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\u4ece\u5df2\u83b7\u6279\u7684\u836f\u7269\u6765\u770b\uff0cLEO Pharma\u7684Tralokinumab\u4e0e\u793c\u6765\u7684Lebrikizumab\u90fd\u662f\u9776\u5411IL\u201113\u7684\u5355\u6297\uff0cGalderma\u7684Nemolizumab\u5219\u662f\u9776\u5411IL\u201131RA\u7684\u5355\u6297\u3002<\/p>\n

IL\u20114\u3001IL\u201113\u548cIL\u201131\u5747\u662fTh2\u578b\u7ec6\u80de\u56e0\u5b50\uff0c\u4e5f\u662f\u8fde\u63a5\u514d\u75ab\u708e\u75c7\u4e0e\u795e\u7ecf\u7619\u75d2\u53cd\u5e94\u7684\u901a\u8def\u5206\u5b50\u3002\u5176\u4e2d\uff0cIL-13–IL-13Rα\u5bf9IL-4Rα\u5177\u6709\u9ad8\u4eb2\u548c\u529b\uff0c\u800cIL-4\u5bf9IL-13\u4eb2\u548c\u529b\u4f4e\uff0c\u8fd9\u63d0\u793aIL-13\u590d\u5408\u7269\u6bd4IL-4\u4f5c\u7528\u66f4\u7a33\u5b9a\uff0c\u8fd9\u4e5f\u4f53\u73b0\u5728\u4e86\u836f\u7269\u4e0a\u3002<\/p>\n

Tralokinumab\u5728\u771f\u5b9e\u4e16\u754c\u7684\u957f\u671f\u968f\u8bbf\u4e2d\u663e\u793a\u51fa\u7a33\u5b9a\u7684\u7597\u6548\uff0c\u56db\u5e74\u968f\u8bbf\u6570\u636e\u663e\u793a\u8fd1\u4e03\u6210\u60a3\u8005\u7619\u75d2\u51cf\u8f7b\u81f3\u8f7b\u5ea6\u6216\u6d88\u5931\uff1b\u800cLebrikizumab\u5219\u901a\u8fc7\u7ed9\u836f\u9891\u7387\u53d1\u6325\u4f18\u52bf\uff0c\u5728\u5b8c\u6210\u521d\u59cb\u8bf1\u5bfc\u6cbb\u7597\u540e\uff0c\u5c06\u7ed9\u836f\u9891\u7387\u8f6c\u4e3a\u6bcf\u56db\u5468\u4e00\u6b21\u7684\u7ef4\u6301\u65b9\u6848\uff0c\u5927\u5e45\u63d0\u5347\u60a3\u8005\u957f\u671f\u4f9d\u4ece\u6027\u3002\u4e00\u9879\u771f\u5b9e\u4e16\u754c\u961f\u5217\u6bd4\u8f83\u7684\u7ed3\u8bba\u4e3alebrikizumab\u8010\u53d7\u6027\u826f\u597d\uff0c\u662f\u4e2d\u91cd\u5ea6AD\u60a3\u8005\u957f\u671f\u6cbb\u7597\u7684\u9009\u62e9\u3002<\/p>\n

\u76f8\u6bd4\u4e4b\u4e0b\uff0cIL\u201131\u4e5f\u53c2\u4e0e\u795e\u7ecf\u514d\u75ab\u901a\u8def\uff0c\u4f46\u66f4\u91cd\u8981\u8eab\u4efd\u662f\u7619\u75d2\u53cd\u5e94\u7684\u91cd\u8981\u4ecb\u8d28\uff0c\u73b0\u6709\u7814\u7a76\u8868\u660e\uff0cAD\u60a3\u8005\u53d7\u635f\u76ae\u80a4\u4e2d\u7684IL\u201131\u6c34\u5e73\u663e\u8457\u5347\u9ad8\u3002<\/p>\n

