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\u9664\u4e86\u4e1a\u52a1\u5c42\u9762\u7684\u5408\u4f5c\uff0c\u793c\u6765\u8fd8\u66fe\u53c2\u4e0e\u4fe1\u8fbe\u751f\u7269\u7684\u878d\u8d44<\/a>\u3002\u5929\u773c\u67e5\u663e\u793a\uff0c\u65e9\u57282012\u5e74\uff0c\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u5c31\u66fe\u9886\u6295\u4fe1\u8fbe\u751f\u7269\u878d\u8d44\u91d1\u989d\u9ad8\u8fbe3000\u4e07\u7f8e\u5143\u7684B\u8f6e\u878d\u8d44\u3002<\/p>\n

\u6b64\u540e\uff0c\u793c\u6765\u591a\u6b21\u62bc\u5b9d\u4fe1\u8fbe\u751f\u7269\u30022018\u5e74\uff0c\u4fe1\u8fbe\u751f\u7269\u6210\u529f\u53e9\u5f00\u6e2f\u4ea4\u6240<\/a>\u7684\u5927\u95e8\u3002<\/p>\n

\u7136\u800c\uff0c\u6210\u529f\u767b\u9646\u8d44\u672c\u5e02\u573a\u540e\uff0c\u4fe1\u8fbe\u751f\u7269\u5728\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\u5185\u90fd\u9762\u4e34\u7740\u521b\u65b0\u836f\u516c\u53f8\u666e\u904d\u5b58\u5728\u7684“\u9ad8\u6295\u5165+\u6301\u7eed\u4e8f\u635f”\u56f0\u5883\u3002<\/p>\n

\u540c\u82b1\u987aiFinD\u6570\u636e\u663e\u793a\uff0c\u81ea2018\u5e74\u4e0a\u5e02\u81f32024\u5e74\uff0c\u4fe1\u8fbe\u751f\u7269\u7d2f\u8ba1\u5f52\u6bcd\u51c0\u5229\u6da6\u4e8f\u635f\u89c4\u6a21\u8d85\u8fc7145\u4ebf\u5143\uff0c\u4ec52018\u5e74\u4e00\u5e74\u5c31\u4e8f\u635f\u8fd158\u4ebf\u5143\u3002<\/p>\n

\u4e0d\u8fc7\uff0c\u8fd1\u5e74\u6765\u4fe1\u8fbe\u751f\u7269\u7684\u7ecf\u8425\u72b6\u51b5\u9010\u6b65\u6539\u5584\uff0c\u4e8f\u635f\u89c4\u6a21\u6301\u7eed\u6536\u7a84\uff0c\u8425\u6536\u89c4\u6a21\u5219\u4e0d\u65ad\u6500\u5347\u3002<\/p>\n

\u53bb\u5e74\u4e0a\u534a\u5e74\uff0c\u4fe1\u8fbe\u751f\u7269\u65a9\u83b7\u8425\u653659.53\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f50.62%\u3002\u540c\u65f6\uff0c\u516c\u53f8\u7ec8\u4e8e\u6446\u8131\u4e8f\u635f\u6ce5\u6cbc\uff0c\u5f55\u5f97\u5f52\u6bcd\u51c0\u5229\u6da68.34\u4ebf\u5143\uff0c\u6210\u529f\u626d\u4e8f\u4e3a\u76c8\u3002<\/p>\n

\u5bf9\u4e8e\u53bb\u5e74\u4e0a\u534a\u5e74\u4ea4\u51fa\u7684\u4e1a\u7ee9<\/a>\u7b54\u5377\uff0c\u4fe1\u8fbe\u751f\u7269\u8868\u793a\uff0c\u6536\u5165\u589e\u957f\u4e3b\u8981\u5f97\u76ca\u4e8e\u80bf\u7624\u4ea7\u54c1\u7684\u5f3a\u52b2\u8868\u73b0\u3001\u7efc\u5408\u4ea7\u54c1\u7ebf\u7684\u6269\u5c55\u4ee5\u53ca\u8bb8\u53ef\u8d39\u6536\u5165\u7684\u589e\u52a0\u3002<\/p>\n

