{"id":739788,"date":"2026-03-08T19:49:30","date_gmt":"2026-03-08T11:49:30","guid":{"rendered":"https:\/\/www.alphaseek.cn\/?p=739788"},"modified":"2026-03-08T19:49:30","modified_gmt":"2026-03-08T11:49:30","slug":"nat-aging%ef%bd%9c%e5%8d%97%e4%ba%ac%e5%a4%a7%e5%ad%a6%e9%83%ad%e4%bf%9d%e7%94%9f-%e8%92%8b%e9%9d%92%e7%ad%89%e6%8f%ad%e7%a4%ba%e8%bf%90%e5%8a%a8%e6%94%b9%e5%96%84ad%e8%ae%a4%e7%9f%a5%e9%9a%9c","status":"publish","type":"post","link":"https:\/\/www.alphaseek.cn\/?p=739788","title":{"rendered":"Nat Aging\uff5c\u5357\u4eac\u5927\u5b66\u90ed\u4fdd\u751f\/\u848b\u9752\u7b49\u63ed\u793a\u8fd0\u52a8\u6539\u5584AD\u8ba4\u77e5\u969c\u788d\u7684\u201c\u808c-\u8111\u901a\u8baf\u201d\u65b0\u673a\u5236"},"content":{"rendered":"
\n

\u6587 | \u8111\u58f0\u5e38\u8c08<\/p>\n<\/blockquote>\n

\u4e3a\u4ec0\u4e48\u575a\u6301\u8fd0\u52a8\u7684\u8001\u4eba\uff0c\u8bb0\u5fc6\u529b\u8870\u9000\u7684\u901f\u5ea6\u5f80\u5f80\u66f4\u6162\uff1f\u8eab\u8fb9\u4e0d\u5c11\u957f\u8f88\u9000\u4f11\u540e\u575a\u6301\u6563\u6b65\u3001\u6253\u592a\u6781\uff0c\u4e0d\u4ec5\u8eab\u4f53\u66f4\u786c\u6717\uff0c\u601d\u7ef4\u4e5f\u66f4\u6e05\u6670\uff0c\u8fd9\u80cc\u540e\u96be\u9053\u53ea\u662f\u7b80\u5355\u7684\u5f3a\u8eab\u5065\u4f53\u5417\uff1f\u6700\u65b0\u7814\u7a76\u53d1\u73b0\uff0c\u8fd0\u52a8\u5bf9\u5927\u8111\u7684\u786e\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u9632\u6cbb\u6253\u5f00\u4e86\u5168\u65b0\u89c6\u89d2\u3002<\/p>\n

2026\u5e743\u67082\u65e5\uff0c\u5357\u4eac\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u9f13\u697c\u533b\u9662\u90ed\u4fdd\u751f\u6559\u6388\u3001\u848b\u9752\u6559\u6388\u3001\u9648\u54cd\u526f\u7814\u7a76\u5458<\/span><\/span><\/strong><\/strong>\u56e2\u961f\u5728\u300aNature Aging\u300b\u4e0a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u7ed9\u51fa\u4e86\u4e00\u4e2a\u6f02\u4eae\u7684\u7b54\u6848\uff1a\u808c\u8089\u4f1a\u91ca\u653e\u4e00\u79cd\u4fe1\u4f7f\uff0c\u8dd1\u5230\u5927\u8111\u5e2e\u795e\u7ecf\u5143“\u6253\u626b\u536b\u751f”\u3002<\/strong><\/p>\n

\u8be5\u8bba\u6587\u9898\u76ee\u4e3a\u300a Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia \u300b\uff0c\u672c\u7814\u7a76\u4ee5 APP\/PS1 \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5c0f\u9f20\u4e3a\u6a21\u578b\uff0c\u53d1\u73b0\u6e38\u6cf3\u8fd0\u52a8\u53ef\u4fc3\u8fdb\u9aa8\u9abc\u808c\u5206\u6ccc\u542b miR-378a-3p \u7684\u7ec6\u80de\u5916\u56ca\u6ce1\uff0c\u8be5\u56ca\u6ce1\u80fd\u4fc3\u8fdb\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u6e05\u9664\uff0c\u6539\u5584\u5c0f\u9f20\u8ba4\u77e5\u969c\u788d\uff0c\u800c\u8fc7\u8868\u8fbe miR-378a-3p \u7684\u808c\u7ba1\u6765\u6e90\u56ca\u6ce1\u53ef\u6a21\u62df\u8be5\u6548\u679c\uff0c\u4e3a AD \u63d0\u4f9b\u4e86\u8fd0\u52a8\u6a21\u62df\u578b\u6cbb\u7597\u65b0\u7b56\u7565<\/a>\u3002<\/p>\n