\u8fd9\u4e5f\u6210\u4e3a\u4e86Nemolizumab\u7684\u5dee\u5f02\u4f18\u52bf\uff0c\u901a\u8fc7\u76f4\u63a5\u963b\u65adIL-31\u7619\u75d2\u7684\u795e\u7ecf\u4fe1\u53f7\u4f20\u5bfc\uff0c\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7597\u540e\u768448\u5c0f\u65f6\u5185\u5373\u53ef\u663e\u8457\u7f13\u89e3\u7619\u75d2\uff0c\u6ee1\u8db3\u60a3\u8005\u6700\u7d27\u8feb\u7684\u9700\u6c42\u3002\u8fd9\u4e5f\u4f7f\u5f97\u8be5\u836f\u5728\u83b7\u6279AD\u9002\u5e94\u75c7\u4ec5\u534a\u5e74\u5c31\u5b9e\u73b0\u4e861.31\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\u3002<\/p>\n

\u9664\u4e86\u5355\u6297\uff0c\u53cc\u6297\u3001\u591a\u6297\u4e5f\u5728\u4e0d\u65ad\u63a2\u7d22\u4e2d\u3002\u4f8b\u5982\u5f3a\u751f\u7684JNJ\u20115939\u540c\u65f6\u9776\u5411IL\u20114Rα\u4e0eIL\u201131\uff0c\u7406\u8bba\u4e0a\u65e2\u53ef\u957f\u671f\u6539\u5584\u76ae\u635f\uff0c\u53c8\u53ef\u5feb\u901f\u6b62\u75d2\uff0c\u4f46\u8be5\u9879\u76ee\u56e0\u7597\u6548\u95ee\u9898\u88ab\u63d0\u524d\u7ec8\u6b62\u3002<\/p>\n

OX40\/OX40L\u9776\u70b9\u4e5f\u662f\u4f17\u591a\u4f01\u4e1a\u7684\u9009\u62e9\u3002\u5176\u4e2d\u8d5b\u8bfa\u83f2\u7684Amlitelimab\u5c31\u662f\u4e00\u6b3eOX40L\u5355\u6297\uff0c\u4f5c\u4e3aDupilumab\u4e13\u5229\u5230\u671f\u540e\u7684\u6838\u5fc3\u7ba1\u7ebf\u5907\u53d7\u671f\u5f85\uff0c\u4f46\u4e34\u5e8a\u6570\u636e\u559c\u5fe7\u53c2\u534a\u30023\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8868\u73b0\u4f18\u4e8e\u5b89\u6170\u5242\uff0c\u4f46\u5bf9\u6bd4\u5ea6\u666e\u5229\u5c24\u5355\u6297\u5e76\u65e0\u4f18\u52bf\uff0c\u51ed\u501f\u4e00\u5e74\u7ed9\u836f4\u6b21\u7684\u4f9d\u4ece\u6027\u4f18\u52bf\uff0c\u516c\u53f8\u4ecd\u8ba1\u5212\u4eca\u5e74\u4e0b\u534a\u5e74\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n

\u534f\u548c\u9e92\u9e9f\u7684Rocatinlimab\u4e5f\u662f\u9776\u5411OX40\u7684\u5355\u6297\uff0c\u6b64\u524d\u56e0\u5728\u7597\u6548\u4e0a\u4e0d\u5177\u5907\u660e\u663e\u7ade\u4e89\u4f18\u52bf\uff0c\u4e14\u53d1\u70e7\u3001\u53d1\u51b7\u7b49\u6ce8\u5c04\u526f\u4f5c\u7528\u53d1\u75c5\u7387\u9ad8\uff0c\u88ab\u5b89\u8fdb\u9000\u56de\u30023\u67083\u65e5\uff0c\u534f\u548c\u9e92\u9e9f\u5ba3\u5e03\uff0c\u56e0\u5b89\u5168\u6027\u95ee\u9898\uff0c\u516c\u53f8\u51b3\u5b9a\u7ec8\u6b62\u6240\u6709\u6b63\u5728\u8fdb\u884c\u7684Rocatinlimab\u4e34\u5e8a\u8bd5\u9a8c\u3002OX40\u9776\u70b9\u53c8\u88ab\u7834\u4e86\u4e00\u76c6\u51b7\u6c34\u3002<\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u8fd8\u6709IL\u20112\u3001IL-7\u3001IL\u201118\u3001IL-33\u7b49\u514d\u75ab\u9776\u70b9\u836f\u7269\u4e5f\u9646\u7eed\u88ab\u8bbe\u8ba1\u5e76\u8fdb\u5165\u4e34\u5e8a\u3002<\/p>\n