\u800c\u516c\u53f8\u5229\u6da6\u8f6c\u4e8f\u4e3a\u76c8\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\uff0c\u5305\u62ec\u5f3a\u52b2\u7684\u6536\u5165\u589e\u957f\u4ee5\u53ca\u7ecf\u8425\u6548\u7387\u7684\u63d0\u5347\u3002<\/p>\n

\u5c31\u5728\u6b64\u756a\u5ba3\u5e03\u4e0e\u793c\u6765\u8fbe\u6210\u6700\u65b0\u5408\u4f5c\u51e0\u5929\u524d\u76842\u67084\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u53d1\u5e032025\u5e74\u5168\u5e74\u53ca\u7b2c\u56db\u5b63\u5ea6\u4ea7\u54c1\u6536\u5165\u5b9e\u73b0\u5f3a\u52b2\u589e\u957f\u7684\u5185\u5e55\u516c\u544a\u3002<\/p>\n

\u516c\u544a\u663e\u793a\uff0c2025\u5e74\uff0c\u4fe1\u8fbe\u751f\u7269\u603b\u4ea7\u54c1\u6536\u5165\u589e\u957f\u7ea645%\uff0c\u8fbe\u5230\u7ea6119\u4ebf\u5143\uff0c\u8fd9\u4e5f\u662f\u516c\u53f8\u6709\u53f2\u4ee5\u6765\u4ea7\u54c1\u6536\u5165\u9996\u6b21\u7a81\u7834\u767e\u4ebf\u5927\u5173\u3002<\/p>\n

\u5176\u4e2d\uff0c\u53bb\u5e74\u7b2c\u56db\u5b63\u5ea6\uff0c\u516c\u53f8\u5b9e\u73b0\u603b\u4ea7\u54c1\u6536\u5165\u7ea633\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f\u8d8560%\uff0c\u4f46\u73af\u6bd4\u7b2c\u4e09\u5b63\u5ea6\u51e0\u4e4e\u6301\u5e73\u3002<\/p>\n

\u4fe1\u8fbe\u751f\u7269\u8868\u793a\uff0c\u4e8e2025\u5e74\u7b2c\u56db\u5b63\u5ea6\uff0c\u56e0\u516d\u6b3e\u65b0\u836f\u9996\u6b21\u7eb3\u51652026\u5e74\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0c\u516c\u53f8\u5c31\u6309\u539f\u4ef7\u683c\u5206\u9500\u81f3\u6e20\u9053\u7684\u4ea7\u54c1\uff0c\u8ba1\u63d0\u4e86\u76f8\u5e94\u91d1\u989d\u7684\u4e00\u6b21\u6027\u5e93\u5b58\u8865\u5dee\u3002<\/p>\n

\u6614\u65e5\u653e\u725b\u5a03\uff0c\u6210\u767e\u4ebf\u533b\u836f\u5927\u4f6c<\/strong><\/h2>\n

\u4f5c\u4e3a\u4fe1\u8fbe\u751f\u7269\u7684\u521b\u59cb\u4eba\uff0c\u4fde\u5fb7\u8d85\u65e0\u7591\u5728\u516c\u53f8\u7684\u53d1\u5c55\u4e4b\u8def\u4e0a\u626e\u6f14\u4e86\u91cd\u8981\u89d2\u8272\u3002<\/p>\n

1964\u5e74\uff0c\u4fde\u5fb7\u8d85\u51fa\u751f\u4e8e\u6d59\u6c5f\u7701\u5929\u53f0\u53bf\u7684\u4e00\u4e2a\u504f\u50fb\u5c0f\u5c71\u6751\u300218\u5c81\u4ee5\u524d\uff0c\u653e\u725b\u780d\u67f4\u662f\u4fde\u5fb7\u8d85\u5370\u8c61\u6700\u6df1\u7684\u7ae5\u5e74\u8bb0\u5fc6\uff0c\u800c\u53bb\u57ce\u91cc\u751f\u6d3b\u662f\u4ed6\u4eba\u751f\u7684\u7b2c\u4e00\u4e2a\u68a6\u60f3\u548c\u76ee\u6807\u3002<\/p>\n