\"Nat<\/p>\n

\u8fd0\u52a8\u80fd\u62a4\u8111\uff0c\u662f\u8c01\u5728\u53d1\u6325\u4f5c\u7528\uff1f<\/h2>\n

\u9996\u5148\uff0c\u4f5c\u8005\u5bf9 6 \u6708\u9f84 APP\/PS1 \u5c0f\u9f20\u8fdb\u884c 4 \u5468\u6e38\u6cf3\u8fd0\u52a8\uff0c\u7ecf\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272\u3001\u6c34\u8ff7\u5bab\u5b9e\u9a8c\u7b49\u53d1\u73b0\uff0c\u5c0f\u9f20\u8111\u5185\u6dc0\u7c89\u6837\u6591\u5757\u51cf\u5c11\u3001\u8ba4\u77e5\u529f\u80fd\u63d0\u5347\u3002\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u3001\u86cb\u767d\u8d28\u5370\u8ff9\u7b49\u68c0\u6d4b\uff0c\u8fd0\u52a8\u540e\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d DAM \u6807\u5fd7\u7269\uff08Trem2\u3001CD11c \u7b49\uff09\u7684\u86cb\u767d\u548c mRNA<\/a> \u8868\u8fbe\u5747\u5347\u9ad8\u3002\u800c\u7528PLX5622\u8017\u7aed\u5c0f\u80f6\u8d28\u7ec6\u80de\u540e\uff0c\u8fd0\u52a8\u7684\u4fdd\u62a4\u4f5c\u7528\u6d88\u5931\uff0c\u5c0f\u9f20\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u3001\u6dc0\u7c89\u6837\u6591\u5757\u79ef\u7d2f\uff0c\u8bf4\u660e\u5c0f\u80f6\u8d28\u7ec6\u80de\u662f\u8fd0\u52a8\u6539\u5584 AD \u8ba4\u77e5\u7684\u5173\u952e\u3002<\/p>\n

\"Nat<\/p>\n

\u8fd0\u52a8\u5982\u4f55\u5411\u5927\u8111\u4f20\u9012\u4fe1\u53f7\uff1f\u7ec6\u80de\u5916\u56ca\u6ce1\u662f\u5173\u952e<\/h2>\n

\u8fd0\u52a8\u7684\u662f\u817f\uff0c\u6307\u6325\u7684\u662f\u5927\u8111\uff0c\u4fe1\u53f7\u662f\u600e\u4e48\u4f20\u8fc7\u53bb\u7684\uff1f<\/strong><\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u8fd0\u52a8\u540e\u7684\u5c0f\u9f20\uff0c\u9aa8\u9abc\u808c\u4f1a\u5927\u91cf\u5206\u6ccc\u4e00\u79cd\u4e1c\u897f\uff1a\u7ec6\u80de\u5916\u56ca\u6ce1<\/strong>\uff08SKM-EVs\uff09——\u4f60\u53ef\u4ee5\u628a\u5b83\u7406\u89e3\u6210\u7ec6\u80de\u53d1\u51fa\u7684“\u5feb\u9012<\/a>\u5c0f\u6ce1”\uff0c\u91cc\u9762\u88c5\u7740\u86cb\u767d\u8d28\u3001\u8102\u8d28\u3001\u8fd8\u6709\u66f4\u91cd\u8981\u7684\uff1amiRNA\u3002\u7ed9\u56ca\u6ce1\u88c5\u4e0a\u7eff\u8272\u8367\u5149\u6807\u8bb0\u540e\uff0c\u89c2\u5bdf\u5230 SKM-EVs \u53ef\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u8fdb\u5165\u5927\u8111\u76ae\u5c42\u548c\u6d77\u9a6c\u4f53\uff0c\u5e76\u5728\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d\u79ef\u7d2f\uff1b\u4e5f\u5c31\u662f\u8bf4\uff0c\u9aa8\u9abc\u808c\u5206\u6ccc\u7684\u56ca\u6ce1\u80fd\u4f5c\u4e3a\u4fe1\u4f7f\uff0c\u4ece\u808c\u8089\u51fa\u53d1\u8fdb\u5165\u5927\u8111\uff0c\u7cbe\u51c6\u627e\u5230\u5c0f\u80f6\u8d28\u7ec6\u80de\u3002<\/p>\n

\"Nat<\/p>\n

\u7ec6\u80de\u5916\u56ca\u6ce1\u91cc\u88c5\u7684\u5565\u5b9d\u8d1d\uff0c\u662f\u6539\u5584 AD \u8ba4\u77e5\u7684\u6838\u5fc3\u5206\u5b50\uff1f<\/h2>\n

