd\u6709\u6548\u6e05\u7406\u5783\u573e\u3001\u53c8\u4fdd\u6301\u76f8\u5bf9\u5065\u5eb7\u548c\u51b7\u9759\u7684“\u6df7\u5408\u4fdd\u62a4\u72b6\u6001”\u3002<\/p>\n

\u6587\u7ae0\u6765\u6e90\uff1a<\/span><\/span><\/p>\n

https:\/\/doi.org\/10.1126\/science.ads3972<\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587 | \u8111\u58f0\u5e38\u8c08 \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u662f\u8001\u5e74\u4eba\u6700\u5e38\u89c1\u7684\u75f4\u5446\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u8bb0\u6027\u8d8a\u6765\u8d8a\u5dee\u3001\u8ba4\u4e0d\u51fa\u5bb6\u4eba\u3001\u751f\u6d3b\u6162\u6162\u4e0d\u80fd\u81ea\u7406\uff0c\u7ed9\u60a3 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[88,367],"views":37,"_links":{"self":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/739789"}],"collection":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=739789"}],"version-history":[{"count":0,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=\/wp\/v2\/posts\/739789\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=739789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=739789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alphaseek.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=739789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}