1982\u5e74\uff0c\u4fde\u5fb7\u8d85\u8003\u4e0a\u6d59\u6c5f\u6797\u5b66\u9662\uff0c\u6210\u4e3a\u5bb6\u4e61\u7684\u7b2c\u4e00\u4f4d\u5927\u5b66\u751f\u3002\u4e4b\u540e\u4ed6\u53c8\u5728\u5357\u4eac\u6797\u4e1a\u5927\u5b66\u548c\u4e2d\u79d1\u9662\u653b\u8bfb\u7855\u58eb\u548c\u535a\u58eb\u5b66\u4f4d\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4fde\u5fb7\u8d85\u7684\u4e13\u4e1a\u9009\u62e9\u6709\u8fc7\u591a\u6b21\u8f6c\u53d8\uff0c\u4ed6\u5927\u5b66\u4e13\u4e1a\u662f\u7ecf\u6d4e\u6797\u4e13\u4e1a\uff0c\u7814\u7a76\u751f\u8bfb\u7684\u662f\u690d\u7269\u751f\u7406\u5b66\uff0c\u62a5\u8003\u535a\u58eb\u65f6\u5219\u88ab\u8c03\u5242\u5230\u5206\u5b50\u9057\u4f20\u5b66\u4e13\u4e1a\u3002<\/p>\n

1993\u5e74\uff0c\u4fde\u5fb7\u8d85\u524d\u5f80\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u836f\u7269\u5316\u5b66\u4e13\u4e1a\u535a\u58eb\u540e\u7ad9\u6df1\u9020\u3002\u6bd5\u4e1a\u540e\uff0c\u4ed6\u8c22\u7edd\u4e86\u54c8\u4f5b\u5927\u5b66\u7684\u9080\u8bf7\uff0c\u5148\u540e\u4f9b\u804c\u4e8e\u5305\u62ecCell Genesis\u3001Applied Genetics\u5728\u5185\u7684\u591a\u5bb6\u751f\u7269\u77e5\u540d\u836f\u4f01\u3002<\/p>\n

\u5728\u8fd9\u671f\u95f4\uff0c\u4fde\u5fb7\u8d85\u7684\u6bcd\u4eb2\u5f97\u4e86\u80c3\u764c\uff0c\u8fd9\u5bf9\u4fde\u5fb7\u8d85\u89e6\u52a8\u5f88\u5927\uff0c\u4e5f\u662f\u8ba9\u4ed6\u51b3\u5fc3\u52a0\u5165\u7f8e\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8\u7684\u52a8\u673a\u4e4b\u4e00\u3002<\/p>\n

\u5728\u79ef\u7d2f\u4e86\u5927\u91cf\u5b9e\u9a8c\u6210\u679c\u548c\u53d1\u660e\u4e13\u5229\uff0c\u5e76\u610f\u8bc6\u5230\u4e2d\u7f8e\u751f\u7269\u5236\u836f\u9886\u57df\u7684\u73b0\u5b9e\u5dee\u8ddd\u540e\uff0c\u4fde\u5fb7\u8d85\u7acb\u5fd7\u8981\u521b\u5efa\u4e00\u5bb6\u5c5e\u4e8e\u4e2d\u56fd\u4eba\u81ea\u5df1\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002<\/p>\n

2006\u5e74\u524d\u540e\uff0c\u4fde\u5fb7\u8d85\u6b63\u5f0f\u56de\u56fd\uff0c\u52a0\u5165\u5eb7\u5f18\u836f\u4e1a\uff0c\u53c2\u4e0e\u7ec4\u5efa\u5b50\u516c\u53f8\u6210\u90fd\u5eb7\u5f18\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff0c\u5e76\u62c5\u4efb\u5eb7\u5f18\u751f\u7269\u8463\u4e8b\u3001\u603b\u88c1\u53ca\u9996\u5e2d\u6267\u884c\u5b98\uff0c\u4ee5\u53ca\u5eb7\u5f18\u836f\u4e1a\u96c6\u56e2\u8463\u4e8b\u3001\u526f\u603b\u88c1\u3002<\/p>\n