\u6d4b\u5e8f\u7ed3\u679c\u663e\u793a\uff0c\u8fd0\u52a8\u540e\u808c\u8089\u5206\u6ccc\u7684\u56ca\u6ce1\u91cc\uff0c\u4e00\u79cd\u53ebmiR-378a-3p\u7684\u5206\u5b50\u542b\u91cf\u98d9\u5347\u3002\u800c\u4e14\uff0c\u5927\u8111\u91cc\u7684miR-378a-3p\uff0c\u7edd\u5927\u90e8\u5206\u6765\u81ea\u808c\u8089\uff0c\u4e0d\u662f\u5927\u8111\u81ea\u5df1\u4ea7\u7684\u3002\u5411 AD \u5c0f\u9f20\u6d77\u9a6c\u6ce8\u5c04 miR-378a-3p \u6fc0\u52a8\u5242\uff0c\u6216\u901a\u8fc7 AAV \u75c5\u6bd2\u5b9e\u73b0\u9aa8\u9abc\u808c\u7279\u5f02\u6027\u8fc7\u8868\u8fbe\u8be5\u5206\u5b50\uff0c\u5747\u80fd\u6fc0\u6d3b DAM\u3001\u51cf\u5c11\u6dc0\u7c89\u6837\u6591\u5757\u3001\u6539\u5584\u8ba4\u77e5\uff1b\u800c\u6572\u4f4e\u8be5\u5206\u5b50\u5219\u4f1a\u62b5\u6d88\u8fd0\u52a8\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5c3e\u9759\u8109\u6ce8\u5c04\u8fd0\u52a8\u6e90\u6027 SKM-EVs \u53ef\u663e\u8457\u6539\u5584 AD \u5c0f\u9f20\u8ba4\u77e5\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e SKM-EVs \u53ca\u5176\u643a\u5e26\u7684 miR-378a-3p \u7684\u6838\u5fc3\u4f5c\u7528\u3002<\/p>\n

\"Nat<\/p>\n

miR-378a-3p \u4fe1\u4f7f\u5982\u4f55\u5de5\u4f5c\uff1f<\/h2>\n

miR-378a-3p\u8fdb\u5165\u5c0f\u80f6\u8d28\u7ec6\u80de\u540e\uff0c\u662f\u5982\u4f55\u53d1\u6325\u4f5c\u7528\u7684\uff1f\u7b80\u5355\u6765\u8bf4\uff0c\u5b83\u7ed9\u6e05\u6d01\u5de5\u52a0\u4e86\u6cb9\u3002\u5c0f\u80f6\u8d28\u7ec6\u80de\u88ab\u6fc0\u6d3b\u9700\u8981\u5927\u91cf\u80fd\u91cf\uff0c\u800cmiR-378a-3p\u5e2e\u5b83\u8c03\u52a8\u8102\u8d28\u3001\u52a0\u901f\u4ee3\u8c22\uff0c\u8ba9\u5b83\u6709\u4f53\u529b\u53bb\u6e05\u7406\u6dc0\u7c89\u6837\u6591\u5757\u3002\u800c\u4eba\u5de5\u6784\u5efa\u8fc7\u8868\u8fbe miR-378a-3p \u7684\u6a21\u578b\uff0c\u5c3e\u9759\u8109\u6ce8\u5c04\u540e\u53ef\u663e\u8457\u6539\u5584 AD \u5c0f\u9f20\u8ba4\u77e5\uff0c\u51cf\u5c11\u6dc0\u7c89\u6837\u6591\u5757\uff0c\u589e\u5f3a\u7a81\u89e6\u53ef\u5851\u6027\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u4eba\u5de5\u6784\u5efa\u5bcc\u542b miR-378a-3p \u7684\u56ca\u6ce1\uff0c\u53ef\u6a21\u62df\u8fd0\u52a8\u7684\u62a4\u8111\u6548\u679c\uff0c\u4e3a AD \u6cbb\u7597\u63d0\u4f9b\u65b0\u5de5\u5177\u3002<\/p>\n