\u65b0\u9776\u70b9\u63a2\u7d22\u4e0d\u65ad\u7684\u540c\u65f6\uff0cJAK\u6291\u5236\u5242\u4e5f\u662fAD\u6cbb\u7597\u7684\u4e00\u5927\u7814\u53d1\u70ed\u70b9\u3002\u76ee\u524d\u5df2\u83b7\u6279AD\u9002\u5e94\u75c7\u7684\u5305\u62ec\u827e\u4f2f\u7ef4\u7684Rinvoq\u3001\u8f89\u745e<\/a>\u7684Cibinqo\u548c\u793c\u6765\u7684Olumiant\u3002<\/p>\n

JAK\u6291\u5236\u5242\u901a\u8fc7\u963b\u65adJanus\u6fc0\u9176\u7684\u6d3b\u6027\u5b9e\u73b0\u708e\u75c7\u56e0\u5b50\u7684\u5e7f\u8c31\u6291\u5236\uff0c\u4f18\u52bf\u5728\u4e8e\u53e3\u670d\u3001\u8d77\u6548\u5feb\u3001\u7619\u75d2\u6539\u5584\u660e\u663e\uff0c\u77ed\u671f\u7597\u6548\u5f80\u5f80\u4f18\u4e8e\u751f\u7269\u5236\u5242\u3002\u4f46\u5176\u957f\u671f\u5b89\u5168\u6027\u4ecd\u9700\u89c2\u5bdf\u3002\u7531\u4e8e\u6f5c\u5728\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08\u8840\u6813\u3001\u5fc3\u810f\u75c5\uff09\uff0cFDA\u8981\u6c42JAK\u7c7b\u4ea7\u54c1\u52a0\u4e0a\u9ed1\u6846\u8b66\u544a\u3002\u8fd9\u4e5f\u610f\u5473\u7740\uff0c\u5728\u9700\u8981\u7ec8\u8eab\u7528\u836f\u7684AD\u9886\u57df\uff0cJAK\u4e0d\u662f\u957f\u671f\u89e3\u51b3\u65b9\u6848\u7684\u9996\u9009\u3002<\/p>\n

\u603b\u4f53\u6765\u770b\uff0cAD\u7814\u53d1\u5df2\u8fdb\u5165\u5168\u9762\u52a0\u901f\u671f\uff0c\u673a\u5236\u8fb9\u754c\u5c1a\u672a\u5c01\u9876\uff0c\u9776\u70b9\u63a2\u7d22\u4ecd\u5728\u7ee7\u7eed\u3002\u4e14\u968f\u7740\u591a\u6b3e\u836f\u7269\u6210\u529f\u4e0a\u5e02\uff0c“\u56f4\u527f”\u5ea6\u666e\u5229\u5c24\u5355\u6297\u7684\u52bf\u5934\u5df2\u7ecf\u5f62\u6210\u3002<\/p>\n