\u5728\u4fde\u5fb7\u8d85\u7684\u9886\u5bfc\u4e0b\uff0c\u5eb7\u67cf\u897f\u666e\u7684\u7814\u53d1\u5de5\u4f5c\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u540e\u6765\u4f9d\u9760\u5eb7\u67cf\u897f\u666e\u7684\u5927\u83b7\u6210\u529f\uff0c\u5eb7\u5f18\u836f\u4e1a\u4e8e2015\u5e74\u987a\u5229\u767b\u9646A\u80a1\u5e02\u573a\u3002<\/p>\n

\u4e0d\u8fc7\uff0c\u4fde\u5fb7\u8d85\u672c\u4eba\u5374\u5728\u5eb7\u67cf\u897f\u666e\u4e0a\u5e02\u524d\u5915\u79bb\u5f00\u5eb7\u5f18\u836f\u4e1a\uff0c\u5e76\u4e8e2011\u5e748\u6708\u5728\u82cf\u5dde\u5de5\u4e1a\u56ed\u533a\u521b\u7acb\u4fe1\u8fbe\u751f\u7269\u3002<\/p>\n

\u521b\u4e1a<\/a>\u521d\u671f\uff0c\u4fe1\u8fbe\u751f\u7269\u9762\u4e34\u7740\u8bf8\u591a\u56f0\u96be\u3002\u8d44\u91d1\u77ed\u7f3a\u3001\u4eba\u624d\u532e\u4e4f\u3001\u6280\u672f\u74f6\u9888\u7b49\u95ee\u9898\u63a5\u8e35\u800c\u81f3\u3002<\/p>\n

\u4f46\u4fde\u5fb7\u8d85\u51ed\u501f\u5176\u5728\u884c\u4e1a\u5185\u7684\u5f71\u54cd\u529b\u548c\u4eba\u683c\u9b45\u529b\uff0c\u8fc5\u901f\u5438\u5f15\u4e86\u4e00\u6279\u5fd7\u540c\u9053\u5408\u7684\u4eba\u624d\u52a0\u5165\u3002\u540c\u65f6\uff0c\u4ed6\u79ef\u6781\u4e0e\u6295\u8d44<\/a>\u673a\u6784\u6c9f\u901a\uff0c\u4e3a\u516c\u53f8\u4e89\u53d6\u5230\u4e86\u5b9d\u8d35\u7684\u8d44\u91d1\u652f\u6301\u3002<\/p>\n

2012\u5e74\uff0c\u51ed\u501f\u654f\u9510\u7684\u884c\u4e1a\u6d1e\u5bdf\u529b\uff0c\u4fde\u5fb7\u8d85\u529b\u6392\u4f17\u8bae\uff0c\u679c\u65ad\u62bc\u6ce8PD-1\u8d5b\u9053\uff0c\u542f\u52a8\u4e86\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7814\u53d1\u9879\u76ee\u3002<\/p>\n

2015\u5e743\u6708\u548c10\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u4e24\u6b21\u4e0e\u793c\u6765\u8fbe\u6210\u4ea7\u54c1\u5f00\u53d1\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u4fe1\u8fbe\u5c064\u79cd\u521b\u65b0\u4ea7\u54c1\u7684\u6d77\u5916\u5e02\u573a\u8f6c\u8ba9\u7ed9\u7f8e\u56fd\u793c\u6765\u5f00\u53d1\uff0c\u83b7\u5f97“\u9996\u4ed8\u53ca\u91cc\u7a0b\u7891\u6b3e”33\u4ebf\u7f8e\u5143\uff0c\u5f00\u521b\u4e86\u4e2d\u56fd\u836f\u4f01\u4e0e\u56fd\u9645\u5de8\u5934\u5168\u9762\u5408\u4f5c\u7684\u5148\u4f8b\u3002<\/p>\n