\"Nat<\/p>\n

\u5168\u6587\u603b\u7ed3<\/h2>\n

\u672c\u7814\u7a76\u7cfb\u7edf\u63ed\u793a\u4e86\u8fd0\u52a8\u6539\u5584\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8ba4\u77e5\u969c\u788d\u7684\u808c - \u8111\u901a\u8baf<\/a>\u673a\u5236\uff1a\u6e38\u6cf3\u8fd0\u52a8\u8bf1\u5bfc\u9aa8\u9abc\u808c\u5206\u6ccc\u5bcc\u542b miR-378a-3p \u7684\u7ec6\u80de\u5916\u56ca\u6ce1\uff0c\u8be5\u56ca\u6ce1\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\u540e\u88ab\u5c0f\u80f6\u8d28\u7ec6\u80de\u6444\u53d6\uff0c\u901a\u8fc7\u9776\u5411 p110α \u8c03\u63a7\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff0c\u6fc0\u6d3b\u75be\u75c5\u76f8\u5173\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u6e05\u9664\u529f\u80fd\uff0c\u6700\u7ec8\u6539\u5584\u8ba4\u77e5\u969c\u788d\u3002\u540c\u65f6\u8bc1\u5b9e\uff0c\u8fc7\u8868\u8fbe miR-378a-3p \u7684\u808c\u7ba1\u6765\u6e90\u56ca\u6ce1\u53ef\u6a21\u62df\u8fd0\u52a8\u7684\u6cbb\u7597\u6548\u679c\uff0c\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u8fd0\u52a8\u6a21\u62df\u578b\u9776\u5411\u6cbb\u7597\u7b56\u7565\uff0c\u4e5f\u4e3a\u7406\u89e3\u5916\u5468\u7ec4\u7ec7\u4e0e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u901a\u8baf\u63d0\u4f9b\u4e86\u65b0\u89c6\u89d2\u3002<\/p>\n

\u7814\u7a76\u610f\u4e49<\/h2>\n

\u7406\u8bba\u610f\u4e49<\/strong>\uff1a\u9996\u6b21\u9610\u660e\u8fd0\u52a8\u4ecb\u5bfc\u7684\u9aa8\u9abc\u808c - \u8111\u901a\u8baf\u5206\u5b50\u673a\u5236\uff0c\u63ed\u793a miR-378a-3p \u8c03\u63a7\u5c0f\u80f6\u8d28\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u4e0e\u6fc0\u6d3b\u7684\u65b0\u901a\u8def\uff0c\u4e30\u5bcc AD \u795e\u7ecf\u708e\u75c7\u4e0e\u4ee3\u8c22\u8c03\u63a7\u7406\u8bba\u3002<\/p>\n

\u5e94\u7528\u610f\u4e49<\/strong>\uff1a\u8bc1\u5b9e\u8fc7\u8868\u8fbe miR-378a-3p \u7684\u808c\u7ba1\u56ca\u6ce1\u53ef\u6a21\u62df\u8fd0\u52a8\u6548\u679c\uff0c\u4e3a AD \u60a3\u8005\u63d0\u4f9b\u975e\u8fd0\u52a8\u4f9d\u8d56\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6848\uff0c\u89e3\u51b3 AD \u60a3\u8005\u8fd0\u52a8\u80fd\u529b\u53d7\u9650\u7684\u6cbb\u7597\u56f0\u5883\u3002<\/p>\n

\u5c0f\u7f16\u5bc4\u8bed\uff1a<\/h2>\n

\u4ee5\u524d\u529d\u957f\u8f88\u4eec\u8fd0\u52a8\uff0c\u8bf4\u7684\u662f“\u5bf9\u8eab\u4f53\u597d”\uff0c\u591a\u5c11\u5e26\u7740\u70b9\u6577\u884d\u3002\u4eca\u5929\u518d\u5f00\u53e3\uff0c\u8111\u5b50\u91cc\u5168\u662f\u90a3\u4e9b\u4ece\u808c\u8089\u51fa\u53d1\u3001\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\u3001\u6700\u540e\u88ab\u5c0f\u80f6\u8d28\u7ec6\u80de\u541e\u4e0b\u540e\u6539\u5584\u8ba4\u77e5\u7684\u8fc7\u7a0b\u3002<\/p>\n

\u539f\u6765\uff0c\u6bcf\u4e00\u6b21\u8fd0\u52a8\uff0c\u54ea\u6015\u53ea\u662f\u996d\u540e\u6563\u6b65\u534a\u5c0f\u65f6\u3001\u516c\u56ed\u91cc\u4e00\u5957\u7f13\u6162\u7684\u592a\u6781\uff0c\u90fd\u5728\u4e3a\u672a\u6765\u7684\u81ea\u5df1\uff0c\u591a\u5b58\u4e00\u70b9\u6e05\u9192\u7684\u5e95\u6c14\u3002<\/p>\n

\u6700\u597d\u7684\u9884\u9632\uff0c\u6c38\u8fdc\u59cb\u4e8e\u811a\u4e0b\u3002<\/strong><\/p>\n

\u539f\u6587\u94fe\u63a5\uff1a<\/span><\/span><\/span><\/span><\/span>https:\/\/doi.org\/10.1038\/s43587-026-01075-5<\/span><\/span><\/span><\/p>\n

(\u6765\u6e90\uff1a\u949b\u5a92\u4f53)<\/p>\n","protected":false},"excerpt":{"rendered":"

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