\u53ea\u4e0d\u8fc7\uff0c\u5bf9\u6240\u6709\u540e\u6765\u8005\u6765\u8bf4\uff0c\u5ea6\u666e\u5229\u5c24\u5355\u6297\u4ecd\u662f\u6a2a\u4e98\u5728AD\u8d5b\u9053\u7684\u4e00\u5ea7\u5927\u5c71\uff0c\u65b0\u836f\u9700\u8981\u98a0\u8986\u6027\u6210\u529f\u624d\u80fd\u7834\u5c40\u3002<\/p>\n

\u4e0d\u53ef\u5ffd\u89c6\u7684\u4e2d\u56fd\u53d8\u91cf<\/h2>\n

\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4e2d\u56fd\u521b\u65b0\u836f\u4f01\u4e5f\u662fAD\u7814\u53d1\u70ed\u6f6e\u4e2d\u7684\u91cd\u8981\u529b\u91cf\u3002<\/p>\n

\u4e00\u65b9\u9762\uff0c\u6211\u56fd\u6210\u4ebaAD\u60a3\u75c5\u7387\u4e3a3%-8%\uff0c\u513f\u7ae510%-15%\uff0c\u5360\u6bd4\u867d\u4f4e\u4e8e\u5168\u7403\u5e73\u5747\u6c34\u5e73\uff0c\u4f46\u589e\u957f\u660e\u663e\u3002<\/p>\n

\u56fd\u5185\u76ee\u524d\u5df2\u83b7\u6279\u4e0a\u5e02\u7684\u514d\u75ab\u6291\u5236\u5242\u836f\u7269\u5305\u62ec\u4e24\u6b3eIL-4α\u5355\u6297\u5ea6\u666e\u5229\u5c24\u5355\u6297\u3001\u53f8\u666e\u5947\u62dc\u5355\u6297\uff0c\u4e09\u6b3eJAK\u6291\u5236\u5242Rinvoq\u3001Cibinqo\u3001\u827e\u739b\u6614\u66ff\u5c3c\uff0c\u4ee5\u53ca3\u67083\u65e5\u521a\u521a\u83b7\u6279\u7684\u793c\u6765IL-13\u5355\u6297Lebrikizumab\u3002\u6cbb\u7597\u9009\u62e9\u5df2\u521d\u5177\u89c4\u6a21\uff0c\u4f46\u60a3\u8005\u7684\u5dee\u5f02\u5316\u9700\u6c42\u4ecd\u5b58\u5728\uff0c\u4e14\u5728\u5b89\u5168\u6027\u548c\u957f\u671f\u7528\u836f\u9009\u62e9\u4e0a\u4ecd\u6709\u4f18\u5316\u7a7a\u95f4\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u4ee5\u8d5b\u8bfa\u83f2\u4e3a\u4ee3\u8868\u7684\u4f01\u4e1a\u901a\u8fc7\u53bf\u57df\u5e02\u573a\u4e0b\u6c89\u63a8\u5e7f\uff0c\u5b8c\u6210\u4e86\u65e9\u671f\u75be\u75c5\u8ba4\u77e5\u4e0e\u6cbb\u7597\u6e17\u900f\uff0c\u8fd9\u4e5f\u4e3a\u56fd\u4ea7\u836f\u7269\u4e0a\u5e02\u94fa\u5e73\u4e86\u5546\u4e1a\u5316\u9053\u8def\u3002<\/p>\n

\u5728\u836f\u4f01\u5728\u9776\u70b9\u9009\u62e9\u4e2d\uff0cIL\u20114Rα\u5360\u6bd4\u6700\u5927\uff0c\u4e14\u90fd\u5df2\u63a8\u8fdb\u81f3\u540e\u671f\u3002<\/p>\n