\u5728\u5f53\u65f6\uff0cPD-1\u88ab\u89c6\u4e3a\u4e0b\u4e00\u4e2a“\u767e\u4ebf\u7f8e\u5143\u5206\u5b50”\u3002\u300a\u534e\u5c14\u8857<\/a>\u65e5\u62a5\u300b\u66f4\u662f\u5927\u80c6\u9884\u6d4b\uff1aPD-1\u5728\u5168\u7403\u7684\u6f5c\u5728\u5e02\u573a\u89c4\u6a21\u8fbe\u5230\u6bcf\u5e74350\u4ebf\u7f8e\u5143\u3002<\/p>\n

\u65f6\u95f4\u8f6c\u773c\u6765\u52302018\u5e7410\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u6210\u529f\u767b\u9646\u6e2f\u4ea4\u6240\uff0c\u5e76\u6253\u7834\u4e86\u6b64\u524d\u591a\u5bb6\u521b\u65b0\u836f\u516c\u53f8\u4e0a\u5e02\u4fbf\u7834\u53d1\u7684\u9b54\u5492\u3002<\/p>\n

\u540c\u5e74\u5e74\u672b\uff0c\u4fe1\u8fbe\u751f\u7269\u7684\u4fe1\u8fea\u5229\u5355\u6297\u6b63\u5f0f\u83b7\u6279\u4e0a\u5e02\u30022019\u5e74\uff0c\u4fe1\u8fbe\u751f\u7269\u7684\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u6210\u4e3a\u5f53\u5e74\u552f\u4e00\u8fdb\u5165\u65b0\u7248\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u7684PD-1\u5355\u6297\u836f\u7269\u3002<\/p>\n

\u6b64\u540e\u4e00\u6bb5\u65f6\u95f4\uff0c\u4fe1\u8fbe\u751f\u7269\u5f00\u542f\u4e86\u98de\u901f\u53d1\u5c55\u4e4b\u8def\u3002\u52302020\u5e74\u5e95\uff0c\u516c\u53f8\u7684\u9500\u552e\u56e2\u961f\u5df2\u7ecf\u591a\u8fbe1300\u4eba\u3002<\/p>\n

2020\u5e74\uff0c\u4fe1\u8fbe\u5728PD-1\u4e0a\u5168\u5e74\u5b9e\u73b0\u9500\u552e\u6536\u516522.9\u4ebf\u5143\uff0c\u8f832019\u540c\u6bd4\u589e\u957f\u4e86125.4%\u30022021\u5e74\uff0c\u5728\u5168\u90e8\u56fd\u4ea7PD-1\u9500\u552e\u6392\u540d\u4e2d\uff0c\u4fe1\u8fbe\u4e5f\u4ec5\u6b21\u4e8e\u6052\u745e\u3002<\/p>\n

\u96f7\u8fbe\u8d22\u7ecf\u6ce8\u610f\u5230\uff0c\u9664\u4e86\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4fe1\u8fbe\u751f\u7269\u8fd8\u5728\u5176\u4ed6\u9886\u57df\u79ef\u6781\u5e03\u5c40\uff0c\u5efa\u7acb\u4e86\u6db5\u76d6\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\u7684\u4e30\u5bcc\u4ea7\u54c1\u7ba1\u7ebf\u3002<\/p>\n

\u8fd9\u4e9b\u5176\u4ed6\u4e1a\u52a1\u7684\u5e03\u5c40\uff0c\u4e5f\u8ba9\u4fe1\u8fbe\u751f\u7269\u9010\u6e10\u8d70\u51fa\u524d\u4e9b\u5e74\u56fd\u4ea7PD-1\u5185\u5377\u964d\u4ef7\u7684\u4f4e\u6f6e\u3002<\/p>\n

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