\u5eb7\u8bfa\u4e9a\u7684\u53f8\u666e\u5947\u62dc\u5355\u6297\u662f\u5168\u7403\u7b2c\u4e8c\u6b3e\u83b7\u6279\u7684IL-4Rα\uff0c\u5728\u6b64\u4e4b\u540e\u591a\u6b3e\u56fd\u4ea7\u836f\u7269\u52a0\u901f\u63a8\u8fdb\u4e34\u5e8a\uff0c\u8fd1\u671f\u8fce\u6765\u4e86\u4e00\u6ce2\u4e0a\u5e02\u9ad8\u6f6e\u3002\u5148\u58f0\u836f\u4e1a\/\u5eb7\u4e43\u5fb7\u7684\u4e50\u5fb7\u5947\u62dc\u5355\u6297\u3001\u5eb7\u54f2\u836f\u4e1a\/\u9ea6\u6d4e\u751f\u7269\u7684\u67ef\u7f8e\u5947\u62dc\u5355\u6297\u3001\u667a\u7fd4\u91d1\u6cf0\u7684\u6cf0\u5229\u5947\u62dc\u5355\u6297\u5df2\u4e8e\u53bb\u5e74\u901a\u8fc7\u4e0a\u5e02\u7533\u8bf7\u3002\u8fd1\u65e5\uff0c\u4e09\u751f\u56fd\u5065\u7684SSGJ\u2011611\u3001\u5eb7\u65b9\u751f\u7269\u7684\u66fc\u591a\u5947\u5355\u6297\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u4e5f\u5df2\u83b7\u5f97NMPA\u53d7\u7406\uff0cIL-4α\u9886\u57df\u7684\u7ade\u4e89\u6fc0\u70c8\u3002<\/p>\n

\u53e6\u4e00\u5927\u9635\u8425JAK\u6291\u5236\u5242\u4e2d\uff0c\u6052\u745e\u533b\u836f\u7684\u827e\u739b\u6614\u66ff\u5c3c\u57282025\u5e74\u987a\u5229\u4e0a\u5e02\u3002\u51cc\u79d1\u836f\u4e1a\u7684\u7b2c\u4e8c\u4ee3JAK1\u6291\u5236\u5242\u6cfd\u666e\u6614\u66ff\u5c3c\u8fd1\u65e5\u5ba3\u5e03\u6cbb\u7597\u4e2d\u91cd\u5ea6AD\u76843\u671f\u9876\u7ebf\u6570\u636e\uff0c\u503c\u5f97\u5173\u6ce8\u7684\u5176\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e0e\u5b89\u6170\u5242\u76f8\u5f53\uff0c\u4e0e\u5df2\u83b7\u6279\u7684JAK\u6291\u5236\u5242\u76f8\u6bd4\u5b89\u5168\u6027\u5177\u6709\u7ade\u4e89\u529b\u3002<\/p>\n

\u5f53\u7136\uff0c\u4e2d\u56fd\u836f\u4f01\u5e76\u4e0d\u53ea\u662f\u66ff\u4ee3\u8ddf\u8dd1\u3002\u8bfa\u8bda\u5065\u534e\u7684ICP-332\u662fTYK2\u6291\u5236\u5242\uff0c\u5728AD\u8fd9\u4e00\u9002\u5e94\u75c7\u4e0a\u662f\u5168\u7403\u8fdb\u5c55\u6700\u5feb\u7684TYK2\u65b0\u836f\uff0c\u76ee\u524d\u6cbb\u7597\u4e2d\u91cd\u5ea6AD\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u5168\u90e8\u5165\u7ec4\u3002<\/p>\n

\u603b\u4f53\u6765\u770b\uff0c\u5e9e\u5927\u7684\u60a3\u8005\u57fa\u6570\u4e0e\u957f\u671f\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\uff0c\u5171\u540c\u63a8\u52a8AD\u7814\u53d1\u8fdb\u5165\u52a0\u901f\u5468\u671f\u3002\u8fd9\u4e5f\u5bf9\u836f\u4f01\u7684\u7597\u6548\u3001\u5b89\u5168\u6027\u3001\u7814\u53d1\u901f\u5ea6\u7b49\u63d0\u51fa\u4e86\u66f4\u9ad8\u7684\u8981\u6c42\u3002<\/p>\n

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